乳酸乳球菌GEN3013菌株及包含其之用於預防或治療癌症之組合物
    3.
    发明专利
    乳酸乳球菌GEN3013菌株及包含其之用於預防或治療癌症之組合物 审中-公开
    乳酸乳球菌GEN3013菌株及包含其之用于预防或治疗癌症之组合物

    公开(公告)号:TW201946637A

    公开(公告)日:2019-12-16

    申请号:TW108112856

    申请日:2019-04-12

    Abstract: 本發明係關於乳酸乳球菌GEN3013菌株及包含其之用於預防或治療癌症及炎性疾病之組合物。具體而言,本發明之乳酸乳球菌GEN3013菌株不僅發揮抑制癌細胞增殖、減少癌細胞移動性、抑制血管生成及增加抗癌免疫應答之作用,而且還發揮減少炎症因子之表現之作用,以預防或治療癌症或炎性疾病。此外,本發明之乳酸乳球菌GEN3013菌株在與用於治療癌症之其他抗癌劑或抗體組合時顯示出更優異之抗癌作用。

    Abstract in simplified Chinese: 本发明系关于乳酸乳球菌GEN3013菌株及包含其之用于预防或治疗癌症及炎性疾病之组合物。具体而言,本发明之乳酸乳球菌GEN3013菌株不仅发挥抑制癌细胞增殖、减少癌细胞移动性、抑制血管生成及增加抗癌免疫应答之作用,而且还发挥减少炎症因子之表现之作用,以预防或治疗癌症或炎性疾病。此外,本发明之乳酸乳球菌GEN3013菌株在与用于治疗癌症之其他抗癌剂或抗体组合时显示出更优异之抗癌作用。

    NOVEL STRAIN HAVING PROPHYLACTIC OR THERAPEUTIC EFFECT ON CANCER

    公开(公告)号:CA3099906A1

    公开(公告)日:2019-11-14

    申请号:CA3099906

    申请日:2019-05-08

    Abstract: The present invention relates to a novel Bifidobacterium bifidum MG731 strain and a composition for prophylaxis or therapy of cancer, which comprises same. Specifically, the Bifidobacterium bifidum MG731 strain of the present invention exhibits effects of inhibiting cancer cell proliferation, decreasing cancer cell motility, suppressing angiogenesis, and increasing anticancer immune responses as well as downregulating the expression of inflammatory factors, thereby preventing or treating cancer or inflammatory diseases. In addition, when used in combination with a chemotherapeutic agent or immunotherapeutic agent, the Bifidobacterium bifidum MG731 strain of the present invention exhibits a better anticancer effect. Further, the present invention relates to a novel Lactococcus lactis GEN3033 strain and a composition for prophylaxis or therapy of cancer, which comprises same. Specifically, the Lactococcus lactis GEN3033 strain of the present invention exhibits the effect of directly inhibiting cancer cell proliferation and enhancing immunity, thereby preventing or treating cancer. Particularly, the strain has an excellent anticancer effect by secreting metabolites having inhibitory activity against cancer while being established in the gut. In addition, when used in combination with a chemotherapeutic agent or an immunotherapeutic agent, the Lactococcus lactis GEN3033 of the present invention exhibits a better anticancer effect.

    NOVEL STRAIN HAVING PROPHYLACTIC OR THERAPEUTIC EFFECT ON CANCER

    公开(公告)号:AU2020277103A1

    公开(公告)日:2020-12-17

    申请号:AU2020277103

    申请日:2020-11-23

    Abstract: The present invention relates to a novel Bifidobacterium bifidum MG731 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Bifidobacterium bifidum MG731 strain of the present invention has effects of inhibiting the proliferation of cancer cells, decreasing the mobility of cancer cells, inhibiting the neoangiogenesis, and increasing the anticancer immune response as well as reducing the expression of inflammatory factors, thereby having effects of preventing or treating cancers or inflammatory diseases. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Bifidobacterium bifidum MG731 strain of the present invention exhibits a better anticancer effect. In addition, the present invention relates to a novel Lactococcus lactis GEN3033 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Lactococcus lactis GEN3033 strain of the present invention exhibits effects of directly inhibiting the proliferation of cancer cells and enhancing immunity, thereby having effects of preventing or treating cancers. In particular, the strain has an excellent anticancer effect by secreting metabolites having an anticancer effect while being established in the gut. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Lactococcus lactis GEN3033 strain of the present invention exhibits a better anticancer effect. ma: Porphyromonadacea b: Prevotellaceae mc: Rikenellaceae Md: Enterococcaceae Me Lactbacillaceae Mf: Leuconostocaceae m :Streptococcaceae mh: unclassified SMi: Lactobacillales mj: Bacilli mk: Clostridiaceae -I: Lachnospiraceae i mRuminococcaceae M n: unclassified Smo Clostridiales - o pClostridia - Mq: Erysipelotrichaceac M r: Erysipelotrichales M s: Erysipelotrichi Mt Comnanonadaceae mu: Burkholderiales M v: Betaproteobacteria \, Mw: Enterobacteriaceae M x: Enterobacteriales my: Gammaproteobacteria M z: Verrucomicrobiaceae Ma: Verrucomicrobiales Mal: Verrucomicrobiae Faecalbacterium_prausnitzu Prevotellacopr Coprococcus unclassified Blautia unclassified Bacteroidesplebeius SMB53_unclassified Lachrnospiraceae_unclassified Megamonasunclassified Bifidobacteriumunclassified Lactobacillales_unclassified Bacteroides_caccae Lactobacillus unclassified Bacteroides uniformis Oscillospiraunclassified Bacteroidesovatus Lactobacillus salivarius Weissellaunclassified Parabacteroidesunclassified Escherichia_coli Bacteroidesfragilis Streptococcus_unclassified Klebsiella_unclassified Akkermansia: muciniphila Clostridiales-unclassified Enterococcus unclassified -4 -2 0 2 4 LDA SCORE (log 10) Lung cancer patients - Normal controls

    NOVEL STRAIN HAVING PROPHYLACTIC OR THERAPEUTIC EFFECT ON CANCER

    公开(公告)号:CA3104023A1

    公开(公告)日:2019-11-14

    申请号:CA3104023

    申请日:2019-05-08

    Abstract: The present invention relates to a novel Bifidobacterium bifidum MG731 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Bifidobacterium bifidum MG731 strain of the present invention has effects of inhibiting the proliferation of cancer cells, decreasing the mobility of cancer cells, inhibiting the neoangiogenesis, and increasing the anticancer immune response as well as reducing the expression of inflammatory factors, thereby having effects of preventing or treating cancers or inflammatory diseases. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Bifidobacterium bifidum MG731 strain of the present invention exhibits a better anticancer effect. In addition, the present invention relates to a novel Lactococcus lactis GEN3033 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Lactococcus lactis GEN3033 strain of the present invention exhibits effects of directly inhibiting the proliferation of cancer cells and enhancing immunity, thereby having effects of preventing or treating cancers. In particular, the strain has an excellent anticancer effect by secreting metabolites having an anticancer effect while being established in the gut. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Lactococcus lactis GEN3033 strain of the present invention exhibits a better anticancer effect.

    NOVEL STRAIN of LACTOBACILLUS PLANTARUM AND USE THEREOF

    公开(公告)号:US20250017987A1

    公开(公告)日:2025-01-16

    申请号:US18711797

    申请日:2022-05-20

    Abstract: The present invention relates to a novel Lactobacillus plantarum strain. In addition, the present invention relates to a composition for preventing, improving, or treating infertility or subfertility comprising the Lactobacillus plantarum strain.
    The Lactobacillus plantarum strain of the present invention reduces the expression of specific genes in cells constituting the placenta to help implantation of the embryo, increases the number of immune cells in the uterus, and enhances the implantation rate of embryos reduced by immune imbalance. Accordingly, it can be effectively utilized as a composition for the prevention, improvement, or treatment of infertility or subfertility.

    NOVEL STRAINS HAVING EFFECTS OF PREVENTING OR TREATING CANCERS

    公开(公告)号:US20210322490A1

    公开(公告)日:2021-10-21

    申请号:US17054433

    申请日:2019-05-08

    Abstract: The present invention relates to a novel Bifidobacterium bifidum MG731 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Bifidobacterium bifidum MG731 strain of the present invention has effects of inhibiting the proliferation of cancer cells, decreasing the mobility of cancer cells, inhibiting the neoangiogenesis, and increasing the anticancer immune response as well as reducing the expression of inflammatory factors, thereby having effects of preventing or treating cancers or inflammatory diseases. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Bifidobacterium bifidum MG731 strain of the present invention exhibits a better anticancer effect. In addition, the present invention relates to a novel Lactococcus lactis GEN3033 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Lactococcus lactis GEN3033 strain of the present invention exhibits effects of directly inhibiting the proliferation of cancer cells and enhancing immunity, thereby having effects of preventing or treating cancers. In particular, the strain has an excellent anticancer effect by secreting metabolites having an anticancer effect while being established in the gut. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Lactococcus lactis GEN3033 strain of the present invention exhibits a better anticancer effect.

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