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    DETERMINATION OF CONCENTRATION OF FK778 BY COMPETITIVE IMMUNOASSAY
    3.
    发明申请
    DETERMINATION OF CONCENTRATION OF FK778 BY COMPETITIVE IMMUNOASSAY 审中-公开
    通过竞争性免疫测定法确定FK778的浓度

    公开(公告)号：WO2007081868A1

    公开(公告)日：2007-07-19

    申请号：PCT/US2007/000389

    申请日：2007-01-05

    Applicant: ABBOTT LABORATORIES ,  SPRING, Thomas, G. ,  BRATE, Elaine, M. ,  HOLETS-MCCORMACK, Shelley ,  REDDY, Rajarathnam, E. ,  JOHNSON, Donald, D. ,  CHEN, Yon-Yih ,  PAN, You

    Inventor： SPRING, Thomas, G. ,  BRATE, Elaine, M. ,  HOLETS-MCCORMACK, Shelley ,  REDDY, Rajarathnam, E. ,  JOHNSON, Donald, D. ,  CHEN, Yon-Yih ,  PAN, You

    IPC: G01N33/94

    CPC classification number: G01N33/9493

    Abstract: Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to FK778 not conjugated to a label, (c) a solid phase containing an antibody to a first hapten, e.g., a fluorescein hapten, and (d) a bihapten comprising a first hapten and FK778 or an analogue of FK778, e.g., a bihapten comprising a fluorescein hapten and a FK778 hapten. In another aspect, the method and kit involve the use of (a) antibody to FK778, (b) a bihapten comprising FK778 or an analogue of FK778 and a first hapten, e.g., a bihapten comprising the fluorescein hapten and the hapten of FK778 or an analogue of FK778, and (c) a pretreatment reagent.

    Abstract translation: 通过免疫测定，优选竞争性免疫测定法测量生物样品中FK778的浓度的方法和试剂盒。 一方面，该方法和试剂盒涉及使用（a）与标记缀合的FK778的抗体，例如吖啶标记，（b）与标记物不缀合的FK778的抗体，（c）含有 第一半抗原的抗体，例如荧光素半抗原，和（d）包含第一半抗原和FK778或FK778的类似物的双突变体，例如包含荧光素半抗原和FK778半抗原的双突变体。 另一方面，该方法和试剂盒涉及使用（a）FK778的抗体，（b）包含FK778或类似物FK778的双突变体和第一半抗原，例如包含荧光素半抗原的双突变体和FK778的半抗原或 FK778的类似物，（c）预处理试剂。

    NON-DENATURING LYSIS REAGENT FOR USE WITH CAPTURE-IN-SOLUTION IMMUNOASSAY
    5.
    发明申请
    NON-DENATURING LYSIS REAGENT FOR USE WITH CAPTURE-IN-SOLUTION IMMUNOASSAY 审中-公开
    用于解决方案免疫测定的非去极化试剂

    公开(公告)号：WO2008082984A3

    公开(公告)日：2008-11-20

    申请号：PCT/US2007088109

    申请日：2007-12-19

    Applicant: ABBOTT LAB ,  HOLETS-MCCORMACK SHELLEY R

    Inventor： HOLETS-MCCORMACK SHELLEY R

    IPC: G01N33/53

    CPC classification number: G01N33/531

    Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and non-specific animal immunoglobulins. Other aspects of the invention include related immunoassays and test kits.

    Abstract translation: 本发明提供了用于制备用于测定中的测试样品的裂解试剂和方法，其中所述方法产生适合用于自动移液系统的均匀溶解混合物，而不需要离心步骤。 裂解试剂包括二醇和非特异性动物免疫球蛋白。 本发明的其它方面包括相关免疫测定和测试试剂盒。

    NON-DENATURING LYSIS REAGENT FOR USE WITH CAPTURE-IN-SOLUTION IMMUNOASSAY
    6.
    发明申请
    NON-DENATURING LYSIS REAGENT FOR USE WITH CAPTURE-IN-SOLUTION IMMUNOASSAY 审中-公开
    非溶解性溶解试剂用于溶液中免疫免疫

    公开(公告)号：WO2008082984A2

    公开(公告)日：2008-07-10

    申请号：PCT/US2007/088109

    申请日：2007-12-19

    Applicant: ABBOTT LABORATORIES ,  HOLETS-MCCORMACK, Shelley R

    Inventor： HOLETS-MCCORMACK, Shelley R

    IPC: G01N33/53

    CPC classification number: G01N33/531

    Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and non-specific animal immunoglobulins. Other aspects of the invention include related immunoassays and test kits.

    Abstract translation: 本发明提供了用于制备用于测定的测试样品的溶解试剂和方法，其中所述方法产生适用于自动移液系统而不需要离心步骤的均质溶解混合物。 裂解剂包括二醇和非特异性动物免疫球蛋白。 本发明的其他方面包括相关的免疫测定和检测试剂盒。

    DETERMINATION OF CONCENTRATION OF FK778 BY COMPETITIVE IMMUNOASSAY
    7.
    发明申请
    DETERMINATION OF CONCENTRATION OF FK778 BY COMPETITIVE IMMUNOASSAY 审中-公开
    竞争免疫法测定FK778的浓度

    公开(公告)号：WO2007081868A9

    公开(公告)日：2007-09-07

    申请号：PCT/US2007000389

    申请日：2007-01-05

    Applicant: ABBOTT LAB ,  SPRING THOMAS G ,  BRATE ELAINE M ,  HOLETS-MCCORMACK SHELLEY ,  REDDY RAJARATHNAM E ,  JOHNSON DONALD D ,  CHEN YON-YIH ,  PAN YOU

    Inventor： SPRING THOMAS G ,  BRATE ELAINE M ,  HOLETS-MCCORMACK SHELLEY ,  REDDY RAJARATHNAM E ,  JOHNSON DONALD D ,  CHEN YON-YIH ,  PAN YOU

    IPC: G01N33/94

    CPC classification number: G01N33/9493

    Abstract: Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to FK778 not conjugated to a label, (c) a solid phase containing an antibody to a first hapten, e.g., a fluorescein hapten, and (d) a bihapten comprising a first hapten and FK778 or an analogue of FK778, e.g., a bihapten comprising a fluorescein hapten and a FK778 hapten. In another aspect, the method and kit involve the use of (a) antibody to FK778, (b) a bihapten comprising FK778 or an analogue of FK778 and a first hapten, e.g., a bihapten comprising the fluorescein hapten and the hapten of FK778 or an analogue of FK778, and (c) a pretreatment reagent.

    Abstract translation: 用于通过免疫测定法，优选竞争性免疫测定法测量生物样品中FK778浓度的方法和试剂盒。 在一个方面，所述方法和试剂盒涉及使用（a）缀合至标记物（例如吖啶鎓标记物）的FK778的抗体，（b）未缀合至标记物的FK778抗体，（c）含有 （d）包含第一半抗原和FK778或FK778类似物的二连胜肽，例如包含荧光素半抗原和FK778半抗原的二连胜蛋白。 另一方面，所述方法和试剂盒涉及使用（a）FK778抗体，（b）包含FK778或FK778类似物的二连胜蛋白和第一半抗原，例如包含荧光素半抗原和FK778的半抗原的二连蛋白，或 FK778的类似物，和（c）预处理试剂。

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