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    SYSTEMS AND METHODS FOR REDUCTION OF PATHOGENS IN A BIOLOGICAL FLUID USING VARIABLE FLUID FLOW AND ULTRAVIOLET LIGHT IRRADIATION
    1.
    发明申请
    SYSTEMS AND METHODS FOR REDUCTION OF PATHOGENS IN A BIOLOGICAL FLUID USING VARIABLE FLUID FLOW AND ULTRAVIOLET LIGHT IRRADIATION 审中-公开
    使用可变流体流和超紫外线照射降低生物流体病原体的系统和方法

    公开(公告)号：US20140091045A1

    公开(公告)日：2014-04-03

    申请号：US14098052

    申请日：2013-12-05

    Applicant: Hemalux Technologies LLC

    Inventor： Ehud Ben-Hur ,  Heather Balji

    IPC: B01J19/12

    CPC classification number: B01J19/123 ,  A61L2/0047 ,  A61L2202/22 ,  B01J2219/00772 ,  B01J2219/00774 ,  B01J2219/00777 ,  B01J2219/0877

    Abstract: A system and method for reducing pathogens in a biological fluid such as whole blood or blood-derived products includes a pump configured to propagate the fluid through a serpentine-shaped flow path while exposing the fluid to UV irradiation. Extensive mixing of flow is accomplished by causing the pump to vary the flow of fluid. In embodiments, the pump may be operated to periodically switch the flow back and forth between a high flow rate and a slow flow rate. Alternatively, the pump may be periodically stopped or even cause the flow to reverse direction for short periods of time.

    Abstract translation: 用于减少诸如全血或血液衍生产品的生物流体中的病原体的系统和方法包括：泵，其配置成在使流体暴露于UV照射的同时将流体传播通过蛇形流动路径。 通过使泵改变流体的流动来实现流动的广泛混合。 在实施例中，可以操作泵以在高流量和慢流速之间来回周期性地切换流。 或者，泵可以周期性地停止，或者甚至使得流动在短​​时间段内反向。

    SYSTEMS AND METHODS FOR REDUCTION OF PATHOGENS IN A BIOLOGICAL FLUID USING VARIABLE FLUID FLOW AND ULTRAVIOLET LIGHT IRRADIATION
    2.
    发明申请
    SYSTEMS AND METHODS FOR REDUCTION OF PATHOGENS IN A BIOLOGICAL FLUID USING VARIABLE FLUID FLOW AND ULTRAVIOLET LIGHT IRRADIATION 审中-公开
    使用可变流体流和超紫外线照射降低生物流体病原体的系统和方法

    公开(公告)号：US20140097353A1

    公开(公告)日：2014-04-10

    申请号：US14101684

    申请日：2013-12-10

    Applicant: Hemalux Technologies LLC

    Inventor： Ehud Ben-Hur ,  Heather Balji

    IPC: A61M1/36

    CPC classification number: A61M1/3681 ,  A61L2/0047 ,  A61L2202/14 ,  A61L2202/22 ,  A61M2205/053 ,  B01J19/123 ,  B01J2219/00772 ,  B01J2219/00774 ,  B01J2219/00777 ,  B01J2219/0877

    Abstract: A system for reducing pathogens in a biological fluid such as whole blood or blood-derived products includes a pump configured to propagate the fluid through a serpentine-shaped flow path while exposing the fluid to UV irradiation. Extensive mixing of flow is accomplished by a pump control system programmed to cause the pump to vary the flow of fluid. In embodiments, the pump may be automatically operated to periodically switch the flow back and forth between a high flow rate and a slow flow rate. Alternatively, the pump may be periodically stopped or even cause the flow to reverse direction for short periods of time.

    Abstract translation: 用于减少诸如全血或血液衍生产品的生物流体中的病原体的系统包括泵，所述泵构造成在使流体暴露于UV照射的同时将流体传播通过蛇形形状的流动路径。 通过编程为使泵改变流体流量的泵控制系统来实现流动的广泛混合。 在实施例中，泵可以被自动操作以在高流量和慢流速之间来回周期性地切换流。 或者，泵可以周期性地停止，或者甚至使得流动在短​​时间段内反向。

    Method of reducing pathogens in whole blood by illuminating with ultraviolet light under low oxygen conditions
    3.
    发明授权
    Method of reducing pathogens in whole blood by illuminating with ultraviolet light under low oxygen conditions 有权
    通过在低氧条件下用紫外线照射来减少全血中的病原体的方法

    公开(公告)号：US08883409B1

    公开(公告)日：2014-11-11

    申请号：US14099963

    申请日：2013-12-08

    Applicant: Hemalux Technologies LLC

    Inventor： Ehud Ben-Hur

    IPC: A61K35/14 ,  A01N1/02

    CPC classification number: A01N1/0294 ,  A61K35/14

    Abstract: Disclosed are methods for pathogen reduction in blood by illuminating with UV light while taking steps for preservation of blood components and reducing oxidative damage from reactive oxygen species generated during UV light exposure. Fresh whole donor blood or products derived therefrom may be submitted to UV light treatment while in a low oxygenation state defined by a partial oxygen pressure below a normal level. Such low oxygenation state occurs naturally shortly after blood collection or may be induced by exposure to low-oxygen environment, reducing temperature or by other disclosed steps.

    Abstract translation: 公开了通过用UV光照射同时采取维持血液成分的步骤并减少在紫外线照射期间产生的活性氧的氧化损伤的方法来降低血液中的病原体。 新鲜的供体血液或其衍生的产品可以进行紫外光处理，同时处于低于正常水平的部分氧气压力定义的低氧合状态。 这种低氧合状态在采血后自然发生，或者可能通过暴露于低氧环境，降低温度或通过其他公开的步骤诱导。

    SYSTEMS AND METHODS FOR PATHOGEN INACTIVATION IN BLOOD USING UV IRRADIATION WHILE MINIMIZING HEAT TRANSFER THERETO
    6.
    发明申请
    SYSTEMS AND METHODS FOR PATHOGEN INACTIVATION IN BLOOD USING UV IRRADIATION WHILE MINIMIZING HEAT TRANSFER THERETO 审中-公开
    使用最小化热转印的紫外线​​辐射在血液中病原体灭活的系统和方法

    公开(公告)号：WO2016064945A1

    公开(公告)日：2016-04-28

    申请号：PCT/US2015/056558

    申请日：2015-10-21

    Applicant: HEMALUX TECHNOLOGIES LLC

    Inventor： BEN-HUR, Ehud

    IPC: A61M1/36 ,  A61L2/10

    CPC classification number: A61M1/3681 ,  A61K41/0019 ,  A61L2/0047 ,  A61L2/10 ,  A61L2202/22 ,  A61M1/3683 ,  A61M2202/0413 ,  A61M2205/053 ,  G01J5/06 ,  G01J2005/065 ,  G01K13/02 ,  G01K2013/026

    Abstract: The systems and methods for pathogen reduction in donor blood operates by exposure of blood to UVC irradiation. Unwanted wavelengths of light, mostly in the infrared spectra, may be precluded from reaching blood by providing a layer of IR-absorbing fluid positioned between blood and the source of UV irradiation, whereby minimizing energy absorption and heating of blood. Some embodiments further disclose a system configured to utilize the same IR-absorbing fluid to actively cool blood by flowing along the flow path thereof.

    Abstract translation: 供体血液中病原体减少的系统和方法是通过将血液暴露于UVC照射来进行的。 大部分在红外光谱中的不需要的波长的光可以通过提供位于血液和UV照射源之间的一层IR吸收流体而被排除以达到血液，从而最小化血液的能量吸收和加热。 一些实施例进一步公开了被配置为利用相同的IR吸收流体通过沿其流动路径流动来主动冷却血液的系统。

    METHODS OF DONOR BLOOD PRESERVATION AND REDUCING PATHOGENS BY ILLUMINATING WITH ULTRAVIOLET LIGHT
    7.
    发明申请
    METHODS OF DONOR BLOOD PRESERVATION AND REDUCING PATHOGENS BY ILLUMINATING WITH ULTRAVIOLET LIGHT 审中-公开
    通过用超紫外线照射降低血液保存和减少病原体的方法

    公开(公告)号：WO2015084623A1

    公开(公告)日：2015-06-11

    申请号：PCT/US2014/067123

    申请日：2014-11-24

    Applicant: HEMALUX TECHNOLOGIES LLC

    Inventor： BEN-HUR, Ehud

    IPC: A01N1/02 ,  A61L2/10

    CPC classification number: A01N1/0294 ,  A61K35/14

    Abstract: Disclosed are methods for pathogen reduction in blood by illuminating with UV light while taking steps for preservation of blood components and reducing oxidative damage from reactive oxygen species generated during UV light exposure. Fresh whole donor blood or products derived therefrom may be submitted to UV light treatment while in a low oxygenation state defined by a partial oxygen pressure below a normal level. Such low oxygenation state occurs naturally shortly after blood collection or may be induced by exposure to low-oxygen environment, reducing temperature or by other disclosed steps.

    Abstract translation: 公开了通过用UV光照射同时采取维持血液成分的步骤并减少在紫外线照射期间产生的活性氧的氧化损伤的方法来降低血液中的病原体。 新鲜的供体血液或其衍生物可以在由低于正常水平的部分氧气压力限定的低氧合状态下进行紫外光处理。 这种低氧合状态在采血后自然发生，或者可能通过暴露于低氧环境，降低温度或通过其他公开的步骤诱导。

    AN EXPOSURE CHAMBER AND A SYSTEM FOR REDUCTION OF PATHOGENS IN A BIOLOGICAL FLUID USING ULTRAVIOLET IRRADIATION BY LIGHT EMITTING DIODES
    8.
    发明申请
    AN EXPOSURE CHAMBER AND A SYSTEM FOR REDUCTION OF PATHOGENS IN A BIOLOGICAL FLUID USING ULTRAVIOLET IRRADIATION BY LIGHT EMITTING DIODES 审中-公开
    暴露室和用于通过发光二极管使用紫外线辐照降低生物流体中病原体的系统

    公开(公告)号：WO2014051906A1

    公开(公告)日：2014-04-03

    申请号：PCT/US2013/056607

    申请日：2013-08-26

    Applicant: HEMALUX TECHNOLOGIES LLC

    Inventor： BEN-HUR, Ehud ,  BALJI, Heather

    IPC: A61L2/10

    CPC classification number: B01J19/123 ,  A61L2/0047 ,  A61L2202/22 ,  B01J2219/00772 ,  B01J2219/00774 ,  B01J2219/00777 ,  B01J2219/0877

    Abstract: An exposure chamber (150) for reducing pathogens in a biological fluid such as whole blood or blood-derived products includes a serpentine-shaped UV-transparent flow path (124) and closely positioned ultraviolet light emitting diodes (142) configured for emanating UV irradiation towards the biological fluid at peak wavelength of 250 nm to 270 nm. The control system is provided to energize UV LEDs using various novel modes of modulating pulse width and current amplitude for LEDs so as to deliver higher UV intensity to the biological fluid but without overheating thereof or the LEDs.

    Abstract translation: 用于减少诸如全血或血液衍生产品的生物流体中的病原体的暴露室（150）包括蛇形形状的UV透明流动路径（124），并且被配置用于发出紫外线照射的紧密定位的紫外线发光二极管（142） 朝向在峰值波长为250nm至270nm的生物流体。 提供控制系统以使用针对LED调制脉冲宽度和电流幅度的各种新颖模式来激励UV LED，以便向生物流体输送更高的UV强度，但不会使其过热或LED发生。

    SYSTEMS AND METHODS FOR REDUCTION OF PATHOGENS IN A BIOLOGICAL FLUID USING VARIABLE FLUID FLOW AND ULTRAVIOLET LIGHT IRRADIATION
    9.
    发明申请
    SYSTEMS AND METHODS FOR REDUCTION OF PATHOGENS IN A BIOLOGICAL FLUID USING VARIABLE FLUID FLOW AND ULTRAVIOLET LIGHT IRRADIATION 审中-公开
    使用可变流体流和超紫外线照射降低生物流体病原体的系统和方法

    公开(公告)号：WO2014051882A1

    公开(公告)日：2014-04-03

    申请号：PCT/US2013/055488

    申请日：2013-08-18

    Applicant: HEMALUX TECHNOLOGIES LLC

    Inventor： BEN-HUR, Ehud ,  BALJI, Heather

    IPC: A61L2/10 ,  A61M1/10

    CPC classification number: B01J19/123 ,  A61L2/0047 ,  A61L2202/22 ,  B01J2219/00772 ,  B01J2219/00774 ,  B01J2219/00777 ,  B01J2219/0877

    Abstract: A system and method for reducing pathogens in a biological fluid such as whole blood or blood-derived products includes a pump (104) configured to propagate the fluid through a serpentine-shaped flow path (124) while exposing the fluid to UV irradiation from a source (120). Extensive mixing of flow is accomplished by causing the pump (104) to vary the flow of fluid. In embodiments, the pump may be operated to periodically switch the flow back and forth between a high flow rate and a slow flow rate. Alternatively, the pump may be periodically stopped or even cause the flow to reverse direction for short periods of time.

    Abstract translation: 用于减少诸如全血或血液衍生产品的生物流体中的病原体的系统和方法包括：泵（104），其构造成使流体通过蛇形流动路径（124）传播，同时将流体从 来源（120）。 通过使泵（104）改变流体的流动来实现流动的广泛混合。 在实施例中，可以操作泵以在高流量和慢流速之间来回周期性地切换流。 或者，泵可以周期性地停止，或者甚至使得流动在短​​时间段内反向。

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