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    WATER SOLUBLE POLYMERS FOR USE IN IMMUNOASSAYS AND DNA HYBRIDIZATION ASSAYS
    5.
    发明申请
    WATER SOLUBLE POLYMERS FOR USE IN IMMUNOASSAYS AND DNA HYBRIDIZATION ASSAYS 审中-公开
    水溶性聚合物用于免疫测定和DNA杂交测定

    公开(公告)号：WO1995002184A1

    公开(公告)日：1995-01-19

    申请号：PCT/US1994007549

    申请日：1994-07-06

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  DIERENFELDT-TROY, Susan

    IPC: G01N33/545

    CPC classification number: G01N33/532 ,  G01N33/545

    Abstract: Methods and compositions are provided for immunoassays in which a specific binding receptor is coupled to a polymer having a linear backbone. The resulting receptor: polymer complex is soluble in aqueous solution. The complex provides the advantage of performing assays without the use of secondary binding reagents or without the use of particles.

    Abstract translation: 提供了用于免疫测定的方法和组合物，其中特异性结合受体与具有线性主链的聚合物偶联。 所得的受体：聚合物复合物可溶于水溶液。 该复合物提供了在不使用二次结合试剂的情况下进行测定或不使用颗粒的优点。

    SYSTEM AND METHOD FOR ULTRASONIC ENERGY COUPLING BY IRRIGATION
    6.
    发明申请
    SYSTEM AND METHOD FOR ULTRASONIC ENERGY COUPLING BY IRRIGATION 审中-公开
    通过灌溉超声波能量耦合的系统和方法

    公开(公告)号：WO1995001845A1

    公开(公告)日：1995-01-19

    申请号：PCT/US1994007550

    申请日：1994-07-06

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  HADDAD, Antoine, E. ,  MAZZA, John, C.

    IPC: B06B03/00

    CPC classification number: B06B3/00

    Abstract: A system (5) for ultrasonic energy coupling includes an ultrasonic transducer (11), a horn member (12) defining a passageway (14), and a pump (17) for moving fluid through the passageway and outwardly of the horn. The method used to accomplish the energy coupling or transfer includes vibrating the horn member with an ultrasonic transducer and pumping fluid through the passageway in the horn member and onto an object.

    Abstract translation: 一种用于超声波能量耦合的系统（5）包括超声换能器（11），限定通道（14）的喇叭部件（12）和用于使流体通过通道和喇叭外部移动的泵（17）。 用于实现能量耦合或传递的方法包括用超声换能器振动喇叭部件，并将流体通过喇叭部件中的通道泵送到物体上。

    PROCESS FOR THE PREPARATION OF FACTOR X DEPLETED PLASMA
    7.
    发明申请
    PROCESS FOR THE PREPARATION OF FACTOR X DEPLETED PLASMA 审中-公开
    制备X因子等离子体的方法

    公开(公告)号：WO1995001571A1

    公开(公告)日：1995-01-12

    申请号：PCT/US1994007258

    申请日：1994-06-28

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  TANG, ShaMay ,  CARD, Kimberlyn, F. ,  MOTLEY, Leslie ,  WONG, Hing

    IPC: G01N33/86

    CPC classification number: C07K16/36 ,  G01N33/86 ,  G01N2333/96444

    Abstract: A process to prepare factor X deficient plasma is provided. In this process, normal plasma is contacted with an immunoadsorbent having a monoclonal antibody to factor X attached. The factor X binds to the immunoadsorbent and the factor X deficient plasma is collected. The antifactor X antibody immunoadsorbent may be reused. Monoclonal antibodies to factor X are also provided.

    Abstract translation: 提供了制备因子X缺乏血浆的方法。 在该过程中，将正常血浆与具有连接的因子X的单克隆抗体的免疫吸附剂接触。 因子X结合免疫吸附剂并收集因子X缺陷血浆。 抗体X抗体免疫吸附剂可以重复使用。 还提供了X因子单克隆抗体。

    IMMOBILIZATION OF SPECIFIC BINDING ASSAY REAGENTS
    8.
    发明申请
    IMMOBILIZATION OF SPECIFIC BINDING ASSAY REAGENTS 审中-公开
    特异性结合测试试剂的固定

    公开(公告)号：WO1994019693A1

    公开(公告)日：1994-09-01

    申请号：PCT/US1994001539

    申请日：1994-02-09

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  LIN, Spencer, H. ,  YU, Kwok, Sum ,  SINGH, Pratap ,  DIAMOND, Steven, E.

    IPC: G01N33/545

    CPC classification number: G01N33/54306 ,  G01N33/545 ,  G01N33/552 ,  Y10S436/817 ,  Y10S436/823 ,  Y10S530/811

    Abstract: Methods and compositions are provided for specific binding assays in which specific binding reagents are immobilized on a solid phase. Immobilization is facilitated by covalently coupling specific binding assay reagents such as polypeptide receptors or analytes with water soluble polymers. Such water soluble polymers, for example star polymers such as dendrimers, provide production advantages of lot-to-lot uniformity and homogeneity, and can enhance sensitivity due to low non-specific binding to the solid phase.

    Abstract translation: 提供了用于特异性结合试验的方法和组合物，其中特异性结合试剂固定在固相上。 通过将特异性结合测定试剂如多肽受体或分析物与水溶性聚合物共价偶联来促进固定化。 这样的水溶性聚合物，例如星形聚合物，例如树枝状聚合物，提供了批次均匀性和均匀性的生产优点，并且由于低固定相的非特异性结合而提高了灵敏度。

    METHOD AND APPARATUS TO DETECT COAGULATION
    9.
    发明申请
    METHOD AND APPARATUS TO DETECT COAGULATION 审中-公开
    检测凝血的方法和装置

    公开(公告)号：WO1993015408A1

    公开(公告)日：1993-08-05

    申请号：PCT/US1993000596

    申请日：1993-01-22

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  BACH, David, T. ,  COLE, Randall, J.

    IPC: G01N35/02

    CPC classification number: G01N35/0092 ,  G01N35/021 ,  G01N35/025 ,  G01N35/1079 ,  G01N2035/0097 ,  G01N2035/0408 ,  G01N2035/0446

    Abstract: The present invention relates to an apparatus for randomly detecting blood coagulation in a sample. The apparatus includes a reaction container wheel (2), a sampling station (6), a reaction container transfer means for transferring the reaction containers to a reaction wheel (14), a driving means for continuously indexing the reaction wheel (14), a plurality of reagent addition means positioned along the reaction wheel to allow for a complete incubation, without changing the rate of indexing of the reaction wheel, prior to detection and a plurality of detection means (48) are positioned along the reaction wheel to detect the rate of reaction without changing the rate of indexing of the reaction wheel. The apparatus is used to detect blood coagulation in a sample.

    Abstract translation: 本发明涉及一种随机检测样品中血液凝固的装置。 该装置包括反应容器轮（2），采样站（6），用于将反应容器传送到反作用轮（14）的反应容器传送装置，用于使反作用轮（14）连续分度的驱动装置， 多个试剂添加装置沿着反应轮定位，以允许在检测之前不改变反作用轮的分度速率的完全孵育，并且沿反应轮定位多个检测装置（48）以检测速率 的反应，而不改变反作用轮的分度率。 该装置用于检测样品中的血液凝固。

    WASHING/ASPIRATION SYSTEMS AND METHODS FOR SOLID PHASE ASSAYS EMPLOYING PARAMAGNETIC PARTICLES
    10.
    发明申请
    WASHING/ASPIRATION SYSTEMS AND METHODS FOR SOLID PHASE ASSAYS EMPLOYING PARAMAGNETIC PARTICLES 审中-公开
    洗涤/吸入系统和使用参比颗粒的固体相测定方法

    公开(公告)号：WO1993013400A2

    公开(公告)日：1993-07-08

    申请号：PCT/US1992011132

    申请日：1992-12-18

    Applicant: BAXTER DIAGNOSTICS INC.

    Inventor： BAXTER DIAGNOSTICS INC. ,  KAUL, Jeffery, W. ,  RAYMO, Joseph, D. ,  HENRY, Michael, R.

    IPC: G01N0

    CPC classification number: G01N35/1004 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1065 ,  G01N2035/0422 ,  G01N2035/0425 ,  G01N2035/0484

    Abstract: Washing/aspiration systems and associated methods for assays employing paramagnetic solid phase binding particles (422) remove fluid and unbound components from the test well (18) without losing the paramagnetic particles (422) in the process. In one arrangement, the surface tension of the fluid in the well (18) is altered in a preselected manner to redistribute larger volumes of fluid away from the center region of the well (18) and toward the side region of the well (18). Fluid is aspirated from the side region, freeing the center region of the well (18) for the collection and concentration of the paramagnetic particles (422) away from the aspiration flow. In another arrangement, the distribution of the paramagnetic particles (422) in the well (18) is altered by subjecting the particles to a dynamic magnetic field (602; 608) that varies the direction and intensity of the magnetic gradient as a function of time. The dynamic magnetic field (602; 608) collects and concentrates the particles (422) within a region of the test well (18) away from the aspiration probe.

    Abstract translation: 清洗/抽吸系统和使用顺磁性固相结合颗粒（422）的测定法的相关方法从测试孔（18）中除去流体和未结合的组分，而不会损失该过程中的顺磁性颗粒（422）。 在一种布置中，井（18）中的流体的表面张力以预先选择的方式改变，以将更大体积的流体重新分布远离井（18）的中心区域并且朝向井（18）的侧部区域， 。 从侧面区域吸出流体，释放孔（18）的中心区域，以将顺磁性颗粒（422）收集和浓缩远离抽吸流。 在另一种布置中，顺磁粒子（422）在孔（18）中的分布通过使颗粒经受改变磁梯度的方向和强度作为时间的函数的动态磁场（602; 608）来改变 。 动态磁场（602; 608）将测试井（18）的区域内的颗粒（422）收集并浓缩远离抽吸探针。

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