公开(公告)号：WO1996007425A1

公开(公告)日：1996-03-14

申请号：PCT/US1995010989

申请日：1995-09-07

Applicant: WASHINGTON UNIVERSITY ,  PERLMUTTER, David, H.

Inventor： WASHINGTON UNIVERSITY

IPC: A61K38/55

CPC classification number: C07K14/8121 ,  A61K38/00 ,  C07K14/8125

Abstract: A method is disclosed for blocking the SEC receptor and also inhibiting the neurotoxic effects of amyloid- beta protein by treating SEC receptor-bearing cells with a synthetic inhibitor peptide, e.g. peptide PB145.

Abstract translation: 公开了一种阻断SEC受体的方法，并且还通过用合成的抑制剂肽例如处理含有SEC受体的细胞来抑制淀粉样蛋白β蛋白的神经毒性作用。 肽PB145。

公开(公告)号：WO1995031183A1

公开(公告)日：1995-11-23

申请号：PCT/US1995006056

申请日：1995-05-15

Applicant: WASHINGTON UNIVERSITY ,  GROSS, Richard, W.

Inventor： WASHINGTON UNIVERSITY

IPC: A61K09/127

CPC classification number: C12N9/0008 ,  A61K9/1271

Abstract: A lipid vesicle composition for use in delivering a vesicle-encapsulated agent to a target cell is disclosed. The composition is formed of vesicle-forming lipids, including at least 10 mole percent plasmalogen phospholipid with a small-volume polar head group. The composition may also include a fusion protein for promoting fusion of the vesicles to the target cells. A novel fusion protein identified as an isoform of glyceraldehyde-3-phosphate dehydrogenase is also disclosed.

Abstract translation: 公开了一种用于将囊泡包封的药物递送至靶细胞的脂质囊泡组合物。 该组合物由囊泡形成脂质形成，包括至少10摩尔％的具有小体积极性头基的磷脂酰磷脂。 组合物还可以包括用于促进囊泡融合到靶细胞的融合蛋白。 还公开了鉴定为甘油醛-3-磷酸脱氢酶同工型的新型融合蛋白。

公开(公告)号：WO1995014028A2

公开(公告)日：1995-05-26

申请号：PCT/US1994013455

申请日：1994-11-18

Applicant: WASHINGTON UNIVERSITY ,  SYMBICOM AKTIEBOLAG ,  HULTGREN, Scott ,  KUEHN, Meta ,  XU, Zheng ,  OGG, Derek ,  HARRIS, Mark ,  LEPISTO, Matti ,  JONES, Charles, Hal ,  KIHLBERG, Jan

Inventor： WASHINGTON UNIVERSITY ,  SYMBICOM AKTIEBOLAG

IPC: C07H15/203

CPC classification number: A61K31/7004 ,  C07H1/00 ,  G01N33/56911 ,  G01N33/68 ,  G01N2500/20 ,  Y02A50/481 ,  Y10S435/849

Abstract: Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

Abstract translation: 公开了用于治疗和/或预防由组织粘附细菌引起的疾病的新方法。 通过与周质分子伴侣相互作用，可以防止或抑制毛细血管的组装，从而减少细菌的感染性。 还公开了用于筛选药物的方法以及用于从头设计这些药物的方法，这些方法依赖于涉及大分子之间的结合自由能的近似计算的新型计算机药物建模方法。 最后，还公开了被认为能够与周质分子伴侣相互作用的新型吡喃糖苷。

公开(公告)号：WO1994025623A1

公开(公告)日：1994-11-10

申请号：PCT/US1994004468

申请日：1994-04-22

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  GROSS, Richard

IPC: C12Q01/34

CPC classification number: C12Q1/44 ,  C12N9/12 ,  C12N9/20 ,  C12Q1/48 ,  G01N2333/918 ,  Y10S435/968 ,  Y10S436/804 ,  Y10T436/12

Abstract: A method of identifying compounds that modulate the activity of myocardial calcium-independent phospholipase A2 is disclosed. In a test assay of the method of the invention, myocardial calcium-independent phospholipase A2 40kDa catalytic subunit, 85kDa phosphofructokinase isoform, ATP, a substrate and a test compound are combined and the myocardial calcium-independent phospholipase A2 activity is determined. The level of activity observed in the test assay is compared to the level of activity generated from a control assay which is similar to the test assay but which does not include the test compound. Essentially pure myocardial calcium-independent phospholipase A2 85kDa phosphofructokinase isoform is also disclosed.

Abstract translation: 公开了鉴定调节心肌钙依赖性磷脂酶A2活性的化合物的方法。 在本发明方法的测试测定中，组合心肌钙依赖性磷脂酶A240kDa催化亚基，85kDa磷酸果糖激酶同种型，ATP，底物和测试化合物，并测定心肌钙依赖性磷脂酶A2活性。 将在测试测定中观察到的活性水平与从对照测定产生的活性水平进行比较，其与测试测定类似，但不包括测试化合物。 还公开了本质上纯的心肌钙依赖性磷脂酶A285kDa磷酸果糖激酶同种型。

公开(公告)号：WO1994003154A1

公开(公告)日：1994-02-17

申请号：PCT/US1993007076

申请日：1993-07-28

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  DIONNE, Keith, E. ,  SCHARP, David, W.

IPC: A61K09/00

CPC classification number: A61K9/0024 ,  A61F2/022

Abstract: A device and method of use are provided for improving the long-term treatment of a patient by surgically implanting encapsulated or unencapsulated cells or cell clusters producing a therapeutic agent and for retrieving such cell bodies. A pouch is placed over a vascularized tissue pedicle in an individual's body so that at least part of the pedicle is encased by projecting into the opening of the pouch. The pouch is attached to the pedicle around the pouch opening.

Abstract translation: 提供了一种使用装置和方法，用于通过手术植入产生治疗剂的包封的或未包封的细胞或细胞簇来改善患者的长期治疗并且用于检索这种细胞体。 将小袋放置在个体体内的血管化组织椎弓根上，使得至少部分椎弓根通过突出到小袋的开口中而被包裹。 该小袋附着在袋口周围的椎弓根上。

公开(公告)号：WO1992016080A1

公开(公告)日：1992-09-17

申请号：PCT/US1992001259

申请日：1992-02-13

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  TURNER, Jonathan, S.

IPC: H04Q11/04

CPC classification number: H04L49/3081 ,  H04L49/30 ,  H04L49/501 ,  H04L2012/5646 ,  H04L2012/565 ,  H04Q11/0478

Abstract: A resequencing buffer (44) and a buffer control circuit (46) is disclosed for resequencing data packets into their timed sequence after traversing a switch fabric (22) which can introduce misordering of data packets because of the varying time intervals required for data packets to traverse the switch fabric (22) in a non-blocking manner. The resequencing buffer controller (46) includes a plurality of bi-directional shift registers (60) for storing each data packet's age and slot number, each bi-directional shift register (60) having an associated slot control circuit (62) for feeding the age and slot number one bit at a time onto a contention bus (64) to thereby determine the oldest data packet eligible for transmission. The contention bus (64) is an exclusive OR wire bus which interconnects the slot control circuits (62) and an output circuit (68) which controls the buffer (44) to output the slot number containing the data packet of oldest age. In the event of ties between data packets having the same age, the slot numbers of the buffer (44) are used to select a data packet for transmission.

公开(公告)号：WO1992012262A1

公开(公告)日：1992-07-23

申请号：PCT/US1992000020

申请日：1992-01-03

Applicant: WASHINGTON UNIVERSITY ,  ADELAIDE MEDICAL CENTER FOR WOMEN AND CHILDREN

Inventor： WASHINGTON UNIVERSITY ,  ADELAIDE MEDICAL CENTER FOR WOMEN AND CHILDREN ,  SUTHERLAND, Grant, R. ,  RICHARDS, Robert, I. ,  SCHLESSINGER, David ,  NAGARAJA, Ramaiah

IPC: C12Q01/68

CPC classification number: C12Q1/6883 ,  C12Q2600/156

Abstract: The DNA sequence spanning the fragile X site on the X human chromosome has been obtained in purified and isolated form. As fragile X is associated with mental retardation, the availability of a DNA which spans this locus permits diagnosis and treatment of the related mental disorders.

Abstract translation: 跨越X人染色体上脆性X位点的DNA序列已经以纯化和分离的形式获得。 由于脆弱的X与精神发育迟滞相关，跨越这个位点的DNA的可用性允许诊断和治疗相关的精神障碍。

公开(公告)号：WO1992009684A1

公开(公告)日：1992-06-11

申请号：PCT/US1991008688

申请日：1991-11-20

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  CURTISS, Roy, III ,  TUNG, Kenneth, S., K.

IPC: C12N01/21

CPC classification number: C12N9/0008 ,  A61K39/00 ,  C07K14/705 ,  C07K16/40 ,  C07K2319/00 ,  C12N15/01 ,  C12Y102/01011

Abstract: Avirulent microbes which include a recombinant expression system encoding a gamete-specific antigen, are disclosed. The microbes can be used in compositions to immunize a vertebrate subject against the gamete-specific antigen, thereby preventing or reducing conception rates in the subject to which they are administered.

Abstract translation: 公开了包含编码配子特异性抗原的重组表达系统的无毒微生物。 这些微生物可用于组合物中，免疫脊椎动物受试者抵抗配子特异性抗原，从而预防或降低受试者施用它们的受孕率。

公开(公告)号：WO1991015786A1

公开(公告)日：1991-10-17

申请号：PCT/US1991002466

申请日：1991-04-10

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  BINNS, W., Robert ,  EPSTEIN, John, W. ,  KLARMANN, Joseph ,  WONG, John, Wai-Chu

IPC: G02B06/06

CPC classification number: G02B6/06 ,  B29C55/00 ,  B29D11/00663 ,  B29L2011/0075

Abstract: Apparatus for generating a reduced-scale optical image of an x-ray beam pattern or the like includes an optical fiber assembly (38) which forms a two-dimensional input array (42) and whose output ends form a reduced-scale two-dimensional output array (44). A beam converter (34) converts the irradiation beam (29) to a corresponding electron beam, and this beam is converted to a two-dimensional light image of the beam which is directed onto the input array (42). In one embodiment, the optical fibers form an array (38) of multifiber reducers (40) which are tapered on progressing between input (48) and output ends (50). In other embodiments, the input array (78, 113) is formed by the elongate input fiber regions of fibers (77, 114) having a parallel, side-by-side arrangement, and the two dimensional image is produced by scanning a linear electron beam and light-generating strip (76) transversely along the length of the array, or by rotating the array (113) below a full-area electron beam.

Abstract translation: 用于产生X射线束图案等的缩小尺度光学图像的装置包括形成二维输入阵列（42）的光纤组件（38），其输出端形成缩小的二维 输出阵列（44）。 光束转换器（34）将照射光束（29）转换成相应的电子束，并将该光束转换成指向输入阵列（42）的光束的二维光图像。 在一个实施例中，光纤形成多光纤减速器（40）的阵列（38），其在输入（48）和输出端（50）之间进行渐缩。 在其它实施例中，输入阵列（78,113）由具有平行的并排布置的细长的纤维（77,114）的输入光纤区域形成，并且通过扫描线性电子产生二维图像 光束和发光条（76）沿着阵列的长度横向延伸，或者将阵列（113）旋转到全区域电子束的下方。

公开(公告)号：WO1991008502A1

公开(公告)日：1991-06-13

申请号：PCT/US1990006901

申请日：1990-11-27

Applicant: WASHINGTON UNIVERSITY

Inventor： WASHINGTON UNIVERSITY ,  LICHTMAN, Jeffrey, M. ,  PEPOSE, Jay, Stuart ,  DAVE, Rakhal

IPC: G02B21/06

CPC classification number: G02B21/082 ,  G02B21/0028 ,  G02B21/0032

Abstract: A single aperture confocal scanning biomicroscope is disclosed with an illumination system (42) having a pair of lenses (50, 52) surrounding an aperture (54) for collimating a field of light, a pivotally mounted flap (60) for blocking a central portion of the lght in order to create peripheral illumination, and an aperture assembly (62) comprised of a cylindrical lens (64), aperture (66), and beam splitter (68) which is oscillated within the light field in order to create an aperture size optical beam for scanning a patient's eye (74) and ocular adnexae. With the illumination system (42) of the present invention, techniques involving both direct illumination and indirect illumination may be utilized in examining the eye (74) to produce a true confocal image thereof. Single aperture confocal scanning techniques may be brought to existing slit lamp biomicroscopes with a kit comprised simply of a pair of lenses (38) and an aperture (36) in one embodiment which utilizes the existing illumination system. In a second embodiment, a completely new illumination system is also utilized which provides for examination techniques utilizing both direct and indirect illumination.

Abstract translation: 公开了一种单孔共聚焦扫描生物显微镜，其具有围绕用于准直光场的孔（54）的一对透镜（50,52）的照明系统（42），枢轴安装的挡板（60），用于阻挡中心部分 以创建外围照明，以及由柱面透镜（64），孔径（66）和分束器（68）组成的孔径组件（62），其在光场内振荡，以便产生孔径 用于扫描患者眼睛（74）和眼睛附属物的大小的光束。 利用本发明的照明系统（42），可以使用涉及直接照明和间接照射的技术来检查眼睛（74）以产生其真实共焦图像。 可以利用现有照明系统的一个实施例中的简单地由一对透镜（38）和孔（36）组成的套件将单孔共聚焦扫描技术带到现有的裂隙灯生物显微镜。 在第二实施例中，还使用全新的照明系统，其提供利用直接照明和间接照明的检查技术。