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    MICROFLUIDIC MICROMIXER
    3.
    发明申请
    MICROFLUIDIC MICROMIXER 审中-公开
    微流控MICROMIXER

    公开(公告)号：WO2003037491A2

    公开(公告)日：2003-05-08

    申请号：PCT/US2002/034244

    申请日：2002-10-25

    Applicant: SCIENCE AND TECHNOLOGY CORPORATION @ UNIVERSITY OF NEW MEXICO ,  SKLAR, Larry ,  BURANDA, Tione ,  EDWARDS, Bruce ,  GALLEGOS, Carlos ,  JACKSON, W., Coyt ,  KUCKUCK, Frederick ,  LOPEZ, Gabriel ,  MAMMOLI, Andrea

    Inventor： SKLAR, Larry ,  BURANDA, Tione ,  EDWARDS, Bruce ,  GALLEGOS, Carlos ,  JACKSON, W., Coyt ,  KUCKUCK, Frederick ,  LOPEZ, Gabriel ,  MAMMOLI, Andrea

    IPC: B01F

    CPC classification number: G01N35/085 ,  B01F13/0071 ,  B01L3/0293 ,  B01L3/5085 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/0099 ,  G01N35/08 ,  G01N35/1011 ,  G01N2015/1413 ,  G01N2015/149 ,  G01N2035/00514 ,  G01N2035/00544

    Abstract: A mixing apparatus is provided comprising: first driving means for driving a plurality of reagent samples from a plurality of respective source wells into a first fluid flow stream; second driving means for introducing a separation gas between each of the plurality of reagent sample in the first fluid flow stream; means for driving a second fluid flow stream comprising a plurality of particles; a junction device comprising: a first inlet port for receiving the first fluid flow stream; a second inlet port for receiving the second fluid flow stream; a reaction zone for forcing mixing between the first fluid flow stream and the second fluid flow stream to thereby form a reaction product stream; and an outlet port for allowing the reaction product stream to exit the junction device; a reaction zone where the plurality of reagent samples and the plurality of particles mix to form a plurality of reaction products, the reaction zone communicating with the outlet port; reaction product driving means for driving the reaction product stream through the reaction zone; and means for selectively analyzing the reaction product stream for the reaction products. A method for mixing materials is also provided comprising: driving a first fluid flow stream comprising a plurality of reagent samples separated by gas bubbles through a second inlet port of a junction device; driving a second fluid flow stream comprising particles through a first inlet port of the junction device; mixing the first fluid stream and the second fluid stream in a reaction zone in the junction device to form a reaction product stream; and driving the reaction product stream through an outlet port of the junction device.

    Abstract translation: 提供了一种混合设备，包括：第一驱动装置，用于将多个试剂样品从多个相应的源阱驱动到第一流体流中; 第二驱动装置，用于在所述第一流体流中的所述多个试剂样品中的每一个之间引入分离气体; 用于驱动包括多个颗粒的第二流体流动流的装置; 连接装置，包括：用于接收第一流体流动的第一入口; 用于接收第二流体流的第二入口; 用于迫使所述第一流体流和所述第二流体流之间的混合从而形成反应产物流的反应区; 以及用于允许反应产物流离开接合装置的出口; 反应区，其中所述多个试剂样品和所述多个颗粒混合以形成多个反应产物，所述反应区与所述出口连通; 用于驱动反应产物流通过反应区的反应产物驱动装置; 以及用于选择性分析反应产物的反应产物流的装置。 还提供了一种用于混合材料的方法，包括：驱动包含通过气泡隔开的多个试剂样品的第一流体流，通过连接装置的第二入口; 通过所述连接装置的第一入口驱动包含颗粒的第二流体流; 将所述第一流体流和所述第二流体流在所述连接装置中的反应区中混合以形成反应产物流; 并且通过连接装置的出口驱动反应产物流。

    FLUORESCENCE AND FRET BASED ASSAYS FOR BIOMOLECULES ON BEADS
    7.
    发明申请
    FLUORESCENCE AND FRET BASED ASSAYS FOR BIOMOLECULES ON BEADS 审中-公开
    用于生物分子的荧光和基于FRET的测定

    公开(公告)号：WO0239083A3

    公开(公告)日：2002-07-11

    申请号：PCT/US0142983

    申请日：2001-11-06

    Applicant: STC UNM ,  BURANDA TIONE ,  HUANG JINMAN ,  PEREZ-LUNA VICTOR H ,  LOPEZ GABRIEL P ,  SIMONS PETER ,  SKLAR LARRY A

    Inventor： BURANDA TIONE ,  HUANG JINMAN ,  PEREZ-LUNA VICTOR H ,  LOPEZ GABRIEL P ,  SIMONS PETER ,  SKLAR LARRY A

    IPC: G01N21/64 ,  G01N33/542 ,  G01N33/543 ,  C07K16/00 ,  C12M1/34 ,  C12M3/00 ,  C12Q1/00 ,  G01N21/00 ,  G01N33/53 ,  G01N33/544 ,  G01N33/545

    CPC classification number: G01N33/542 ,  G01N33/54313

    Abstract: The invention provides a sensing device comprising: a vessel; a plurality of sensor beads located within the vessel to form interstitial spaces there through; and a plurality of biomolecules bound to at least at portion of the plurality of beads, each of the biomolecules having a fluorescent tag. A sensing device comprised a suspension of a plurality of sensor beads. The invention also provides a method for detecting the binding of two biomolecules comprising the following steps: providing a plurality of first biomolecules, each of the first biomolecules having a first fluorescent tag; and providing a plurality of second biomolecules, each of the second biomolecules having a second fluorescent tag. The binding step have a pre-complexing total fluorescence and detecting any difference between the pre-complexing total fluorescence and the post-complexing total fluorescence.

    Abstract translation: 本发明提供一种感测装置，包括：容器; 位于容器内的多个传感器珠，以在其间形成间隙空间; 并且多个生物分子结合到所述多个珠粒的至少一部分上，每个生物分子具有荧光标签。 感测装置包括多个传感器珠的悬架。 本发明还提供了检测两种生物分子的结合的方法，包括以下步骤：提供多个第一生物分子，每个第一生物分子具有第一荧光标记; 并且提供多个第二生物分子，每个第二生物分子具有第二荧光标记。 结合步骤具有预络合的总荧光并检测预络合总荧光和后络合总荧光之间的任何差异。

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