-
1.发明申请POLYMORPHIC FORMS OF (S)-1-CYANOBUTAN-2-YL (S)-1-(3-(3-(3-METHOXY-4-(OXAZOL-5-YL) PHENYL) UREIDO) PHENYL) ETHYLCARBAMATE 审中-公开（S）-1-氰基丁-2-炔（S）-1-（3-（3-（3-甲氧基-4-（氧杂唑-5-基）苯基）脲基）苯基）苯基]乙酸甲酯的多晶型
公开(公告)号：WO2006127909A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/020256
申请日：2006-05-25
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , BLYTHE, Todd, A. , VLAHOVA, Petinka
Inventor： BLYTHE, Todd, A. , VLAHOVA, Petinka
IPC: C07D263/32 , A61K31/421 , A61P35/00
CPC classification number: C07D263/32
Abstract: The present invention relates to polymorphic forms of ( S ) -l-cyanobutan-2-yl ( S ) -1- ( 3 - ( 3 - ( 3 -methoxy-4- ( oxazol-5- yl ) phenyl ) urei do ) phenyl ) ethyl carbamate , pharmaceutical compositions thereof , processes to prepare therein, and uses therewith .
Abstract translation: 本发明涉及（S）-1-氰基丁-2-基（S）-1-（3-（3-（3-甲氧基-4-（恶唑-5-基）苯基）脲）的多晶型物， 苯基）乙基氨基甲酸酯，其药物组合物，其制备方法及其用途。
-
公开(公告)号：WO2006122072A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/017817
申请日：2006-05-09
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , ANSELL, Graham , BLYTHE, Todd, A. , JONES, Andrew, D. , LITTLER, Benjamin , LOOKER, Adam , NYCE, Philip, L. , SNOONIAN, John, R.
Inventor： ANSELL, Graham , BLYTHE, Todd, A. , JONES, Andrew, D. , LITTLER, Benjamin , LOOKER, Adam , NYCE, Philip, L. , SNOONIAN, John, R.
IPC: C07C275/42 , C07D307/16 , C07D413/12 , C07C271/34
CPC classification number: C07D307/20 , C07D413/12
Abstract: The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.
Abstract translation: 本发明涉及制备联芳基脲衍生物及其类似物的方法。 本发明还提供了可用作本发明方法中的中间体的化合物。 该方法可用于制备抑制IMPDH的化合物。
-
Patent Agency Ranking
公开(公告)号：WO2006066044A3
公开(公告)日：2007-05-10
申请号：PCT/US2005045506
申请日：2005-12-15
Applicant: VERTEX PHARMA , SILVA RICHARD A , JONES ANDREW , BLYTHE TODD A
Inventor： SILVA RICHARD A , JONES ANDREW , BLYTHE TODD A
IPC: C07D265/24 , C07C255/50 , C07C271/40 , C07D239/91 , C07D239/94
CPC classification number: C07D265/24 , C07C271/58 , C07D239/91 , C07D239/94
Abstract: The present invention relates to methods for preparing compounds of formula (I): or suitable salts thereof useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also relates to methods for preparing intermediates related thereto.
Abstract translation: 本发明涉及制备式（I）化合物的方法：或其可用作电压门控钠通道和钙通道抑制剂的合适的盐。 本发明还涉及制备与其有关的中间体的方法。
-
4.发明申请POLYMORPHIC FORMS OF (S)-1-CYANOBUTAN-2-YL (S)-1-(3-(3-(3-METHOXY-4-(OXAZOL-5-YL) PHENYL) UREIDO) PHENYL) ETHYLCARBAMATE 审中-公开（S）-1-氰基丁-2-炔（S）-1-（3-（3-（3-甲氧基-4-（氧杂唑-5-基）苯基）脲基）苯基）苯基]乙酸甲酯的多晶型
公开(公告)号：WO2006127909A3
公开(公告)日：2007-03-29
申请号：PCT/US2006020256
申请日：2006-05-25
Applicant: VERTEX PHARMA , BLYTHE TODD A , VLAHOVA PETINKA
Inventor： BLYTHE TODD A , VLAHOVA PETINKA
IPC: C07D263/32 , A61K31/421 , A61P35/00
CPC classification number: C07D263/32
Abstract: The present invention relates to polymorphic forms of ( S ) -l-cyanobutan-2-yl ( S ) -1- ( 3 - ( 3 - ( 3 -methoxy-4- ( oxazol-5- yl ) phenyl ) urei do ) phenyl ) ethyl carbamate , pharmaceutical compositions thereof , processes to prepare therein, and uses therewith .
Abstract translation: 本发明涉及（S）-1-氰基丁-2-基（S）-1-（3-（3-（3-甲氧基-4-（恶唑-5-基）苯基）脲）的多晶型物， 苯基）乙基氨基甲酸酯，其药物组合物，其制备方法及其用途。
-
公开(公告)号：WO2006122072A3
公开(公告)日：2007-05-03
申请号：PCT/US2006017817
申请日：2006-05-09
Applicant: VERTEX PHARMA , ANSELL GRAHAM , BLYTHE TODD A , JONES ANDREW D , LITTLER BENJAMIN , LOOKER ADAM , NYCE PHILIP L , SNOONIAN JOHN R
Inventor： ANSELL GRAHAM , BLYTHE TODD A , JONES ANDREW D , LITTLER BENJAMIN , LOOKER ADAM , NYCE PHILIP L , SNOONIAN JOHN R
IPC: C07C275/42 , C07C271/34 , C07D307/16 , C07D413/12
CPC classification number: C07D307/20 , C07D413/12
Abstract: The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.
Abstract translation: 本发明涉及制备联芳基脲衍生物及其类似物的方法。 本发明还提供了可用作本发明方法中的中间体的化合物。 该方法可用于制备抑制IMPDH的化合物。
-
公开(公告)号：WO2006066044A2
公开(公告)日：2006-06-22
申请号：PCT/US2005/045506
申请日：2005-12-15
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , SILVA, Richard, A. , JONES, Andrew , BLYTHE, Todd, A.
Inventor： SILVA, Richard, A. , JONES, Andrew , BLYTHE, Todd, A.
CPC classification number: C07D265/24 , C07C271/58 , C07D239/91 , C07D239/94
Abstract: The present invention relates to methods for preparing compounds of formula (I): or suitable salts thereof useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also relates to methods for preparing intermediates related thereto.
Abstract translation: 本发明涉及制备式（I）化合物的方法：或其可用作电压门控钠通道和钙通道抑制剂的合适的盐。 本发明还涉及制备与其有关的中间体的方法。
-
7.发明申请POLYMORPHIC FORMS OF (1-{3-[3-(4-CYANO-3-METHOXY-PHENYL)UREIDO]-PHENYL}-ETHYL)-CARBAMIC ACID-2-CYANO-1-ETHYL-ETHYL ESTER 审中-公开（1- {3- [3-（4-氰基-3-甲氧基 - 苯基）尿嘧啶] - 苯基} - 乙基） - 氨基] -2-氰基-1-乙基 - 乙酯的多晶型
公开(公告)号：WO2005095333A1
公开(公告)日：2005-10-13
申请号：PCT/US2005/009516
申请日：2005-03-22
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , NYCE, Philip, L. , BLYTHE, Todd, A. , CUI, Yong
Inventor： NYCE, Philip, L. , BLYTHE, Todd, A. , CUI, Yong
IPC: C07C275/40
CPC classification number: C07C275/40 , C07C273/189 , C07C275/42
Abstract: The present invention relates to polymorphic forms of (1-{3-[3-(4-cyano-3-methoxy-phenyl)ureido]-phenyl}-ethyl)-carbamic acid-2-cyano-1-ethyl-ethyl ester, processes therein, pharmaceutical compositions thereof, and uses therewith.
Abstract translation: 本发明涉及（1- {3- [3-（4-氰基-3-甲氧基 - 苯基）脲基] - 苯基} - 乙基） - 氨基甲酸-2-氰基-1-乙基 - 乙酯 ，其中的方法，其药物组合物及其用途。
-
-
-
-
-
-
Search Results
7
records
(took 0.021 seconds)
