公开(公告)号：HK1186479A1

公开(公告)日：2014-03-14

申请号：HK13113804

申请日：2013-12-12

Applicant: UCB PHARMA SA

Inventor： POPPLEWELL ANDREW GEORGE ,  TICKLE SIMON PETER ,  LADYMAN HEATHER MARGARET

IPC: C07K20060101 ,  C07K16/18 ,  A61K38/16 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C12N15/13 ,  C12N15/63 ,  C12P21/00

公开(公告)号：SG196697A1

公开(公告)日：2014-02-13

申请号：SG2012055786

申请日：2008-03-21

Applicant: BIOGEN IDEC INC ,  UCB PHARMA SA

Inventor： BURKLY LINDA C ,  FERRANT-ORGETTAS JANINE L ,  GARBER ELLEN A ,  HSU YEN-MING ,  SU LIHE ,  TAYLOR FREDERICK R ,  ADAMS RALPH ,  BROWN DEREK THOMAS ,  POPPLEWELL ANDREW GEORGE ,  ROBINSON MARTYN KIM ,  SHOCK ANTHONY ,  TYSON KERRY LOUISE

Abstract: - 126 - Abstract BINDING PROTEINS, INCLUDING ANTIBODIES, ANTIBODYDERIVATIVES AND ANTIBODY FRAGMENTS, THAT SPECIFICALLY BIND CD154 ANDUSES THEREOF This invention provides binding proteins, includingantibodies, antibody derivatives and antibody fragments, thatspecifically bind a CD 154 (CD4OL) protein. This invention alsoprovides a chimeric, humanized or fully human antibody, antibodyderivative or antibody fragment that specifically binds to an epitopeto which a humanized Fab fragment comprising a variable heavy chainsequence according to SEQ ID NO: 1 and comprising a variable lightchain sequence according to SEQ ID NO: 2 specifically binds. CD154binding proteins of this invention may elicit reduced effectorfunction relative to a second anti-CD154 antibody. CD154 bindingproteins of this invention are useful in diagnostic and therapeuticmethods, such as in the treatment and prevention of diseasesincluding those that involve undesirable immune responses that aremediated by CD154-CD40 interactions. Fig. 19

公开(公告)号：BRPI0717768A2

公开(公告)日：2013-11-05

申请号：BRPI0717768

申请日：2007-10-18

Applicant: UCB PHARMA SA

Inventor： ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE ,  RAPECKI STEPHEN EDWARD

IPC: C07K16/24 ,  A61K39/395 ,  A61P35/00 ,  A61P37/06 ,  C12N15/13

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：HK1177470A1

公开(公告)日：2013-08-23

申请号：HK13104585

申请日：2013-04-16

Applicant: UCB PHARMA SA

Inventor： LAWSON ALASTAIR DAVID GRIFFITHS ,  NESBITT ANDREW MALCOLM ,  POPPLEWELL ANDREW GEORGE ,  SHAW STEVAN GRAHAM ,  SHPEKTOR DIANA ,  ZHANG YI

IPC: C07K20060101 ,  A61K20060101

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：SI2230308T1

公开(公告)日：2013-06-28

申请号：SI200131020

申请日：2001-06-05

Applicant: UCB PHARMA SA

Inventor： ATHWAL DILJEET SINGH ,  BROWN DEREK THOMAS ,  WEIR ANDREW NEIL CHARLES ,  POPPLEWELL ANDREW GEORGE ,  CHAPMAN ANDREW PAUL ,  KING DAVID JOHN

IPC: C12N15/00 ,  A61K39/00 ,  C12N15/09 ,  A61K39/395 ,  A61K47/00 ,  A61K47/48 ,  A61P19/00 ,  A61P19/02 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  C07K16/00 ,  C07K16/24 ,  C07K16/46 ,  C07K19/00 ,  C12N1/00 ,  C12N1/21 ,  C12N15/13 ,  C12P21/02 ,  C12P21/08

公开(公告)号：TN2011000374A1

公开(公告)日：2013-03-27

申请号：TN2011000374

申请日：2011-08-02

Applicant: UCB PHARMA SA

Inventor： LAWSON ALASTAIR DAVID GRIFFITHS ,  NESBITT ANDREW MALCOLM ,  POPPLEWELL ANDREW GEORGE ,  SHAW STEPHEN GRAHAM ,  SHPEKTOR DIANA ,  ZHANG YI

IPC: A61K39/395 ,  A61P37/02 ,  C07H21/04 ,  C07K2/00 ,  C07K16/16 ,  C12N5/10 ,  C12N15/74 ,  C12P21/00

公开(公告)号：BRPI0713300A2

公开(公告)日：2012-04-17

申请号：BRPI0713300

申请日：2007-06-25

Applicant: UCB PHARMA SA

Inventor： RAPECKI STEPHEN EDWARD ,  POPPLEWELL ANDREW GEORGE ,  ADAMS RALPH

IPC: C07K16/24 ,  A61K39/395 ,  C12N5/20 ,  C12N15/13

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecules and methods of producing the antibody molecules.

公开(公告)号：NZ580245A

公开(公告)日：2012-01-12

申请号：NZ58024508

申请日：2008-03-21

Applicant: BIOGEN IDEC INC ,  UCB PHARMA SA

Inventor： BURKLY LINDA C ,  FERRANT-ORGETTAS JANINE L ,  GARBER ELLEN A ,  HSU YEN-MING ,  SU LIHE ,  TAYLOR FREDERICK R ,  ADAMS RALPH ,  BROWN DEREK THOMAS ,  POPPLEWELL ANDREW GEORGE ,  ROBINSON MARTYN KIM ,  SHOCK ANTHONY ,  TYSON KERRY LOUISE

IPC: C07K16/28 ,  A61K39/395 ,  C12N15/13 ,  C12N15/63

Abstract: An anti-CD154 antibody that comprises the heavy chain CDR1, CDR2 and CDR3 sequence SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5 respectively and the light chain CDR1, CDR2 and CDR3 sequences SEQ ID NO: 6, SEQ ID NO: 7 and SEQ ID NO: 8 respectively. Also disclosed are methods of the production of the antibody and uses thereof for treating rheumatoid arthritis, systemic lupus erythematosus, spondyloarthritis, inflammatory bowel disease, Crohn's disease, psoriasis, scleroderma and multiple sclerosis.

公开(公告)号：SG175652A1

公开(公告)日：2011-11-28

申请号：SG2011076213

申请日：2007-10-18

Applicant: UCB PHARMA SA

Inventor： ADAMS RALPH ,  POPPLEWELL ANDREW GEORGE ,  RAPECKI STEPHEN EDWARD

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.(No figure to be indicated)

公开(公告)号：AU2004210776B2

公开(公告)日：2011-04-07

申请号：AU2004210776

申请日：2004-02-06

Applicant: UCB PHARMA SA

Inventor： LAWSON ALASTAIR DAVID GRIFFITHS ,  POPPLEWELL ANDREW GEORGE

IPC: C07K16/24 ,  A61K47/48 ,  C12N15/13

Abstract: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-1², therapeutic uses of the antibody molecule and methods for producing said antibody molecule.