公开(公告)号：IL183332D0

公开(公告)日：2007-10-31

申请号：IL18333207

申请日：2007-05-21

Applicant: ALGORX PHARMACEUTICALS INC ,  BURCH RONALD ,  ANDERSON TIMOTHY A ,  LAZAR JEFF

IPC: A61K20100101

公开(公告)号：WO2005009205A3

公开(公告)日：2005-02-03

申请号：PCT/US2004/017662

申请日：2004-06-07

Applicant: GENSYM CORPORATION ,  ANDERSON, Timothy, A. ,  LEBLING, David, P. ,  HAWKINSON, Lowell, B.

Inventor： ANDERSON, Timothy, A. ,  LEBLING, David, P. ,  HAWKINSON, Lowell, B.

IPC: G01L15/00

Abstract: Systems and methods for the self management of health using a natural language interface. A system or method for self-management of health initiates dialogue with a user to solicit health information from the user using a natural language (NL) interface; In addition, the system or method may respond unsolicited health information from the user provided via a NL interface. The health information from the user is semantically processed in accordance with pre-specified health management rules to facilitate user self management of health. The natural language interface is a constrained natural language. The natural language interface interact with a speech recognition system. The health management logic includes a common sense reasoning logic to semantically process NL input from the user according to rules to emulate common sense reasoning.

公开(公告)号：WO2005009205A2

公开(公告)日：2005-02-03

申请号：PCT/US2004017662

申请日：2004-06-07

Applicant: GENSYM CORP ,  ANDERSON TIMOTHY A ,  LEBLING DAVID P ,  HAWKINSON LOWELL B

Inventor： ANDERSON TIMOTHY A ,  LEBLING DAVID P ,  HAWKINSON LOWELL B

IPC: G06F17/27 ,  G06F17/30 ,  G06F19/00 ,  G10L15/26 ,  A61B

CPC classification number: G06F17/2785 ,  G06F17/27 ,  G10L15/26 ,  G16H40/63

Abstract: Systems and methods for the self management of health using a natural language interface. A system or method for self-management of health initiates dialogue with a user to solicit health information from the user using a natural language (NL) interface; In addition, the system or method may respond unsolicited health information from the user provided via a NL interface. The health information from the user is semantically processed in accordance with pre-specified health management rules to facilitate user self management of health. The natural language interface is a constrained natural language. The natural language interface interact with a speech recognition system. The health management logic includes a common sense reasoning logic to semantically process NL input from the user according to rules to emulate common sense reasoning.

Abstract translation: 使用自然语言界面进行健康自我管理的系统和方法。 用于健康自我管理的系统或方法启动与用户的对话，以使用自然语言（NL）接口从用户请求健康信息; 此外，系统或方法可以响应来自通过NL接口提供的用户的未经请求的健康信息。 来自用户的健康信息根据预先规定的健康管理规则进行语义处理，以便于用户对健康的自我管理。 自然语言界面是受限的自然语言。 自然语言界面与语音识别系统相互作用。 健康管理逻辑包括常规推理逻辑，以根据规则语义地处理来自用户的NL输入以模拟常识推理。

公开(公告)号：WO2004092122A3

公开(公告)日：2005-12-29

申请号：PCT/US2004010745

申请日：2004-04-08

Applicant: ALGORX PHARMACEUTICALS INC ,  MCILVAIN SHARON ,  CHEN WEI ,  RAMIYA PREMCHANDRAN H ,  BURCH RONALD ,  CARTER RICHARD B ,  ANDERSON TIMOTHY A ,  ZHANG HEPING

Inventor： MCILVAIN SHARON ,  CHEN WEI ,  RAMIYA PREMCHANDRAN H ,  BURCH RONALD ,  CARTER RICHARD B ,  ANDERSON TIMOTHY A ,  ZHANG HEPING

IPC: A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  C07C231/02 ,  C07C233/20 ,  C07D201/00

CPC classification number: C07C231/02 ,  A61K31/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/5415 ,  A61K31/551 ,  A61K45/06 ,  C07C51/36 ,  A61K2300/00 ,  C07C57/03 ,  C07C233/20

Abstract: The present invention provides methods for synthesizing the trans isomer of capsaicin and/or capsaicin-like compounds by utilizing a process wherein the trans geometry is set from the beginning of the synthesis reaction and carried through the entire synthesis process.

Abstract translation: 本发明提供了通过利用反应几何形式从合成反应开始设定并通过整个合成过程进行的方法来合成辣椒素和/或辣椒素样化合物的反式异构体的方法。

公开(公告)号：WO2006058140A3

公开(公告)日：2007-01-04

申请号：PCT/US2005042578

申请日：2005-11-23

Applicant: ALGORX PHARMACEUTICALS INC ,  BURCH RONALD ,  ANDERSON TIMOTHY A ,  LAZAR JEFF

Inventor： BURCH RONALD ,  ANDERSON TIMOTHY A ,  LAZAR JEFF

IPC: A61K31/04

CPC classification number: A61K47/26 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/16 ,  A61K36/81 ,  A61K47/36 ,  A61K47/38

Abstract: The present invention provides capsaicinoid gel formulations and methods for relieving pre- and post-surgical pain at a site in a human or animal by administering at a surgical site in a human or animal in need thereof a dose of capsaicinoid gel in an amount effective to attenuate post-surgical pain at the surgical site, the dose of capsaicin ranging from 100 µg to 10,000µg.

Abstract translation: 本发明提供辣椒素类凝胶制剂和方法，其通过在有需要的人或动物的手术部位施用一定剂量的辣椒素凝胶来减轻人或动物的部位的手术前和手术后疼痛， 减轻手术部位的手术后疼痛，辣椒素的剂量范围为100μg〜10,000μg。

公开(公告)号：WO2006058140A2

公开(公告)日：2006-06-01

申请号：PCT/US2005/042578

申请日：2005-11-23

Applicant: ALGORX PHARMACEUTICALS, INC. ,  BURCH, Ronald ,  ANDERSON, Timothy, A. ,  LAZAR, Jeff

Inventor： BURCH, Ronald ,  ANDERSON, Timothy, A. ,  LAZAR, Jeff

IPC: A61K31/16 ,  A61K36/81

CPC classification number: A61K47/26 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/16 ,  A61K36/81 ,  A61K47/36 ,  A61K47/38

Abstract: The present invention provides capsaicinoid gel formulations and methods for relieving pre- and post-surgical pain at a site in a human or animal by administering at a surgical site in a human or animal in need thereof a dose of capsaicinoid gel in an amount effective to attenuate post-surgical pain at the surgical site, the dose of capsaicin ranging from 100 µ g to 10,000 µ g.

Abstract translation: 本发明提供辣椒素类凝胶制剂和方法，其通过在有需要的人或动物的手术部位施用一定剂量的辣椒素凝胶来减轻人或动物的部位的手术前和手术后疼痛， 减轻手术部位的手术后疼痛，辣椒素的剂量范围为100μg〜10,000μg。