公开(公告)号：WO2021205232A1

公开(公告)日：2021-10-14

申请号：PCT/IB2021/000245

申请日：2021-04-05

Applicant: BURRELL, Robert, E.

Inventor： BURRELL, Robert, E.

IPC: C23C14/35 ,  A61L27/30 ,  C23C14/08 ,  C23C14/14

Abstract: Provided herein are methods for preparing a metal matrix composite material by a deposition process. The metal matrix composite materials described herein are useful for anti-inflammatory, antibacterial, antifungal and viricidal applications.

公开(公告)号：WO2004037187A2

公开(公告)日：2004-05-06

申请号：PCT/US2003/033446

申请日：2003-10-22

Applicant: NUCRYST PHARMACEUTICALS CORP. ,  GILLIS, Scott, H. ,  BURRELL, Robert, E. ,  WRIGHT, John, B. ,  LAM, Kan ,  YIN, Hua Qing ,  NAYLOR, Antony, G. ,  MOXHAM, Peter, H. ,  SCHECHTER, Paul

Inventor： BURRELL, Robert, E. ,  WRIGHT, John, B. ,  LAM, Kan ,  YIN, Hua Qing ,  NAYLOR, Antony, G. ,  MOXHAM, Peter, H. ,  SCHECHTER, Paul

IPC: A61K

CPC classification number: A61K9/0095 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/14 ,  A61K9/7023 ,  A61K31/28 ,  A61K33/38 ,  A61K47/36 ,  A61K47/38

Abstract: Metal-containing materials, compositions and methods are disclosed. The metal-containing material can be, for example, an antimicrobial material, an anti-biofilm material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, anti-proliferative, MMP modulating material, an atomically disordered, crystalline material, and/or a nanocrystalline material. In certain embodiments, the metal-containing material is an atomically disordered, nanocrystalline silver-containing material.

Abstract translation: 公开了含金属的材料，组合物和方法。 含金属材料可以是例如抗微生物材料，抗生物膜材料，抗菌材料，抗炎材料，抗真菌材料，抗病毒材料，抗癌材料，抗癌材料 促凋亡物质，抗增殖性MMP调节物质，原子无序的结晶物质和/或纳米晶体物质。 在某些实施方案中，含金属材料是原子无序的纳米晶体含银材料。

公开(公告)号：WO2004037187A3

公开(公告)日：2004-09-02

申请号：PCT/US0333446

申请日：2003-10-22

Applicant: NUCRYST PHARM CORP ,  BURRELL ROBERT E ,  WRIGHT JOHN B ,  LAM KAN ,  YIN HUA QING ,  NAYLOR ANTONY G ,  MOXHAM PETER H ,  SCHECHTER PAUL ,  STILES JAMES ALEXANDER ROBERT

Inventor： BURRELL ROBERT E ,  WRIGHT JOHN B ,  LAM KAN ,  YIN HUA QING ,  NAYLOR ANTONY G ,  MOXHAM PETER H ,  GILLIS SCOTT H ,  SCHECHTER PAUL ,  STILES JAMES ALEXANDER ROBERT

IPC: A61K9/00 ,  A61K9/70 ,  A61K31/28 ,  A61K33/38 ,  A61K47/36 ,  A61K47/38 ,  A61P1/02 ,  A61P11/02 ,  A61P11/04 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10 ,  A61P35/00 ,  A61P43/00 ,  A61K9/14

CPC classification number: A61K9/0095 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/14 ,  A61K9/7023 ,  A61K31/28 ,  A61K33/38 ,  A61K47/36 ,  A61K47/38

Abstract: Metal-containing materials, compositions and methods are disclosed. The metal-containing material can be, for example, an antimicrobial material, an anti-biofilm material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, anti-proliferative, MMP modulating material, an atomically disordered, crystalline material, and/or a nanocrystalline material. In certain embodiments, the metal-containing material is an atomically disordered, nanocrystalline silver-containing material.

Abstract translation: 公开了含金属的材料，组合物和方法。 含金属材料可以是例如抗菌材料，抗生物膜材料，抗菌材料，抗炎材料，抗真菌材料，抗病毒材料，抗癌材料，抗癌材料 促凋亡物质，抗增殖物，MMP调节材料，原子无序的结晶材料和/或纳米晶体材料。 在某些实施方案中，含金属的材料是原子上无序的纳米晶体含银材料。

公开(公告)号：WO2004037187A8

公开(公告)日：2004-07-22

申请号：PCT/US0333446

申请日：2003-10-22

Applicant: NUCRYST PHARM CORP ,  BURRELL ROBERT E ,  WRIGHT JOHN B ,  LAM KAN ,  YIN HUA QING ,  NAYLOR ANTONY G ,  MOXHAM PETER H ,  SCHECHTER PAUL ,  STILES JAMES ALEXANDER ROBERT

Inventor： BURRELL ROBERT E ,  WRIGHT JOHN B ,  LAM KAN ,  YIN HUA QING ,  NAYLOR ANTONY G ,  MOXHAM PETER H ,  GILLIS SCOTT H ,  SCHECHTER PAUL ,  STILES JAMES ALEXANDER ROBERT

IPC: A61K9/00 ,  A61K9/70 ,  A61K31/28 ,  A61K33/38 ,  A61K47/36 ,  A61K47/38 ,  A61P1/02 ,  A61P11/02 ,  A61P11/04 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10 ,  A61P35/00 ,  A61P43/00 ,  A61K

CPC classification number: A61K9/0095 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/14 ,  A61K9/7023 ,  A61K31/28 ,  A61K33/38 ,  A61K47/36 ,  A61K47/38

Abstract: Metal-containing materials, compositions and methods are disclosed. The metal-containing material can be, for example, an antimicrobial material, an anti-biofilm material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, anti-proliferative, MMP modulating material, an atomically disordered, crystalline material, and/or a nanocrystalline material. In certain embodiments, the metal-containing material is an atomically disordered, nanocrystalline silver-containing material.

Abstract translation: 公开了含金属的材料，组合物和方法。 含金属材料可以是例如抗微生物材料，抗生物膜材料，抗菌材料，抗炎材料，抗真菌材料，抗病毒材料，抗癌材料，抗癌材料 促凋亡物质，抗增殖性MMP调节物质，原子无序的结晶物质和/或纳米晶体物质。 在某些实施方案中，含金属材料是原子无序的纳米晶体含银材料。

公开(公告)号：CA2136455A1

公开(公告)日：1995-05-19

申请号：CA2136455

申请日：1994-10-31

Applicant: BURRELL ROBERT E ,  APTE PRASAD S ,  GILL KASHMIR S ,  PRECHT RODERICK J ,  MORRIS LARRY R ,  WESTAIM TECHNOLOGIES INC

Inventor： BURRELL ROBERT E ,  APTE PRASAD S ,  GILL KASHMIR S ,  PRECHT RODERICK J ,  MORRIS LARRY R

IPC: A61L2/16 ,  A01N37/50 ,  A01N47/30 ,  A01N59/00 ,  A01N59/16 ,  A01N59/20 ,  A01N59/26 ,  A61L17/14 ,  A61L29/10 ,  C23C14/00 ,  C23C14/02 ,  C23C14/06 ,  C23C14/08 ,  C23C14/14 ,  C23C14/16 ,  C23C14/35 ,  C23C14/58 ,  A61L27/00 ,  A61L31/00

公开(公告)号：CA2136454A1

公开(公告)日：1995-05-19

申请号：CA2136454

申请日：1994-10-31

Applicant: BURRELL ROBERT E ,  MCINTOSH CATHERINE L ,  MORRIS LARRY R ,  WESTAIM TECHNOLOGIES INC

Inventor： BURRELL ROBERT E ,  MCINTOSH CATHERINE L ,  MORRIS LARRY R

IPC: A61L2/16 ,  A01N37/50 ,  A01N47/30 ,  A01N59/00 ,  A01N59/16 ,  A01N59/20 ,  A01N59/26 ,  A61L17/14 ,  A61L29/10 ,  C23C14/00 ,  C23C14/02 ,  C23C14/06 ,  C23C14/08 ,  C23C14/14 ,  C23C14/16 ,  C23C14/35 ,  C23C14/58 ,  A61L27/00 ,  A61L31/00

Abstract: Anti-microbial coatings and powders and method of forming same on medical devices are provided. The coatings are formed by depositing an anti-microbial biocompatible metal by vapour deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux. Anti-microbial powders formed by mechanical working to produce atomic disorder are also provided. The anti-microbial effect of the coatings or powders may be further activated or enhanced by irradiating with a low linear energy transfer form of radiation such as gamma radiation.

公开(公告)号：CA2136456A1

公开(公告)日：1995-05-19

申请号：CA2136456

申请日：1994-11-01

Applicant: BURRELL ROBERT E ,  MORRIS LARRY R ,  APTE PRASAD S ,  SANT SUDHINDRA B ,  GILL KASHMIR S

Inventor： BURRELL ROBERT E ,  MORRIS LARRY R ,  APTE PRASAD S ,  SANT SUDHINDRA B ,  GILL KASHMIR S

IPC: A01N20060101 ,  A01N59/00 ,  A01N59/16 ,  A61L20060101 ,  A61L27/00 ,  A61L31/00 ,  C01G20060101 ,  C04B37/00

公开(公告)号：CA2033107A1

公开(公告)日：1992-06-25

申请号：CA2033107

申请日：1990-12-24

Applicant: BURRELL ROBERT E ,  ROSENFELD ARON M ,  SMITH TIMOTHY J N

Inventor： BURRELL ROBERT E ,  ROSENFELD ARON M ,  SMITH TIMOTHY J N

IPC: A61L15/00 ,  A61F2/00 ,  A61L15/46 ,  A61L27/54 ,  A61L29/16 ,  A61L31/00 ,  A61L31/16 ,  A61M35/00 ,  A61L27/00

Abstract: An actively sterile surface for a substrate and for use in a dynamicall y biological environment, such as for treating and preventing microbial infections, comprises a film consisting of at least an antimicrobial element and another electrochemically nobler element and which forms multitudinous galvanic cell s with electrolyte containing biological fluids, such as body fluids from wounds, etc., for releasing the antimicrobial element at the surface.