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1.发明公开시프로플록사신이 담지된 폴리락타이드글리콜라이드공중합체의 서방출 및 생분해성 나노입자 및 그 제조방법 有权具有扩展性能的聚（DL-柠檬酸 - 碳酸甘油酯）包封CIPROFLOXACIN HC的生物降解纳米颗粒及其制备方法
公开(公告)号：KR1020080039645A
公开(公告)日：2008-05-07
申请号：KR1020060107212
申请日：2006-11-01
CPC classification number: A61K9/5153 , A61K9/5089 , A61K9/5192
Abstract: A sustained release and bio-degradable nano-particle of a poly(DL-lactide-co-glycolide) copolymer is provided to release ciprofloxacin HCl gradually through controlling of physicochemical characteristics and drug release characteristics by encapsulating the ciprofloxacin into polylactide glycolide. A sustained release and bio-degradable nano-particle of a poly(DL-lactide-co-glycolide) copolymer is characterized in that it has a particle size of 100-500 nanometers and the poly(DL-lactide-co-glycolide) copolymer encapsulates ciprofloxacin HCl. A method for preparing the nano-particle comprises the steps of: (a) dissolving polylactideglycolide in dichloromethane to have a concentration of 2-6 weight/volume%; (b) dissolving ciprofloxacin in distilled water to have a concentration of 1-2 weight/volume%; (c) after mixing the solution obtained from the step(a) with the solution obtained from the step(b) in a weight ratio of 8-10:1, treating the mixture with an ultrasonic homogenizer with an output of 30-40 watts for 1-3 minutes per 10 ml to prepare a water in oil emulsion; and (d) after putting the W/O emulsion in an aqueous solution of polyvinyl alcohol having a concentration of 1.0 weight/volume%, treating the solution with a high-pressure homogenizer under a pressure of 600-800 bar with one minute cycle per 100 ml for 5-7 cycles to prepare a W/O/W emulsion. Further, a 4.5 to 5.0 wt.% of ciprofloxacin HCl is comprised in a 100 wt.% of nano-particle, and the ciprofloxacin HCl is emitted from the nano-particle for 10 days or more.
Abstract translation: 提供聚（DL-丙交酯 - 共 - 乙交酯）共聚物的持续释放和生物降解纳米颗粒，通过将环丙沙星包封在聚丙交酯乙交酯中，通过控制理化特性和药物释放特性逐渐释放环丙沙星HCl。 聚（DL-丙交酯 - 共 - 乙交酯）共聚物的持续释放和生物可降解纳米颗粒的特征在于其具有100-500纳米的粒度和聚（DL-丙交酯 - 共 - 乙交酯）共聚物 封装盐酸环丙沙星。 制备纳米颗粒的方法包括以下步骤：（a）将聚丙交酯乙二醇酸溶解在二氯甲烷中以具有2-6重量/体积％的浓度; （b）将环丙沙星溶解于蒸馏水中至浓度为1-2重量/体积％; （c）将由步骤（a）获得的溶液与步骤（b）获得的溶液以8-10:1的重量比混合后，用输出为30-40瓦的超声波均化器处理该混合物 每10ml处理1-3分钟，制备油包水乳液; 和（d）在将W / O乳液放入浓度为1.0重量/体积％的聚乙烯醇的水溶液中之后，在600-800巴的压力下用高压均化器处理该溶液，每1分钟循环 100毫升5-7个循环以制备W / O / W乳液。 此外，在100重量％的纳米颗粒中包含4.5-5.0重量％的环丙沙星HCl，并且从纳米颗粒中排出环丙沙星HCl 10天或更长时间。
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公开(公告)号：KR1020070072301A
公开(公告)日：2007-07-04
申请号：KR1020060022820
申请日：2006-03-10
CPC classification number: A61K8/736 , A61K8/11 , A61K8/671 , A61K2800/522 , A61K2800/84 , A61Q19/00
Abstract: Provided are a retinol encapsulated water-soluble chitosan nano-particle which is able to secure the stability and water-solubility of retinol, and a method for preparing the retinol encapsulated water-soluble chitosan nano-particle. The retinol encapsulated water-soluble chitosan nano-particle is characterized in that it has low molecular weight of 1,000-50,000Da and a particle size of 50-150 nanometers. The method comprises the steps of: (a) preparing a low molecular weight water-soluble chitosan solution; (b) preparing a retinol solution; (c) mixing the retinol solution with the chitosan solution and agitating it; and (c) freeze-drying the mixture solution.
Abstract translation: 提供了能够确保视黄醇的稳定性和水溶性的视黄醇包封的水溶性壳聚糖纳米粒子，以及制备视黄醇包封的水溶性壳聚糖纳米粒子的方法。 视黄醇包封的水溶性壳聚糖纳米颗粒的特征在于其具有1,000-50,000Da的低分子量和50-150纳米的粒度。 该方法包括以下步骤：（a）制备低分子量水溶性壳聚糖溶液; （b）制备视黄醇溶液; （c）将视黄醇溶液与壳聚糖溶液混合并搅拌; 和（c）冷冻干燥混合物溶液。
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公开(公告)号：KR100735740B1
公开(公告)日：2007-07-06
申请号：KR1020050072114
申请日：2005-08-08
CPC classification number: C07K14/79
Abstract: 본 발명은 트랜스페린 수용체 영상제제 및 그 제조 방법에 관한 것으로, 보다 상세하게는 방사성핵종으로 표지된 HYNIC-키토산-트랜스페린 배합체를 함유하는 트랜스페린 수용체 영상제제 및 그 제조 방법에 대한 것으로서, 본 발명에 따른 트랜스페린 수용체 영상제제는 세포독성이 없을 뿐만 아니라 표지효율이 높아 빠른 시간 안에 트랜스페린 수용체를 표적하여 감염부위의 영상을 얻을 수 있으므로 생체의 염증 및 종양과 같은 병리적 상태를 조기에 진단 및 치료하는 조영제로 유용하게 이용될 수 있다.
핵의학 영상, 감마 영상, 조영제, 키토산, 트랜스페린, HYNIC, 테크네튬-
公开(公告)号：KR1020070013747A
公开(公告)日：2007-01-31
申请号：KR1020050068329
申请日：2005-07-27
IPC: C08B37/08
CPC classification number: C08B37/003 , A21D2/18 , A21D2/34 , A23G9/32 , A23L2/02 , A23L2/52 , A23L5/00 , A23L7/00 , A23L23/00 , A23L25/30 , A23L27/63 , A23L29/20 , A23L29/275 , A23L29/30 , A23L33/10 , A23L33/125 , A23V2002/00 , A23V2250/511 , B01D61/145
Abstract: Provided are a water-soluble chitosan oligosaccharide having high purity which has an average molecular weight of 1000-11000 Da and an average molecular weight distribution of 1-1-1.5, a method for preparing the same, and a composition comprising the same. The water-soluble chitosan oligosaccharide has an average molecular weight of 1000-11000 Da, and an average molecular weight distribution of 1-1.5. The method for preparing the water-soluble chitosan oligosaccharide comprises the steps of (i) classifying/separating a water-soluble chitosan oligosaccharide according to molecular weight by using ultrafiltration membrane, (ii) removing and lyophilizing impurities of water-soluble chitosan oligosaccharide solution obtained respectively, (iii) precipitating the lyophilized water-soluble chitosan oligosaccharide in organic solvent to obtain a water-soluble chitosan oligosaccharide of powder type, and (iv) drying the water-soluble chitosan oligosaccharide of powder type under vacuum.
Abstract translation: 本发明提供平均分子量为1000〜1000Da，平均分子量分布为1-1〜1.5的纯度高的水溶性壳聚糖寡糖及其制备方法及其组合物。 水溶性壳聚糖寡糖的平均分子量为1000〜1000Da，平均分子量分布为1-1.5。 制备水溶性壳聚糖寡糖的方法包括以下步骤：（i）通过使用超滤膜将水溶性壳聚糖寡糖按分子量进行分类/分离，（ii）除去并冻干获得的水溶性壳聚糖寡糖溶液的杂质 （iii）将冻干的水溶性壳聚糖寡糖在有机溶剂中沉淀，得到粉末型的水溶性壳聚糖寡糖，（iv）在真空下干燥粉末状的水溶性壳聚糖寡糖。
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公开(公告)号：KR1020030026191A
公开(公告)日：2003-03-31
申请号：KR1020010070052
申请日：2001-11-12
IPC: C08B37/08
Abstract: PURPOSE: A method for preparing a water-soluble free amine chitosan is provided, to obtain a pure water-soluble free amine chitosan with a molecular weight of 1,000-100,000 Dalton. CONSTITUTION: The method comprises the steps of treating a solution of salts of an organic acid or an inorganic acid of chitosan oligosaccharide with a trialkylamine; adding an organic solvent to the solution to recover the chitosan oligosaccharide by removing an organic acid or an inorganic acid in the form of a trialkylamine salt; and treating the chitosan oligosaccharide solution with an inorganic acid and purifying the solution with an activated carbon/ion exchange resin column. Preferably the organic acid is selected from the group consisting of lactic acid, acetic acid, propionic acid, formic acid, ascorbic acid and tartaric acid; and the inorganic acid is selected from the group consisting of HCl, HNO3 and H2SO4.
Abstract translation: 目的：提供一种制备水溶性游离胺壳聚糖的方法，以获得分子量为1,000-100,000道尔顿的纯水溶性游离胺壳聚糖。 方法：该方法包括用三烷基胺处理壳聚糖寡糖的有机酸或无机酸的溶液的步骤; 向溶液中加入有机溶剂以通过除去三烷基胺盐形式的有机酸或无机酸来回收壳聚糖寡糖; 用无机酸处理壳聚糖寡糖溶液，用活性炭/离子交换树脂柱纯化溶液。 优选有机酸选自乳酸，乙酸，丙酸，甲酸，抗坏血酸和酒石酸; 无机酸选自HCl，HNO 3和H 2 SO 4。
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Patent Agency Ranking
公开(公告)号：KR1019990045374A
公开(公告)日：1999-06-25
申请号：KR1019980049416
申请日：1998-11-18
Inventor： 김세권
IPC: C12P19/26
Abstract: 본 발명은 키틴에 고정화한 효소를 이용하여 키토산 올리고당을 연속적을 생산하는 방법에 관한 것으로, 효소 활성의 저하가 없고, 막반응기에서의 파울링현상을 효과적으로 제어할 수 있으므로 연속적으로 키토산 올리고당을 대량으로 생산할 수 있다. 또한, 본원 발명은 기존의 회분식법에 비해 값비싼 키토산 가수분해효소의 효율적인 사용을 가능케하므로 보다 경제적인 생산방법이다.
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公开(公告)号：KR102176783B1
公开(公告)日：2020-11-10
申请号：KR20190070382
申请日：2019-06-14
Applicant: 정특래
Inventor： JEONG TEUK RAE , YANG HYUN PIL , EUN KYUNG KIM , YOUNG JIN CHOI , MEIQI FAN
IPC: A61K31/352 , A61P13/08
Abstract: 본발명은전립선비대증치료조성물에관한것으로서, 전립선비대증치료에효과를타나내는안토시아닌올리고머를포함한다. 상기와같은본 발명에따르면, 안토시아닌올리고머를포함하는전립선비대증치료조성물을제공함으로써, 전립선비대증의 5알파환원효소및 전립선비대증의세포생장인자작용을저해하여전립선비대증을치료또는완화하는효과가있다.
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公开(公告)号：KR1020070078196A
公开(公告)日：2007-07-31
申请号：KR1020060008233
申请日：2006-01-26
CPC classification number: A61K31/722 , A61K9/0019 , A61K9/1075 , A61K9/5161 , A61K47/36
Abstract: Provided is an anticancer agent-encapsulated and a hydrophobic bile acid-conjugated hydrophilic chitosan oligosaccharide nanoparticle which shows high encapsulation rate of anti-cancer agent, high cytotoxicity against cancer cells and continuous anti-cancer effect by releasing the anti-cancer agent for a long period of time in vivo so as to be usefully used for chemotherapy. The hydrophilic chitosan oligosaccharide nanoparticle encapsulates an anti-cancer agent and is conjugated with a hydrophobic bile acid which is selected from the group consisting of lithocholic acid, deoxycholic acid, cholic acid, chenodeoxycholic acid, 7-oxo-lithocholic acid and 5beta-cholanic acid. The method comprises the steps of: (a) preparing a bile acid solution by dissolving a hydrophobic bile acid together with an activating agent in a solvent with agitation to activate the bile acid; (b) dissolving a hydrophilic chitosan oligosaccharide in a solvent to prepare a chitosan oligosaccharide solution; (c) reacting the chitosan oligosaccharide solution with the activated bile acid solution to prepare a bile acid-conjugated chitosan oligosaccharide solution; (d) dialyzing and filtering the bile acid-conjugated chitosan oligosaccharide solution to prepare an auto-coagulative type bile acid-conjugated chitosan oligosaccharide nanoparticle solution; and (e) adding an anti-cancer solution to the auto-coagulative type of bile acid-conjugated chitosan oligosaccharide nanoparticle solution so as to encapsulate the anti-cancer agent into the nanoparticle.
Abstract translation: 本发明提供了一种抗癌剂包封和疏水性胆汁酸共轭的亲水性壳聚糖寡糖纳米粒子，其显示出抗癌剂的高包封率，对癌细胞的高细胞毒性和持续的抗癌作用，通过将抗癌剂长时间释放 一段时间在体内，以便有用地用于化疗。 亲水性壳聚糖寡糖纳米粒子包封抗癌剂，并与选自石胆酸，脱氧胆酸，胆酸，鹅脱氧胆酸，7-氧代 - 石胆酸和5β-胆酸的疏水性胆汁酸共轭 。 该方法包括以下步骤：（a）通过在搅拌下将疏水性胆汁酸与活化剂一起溶解在溶剂中以活化胆汁酸来制备胆汁酸溶液; （b）将亲水性壳聚糖寡糖溶解在溶剂中以制备壳聚糖寡糖溶液; （c）使壳聚糖寡糖溶液与活化胆汁酸溶液反应，制备胆汁酸结合的壳聚糖寡糖溶液; （d）透析和过滤胆汁酸结合的壳聚糖寡糖溶液，制备自凝凝型胆汁酸结合的壳聚糖寡糖纳米颗粒溶液; 和（e）将抗癌溶液加入到自凝凝型胆汁酸结合的壳聚糖寡糖纳米颗粒溶液中，以将抗癌剂包封在纳米颗粒中。
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公开(公告)号：KR1020070017628A
公开(公告)日：2007-02-13
申请号：KR1020050072114
申请日：2005-08-08
CPC classification number: C07K14/79 , A61K51/088 , C07K19/00 , C08B37/003
Abstract: 본 발명은 트랜스페린 수용체 영상제제 및 그 제조 방법에 관한 것으로, 보다 상세하게는 방사성핵종으로 표지된 HYNIC-키토산-트랜스페린 배합체를 함유하는 트랜스페린 수용체 영상제제 및 그 제조 방법에 대한 것으로서, 본 발명에 따른 트랜스페린 수용체 영상제제는 세포독성이 없을 뿐만 아니라 표지효율이 높아 빠른 시간 안에 트랜스페린 수용체를 표적하여 감염부위의 영상을 얻을 수 있으므로 생체의 염증 및 종양과 같은 병리적 상태를 조기에 진단 및 치료하는 조영제로 유용하게 이용될 수 있다.
핵의학 영상, 감마 영상, 조영제, 키토산, 트랜스페린, HYNIC, 테크네튬Abstract translation: 本发明涉及一种转铁蛋白受体成像剂，更具体地涉及含有用放射性核素标记的HYNIC-壳聚糖 - 转铁蛋白缀合物的转铁蛋白受体显像剂及其制备方法。 根据本发明的转铁蛋白受体显像剂具有高的标记效率和无细胞毒性，并且可有效地用作早期诊断和治疗诸如生物体的炎症和肿瘤的病理状态的显像剂，因为感染的图像 区域可以通过在短时间内靶向运铁蛋白受体来获得。
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公开(公告)号：KR100399722B1
公开(公告)日：2003-09-29
申请号：KR1020000053070
申请日：2000-09-07
IPC: C12P21/00
Abstract: PURPOSE: Provided is a method for manufacturing fish bone powers and peptides which facilitate the absorption of calcium, thereby providing calcium and facilitating the absorption of calcium to be used as a row material for foods, beverages, pharmaceuticals and the like. CONSTITUTION: The manufacturing method comprises the steps of: reacting fish wastes, which are obtained from the process of making a fish filet, with enzyme extracted from the insides from a fish, such as a tuna and a mackerel; preparing fish bone powders containing rich calcium components from the reaction deposition; and preparing peptide components facilitating he absorption of calcium from the reaction supernatant.
Abstract translation: 目的：提供一种制造鱼骨粉和肽的方法，其有助于钙的吸收，由此提供钙并促进钙的吸收，以用作食品，饮料，药品等的行材料。 组成：该制造方法包括以下步骤：将从制造鱼片的过程中获得的鱼废物与从内部从金枪鱼和鲭鱼等鱼类提取的酶反应; 从反应沉积制备含有丰富钙组分的鱼骨粉; 并制备有助于从反应上清液中吸收钙的肽组分。
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