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    BIOACTIVE COATING COMPOSITIONS FOR MEDICAL DEVICES
    2.
    发明申请
    BIOACTIVE COATING COMPOSITIONS FOR MEDICAL DEVICES 审中-公开
    用于医疗器械的生物涂料组合物

    公开(公告)号：WO2006107336A1

    公开(公告)日：2006-10-12

    申请号：PCT/US2005/035957

    申请日：2005-10-06

    Applicant: SURMODICS, INC. ,  DEWITT, David, M. ,  FINLEY, Michael, J. ,  LAWIN, Laurie, R.

    Inventor： DEWITT, David, M. ,  FINLEY, Michael, J. ,  LAWIN, Laurie, R.

    IPC: A61L31/10 ,  A61L31/16

    CPC classification number: A61L27/50

    Abstract: A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable medical device, such as a stent or catheter, in order to permit the device to release bioactive agent to the surrounding tissue over time. The composition includes a plurality of compatible polymers having different properties that can permit them to be combined together to provide an optimal combination of such properties as durability, biocompatibility, and release kinetics.

    Abstract translation: 一种用于将生物活性剂施用于表面的涂料组合物和相关方法，其方式将允许生物活性剂在体内从涂层中释放。 组合物特别适用于涂覆可植入医疗装置（例如支架或导管）的表面，以便允许装置随着时间的推移向周围组织释放生物活性剂。 该组合物包括具有不同性质的多种相容性聚合物，其可以将它们组合在一起，以提供诸如耐久性，生物相容性和释放动力学之类的最佳组合。

    METHOD AND APPARATUS FOR COMPOSITE DRUG DELIVERY MEDICAL DEVICES
    4.
    发明申请
    METHOD AND APPARATUS FOR COMPOSITE DRUG DELIVERY MEDICAL DEVICES 审中-公开
    用于复合药物递送医疗装置的方法和装置

    公开(公告)号：WO2009020607A3

    公开(公告)日：2009-04-16

    申请号：PCT/US2008009423

    申请日：2008-08-06

    Applicant: ARSENAL MEDICAL INC ,  ZUGATES GREG ,  DEWITT DAVID M ,  KENDALE AMAR ,  GITLIN IRINA ,  CARBECK JEFFREY

    Inventor： ZUGATES GREG ,  DEWITT DAVID M ,  KENDALE AMAR ,  GITLIN IRINA ,  CARBECK JEFFREY

    IPC: A61K9/00 ,  A61L29/16 ,  A61L31/16

    CPC classification number: A61K9/0024 ,  A61K9/70 ,  A61L27/54 ,  A61L2300/604

    Abstract: A medical device and method for drug delivery employing a 3 -dimensional pattern of a polymer support material (e.g., that is degradable after implant in a body), a drug associated with the polymer support material, and an adhesive that adheres the polymer support material and associated drug to body tissue. The adhesive may persist to maintain the device in a suitable position for a suitable time (e.g., until after the polymer support material begins to degrade to release the drug), and the drug may be arranged in discrete areas of the 3- dimensional pattern that are separated from each other. The pattern may be produced in whole or in part before deployment at a body site, or may be produced in whole or in part directly at a tissue surface.

    Abstract translation: 用于药物递送的医疗装置和方法，其使用聚合物支持材料的3维图案（例如，在植入体内可降解的），与聚合物支持材料相关联的药物和粘合聚合物支持材料的粘合剂 和相关药物与身体组织。 粘合剂可能持续以将装置保持在合适的位置达合适的时间（例如，直到聚合物支撑材料开始降解以释放药物之后），并且药物可以排列在三维图案的离散区域中， 彼此分离。 该图案可以在部署在身体部位之前全部或部分地产生，或者可以全部或部分地直接在组织表面处产生。

    METHOD AND APPARATUS FOR COMPOSITE DRUG DELIVERY MEDICAL DEVICES
    7.
    发明申请
    METHOD AND APPARATUS FOR COMPOSITE DRUG DELIVERY MEDICAL DEVICES 审中-公开
    用于复合药物递送医疗装置的方法和设备

    公开(公告)号：WO2009020607A2

    公开(公告)日：2009-02-12

    申请号：PCT/US2008/009423

    申请日：2008-08-06

    Applicant: ARSENAL MEDICAL, INC. ,  ZUGATES, Greg ,  DEWITT, David, M. ,  KENDALE, Amar ,  GITLIN, Irina ,  CARBECK, Jeffrey

    Inventor： ZUGATES, Greg ,  DEWITT, David, M. ,  KENDALE, Amar ,  GITLIN, Irina ,  CARBECK, Jeffrey

    IPC: A61K9/00 ,  A61L29/16 ,  A61L31/16

    CPC classification number: A61K9/0024 ,  A61K9/70 ,  A61L27/54 ,  A61L2300/604

    Abstract: A medical device and method for drug delivery employing a 3 -dimensional pattern of a polymer support material (e.g., that is degradable after implant in a body), a drug associated with the polymer support material, and an adhesive that adheres the polymer support material and associated drug to body tissue. The adhesive may persist to maintain the device in a suitable position for a suitable time (e.g., until after the polymer support material begins to degrade to release the drug), and the drug may be arranged in discrete areas of the 3- dimensional pattern that are separated from each other. The pattern may be produced in whole or in part before deployment at a body site, or may be produced in whole or in part directly at a tissue surface.

    Abstract translation: 用于使用聚合物载体材料（例如，植入体内后可降解的）的3维图案的药物递送的医疗装置和方法，与聚合物载体材料缔合的药物和 将聚合物载体材料和相关药物粘附到身体组织上的粘合剂。 粘合剂可以持续以将装置保持在合适的位置达合适的时间（例如，直到聚合物支撑材料开始降解以释放药物之后），并且药物可以布置在三维图案的离散区域中， 彼此分开。 图案可以在部署在身体部位之前全部或部分地产生，或者可以全部或部分直接在组织表面产生。

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