公开(公告)号：GR852097B

公开(公告)日：1986-01-02

申请号：GR850102097

申请日：1985-08-29

Applicant: ARAI TADASHI

Inventor： ARAI TADASHI ,  MIKAMI VUZURU

IPC: A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C12P17/18 ,  C12R1/56

Abstract: Disclosed are compounds of the formulawherein R represents hydrogen or C 1 -C 4 -alkyl. These compounds are obtained by fermentation of the known saframycin A producing strain Streptomyces lavendulae No. 314 and by reaction with the amino acids L-tyrosine, L-methionine, glycine and HOOC - (CH)NH 2 -CH 2 -R. When R is hydrogen, saframycin Y 3 and when R is methyl, saframycein Y d-1 are produced.