公开(公告)号：WO0211550A3

公开(公告)日：2002-05-30

申请号：PCT/JP0106778

申请日：2001-08-07

Applicant: KAO CORP ,  KOIKE SHIN ,  YASUMASU TAKESHI ,  HASE TADASHI ,  MURASE TAKATOSHI ,  YASUKAWA TAKUJI ,  KATSURAGI YOSHIHISA ,  TAKEI AKIRA

Inventor： KOIKE SHIN ,  YASUMASU TAKESHI ,  HASE TADASHI ,  MURASE TAKATOSHI ,  YASUKAWA TAKUJI ,  KATSURAGI YOSHIHISA ,  TAKEI AKIRA

IPC: A21D2/16 ,  A21D13/02 ,  A21D13/06 ,  A21D13/08 ,  A23D7/01 ,  A23D7/015 ,  A23D9/013 ,  A23K1/16 ,  A23L1/24 ,  A23L1/29 ,  A23L1/30 ,  A23L1/32 ,  A61K31/232 ,  A61K31/56 ,  A61K45/06 ,  A23D9/00 ,  A61K31/20

CPC classification number: A21D13/068 ,  A21D2/16 ,  A21D13/02 ,  A21D13/80 ,  A23D7/011 ,  A23D7/013 ,  A23D7/015 ,  A23D9/013 ,  A23K20/158 ,  A23L15/20 ,  A23L27/60 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/232 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/1882 ,  A23V2250/182 ,  A23V2250/192 ,  A23V2250/194 ,  A23V2250/5108 ,  A23V2250/1874 ,  A23V2250/156 ,  A23V2250/70 ,  A23V2250/5118 ,  A23V2250/54246

Abstract: Provided is an oil/fat composition comprising 10.1 to 94.9 wt.% of a triglyceride, 0.1 to 30 wt.% of a monoglyceride and 5 to 59.9 wt.% of a diglyceride which has, as a fatty acid constituent thereof, 15 to 90 wt.% of an omega 3-unsaturated fatty acid having less than 20 carbon atoms. The oil/fat composition of the present invention has excellent heat stability, has body-fat-accumulation resisting action, visceral-fat-accumulation resisting action, blood-sugar-level lowering action, insulin resistance improving action and leptin lowering action and is useful for, as well as pharmaceuticals, preventive or remedial food for diabetes or obesity, and feed.

Abstract translation: 本发明提供一种油脂组合物，其含有10.1〜94.9重量％的甘油三酯，0.1〜30重量％的甘油单酯和5〜59.9重量％的甘油二酯，其脂肪酸成分为15〜90 具有少于20个碳原子的ω-3-不饱和脂肪酸的重量％。 本发明的油/脂肪组合物具有优异的热稳定性，具有体脂肪积累抵抗作用，内脏脂肪蓄积阻力作用，血糖降低作用，胰岛素抵抗改善作用和瘦素降低作用，是有用的 以及药物，预防或补救性食物用于糖尿病或肥胖，以及饲料。

公开(公告)号：WO0211551A3

公开(公告)日：2002-06-06

申请号：PCT/JP0106779

申请日：2001-08-07

Applicant: KAO CORP ,  KOIKE SHIN ,  YASUMASU TAKESHI ,  HASE TADASHI ,  MURASE TAKATOSHI ,  YASUKAWA TAKUJI

Inventor： KOIKE SHIN ,  YASUMASU TAKESHI ,  HASE TADASHI ,  MURASE TAKATOSHI ,  YASUKAWA TAKUJI

IPC: A21D2/16 ,  A23D9/00 ,  A23D9/007 ,  A23D9/013 ,  A23G1/00 ,  A23G1/36 ,  A23G3/00 ,  A23G3/40 ,  A23G9/32 ,  A23K1/16 ,  A23K1/165 ,  A23L1/16 ,  A23L1/30 ,  A23L1/314 ,  A23L1/317 ,  A23L1/48 ,  A61K31/22 ,  A61K31/575 ,  A61K45/06 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/12 ,  A61P43/00 ,  C11C3/00 ,  C11C3/02 ,  C11C3/06 ,  C11C3/10 ,  A61K31/20

CPC classification number: A23G1/36 ,  A21D2/16 ,  A21D2/165 ,  A23D9/00 ,  A23D9/013 ,  A23G3/40 ,  A23G9/327 ,  A23K20/158 ,  A23L7/111 ,  A23L13/428 ,  A23L13/43 ,  A23L13/60 ,  A23L33/11 ,  A23L33/115 ,  A23L33/12 ,  A23V2002/00 ,  A61K45/06 ,  C11C3/02 ,  C11C3/06 ,  A23V2250/1882 ,  A23V2250/2136 ,  A23V2250/6422 ,  A23V2250/642 ,  A23V2250/032 ,  A23V2250/182 ,  A23V2250/192 ,  A23V2250/194 ,  A23V2250/5108 ,  A23V2250/1874 ,  A23V2250/156 ,  A23V2250/70 ,  A23V2250/5118 ,  A23V2250/54246 ,  A23V2250/628

Abstract: An oil/fat composition comprising 5 to 99.9 wt.% of a monoglyceride having, as fatty acid constituents thereof, 15 to 90 wt% of an omega 3-unsaturated fatty acid having less than 20 carbon atoms, 1 to 80 wt.% of an omega 9-unsaturated fatty acid and 2 to 50 wt.% of an omega 9-unsaturated fatty acid; and 0.1 to 49.9 wt.% of a diglyceride, wherein a weight ratio of the diglyceride to the monoglyceride is less than 1 and the content of a polyunsaturated fatty acid having at least 4 carbon-to-carbon double bonds is 20% or less in all the fatty acid constituents. The oil/fat composition according to the present invention has excellent processing properties, good taste and excellent lowering action against glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels in blood. It is useful not only for pharmaceuticals but also for preventive or remedial foods of feeds effective for hepatic function disturbances or obesity.

Abstract translation: 一种油脂组合物，其特征在于，含有5〜99.9重量％的作为脂肪酸成分的甘油单酯，15〜90重量％的碳原子数小于20的ω3-不饱和脂肪酸，1〜80重量％ ω9-不饱和脂肪酸和2-50重量％的ω9-不饱和脂肪酸; 和甘油二酯0.1〜49.9重量％，甘油二酯与甘油单酯的重量比小于1，碳原子数4以上的双键的多元不饱和脂肪酸的含量为20％以下 所有的脂肪酸成分。 本发明的油脂组合物具有优异的加工性能，良好的口感和对血液中谷氨酸草酰乙酸转氨酶（GOT）和谷氨酸丙酮酸转氨酶（GPT）水平的优异降低作用。 它不仅适用于药物，而且适用于对肝功能紊乱或肥胖有效的预防性或补救性饲料。

公开(公告)号：WO0211552A3

公开(公告)日：2002-04-18

申请号：PCT/JP0106777

申请日：2001-08-07

Applicant: KAO CORP ,  KOIKE SHIN ,  YASUMASU TAKESHI ,  HASE TADASHI ,  MURASE TAKATOSHI ,  YASUKAWA TAKUJI ,  KATSURAGI YOSHIHISA ,  TAKEI AKIRA

Inventor： KOIKE SHIN ,  YASUMASU TAKESHI ,  HASE TADASHI ,  MURASE TAKATOSHI ,  YASUKAWA TAKUJI ,  KATSURAGI YOSHIHISA ,  TAKEI AKIRA

IPC: A21D2/16 ,  A23D7/01 ,  A23D7/015 ,  A23D9/013 ,  A23G3/00 ,  A23G3/34 ,  A23G3/40 ,  A23K1/16 ,  A23L1/24 ,  A23L1/29 ,  A23L1/30 ,  C11B5/00 ,  C11C1/04 ,  C11C3/02 ,  C11C3/06 ,  A23D9/00 ,  A61K31/20

CPC classification number: A23G3/40 ,  A21D2/16 ,  A23D7/011 ,  A23D7/013 ,  A23D7/015 ,  A23D9/013 ,  A23G3/346 ,  A23G2200/08 ,  A23K20/158 ,  A23L27/60 ,  A23L33/11 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  C11B5/0092 ,  C11C1/04 ,  C11C3/02 ,  C11C3/06 ,  A23V2250/182 ,  A23V2250/194 ,  A23V2250/1874 ,  A23V2250/188 ,  A23V2250/1882

Abstract: Abstract Provided is an oil/fat composition comprising 60 to 100 wt.% of a diglyceride wherein the diglyceride has, as the fatty acid constituent thereof, 15 to 90 wt.% of an omega 3-unsaturated fatty acid having less than 20 carbon atoms and a cis omega 3-unsaturated fatty acid/(cis omega 6-unsaturated fatty acid + saturated fatty acid + trans unsaturated fatty acid) at a weight ratio of 1 to 6. The composition is excellent in visceral fat burning property, body fat burning property and stability against autoxidation.

Abstract translation: 提供一种油脂组合物，其包含60至100重量％的甘油二酯，其中所述甘油二酯具有作为其脂肪酸组分的15至90重量％的具有少于20个碳原子的ω-3不饱和脂肪酸 和顺式ω3-不饱和脂肪酸/（顺式ω6-不饱和脂肪酸+饱和脂肪酸+反式不饱和脂肪酸），重量比为1〜6。该组合物具有优异的内脏脂肪燃烧性能，体脂肪燃烧 对自动氧化的性质和稳定性。

公开(公告)号：DE60123849D1

公开(公告)日：2006-11-23

申请号：DE60123849

申请日：2001-08-07

Applicant: KAO CORP

Inventor： KOIKE SHIN ,  YASUMASU TAKESHI ,  HASE TADASHI ,  MURASE TAKATOSHI ,  KATSURAGI YOSHIHISA ,  TAKEI AKIRA

IPC: A23D9/00 ,  A21D2/16 ,  A21D13/02 ,  A21D13/06 ,  A21D13/08 ,  A23D7/01 ,  A23D7/015 ,  A23D9/013 ,  A23K1/16 ,  A23L1/30 ,  A23L15/00 ,  A23L27/60 ,  A23L33/00 ,  A61K31/20 ,  A61K31/232 ,  A61K31/56 ,  A61K45/06

Abstract: Provided is an oil/fat composition comprising 10.1 to 94.9 wt.% of a triglyceride, 0.1 to 30 wt.% of a monoglyceride and 5 to 59.9 wt.% of a diglyceride which has, as a fatty acid constituent thereof, 15 to 90 wt.% of an omega 3-unsaturated fatty acid having less than 20 carbon atoms. The oil/fat composition of the present invention has excellent heat stability, has body-fat-accumulation resisting action, visceral-fat-accumulation resisting action, blood-sugar-level lowering action, insulin resistance improving action and leptin lowering action and is useful for, as well as pharmaceuticals, preventive or remedial food for diabetes or obesity, and feed.

公开(公告)号：BR0113108A

公开(公告)日：2003-06-10

申请号：BR0113108

申请日：2001-08-07

Applicant: KAO CORP

Inventor： KOIKE SHIN ,  YASUMASU TAKESHI ,  HASE TADASHI ,  MURASE TAKATOSHI ,  KATSURAGI YOSHIHISA ,  TAKEI AKIRA

IPC: A21D2/16 ,  A21D13/02 ,  A21D13/06 ,  A21D13/08 ,  A23D7/01 ,  A23D7/015 ,  A23D9/013 ,  A23K1/16 ,  A23L1/30 ,  A23L15/00 ,  A23L27/60 ,  A23L33/00 ,  A61K31/232 ,  A61K31/56 ,  A61K45/06 ,  A23D9/00 ,  A61K31/20

Abstract: Provided is an oil/fat composition comprising 10.1 to 94.9 wt.% of a triglyceride, 0.1 to 30 wt.% of a monoglyceride and 5 to 59.9 wt.% of a diglyceride which has, as a fatty acid constituent thereof, 15 to 90 wt.% of an omega 3-unsaturated fatty acid having less than 20 carbon atoms. The oil/fat composition of the present invention has excellent heat stability, has body-fat-accumulation resisting action, visceral-fat-accumulation resisting action, blood-sugar-level lowering action, insulin resistance improving action and leptin lowering action and is useful for, as well as pharmaceuticals, preventive or remedial food for diabetes or obesity, and feed.

公开(公告)号：DE69120715T2

公开(公告)日：1996-11-28

申请号：DE69120715

申请日：1991-04-17

Applicant: KAO CORP

Inventor： HORI KIMIHIKO ,  SUZUKI YASUTO ,  MORIOKA TOMOKI ,  MORIWAKI SHIGERU ,  HIROTA OSAMU ,  TSUCHIYA SHUICHI ,  HASE TADASHI

IPC: C07J41/00 ,  C07J71/00 ,  A61K31/57 ,  A61K31/58

Abstract: A 21-substituted steroid compound is disclosed. The compound has a structure of formula (I), wherein R is a hydrogen atom, a lower alkyl, lower alkenyl, lower alkoxy, or phenyl group, R is a hydroxyl group or an acyloxy group having 1-6 carbon atoms, R is a hydrogen atom or a lower alkyl group, or R and R may together form a lower alkylidenedioxy group, X and X may be the same or different and individually represents a hydrogen atom or a halogen atom, Y and Y may be the same or different and individually represents a methylene group or a sulfur atom, Z is a sulfur atom or an imino group, the wave line means that the configuration of R may be of either alpha or beta , and dotted line between the 1 and 2 position means that the bond may be the double bond. It has excellent anti-inflammatory, anti-allergic and anti-asthma activities with little side effects, and is useful for the prevention, cure, and treatment of on inflammation, allergic diseases, rheumatism, and the like.

公开(公告)号：CA2417971C

公开(公告)日：2010-01-19

申请号：CA2417971

申请日：2001-08-07

Applicant: KAO CORP

Inventor： TAKEI AKIRA ,  KOIKE SHIN ,  YASUMASU TAKESHI ,  HASE TADASHI ,  MURASE TAKATOSHI ,  KATSURAGI YOSHIHISA

IPC: A23D9/00 ,  A21D2/16 ,  A21D13/02 ,  A21D13/06 ,  A21D13/08 ,  A23D7/01 ,  A23D7/015 ,  A23D9/013 ,  A23K1/16 ,  A23L1/30 ,  A23L15/00 ,  A23L27/60 ,  A23L33/00 ,  A61K31/20 ,  A61K31/232 ,  A61K31/56 ,  A61K45/06

Abstract: Provided is an oil/fat composition comprising 10.1 to 94.9 wt.% of a triglyceride, 0.1 to 30 wt.% of a monoglyceride and 5 to 59.9 wt.% of a diglyceride which has, as a fatty acid constituent thereof, 15 to 90 wt.% of an .omega. 3- unsaturated fatty acid having less than 20 carbon atoms. The oil/fat composition of the present invention has excellent heat stabilit y, has body-fat-accumulation resisting action, visceral-fat-accumulation resisting action, blood-sugar-level lowering action, insulin resistance improving action and leptin lowering action and is useful for, as well as pharmaceuticals, preventive or remedial food for diabetes or obesity, and feed.

公开(公告)号：CA2495146A1

公开(公告)日：2003-03-27

申请号：CA2495146

申请日：2002-09-12

Applicant: KAO CORP

Inventor： TAKASE HIDETO ,  SAKAI HIDEAKI ,  KOIKE SHIN ,  NISHIDE TSUTOMU ,  MURASE TAKATOSHI ,  HASE TADASHI

IPC: A21D2/16 ,  A23D7/005 ,  A23D9/00 ,  A23D9/007 ,  A23L27/60 ,  A23L33/12 ,  A23L33/20 ,  A61K31/231 ,  A61K31/232 ,  A61K31/575 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/12 ,  C11B5/00 ,  C11C3/00 ,  C11C3/02 ,  C11C3/06 ,  C11C3/10 ,  A23D7/00 ,  A23K1/16 ,  A23L1/30

Abstract: Disclosed herein is an oil composition comprising the following components ( A) and (B):(A) 15 to 70% by weight of diglycerides in which less than 15% by weight of the constitutive fatty acids are (3 type unsaturated fatty acids; and(B) 30 to 85% by weight of a triglyceride in which at least 15% by weight of the constitutive fatty acids are (3 type unsaturated fatty acids.The oil composition is good in flavor, hard to be colored, excellent in hydrolytic stability and resistance to oxidation, good in emulsion stability and excellent in intake balance among fatty acids even under severe conditions that heating is performed at a high temperature for a long period of time, c an be widely developed to medicinal preparations and foods and moreover exhibit an excellent inhibitory effect on accumulation of body fat by ingestion of a small amount of diglycerides.

公开(公告)号：DE69023717T2

公开(公告)日：1996-04-18

申请号：DE69023717

申请日：1990-08-02

Applicant: KAO CORP

Inventor： OSAWA TOSHIAKI ,  HASE TADASHI ,  YOSHIZUKA NAONOBU

IPC: G01N33/53 ,  A61K39/395 ,  C07K16/24 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577

Abstract: The present invention relates to a monoclonal antibody capable of specifically binding to a peptide or protein having amino acid sequence (I) described below or having in part at least continuous 4 amino acid sequences of the amino acid sequence (I), and also to a process for producing a monoclonal antibody capable of specifically binding to the peptide or protein: H-Y-Leu-Gly-Arg-X-Asp-Gly-Ser-Glu-OH (I) wherein X represents Glu or Gln and Y represents Trp or Arg.

公开(公告)号：CA2418350C

公开(公告)日：2010-01-19

申请号：CA2418350

申请日：2001-08-07

Applicant: KAO CORP

Inventor： TAKEI AKIRA ,  KATSURAGI YOSHIHISA ,  KOIKE SHIN ,  YASUMASU TAKESHI ,  MURASE TAKATOSHI ,  HASE TADASHI

IPC: A23D9/013 ,  A21D2/16 ,  A23D7/01 ,  A23D7/015 ,  A23D9/00 ,  A23G3/00 ,  A23G3/34 ,  A23G3/40 ,  A23K1/16 ,  A23L1/30 ,  A23L27/60 ,  A23L33/00 ,  A61K31/20 ,  C11B5/00 ,  C11C1/04 ,  C11C3/02 ,  C11C3/06

Abstract: Provided is an oil/fat composition comprising 60 to 100 wt.% of a diglycerid e wherein the diglyceride has, as the fatty acid constituent thereof, 15 to 90 wt.% of an .omega. 3-unsaturated fatty acid having less than 20 carbon atoms and a cis .omega. 3-unsaturated fatty acid/(cis .omega. 6-unsaturated fatty acid + saturated fatty acid + trans unsaturated fatty acid) at a weight ratio of 1 to 6. The composition is excellent in visceral fat burning property, body fat burning property and stability against autoxidation.