公开(公告)号：WO2007128480A2

公开(公告)日：2007-11-15

申请号：PCT/EP2007003875

申请日：2007-05-02

Applicant: MAX PLANCK GESELLSCHAFT ,  CASTANEDA FRANCISCO ,  KINNE ROLF K-H ,  BOLAND WILHELM ,  BURSE ANTJE

Inventor： CASTANEDA FRANCISCO ,  KINNE ROLF K-H ,  BOLAND WILHELM ,  BURSE ANTJE

IPC: C07H15/14 ,  A61K31/7028 ,  A61P3/10 ,  C07H15/203

CPC classification number: C07H15/203 ,  C07H15/14

Abstract: The present invention relates to thioglycosides and stereoisomeric forms, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds, as well as pharmaceutical compositions containing at least one of these thioglycosides together with pharmaceutically acceptable carrier, excipient and/or diluents. Said thioglycosides have been identified as specific inhibitors of the sodium dependent glucose transporter 1 (SGLT1) and 2 (SGLT2), and are useful for the prophylaxis and/or treatment of hyperglycemia and hyperglycemia related diseases and conditions.

Abstract translation: 本发明涉及这些化合物的硫代糖苷类和立体异构形式，溶剂合物，水合物和/或药学上可接受的盐，以及含有这些硫代糖苷类中的至少一种以及药学上可接受的载体，赋形剂和/或稀释剂的药物组合物。 所述硫代糖苷被鉴定为钠依赖性葡萄糖转运蛋白1（SGLT1）和2（SGLT2）的特异性抑制剂，可用于预防和/或治疗高血糖症和高血糖相关疾病和病症。

公开(公告)号：WO2007128480A3

公开(公告)日：2007-11-15

申请号：PCT/EP2007/003875

申请日：2007-05-02

Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. ,  CASTANEDA, Francisco ,  KINNE, Rolf, K.-H. ,  BOLAND, Wilhelm ,  BURSE, Antje

Inventor： CASTANEDA, Francisco ,  KINNE, Rolf, K.-H. ,  BOLAND, Wilhelm ,  BURSE, Antje

IPC: C07H15/14 ,  C07H15/203 ,  A61K31/7028 ,  A61P3/10

Abstract: The present invention relates to thioglycosides and stereoisomeric forms, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds, as well as pharmaceutical compositions containing at least one of these thioglycosides together with pharmaceutically acceptable carrier, excipient and/or diluents. Said thioglycosides have been identified as specific inhibitors of the sodium dependent glucose transporter 1 (SGLT1) and 2 (SGLT2), and are useful for the prophylaxis and/or treatment of hyperglycemia and hyperglycemia related diseases and conditions.