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公开(公告)号:TW202003578A
公开(公告)日:2020-01-16
申请号:TW108116930
申请日:2019-05-16
Applicant: 南韓商韓國億諾生物有限公司 , GENOME AND COMPANY
Inventor: 朴漢洙 , PARK, HANSOO , 尹京婉 , YOON, KYOUNG WAN , 許允景 , HOUH, YOUN KYUNG , 全富男 , JEON, BU-NAM , 孫珍英 , SOHN, JINYOUNG , 金允淵 , KIM, YUN YEON , 李洙魯 , LEE, SURO , 鄭朱然 , CHUNG, JOO-YEON , 鄭亞凜 , JEONG, AREUM
IPC: C07K16/28 , A61K39/395 , C07H21/04 , C12N15/13 , A61P35/00
Abstract: 本發明有關一種用於預防或治療癌症的藥學組成物,其包含LRIT2抑制劑作為活性成分。根據本發明之LRIT2抑制劑可增加免疫細胞的活性,因此可用作免疫增強劑。此外,根據本發明之LRIT2抑制劑可增強個體的免疫力,因此可用於有效地預防或治療癌症。
Abstract in simplified Chinese: 本发明有关一种用于预防或治疗癌症的药学组成物,其包含LRIT2抑制剂作为活性成分。根据本发明之LRIT2抑制剂可增加免疫细胞的活性,因此可用作免疫增强剂。此外,根据本发明之LRIT2抑制剂可增强个体的免疫力,因此可用于有效地预防或治疗癌症。
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公开(公告)号:TW202003850A
公开(公告)日:2020-01-16
申请号:TW108118782
申请日:2019-05-30
Applicant: 南韓商韓國億諾生物有限公司 , GENOME AND COMPANY
Inventor: 朴漢洙 , PARK, HANSOO , 尹京婉 , YOON, KYOUNG WAN , 許允景 , HOUH, YOUN KYUNG , 全富男 , JEON, BU-NAM , 孫珍英 , SOHN, JINYOUNG , 金允淵 , KIM, YUN YEON , 李洙魯 , LEE, SURO , 鄭朱然 , CHUNG, JOO-YEON , 鄭亞凜 , JEONG, AREUM
IPC: C12N15/113 , C07K14/705 , C07K16/28
Abstract: 本發明有關一種用於預防或治療癌症的藥學組成物,其包含CD300E抑制劑作為活性成分。根據本發明之CD300E抑制劑可增加免疫細胞的活性,因此可用作免疫增強劑。此外,根據本發明之CD300E抑制劑可增強個體的免疫力,因此可用於有效地預防或治療癌症。
Abstract in simplified Chinese: 本发明有关一种用于预防或治疗癌症的药学组成物,其包含CD300E抑制剂作为活性成分。根据本发明之CD300E抑制剂可增加免疫细胞的活性,因此可用作免疫增强剂。此外,根据本发明之CD300E抑制剂可增强个体的免疫力,因此可用于有效地预防或治疗癌症。
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公开(公告)号:TW201946637A
公开(公告)日:2019-12-16
申请号:TW108112856
申请日:2019-04-12
Applicant: 南韓商韓國億諾生物有限公司 , GENOME AND COMPANY , 光州科學技術院 , GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: 朴漢洙 , PARK, HANSOO
IPC: A61K35/744 , A23L33/135 , A61P35/00
Abstract: 本發明係關於乳酸乳球菌GEN3013菌株及包含其之用於預防或治療癌症及炎性疾病之組合物。具體而言,本發明之乳酸乳球菌GEN3013菌株不僅發揮抑制癌細胞增殖、減少癌細胞移動性、抑制血管生成及增加抗癌免疫應答之作用,而且還發揮減少炎症因子之表現之作用,以預防或治療癌症或炎性疾病。此外,本發明之乳酸乳球菌GEN3013菌株在與用於治療癌症之其他抗癌劑或抗體組合時顯示出更優異之抗癌作用。
Abstract in simplified Chinese: 本发明系关于乳酸乳球菌GEN3013菌株及包含其之用于预防或治疗癌症及炎性疾病之组合物。具体而言,本发明之乳酸乳球菌GEN3013菌株不仅发挥抑制癌细胞增殖、减少癌细胞移动性、抑制血管生成及增加抗癌免疫应答之作用,而且还发挥减少炎症因子之表现之作用,以预防或治疗癌症或炎性疾病。此外,本发明之乳酸乳球菌GEN3013菌株在与用于治疗癌症之其他抗癌剂或抗体组合时显示出更优异之抗癌作用。
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公开(公告)号:CA3099906A1
公开(公告)日:2019-11-14
申请号:CA3099906
申请日:2019-05-08
Applicant: GENOME AND COMPANY
Inventor: PARK HANSOO , PARK SHINYOUNG , LEE EUN JU , YEON JAE-SUNG , JEON HYE HEE , KIM WONDUCK , CHUNG JOO-YEON , JEONG AREUM , HOUH YOUN KYUNG , SOHN JINYOUNG , KIM YUN YEON , KIM SANG GYUN , LEE SURO
IPC: C12N1/20 , A23K10/16 , A23L33/135 , A61K35/745 , A61K35/747 , A61P35/00
Abstract: The present invention relates to a novel Bifidobacterium bifidum MG731 strain and a composition for prophylaxis or therapy of cancer, which comprises same. Specifically, the Bifidobacterium bifidum MG731 strain of the present invention exhibits effects of inhibiting cancer cell proliferation, decreasing cancer cell motility, suppressing angiogenesis, and increasing anticancer immune responses as well as downregulating the expression of inflammatory factors, thereby preventing or treating cancer or inflammatory diseases. In addition, when used in combination with a chemotherapeutic agent or immunotherapeutic agent, the Bifidobacterium bifidum MG731 strain of the present invention exhibits a better anticancer effect. Further, the present invention relates to a novel Lactococcus lactis GEN3033 strain and a composition for prophylaxis or therapy of cancer, which comprises same. Specifically, the Lactococcus lactis GEN3033 strain of the present invention exhibits the effect of directly inhibiting cancer cell proliferation and enhancing immunity, thereby preventing or treating cancer. Particularly, the strain has an excellent anticancer effect by secreting metabolites having inhibitory activity against cancer while being established in the gut. In addition, when used in combination with a chemotherapeutic agent or an immunotherapeutic agent, the Lactococcus lactis GEN3033 of the present invention exhibits a better anticancer effect.
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公开(公告)号:AU2020277103A1
公开(公告)日:2020-12-17
申请号:AU2020277103
申请日:2020-11-23
Applicant: GENOME AND COMPANY
Inventor: PARK HANSOO , PARK SHINYOUNG , LEE EUN JU , YEON JAE-SUNG , JEON HYE-HEE , KIM WONDUCK , CHUNG JOO-YEON , JEONG AREUM , HOUH YOUN KYUNG , SOHN JINYOUNG , KIM YUN YEON , KIM SANG GYUN , LEE SURO
IPC: C12N1/20 , A23K10/16 , A23L33/135 , A61K35/745 , A61K35/747 , A61P35/00 , C12R1/46
Abstract: The present invention relates to a novel Bifidobacterium bifidum MG731 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Bifidobacterium bifidum MG731 strain of the present invention has effects of inhibiting the proliferation of cancer cells, decreasing the mobility of cancer cells, inhibiting the neoangiogenesis, and increasing the anticancer immune response as well as reducing the expression of inflammatory factors, thereby having effects of preventing or treating cancers or inflammatory diseases. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Bifidobacterium bifidum MG731 strain of the present invention exhibits a better anticancer effect. In addition, the present invention relates to a novel Lactococcus lactis GEN3033 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Lactococcus lactis GEN3033 strain of the present invention exhibits effects of directly inhibiting the proliferation of cancer cells and enhancing immunity, thereby having effects of preventing or treating cancers. In particular, the strain has an excellent anticancer effect by secreting metabolites having an anticancer effect while being established in the gut. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Lactococcus lactis GEN3033 strain of the present invention exhibits a better anticancer effect. ma: Porphyromonadacea b: Prevotellaceae mc: Rikenellaceae Md: Enterococcaceae Me Lactbacillaceae Mf: Leuconostocaceae m :Streptococcaceae mh: unclassified SMi: Lactobacillales mj: Bacilli mk: Clostridiaceae -I: Lachnospiraceae i mRuminococcaceae M n: unclassified Smo Clostridiales - o pClostridia - Mq: Erysipelotrichaceac M r: Erysipelotrichales M s: Erysipelotrichi Mt Comnanonadaceae mu: Burkholderiales M v: Betaproteobacteria \, Mw: Enterobacteriaceae M x: Enterobacteriales my: Gammaproteobacteria M z: Verrucomicrobiaceae Ma: Verrucomicrobiales Mal: Verrucomicrobiae Faecalbacterium_prausnitzu Prevotellacopr Coprococcus unclassified Blautia unclassified Bacteroidesplebeius SMB53_unclassified Lachrnospiraceae_unclassified Megamonasunclassified Bifidobacteriumunclassified Lactobacillales_unclassified Bacteroides_caccae Lactobacillus unclassified Bacteroides uniformis Oscillospiraunclassified Bacteroidesovatus Lactobacillus salivarius Weissellaunclassified Parabacteroidesunclassified Escherichia_coli Bacteroidesfragilis Streptococcus_unclassified Klebsiella_unclassified Akkermansia: muciniphila Clostridiales-unclassified Enterococcus unclassified -4 -2 0 2 4 LDA SCORE (log 10) Lung cancer patients - Normal controls
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公开(公告)号:CA3104023A1
公开(公告)日:2019-11-14
申请号:CA3104023
申请日:2019-05-08
Applicant: GENOME AND COMPANY
Inventor: PARK HANSOO , PARK SHINYOUNG , LEE EUN JU , YEON JAE-SUNG , JEON HYE HEE , KIM WONDUCK , CHUNG JOO-YEON , JEONG AREUM , HOUH YOUN KYUNG , SOHN JINYOUNG , KIM YUN YEON , KIM SANG GYUN , LEE SURO
IPC: C12N1/20 , A23K10/16 , A23L33/135 , A61K35/744 , A61P35/00
Abstract: The present invention relates to a novel Bifidobacterium bifidum MG731 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Bifidobacterium bifidum MG731 strain of the present invention has effects of inhibiting the proliferation of cancer cells, decreasing the mobility of cancer cells, inhibiting the neoangiogenesis, and increasing the anticancer immune response as well as reducing the expression of inflammatory factors, thereby having effects of preventing or treating cancers or inflammatory diseases. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Bifidobacterium bifidum MG731 strain of the present invention exhibits a better anticancer effect. In addition, the present invention relates to a novel Lactococcus lactis GEN3033 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Lactococcus lactis GEN3033 strain of the present invention exhibits effects of directly inhibiting the proliferation of cancer cells and enhancing immunity, thereby having effects of preventing or treating cancers. In particular, the strain has an excellent anticancer effect by secreting metabolites having an anticancer effect while being established in the gut. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Lactococcus lactis GEN3033 strain of the present invention exhibits a better anticancer effect.
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公开(公告)号:US20250017987A1
公开(公告)日:2025-01-16
申请号:US18711797
申请日:2022-05-20
Applicant: GENOME AND COMPANY
Inventor: Hyerim KIM , Suro LEE , Jaesung YEON , Hyeyoung KIM , Donghun LEE
IPC: A61K35/747
Abstract: The present invention relates to a novel Lactobacillus plantarum strain. In addition, the present invention relates to a composition for preventing, improving, or treating infertility or subfertility comprising the Lactobacillus plantarum strain.
The Lactobacillus plantarum strain of the present invention reduces the expression of specific genes in cells constituting the placenta to help implantation of the embryo, increases the number of immune cells in the uterus, and enhances the implantation rate of embryos reduced by immune imbalance. Accordingly, it can be effectively utilized as a composition for the prevention, improvement, or treatment of infertility or subfertility.-
公开(公告)号:US11478513B2
公开(公告)日:2022-10-25
申请号:US17270516
申请日:2019-05-24
Applicant: GENOME AND COMPANY
Inventor: Han-Soo Park
Abstract: The present invention relates to Cutibacterium avidum GENSC01 strain (KCTC 13596BP). The present invention also relates to a composition comprising the strain or its culture, and use thereof. The present invention is effective in improvement, prevention or treatment of atopic dermatitis, acne or skin inflammation by fine dust.
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公开(公告)号:US20210322490A1
公开(公告)日:2021-10-21
申请号:US17054433
申请日:2019-05-08
Applicant: Genome And Company
Inventor: Hansoo Park , Shinyoung Park , Eun Ju Lee , Jae-Sung Yeon , Hye Hee Jeon , Wonduck Kim , Joo-Yeon Chung , Areum Jeong , Youn Kyung Houh , Jinyoung Sohn , Yun Yeon Kim , Sang Gyun Kim , Suro Lee
IPC: A61K35/745 , C12N1/20 , A61K45/06 , C07K16/28
Abstract: The present invention relates to a novel Bifidobacterium bifidum MG731 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Bifidobacterium bifidum MG731 strain of the present invention has effects of inhibiting the proliferation of cancer cells, decreasing the mobility of cancer cells, inhibiting the neoangiogenesis, and increasing the anticancer immune response as well as reducing the expression of inflammatory factors, thereby having effects of preventing or treating cancers or inflammatory diseases. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Bifidobacterium bifidum MG731 strain of the present invention exhibits a better anticancer effect. In addition, the present invention relates to a novel Lactococcus lactis GEN3033 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Lactococcus lactis GEN3033 strain of the present invention exhibits effects of directly inhibiting the proliferation of cancer cells and enhancing immunity, thereby having effects of preventing or treating cancers. In particular, the strain has an excellent anticancer effect by secreting metabolites having an anticancer effect while being established in the gut. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Lactococcus lactis GEN3033 strain of the present invention exhibits a better anticancer effect.
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公开(公告)号:US20210315801A1
公开(公告)日:2021-10-14
申请号:US17270494
申请日:2019-05-24
Applicant: GENOME AND COMPANY
Inventor: Han-Soo PARK
IPC: A61K8/99 , A61Q19/00 , C12N1/20 , A61K35/741 , A61P17/10
Abstract: The present invention relates to Cutibacterium granulosum GENSC02 strain (KCTC 13597BP). The present invention also relates to a composition comprising the strain or its culture, and use thereof. The present invention is effective in improvement, prevention or treatment of acne, atopic dermatitis or skin inflammation by fine dust.
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