公开(公告)号：WO9929280A2

公开(公告)日：1999-06-17

申请号：PCT/US9826352

申请日：1998-12-11

Applicant: HARVARD COLLEGE ,  JOSEPH MCCARTHY DIANE M ,  ISAACS LYLE D ,  WHITESIDES GEORGE M ,  KARPLUS MARTIN ,  HOGLE JAMES M ,  CHEH JAMES LI WEN

Inventor： JOSEPH-MCCARTHY DIANE M ,  ISAACS LYLE D ,  WHITESIDES GEORGE M ,  KARPLUS MARTIN ,  HOGLE JAMES M ,  CHEH JAMES LI-WEN

IPC: A61K47/48 ,  A61K

CPC classification number: A61K47/6901 ,  Y10T436/14 ,  Y10T436/141111 ,  Y10T436/147777

Abstract: The present invention provides structure-based combinatorial libraries of compounds containing the functional group minima of picornaviruses including poliovirus and rhinovirus. The libraries can be used to screen for therapeutical antiviral compounds, e.g., anti-picornaviral capsid-binding compounds.

Abstract translation: 本发明提供了包含小核糖核酸病毒（包括脊髓灰质炎病毒和鼻病毒）的功能组最小值的化合物的基于结构的组合文库。 文库可以用于筛选治疗性抗病毒化合物，例如抗小RNA病毒衣壳结合化合物。