公开(公告)号：WO03090666A2

公开(公告)日：2003-11-06

申请号：PCT/EP0304900

申请日：2003-04-25

Applicant: KAROBIO AB ,  ABBOTT LAB ,  JAKOB CLARISSA G ,  MUCHMORE STEVEN ,  KAUPPI BJOERN ,  FARNEGAARDH MATHIAS ,  HARLAN JOHN E ,  YANG JIE ,  CARLQUIST MATS ,  ENGSTROEM OWE ,  AHOLA HARRI ,  OEHMAN LARS

Inventor： JAKOB CLARISSA G ,  MUCHMORE STEVEN ,  KAUPPI BJOERN ,  FARNEGAARDH MATHIAS ,  HARLAN JOHN E ,  YANG JIE ,  CARLQUIST MATS ,  ENGSTROEM OWE ,  AHOLA HARRI ,  OEHMAN LARS

IPC: A61K20060101 ,  C07K14/72 ,  G01N33/48 ,  G06F19/00 ,  A61K

CPC classification number: C07K14/72 ,  G01N33/48 ,  G06F19/00 ,  Y02A90/26

Abstract: The present invention is in the fields of biotechnology, protein purification and crystallization, x-ray diffraction analysis, three-dimensional computer molecular modeling and rational drug design. The invention is directed to the glucocorticoid receptor and ligands for this receptor, and in particular to crystalline glucocorticoid receptor (GR) and to methods of identifying ligands utilizing GR, as well as to compounds, compositions and methods for selecting, making, and using therapeutic or diagnostic agents having GR modulating or binding activity.

Abstract translation: 本发明涉及生物技术，蛋白质纯化和结晶，X射线衍射分析，三维计算机分子建模和合理药物设计领域。 本发明涉及用于该受体的糖皮质激素受体和配体，特别是结晶糖皮质激素受体（GR）和鉴定使用GR的配体的方法，以及用于选择，制备和使用治疗的化合物，组合物和方法 或具有GR调节或结合活性的诊断剂。

公开(公告)号：WO9856812A3

公开(公告)日：1999-04-01

申请号：PCT/GB9801708

申请日：1998-06-10

Applicant: KAROBIO AB ,  OEHMAN LARS ,  BONN TOMAS ,  CARLQUIST MATS ,  ENGSTROEM OWE ,  GOEDE PATRICK ,  HEDFORS AASA ,  HOLMGREN ERIK ,  KOEHLER KONRAD ,  BZOZOWSKI ANDRZEJI MAREK ,  PIKE ASHLEY CHARLES WILLIAM ,  HUBBARD RODERICK ELIOT

Inventor： OEHMAN LARS ,  BONN TOMAS ,  CARLQUIST MATS ,  ENGSTROEM OWE ,  GOEDE PATRICK ,  HEDFORS AASA ,  HOLMGREN ERIK ,  KOEHLER KONRAD ,  BZOZOWSKI ANDRZEJI MAREK ,  PIKE ASHLEY CHARLES WILLIAM ,  HUBBARD RODERICK ELIOT

IPC: A61K31/381 ,  A61K31/5685 ,  A61K38/00 ,  A61K45/00 ,  A61P5/30 ,  C07B61/00 ,  C07D333/54 ,  C07D333/56 ,  C07D333/58 ,  C07D409/04 ,  C07D409/06 ,  C07D417/04 ,  C07J41/00 ,  C07K14/72 ,  C07D333/60 ,  C07J1/00

CPC classification number: C07D333/54 ,  C07D333/56 ,  C07D333/58 ,  C07D409/04 ,  C07D409/06 ,  C07D417/04 ,  C07J41/0005 ,  C07J41/0044 ,  C07K14/721

Abstract: Crystal comprising at least part of the ER alpha ligand binding domain, optionally bound to a ligand, ligands that bind to ER receptors, and methods of designing them, and a homology model of the ER beta receptor.

Abstract translation: 包含至少部分ERα配体结合域的晶体，任选地结合配体，与ER受体结合的配体，及其设计方法，以及ERβ受体的同源性模型。