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公开(公告)号：AU2003299691B2
公开(公告)日：2008-06-05
申请号：AU2003299691
申请日：2003-12-18
Applicant: ALGORX PHARMACEUTICALS INC
Inventor： LAZAR JEFF , CARTER RICHARD B , BURCH RONALD
IPC: A61K31/05 , A61K9/00 , A61K31/16 , A61K31/165 , A61K31/5415 , A61K31/551 , A61K36/81 , A61K45/06 , A61K47/10 , C07C231/02 , C07C233/20
Abstract: The present invention is directed to methods for attenuating pain associated with a surgical site or an open wound by administration of single doses of a capsaicinoid formulation in proximity to a surgical site or wound opening.
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公开(公告)号：AU2005309586A1
公开(公告)日：2006-06-01
申请号：AU2005309586
申请日：2005-11-23
Applicant: ALGORX PHARMACEUTICALS INC
Inventor： ANDERSON TIMOTHY A , BURCH RONALD , LAZAR JEFF
IPC: A61K31/04
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公开(公告)号：AR055274A1
公开(公告)日：2007-08-15
申请号：ARP050104230
申请日：2005-10-07
Applicant: ALGORX PHARMACEUTICALS INC
Inventor： MC ILVAIN SHARON , CHEN WEI , RAMIYA PREMCHANDRA , BURCH RONALD B , CARTER RICHARD B , ANDERSON THIMOTHY
IPC: C07C233/02
Abstract: La presente provee métodos para sintetizar el trans isomero de la capsaicina y/o compuestos similares a la capsaicina utilizando un proceso en donde la trans geometría se encuentra configurada desde el principio de la reaccion de síntesis y llevada a lo largo de todo el proceso de síntesis.
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公开(公告)号：WO2004092122A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/010745
申请日：2004-04-08
Applicant: ALGORX PHARMACEUTICALS, INC. , McILVAIN, Sharon , CHEN, Wei , RAMIYA, Premchandran, H. , BURCH, Ronald , CARTER, Richard, B. , ANDERSON, Thimothy, A.
Inventor： McILVAIN, Sharon , CHEN, Wei , RAMIYA, Premchandran, H. , BURCH, Ronald , CARTER, Richard, B. , ANDERSON, Thimothy, A.
IPC: C07D
CPC classification number: C07C231/02 , A61K31/05 , A61K31/16 , A61K31/165 , A61K31/5415 , A61K31/551 , A61K45/06 , C07C51/36 , A61K2300/00 , C07C57/03 , C07C233/20
Abstract: The present invention provides methods for synthesizing the trans isomer of capsaicin and/or capsaicin-like compounds by utilizing a process wherein the trans geometry is set from the beginning of the synthesis reaction and carried through the entire synthesis process.
Abstract translation: 本发明提供了通过利用反应几何形式从合成反应开始设定并通过整个合成过程进行的方法来合成辣椒素和/或辣椒素样化合物的反式异构体的方法。
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公开(公告)号：WO2006058140A3
公开(公告)日：2007-01-04
申请号：PCT/US2005042578
申请日：2005-11-23
Applicant: ALGORX PHARMACEUTICALS INC , BURCH RONALD , ANDERSON TIMOTHY A , LAZAR JEFF
Inventor： BURCH RONALD , ANDERSON TIMOTHY A , LAZAR JEFF
IPC: A61K31/04
CPC classification number: A61K47/26 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K31/16 , A61K36/81 , A61K47/36 , A61K47/38
Abstract: The present invention provides capsaicinoid gel formulations and methods for relieving pre- and post-surgical pain at a site in a human or animal by administering at a surgical site in a human or animal in need thereof a dose of capsaicinoid gel in an amount effective to attenuate post-surgical pain at the surgical site, the dose of capsaicin ranging from 100 µg to 10,000µg.
Abstract translation: 本发明提供辣椒素类凝胶制剂和方法，其通过在有需要的人或动物的手术部位施用一定剂量的辣椒素凝胶来减轻人或动物的部位的手术前和手术后疼痛， 减轻手术部位的手术后疼痛，辣椒素的剂量范围为100μg〜10,000μg。
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Patent Agency Ranking
公开(公告)号：WO2006058140A2
公开(公告)日：2006-06-01
申请号：PCT/US2005/042578
申请日：2005-11-23
Applicant: ALGORX PHARMACEUTICALS, INC. , BURCH, Ronald , ANDERSON, Timothy, A. , LAZAR, Jeff
Inventor： BURCH, Ronald , ANDERSON, Timothy, A. , LAZAR, Jeff
CPC classification number: A61K47/26 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K31/16 , A61K36/81 , A61K47/36 , A61K47/38
Abstract: The present invention provides capsaicinoid gel formulations and methods for relieving pre- and post-surgical pain at a site in a human or animal by administering at a surgical site in a human or animal in need thereof a dose of capsaicinoid gel in an amount effective to attenuate post-surgical pain at the surgical site, the dose of capsaicin ranging from 100 µ g to 10,000 µ g.
Abstract translation: 本发明提供辣椒素类凝胶制剂和方法，其通过在有需要的人或动物的手术部位施用一定剂量的辣椒素凝胶来减轻人或动物的部位的手术前和手术后疼痛， 减轻手术部位的手术后疼痛，辣椒素的剂量范围为100μg〜10,000μg。
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公开(公告)号：CA2510181C
公开(公告)日：2011-03-08
申请号：CA2510181
申请日：2003-12-18
Applicant: ALGORX PHARMACEUTICALS INC
Inventor： BURCH RONALD , CARTER RICHARD B , LAZAR JEFF
IPC: A61K31/165 , A61K9/00 , A61K31/05 , A61K31/16 , A61K31/5415 , A61K31/551 , A61K36/81 , A61K45/06 , A61K47/10 , C07C231/02 , C07C233/20
Abstract: The present invention provides compositions and methods for relieving pain at a site in a human or animal in need thereof by administering at a site in a human or animal in need thereof a dose of capsaicinoid.
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公开(公告)号：EA011708B1
公开(公告)日：2009-04-28
申请号：EA200500986
申请日：2003-12-18
Applicant: ALGORX PHARMACEUTICALS INC
Inventor： BURCH RONALD , CARTER RICHARD B , LAZAR JEFF
IPC: A61K31/045 , A61K9/00 , A61K31/05 , A61K31/16 , A61K31/165 , A61K31/5415 , A61K31/551 , A61K36/81 , A61K45/00 , A61K45/06 , A61K47/10 , A61P29/02 , C07C231/02 , C07C233/20
Abstract: Настоящееизобретениеотноситсяк композициями способамдляоблегченияболив участкеорганизмачеловекаилиживотногопосредствомвведенияинъецируемой, имплантируемойилиинфильтрируемойкомпозиции, содержащейдозусинтетическоготранс-капсаицинав количестве, эффективномдляденервацииданногоучасткабезоказаниядействиявнеотдельногоместоположения, идляослабленияболи, исходящейизуказанногоучастка, причемданнаядозанаходитсяв пределахприблизительноот 1 до 5000 мкгсинтетическоготранс-капсаицинас чистотойпоменьшеймереприблизительно 95%, гдеуказаннуюдозуинъецируютилиимплантируютв отдельныйучастокорганизмачеловекаилиживотного, иданнаядозаварьируетприблизительноот 1 до 15000 мкгсинтетическоготранс-капсаицинас чистотойпоменьшеймереприблизительно 95%, гдеуказаннуюдозуинфильтрируютв участокхирургическоговмешательстваилив открытуюрану.
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公开(公告)号：IL183332D0
公开(公告)日：2007-10-31
申请号：IL18333207
申请日：2007-05-21
Applicant: ALGORX PHARMACEUTICALS INC , BURCH RONALD , ANDERSON TIMOTHY A , LAZAR JEFF
IPC: A61K20100101
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公开(公告)号：CA2596194A1
公开(公告)日：2006-06-01
申请号：CA2596194
申请日：2005-11-23
Applicant: ALGORX PHARMACEUTICALS INC
Inventor： LAZAR JEFF , ANDERSON TIMOTHY A , BURCH RONALD
IPC: A61K31/04
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