公开(公告)号：WO2008128050A3

公开(公告)日：2009-02-26

申请号：PCT/US2008060043

申请日：2008-04-11

Applicant: OSI PHARM INC ,  SGX PHARMACEUTICALS INC ,  FOREMAN KENNETH WILLIAM ,  SHAABAN SALAM ,  PARK FRANCES E ,  SAUDER MICHAEL

Inventor： FOREMAN KENNETH WILLIAM ,  SHAABAN SALAM ,  PARK FRANCES E ,  SAUDER MICHAEL

IPC: C12N9/10 ,  C12Q1/48 ,  G06F19/00

CPC classification number: C12N9/1029 ,  C07K2299/00

Abstract: This invention relates to CARM1, CARM1 binding pockets, or CARM1-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to CARM1 protein, complexes of CARM1 protein, homologs thereof, or CARM1-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising a CARM1 protein or homologs thereof. The invention also relates to methods of identifying binders of CARM1 proteins. The invention also relates to methods for determining the intracellular activity of CARM1 methyltransferase and methods for identifying an agent that inhibits the intracellular activity of CARM1 methyltransferase.

Abstract translation: 本发明涉及CARM1，CARM1结合袋或CARM1样结合袋。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标来筛选和设计结合CARM1蛋白，CARM1蛋白的复合物，其同系物或CARM1样蛋白或蛋白质复合物的化合物的方法。 本发明还涉及可结晶组合物和包含CARM1蛋白或其同系物的晶体。 本发明还涉及鉴定CARM1蛋白的结合物的方法。 本发明还涉及确定CARM1甲基转移酶的细胞内活性的方法以及鉴定抑制CARM1甲基转移酶细胞内活性的试剂的方法。

公开(公告)号：WO2008128050A2

公开(公告)日：2008-10-23

申请号：PCT/US2008/060043

申请日：2008-04-11

Applicant: OSI PHARMACEUTICALS, INC. ,  SGX PHARMACEUTICALS, INC. ,  FOREMAN, Kenneth, William ,  SHAABAN, Salam ,  PARK, Frances, E. ,  SAUDER, Michael

Inventor： FOREMAN, Kenneth, William ,  SHAABAN, Salam ,  PARK, Frances, E. ,  SAUDER, Michael

IPC: C12N9/10 ,  G06F19/00 ,  C12Q1/48

CPC classification number: C12N9/1029 ,  C07K2299/00

Abstract: This invention relates to CARM1, CARM1 binding pockets, or CARM1-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to CARM1 protein, complexes of CARM1 protein, homologs thereof, or CARM1-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising a CARM1 protein or homologs thereof. The invention also relates to methods of identifying binders of CARM1 proteins. The invention also relates to methods for determining the intracellular activity of CARM1 methyltransferase and methods for identifying an agent that inhibits the intracellular activity of CARM1 methyltransferase.

Abstract translation: 本发明涉及CARM1，CARM1结合袋或CARM1样结合袋。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标来筛选和设计结合CARM1蛋白，CARM1蛋白的复合物，其同系物或CARM1样蛋白或蛋白质复合物的化合物的方法。 本发明还涉及可结晶组合物和包含CARM1蛋白或其同系物的晶体。 本发明还涉及鉴定CARM1蛋白的结合物的方法。 本发明还涉及确定CARM1甲基转移酶的细胞内活性的方法以及鉴定抑制CARM1甲基转移酶细胞内活性的试剂的方法。

公开(公告)号：WO2008137834A2

公开(公告)日：2008-11-13

申请号：PCT/US2008/062636

申请日：2008-05-05

Applicant: OSI PHARMACEUTICALS, INC. ,  SGX PHARMACEUTICALS, INC. ,  FOREMAN, Kenneth, William ,  PARK, Frances, E. ,  ARNOLD, Lee

Inventor： FOREMAN, Kenneth, William ,  PARK, Frances, E. ,  ARNOLD, Lee

IPC: C12N9/10 ,  C12Q1/48 ,  G01N33/68 ,  A61K38/43

CPC classification number: C12N9/1007 ,  C07K2299/00 ,  G01N2500/04

Abstract: The invention relates to SMYD3 methyltransferase (SMYD3), SMYD3 binding pockets or SMYD3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to SMYD3 methyltransferase protein, complexes of SMYD3 methyltransferase protein, homologues thereof, or SMYD3-like protein or protein complexes.

Abstract translation: 本发明涉及SMYD3甲基转移酶（SMYD3），SMYD3结合口袋或SMYD3样结合口袋。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标来筛选和设计结合SMYD3甲基转移酶蛋白质的化合物，SMYD3甲基转移酶蛋白质的复合物，其同源物或SMYD3样蛋白质或蛋白质复合物的方法。

公开(公告)号：WO2008137834A3

公开(公告)日：2009-02-26

申请号：PCT/US2008062636

申请日：2008-05-05

Applicant: OSI PHARM INC ,  SGX PHARMACEUTICALS INC ,  FOREMAN KENNETH WILLIAM ,  PARK FRANCES E ,  ARNOLD LEE

Inventor： FOREMAN KENNETH WILLIAM ,  PARK FRANCES E ,  ARNOLD LEE

IPC: C12N9/10 ,  A61K38/43 ,  C12Q1/48 ,  G01N33/68

CPC classification number: C12N9/1007 ,  C07K2299/00 ,  G01N2500/04

Abstract: The invention relates to SMYD3 methyltransferase (SMYD3), SMYD3 binding pockets or SMYD3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to SMYD3 methyltransferase protein, complexes of SMYD3 methyltransferase protein, homologues thereof, or SMYD3-like protein or protein complexes.

Abstract translation: 本发明涉及SMYD3甲基转移酶（SMYD3），SMYD3结合口袋或SMYD3样结合口袋。 本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 本发明涉及使用结构坐标来筛选和设计结合SMYD3甲基转移酶蛋白质的化合物，SMYD3甲基转移酶蛋白质的复合物，其同源物或SMYD3样蛋白质或蛋白质复合物的方法。