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    SENSORS EMPLOYING COMBINATORIAL ARTIFICIAL RECEPTORS
    1.
    发明公开
    SENSORS EMPLOYING COMBINATORIAL ARTIFICIAL RECEPTORS 审中-公开
    组合人工受体使用的传感器

    公开(公告)号：EP2220495A1

    公开(公告)日：2010-08-25

    申请号：EP08855984.4

    申请日：2008-12-01

    Applicant: Receptors LLC ,  Carlson, Robert E. ,  Weller Roska, Rachel L. ,  Brose, Stephen A.

    Inventor： CARLSON, Robert, E. ,  WELLER ROSKA, Rachel, L. ,  BROSE, Stephen, A.

    IPC: G01N33/543 ,  A61B5/00

    CPC classification number: G01N33/543 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14865

    Abstract: The present invention relates to sensors including artificial receptors and methods of using them. In an embodiment, the present invention includes an artificial receptor as a component of a receptor system including a ligand permeable interface that isolates the artificial receptor from certain components of the surrounding environment. In an embodiment, the present invention includes an artificial receptor and a competitor against a ligand of interest. hi an embodiment, the present invention includes a competitive artificial receptor as a component of a detector system including a semipermeable membrane that isolates the competitive artificial receptor from certain components of the surrounding environment. This embodiment also includes the competitor and a detector operatively coupled to the competitive artificial receptor. The detector produces a signal indicating binding of the competitor and/or the ligand of interest to the artificial receptor. The detector system is configured so that the competitor is retained in the environs of the artificial receptor at least in part by the ligand permeable interface.

    SENSORS EMPLOYING COMBINATORIAL ARTIFICIAL RECEPTORS
    2.
    发明申请
    SENSORS EMPLOYING COMBINATORIAL ARTIFICIAL RECEPTORS 审中-公开
    使用组合人工受体的传感器

    公开(公告)号：WO2009073625A1

    公开(公告)日：2009-06-11

    申请号：PCT/US2008/085181

    申请日：2008-12-01

    Applicant: RECEPTORS LLC ,  CARLSON, Robert, E. ,  WELLER ROSKA, Rachel, L. ,  BROSE, Stephen, A.

    Inventor： CARLSON, Robert, E. ,  WELLER ROSKA, Rachel, L. ,  BROSE, Stephen, A.

    IPC: G01N33/543 ,  A61B5/00

    CPC classification number: G01N33/543 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14865

    Abstract: The present invention relates to sensors including artificial receptors and methods of using them. In an embodiment, the present invention includes an artificial receptor as a component of a receptor system including a ligand permeable interface that isolates the artificial receptor from certain components of the surrounding environment. In an embodiment, the present invention includes an artificial receptor and a competitor against a ligand of interest. hi an embodiment, the present invention includes a competitive artificial receptor as a component of a detector system including a semipermeable membrane that isolates the competitive artificial receptor from certain components of the surrounding environment. This embodiment also includes the competitor and a detector operatively coupled to the competitive artificial receptor. The detector produces a signal indicating binding of the competitor and/or the ligand of interest to the artificial receptor. The detector system is configured so that the competitor is retained in the environs of the artificial receptor at least in part by the ligand permeable interface.

    Abstract translation: 本发明涉及包括人造受体的传感器及其使用方法。 在一个实施方案中，本发明包括作为受体系统的组分的人造受体，其包括将人造受体与周围环境的某些组分隔离的配体可渗透界面。 在一个实施方案中，本发明包括人造受体和针对目的配体的竞争物。 在一个实施方案中，本发明包括作为检测器系统的组分的竞争性人造受体，其包括将竞争性人造受体与周围环境的某些组分隔离的半透膜。 该实施例还包括竞争者和可操作地耦合到竞争性人造受体的检测器。 检测器产生指示竞争剂和/或目标配体与人造受体结合的信号。 检测器系统被配置为使得竞争者至少部分地通过配体可渗透界面保留在人造受体的环境中。

    COMBINATORIAL ARTIFICIAL RECEPTORS INCLUDING PEPTIDE BUILDING BLOCKS
    4.
    发明申请
    COMBINATORIAL ARTIFICIAL RECEPTORS INCLUDING PEPTIDE BUILDING BLOCKS 审中-公开

    公开(公告)号：WO2006029383A2

    公开(公告)日：2006-03-16

    申请号：PCT/US2005/032345

    申请日：2005-09-09

    Applicant: RECEPTORS LLC ,  CARLSON, Robert, E.

    Inventor： CARLSON, Robert, E.

    IPC: G01N33/543

    CPC classification number: C40B30/04 ,  C07K7/06 ,  C07K14/705 ,  Y02P20/55

    Abstract: The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds. In an embodiment, at least one of the building blocks includes or is a peptide moiety. In an embodiment, the building block can be a peptide or peptidomimetic of Formula A: R I R 2 N-R 3 -(R 4 ) n -X-(R 5 ) m -Y-C(O)-R 6 in which R 1 and R 2 can independently be hydrogen or any suitable blocking or protecting group for an amino-terminal nitrogen of a peptide. Suitable blocking or protecting groups include those described in Green, TW; Wuts, PGM (1999), Protective Groups in Organic Synthesis Third Edition, Wiley-Interscience, New York, 779 pp. In an embodiment, R 1 or R 2 is hydrogen. In an embodiment, R 1 is hydrogen and R 2 is R 7 (O)C-, in which R 7 can be lower (e.g., Cl to C6) alkyl, substituted lower (e.g., C1 to C6) alkyl, aryl, substituted aryl, or the like. In an embodiment, R 1 is hydrogen and R 2 is CH 3 (O)C-. In an embodiment, R 1 and R 2 are hydrogen. R 3 can be absent or can be an amino acid, for example, an amino acid with a heteroatom on its side chain. Such amino acids include arginine, lysine, aspartic acid, glutamic acid, cysteine, glutamine, histidine, leucine, valine, methionine, phenylalanine, tyrosine, serine, threonine, and tryptophan. In an embodiment, R 3 is arginine, lysine, aspartic acid, glutamic acid, cysteine, tyrosine, serine, or threonine. In an embodiment, R 3 is arginine, lysine, aspartic acid, or glutamic acid. In an embodiment, R 3 is arginine or lysine. In an embodiment, R 3 is lysine. n can be 0, or n can be, for example, 1-25. In an embodiment, n=4-16. In an embodiment, n=3-6. In an embodiment, n=4. Each of the n R 4 can independently be an amino acid. Suitable amino acids include any of the 20 naturally occurring amino acids. Each of the n R 4 can independently be an amino acid with a small or unreactive side chain. In an embodiment, each of the n R 4 is independently alanine, valine, proline, or glycine. In an embodiment, each of the n R 4 is independently alanine or glycine. In an embodiment, each of the R 4 is independently alanine or glycine and n=4. In an embodiment, each of the (R 4 ) n is -Ala-Gly-Ala-Gly-. m can be 0, or m can be, for example, 1-6. In an embodiment, m=l-3. In an embodiment, m=1. In an embodiment, m=2. Each of the m R 5 can independently be an amino acid. Suitable amino acids include any of the 20 naturally occurring amino acids. Each of the m R 5 can independently be an amino acid with a small or unreactive side chain. In an embodiment, each of the m R 5 is independently alanine, valine, proline, or glycine. In an embodiment, each of the m R 5 is independently alanine or glycine. In an embodiment, R 5 is alanine or glycine and m=1. In an embodiment, R 5 is glycine and m=l. In an embodiment, R 5 is alanine and m=l. In an embodiment, (R 5 ) m has the formula -NR 8 -R 9 -CO- in which R 8 can be H or an organic moiety and R 9 can be an organic moiety. In certain embodiments, R 8 is H, lower (e.g., C1 to C6) alkyl, substituted lower (e.g., Cl to C6) alkyl, aryl, substituted aryl, or the like; and R 9 is lower (e.g., C1 to C6) alkyl, substituted lower (e.g., C1 to C6) alkyl, aryl, substituted aryl, or the like. In certain embodiments, R 8 is H; and R 9 is lower (e.g., C1 to C6) alkyl (e.g., branched lower alkyl). X and Y can independently be an amino acid, a dipeptide moiety (e.g., two amino acids linked by a peptide bond) or a tripeptide moiety (e.g., three amino acids linked by peptide bonds). Suitable amino acids include any of the 20 naturally occurring amino acids. Suitable dipeptide moieties include any two of the 20 naturally occurring amino acids. Suitable tripeptide moieties include any three of the 20 naturally occurring amino acids. In an embodiment, the amino acid or amino acids include or are arginine, glutamine, histidine, leucine, valine, methionine, phenylalanine, tyrosine, serine, threonine, or tryptophan. In an embodiment, the amino acid or amino acids include or are arginine, glutamine, histidine, methionine, threonine, tryptophan, aspartic acid, glutamic acid, leucine, phenylalanine, asparagine, isoleucine, serine, valine, tyrosine, or alanine. In an embodiment, X and Y are independently arginine, glutamine, histidine, methionine, threonine, tryptophan, aspartic acid, glutamic acid, leucine, phenylalanine, asparagine, isoleucine, serine, valine, tyrosine, or alanine. In an embodiment, X is arginine, glutamine, histidine, methionine, threonine, tryptophan, aspartic acid, glutamic acid, leucine, henylalanine, asparagine, isoleucine, serine, valine, tyrosine, or alanine. In an embodiment, Y is arginine, glutamine, histidine, methionine, threonine, tryptophan, aspartic acid, glutamic acid, leucine, phenylalanine, asparagine, isoleucine, serine, valine, tyrosine, or alanine. In an embodiment, X and Y are independently arginine, glutamine, histidine, methionine, tyrosine, threonine, or tryptophan. In an embodiment, X is arginine, glutamine, histidine, methionine, tyrosine, threonine, or tryptophan. In an embodiment, Y is arginine, glutamine, histidine, methionine, tyrosine, threonine, or tryptophan. R 6 can be hydrogen or any suitable blocking or protecting group for an carboxyl-tenninal carboxyl

    COMBINATORIAL ARTIFICIAL RECEPTORS INCLUDING TETHER BUILDING BLOCKS ON SCAFFOLDS
    5.
    发明申请
    COMBINATORIAL ARTIFICIAL RECEPTORS INCLUDING TETHER BUILDING BLOCKS ON SCAFFOLDS 审中-公开
    组合式人工受体，包括牙槽骨上的积木块

    公开(公告)号：WO2006028930A2

    公开(公告)日：2006-03-16

    申请号：PCT/US2005/031213

    申请日：2005-09-01

    Applicant: RECEPTORS LLC ,  CARLSON, Robert, E.

    Inventor： CARLSON, Robert, E.

    IPC: G01N33/543

    CPC classification number: G01N33/566 ,  G01N33/531 ,  G01N33/543 ,  G01N33/54353 ,  G01N33/6845 ,  G01N2500/00 ,  G01N2600/00

    Abstract: The present invention relates to artificial receptors on scaffolds, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds coupled to a scaffold. In an embodiment, at least one of the building blocks includes a tether moiety. The tether can provide spacing or distance between the recognition element and the scaffold to which the building block is immobilized. A tether moiety can have any of a variety of characteristics or properties including flexibility, rigidity or stiffness, ability to bond to another tether moiety, and the like.

    Abstract translation: 本发明涉及支架上的人造受体，制备它们的方法和组合物，以及使用它们的方法。 每个人造受体包括与支架偶联的多种结构单元化合物。 在一个实施方案中，至少一个构件包括系链部分。 系绳可以在识别元件和构件被固定到的支架之间提供间隔或距离。 系链部分可具有多种特性或性质中的任何一种，包括柔韧性，刚性或刚性，与另一系链部分结合的能力等。

    NANODEVICES EMPLOYING COMBINATORIAL ARTIFICIAL RECEPTORS
    6.
    发明申请
    NANODEVICES EMPLOYING COMBINATORIAL ARTIFICIAL RECEPTORS 审中-公开
    纳米组合使用组合人工受体

    公开(公告)号：WO2005024382A9

    公开(公告)日：2005-06-09

    申请号：PCT/US2004029046

    申请日：2004-09-03

    Applicant: RECEPTORS LLC ,  CARLSON ROBERT E

    Inventor： CARLSON ROBERT E

    IPC: B01J19/00 ,  G01N33/543 ,  G01N33/566 ,  G01N33/68

    CPC classification number: G01N33/588 ,  B01J19/0046 ,  B01J2219/00524 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01J2219/00738 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  B82Y30/00 ,  C07K14/705 ,  C12N2810/00 ,  C12N2810/50 ,  C40B80/00 ,  G01N33/54326 ,  G01N33/54346 ,  G01N33/552

    Abstract: The present invention includes nanodevices employing combinatorial artificial receptors and methods for making and using the same. In an embodiment the invention includes a method of adhering components together. In an embodiment, the invention includes a device including a first component adhered to a second component via a binding pair of artificial receptors. In an embodiment, the invention includes an agent delivery device having a capsule, and an active agent. In an embodiment, the invention can include a detection device having a magnetic particle and an artificial receptor disposed thereon. In an embodiment, the invention can include a detection device having a quantum dot and an artificial receptor disposed on the quantum dot. In an embodiment, the invention includes a detection device having first particles and second particles that aggregate in the present of a target ligand. In an embodiment, the invention includes a detection device having a cantilever and an artificial receptor disposed thereon. In an embodiment, the invention can include a detection device having a substrate and an artificial receptor disposed thereon. In an embodiment, the invention can include a device for selective removal of a target component including a substrate and an artificial receptor disposed thereon.

    Abstract translation: 本发明包括采用组合人工受体的纳米器件及其制备和使用方法。 在一个实施例中，本发明包括将组件粘合在一起的方法。 在一个实施方案中，本发明包括一种装置，该装置包括经由人造受体的结合对粘附到第二组分的第一组分。 在一个实施方案中，本发明包括具有胶囊和活性剂的药剂递送装置。 在一个实施例中，本发明可以包括具有设置在其上的磁性颗粒和人造受体的检测装置。 在一个实施例中，本发明可以包括具有设置在量子点上的量子点和人造受体的检测装置。 在一个实施方案中，本发明包括具有第一颗粒和第二颗粒的​​检测装置，所述第一颗粒和第二颗粒在靶配体存在时聚集。 在一个实施例中，本发明包括具有悬臂和位于其上的人造接收器的检测装置。 在一个实施例中，本发明可以包括具有衬底和设置在其上的人造受体的检测装置。 在一个实施例中，本发明可以包括用于选择性去除包括衬底和位于其上的人造受体的目标组件的装置。

    COMBINATORIAL ARTIFICIAL RECEPTORS INCLUDING TETHER BUILDING BLOCKS
    9.
    发明申请
    COMBINATORIAL ARTIFICIAL RECEPTORS INCLUDING TETHER BUILDING BLOCKS 审中-公开
    组合人体受体，包括四面体块

    公开(公告)号：WO2006029234A1

    公开(公告)日：2006-03-16

    申请号：PCT/US2005/031922

    申请日：2005-09-02

    Applicant: RECEPTORS LLC ,  CARLSON, Robert, E.

    Inventor： CARLSON, Robert, E.

    IPC: G01N33/543

    CPC classification number: G01N33/566 ,  G01N33/531 ,  G01N33/543 ,  G01N33/54353 ,  G01N33/6845 ,  G01N2500/00 ,  G01N2600/00

    Abstract: The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds. In an embodiment, at least one of the building blocks includes a tether moiety. The tether can provide spacing or distance between the recognition element and the support or scaffold to which the building block is immobilized. A tether moiety can have any of a variety of characteristics or properties including flexibility, rigidity or stiffness, ability to bond to another tether moiety, and the like.

    Abstract translation: 本发明涉及人造受体，人造受体或候选人受体的阵列或微阵列，其制备方法和组合物，以及使用它们的方法。 每个人造受体包括多个构建块化合物。 在一个实施方案中，至少一个构建块包括系链部分。 系链可以在识别元件和构建块固定到其上的支撑物或支架之间提供间隔或距离。 系链部分可以具有包括柔性，刚性或刚度，结合到另一系链部分的能力等各种特性或性质中的任何一种。

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