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公开(公告)号：US20160290895A1
公开(公告)日：2016-10-06
申请号：US15084186
申请日：2016-03-29
Applicant: 3Scan Inc.
Inventor： Cody DANIEL , Matthew GOODMAN , Sean KOLK , Todd HUFFMAN
CPC classification number: G01N1/06 , G01N1/14 , G01N1/28 , G01N1/286 , G01N1/4077 , G01N1/44 , G01N35/00009 , G01N35/00871 , G01N35/04 , G01N35/08 , G01N2001/066 , G01N2001/2873 , G01N2001/4088
Abstract: The present disclosure relates to methods and apparatuses for sectioning and imaging tissue or other samples, which are then automatically captured to enable subsequent analysis. The apparatus acts as a slice capture mechanism for serial sectioning microscopy in a fashion which enables subsequent interfacing with secondary microscopic interrogations or for processing with molecular diagnostic tools. The slices are spatially indexed to allow specific slices to be recalled from a library via automated handling techniques described herein.
Abstract translation: 本公开涉及用于对组织或其他样品进行切片和成像的方法和装置，然后将其自动捕获以便能够进行后续分析。 该装置以串联切片显微镜的切片捕获机构的方式起作用，其能够与二次显微询问接口或用分子诊断工具进行处理。 这些切片被空间索引，以允许通过本文所述的自动处理技术从库中调用特定切片。
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公开(公告)号：US20190355135A1
公开(公告)日：2019-11-21
申请号：US16416211
申请日：2019-05-18
Applicant: 3Scan Inc.
Inventor： CHRISTOPHER RHODES
Abstract: An automated tissue section slicing, staining, and imaging system efficiently registers full-resolution tissue section images by applying scaled transformation matrices computed to register downsampled tissue section images to the full-resolution tissue section images.
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公开(公告)号：WO2015066534A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/063544
申请日：2014-10-31
Applicant: 3SCAN INC.
Inventor： GOODMAN, Matthew , DANIEL, Cody
IPC: G01N1/06
CPC classification number: G02B21/362 , B26D5/007 , G01N1/06 , G01N1/286 , G01N21/55 , G01N2001/2873 , G01N2201/02 , G01N2201/06113 , G02B21/002 , G02B21/32
Abstract: Motion strategies in two and three dimensions for scanning microscope imaging are described. An object, sample, or specimen is mounted on a precision three- dimensional stage. The object is moved concurrently with respect to a first axis and a second axis orthogonal to the first against a cutting tool to cut the object. An image of the cut portion is generated as the object is moved. The cutting tool may act as an optical waveguide for illuminating the portion of the object cut. An optical element captures images of the cut and illuminated object. The object may further be concurrently moved with respect to a third axis orthogonal to both the first and second.
Abstract translation: 描述扫描显微镜成像的二维和三维运动策略。 物体，样品或样品安装在精密三维平台上。 该物体相对于第一轴线和与第一轴线正交的第二轴线相对于切割工具同时移动以切割物体。 当物体移动时，产生切割部分的图像。 切割工具可以用作用于照射被切割部分的光波导。 光学元件捕获切割和照射的物体的图像。 该物体可以进一步相对于与第一和第二两者正交的第三轴同时移动。
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公开(公告)号：WO2019191479A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/024658
申请日：2019-03-28
Applicant: 3SCAN INC.
Inventor： RHODES, Christopher , DANIEL, Cody , SPRINGER, Joey , PARKER, Kristy
Abstract: An apparatus and a method for automated slicing, staining, and imaging of tissue section are provided. The apparatus comprises a tissue sample carrier that moves a tissue sample along a path, a continuous substrate that adheres to a face of the tissue sample, a knife that slices the tissue sample, an applicator that applies pressure to the continuous substrate and an imaging device.
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公开(公告)号：US20210073980A1
公开(公告)日：2021-03-11
申请号：US16950870
申请日：2020-11-17
Applicant: 3Scan Inc.
Inventor： Matthew Goodman , Todd Huffman , Cody Daniel
Abstract: The following concerns a method for co-localization of microscopy or histology stains by the assembly of a virtual image from one or more imaging operations. In particular, the method decreases the time required to obtain multiple labeled antigen or protein histology images of a biological sample. The method includes imaging the tissue as it is sliced by a microtome with a knife edge scanning microscope and spatially aligning the samples by the generated images. The spatial alignment of samples enabled by the method allows a panel of different antigen or protein secondary or functional stains to be compared across different sample slices, thereby allowing concurrent secondary stains of tissues and cells.
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Patent Agency Ranking
公开(公告)号：US20200041387A1
公开(公告)日：2020-02-06
申请号：US16367141
申请日：2019-03-27
Applicant: 3Scan, Inc.
Inventor： Christopher Rhodes , Cody Daniel , Joey Springer , Kristy Parker
Abstract: An automated tissue section slicing, staining, and imaging system sequentially adheres tissue sections to a continuous substrate such that the staining, imaging, and interpretation of the tissue sections are readily carried out at high speed under machine control.
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公开(公告)号：US20150138532A1
公开(公告)日：2015-05-21
申请号：US14529503
申请日：2014-10-31
Applicant: 3SCAN INC.
Inventor： Matthew GOODMAN , Cody DANIEL
CPC classification number: G02B21/362 , B26D5/007 , G01N1/06 , G01N1/286 , G01N21/55 , G01N2001/2873 , G01N2201/02 , G01N2201/06113 , G02B21/002 , G02B21/32
Abstract: Motion strategies in two and three dimensions for scanning microscope imaging are described. An object, sample, or specimen is mounted on a precision three-dimensional stage. The object is moved concurrently with respect to a first axis and a second axis orthogonal to the first against a cutting tool to cut the object. An image of the cut portion is generated as the object is moved. The cutting tool may act as an optical waveguide for illuminating the portion of the object cut. An optical element captures images of the cut and illuminated object. The object may further be concurrently moved with respect to a third axis orthogonal to both the first and second.
Abstract translation: 描述扫描显微镜成像的二维和三维运动策略。 物体，样品或样品安装在精密三维平台上。 该物体相对于第一轴线和与第一轴线正交的第二轴线相对于切割工具同时移动以切割物体。 当物体移动时，产生切割部分的图像。 切割工具可以用作用于照射被切割部分的光波导。 光学元件捕获切割和照射的物体的图像。 该物体可以进一步相对于与第一和第二两者正交的第三轴同时移动。
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公开(公告)号：TW201709150A
公开(公告)日：2017-03-01
申请号：TW105121804
申请日：2016-07-11
Applicant: 三斯坎公司 , 3SCAN, INC.
Inventor： 古德曼 馬修 , GOODMAN, MATTHEW , 赫夫曼 陶德 , HUFFMAN, TODD , 丹尼爾 寇迪 , DANIEL, CODY
CPC classification number: G06T7/0012 , G01N1/06 , G01N1/30 , G06K9/00134 , G06K9/0014 , G06K9/32 , G06T7/33 , G06T2207/10056 , G06T2207/30024
Abstract: 以下係關於藉由組裝來自一或多個成像操作之虛擬影像使顯微術或組織學染色共定位之方法。具體而言，該方法減少獲得生物樣品之經多重標記之抗原或蛋白質之組織學影像所需之時間。該方法包括使組織當藉由薄片切片機將其切片時利用刀口掃描顯微鏡成像並藉由所生成之該等影像使該等樣品空間對準。該方法所實現之樣品之空間對準容許跨越不同樣品切片比較一組不同抗原或蛋白質次級或功能性染色，藉此允許組織及細胞之同時次級染色。
Abstract in simplified Chinese: 以下系关于借由组装来自一或多个成像操作之虚拟影像使显微术或组织学染色共定位之方法。具体而言，该方法减少获得生物样品之经多重标记之抗原或蛋白质之组织学影像所需之时间。该方法包括使组织当借由薄片切片机将其切片时利用刀口扫描显微镜成像并借由所生成之该等影像使该等样品空间对准。该方法所实现之样品之空间对准容许跨越不同样品切片比较一组不同抗原或蛋白质次级或功能性染色，借此允许组织及细胞之同时次级染色。
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公开(公告)号：TW201640177A
公开(公告)日：2016-11-16
申请号：TW105110099
申请日：2016-03-30
Applicant: 三斯坎公司 , 3SCAN, INC.
Inventor： 丹尼爾 寇迪 , DANIEL, CODY , 古德曼 馬修 , GOODMAN, MATTHEW , 寇克 西恩 , KOLK, SEAN , 赫夫曼 陶德 , HUFFMAN, TODD
CPC classification number: G01N1/06 , G01N1/14 , G01N1/28 , G01N1/286 , G01N1/4077 , G01N1/44 , G01N35/00009 , G01N35/00871 , G01N35/04 , G01N35/08 , G01N2001/066 , G01N2001/2873 , G01N2001/4088
Abstract: 本發明係關於用於分段及成像接著將經自動擷取以進行隨後分析之組織或其他樣本之方法及裝置。該裝置用作為用於序列分段顯微術之一切片擷取機構，其係以隨後介接二次顯微診查之方式或運用分子診斷工具處理之方式來實現。該等切片經空間索引以允許特定切片經由本文中描述之自動化處理技術自一儲存庫回復。
Abstract in simplified Chinese: 本发明系关于用于分段及成像接着将经自动截取以进行随后分析之组织或其他样本之方法及设备。该设备用作为用于串行分段显微术之一切片截取机构，其系以随后介接二次显微诊查之方式或运用分子诊断工具处理之方式来实现。该等切片经空间索引以允许特定切片经由本文中描述之自动化处理技术自一存储库回复。
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公开(公告)号：US11754473B2
公开(公告)日：2023-09-12
申请号：US16367141
申请日：2019-03-27
Applicant: 3Scan, Inc.
Inventor： Christopher Rhodes , Cody Daniel , Joey Springer , Kristy Parker
Abstract: An automated tissue section slicing, staining, and imaging system sequentially adheres tissue sections to a continuous substrate such that the staining, imaging, and interpretation of the tissue sections are readily carried out at high speed under machine control.
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