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    AN IMPROVED IN VITRO METHOD OF CULTURING MAMMALIAN CELLS FOR AUTOLOGOUS CELL IMPLANTATION/TRANSPLANTATION METHODS
    2.
    发明申请
    AN IMPROVED IN VITRO METHOD OF CULTURING MAMMALIAN CELLS FOR AUTOLOGOUS CELL IMPLANTATION/TRANSPLANTATION METHODS 审中-公开

    公开(公告)号：WO2002061052A3

    公开(公告)日：2002-08-08

    申请号：PCT/DK2002/000065

    申请日：2002-01-29

    Applicant: INTERFACE BIOTECH A/S ,  STORGAARD, Peter ,  OSTHER, Kurt

    Inventor： STORGAARD, Peter ,  OSTHER, Kurt

    IPC: C12N5/00

    Abstract: A production method for producing cell colony forming units in vitro from a mammalian tissue explant, the method comprises the steps of a) growing a piece of the mammalian tissue explant in a growth medium to obtain cell colony forming units from immature cells from the piece of explant, and b) harvesting cells from one or more of the cell colony forming units for use in Autologous Cell Implantation/transplantation methods. The mammalian tissue explant is selected from the group consisting of cartilage; bone such as, e.g., bone marrow; connective tissue; muscle tissue such as, e.g., smooth muscle tissue, heart tissue, liver tissue and skeletal muscle tissue; skin tissue such as, e.g., periosteum; mucosal tissue; brain tissue, pancreas tissue and blood vessels. In particularly, the mammalian tissue explant is cartilage, such as elastic, fibro, hyalin or articular hyalin cartilage. The cells obtained are suitable for use in autologous implantation/transplantation methods. In a specific embodiment, the cell obtained are chondroytes, especially for use in autologous chondrocyte implantation (ACI) methods.

    A METHOD FOR CELL IMPLANTATION
    3.
    发明申请
    A METHOD FOR CELL IMPLANTATION 审中-公开
    一种细胞植入方法

    公开(公告)号：WO2007028169A2

    公开(公告)日：2007-03-08

    申请号：PCT/US2006/034673

    申请日：2006-09-05

    Applicant: INTERFACE BIOTECH A/S ,  EVERLAND, Hanne ,  CLAUSEN, Christian ,  OSTHER, Kurt

    Inventor： EVERLAND, Hanne ,  CLAUSEN, Christian ,  OSTHER, Kurt

    IPC: A61K35/12

    CPC classification number: A61K38/4833 ,  A61K35/32 ,  A61K38/363 ,  A61L27/3843 ,  A61K2300/00

    Abstract: The present invention provides for a method for tissue engineering by cell implantation that involves the use of a scaffold in situ at the site of a defect, where the therapeutic cells are fixed in place into the scaffold only once the scaffold is inserted at the site of the tissue defect, thereby locking not only the cells to the scaffold, but also the scaffold to the tissue defect. The invention also provides a kit of parts suitable for performing the method of the invention.

    Abstract translation: 本发明提供了一种通过细胞移植进行组织工程的方法，该方法涉及在缺损部位的原位使用支架，其中一旦将支架插入到位于 组织缺陷，从而不仅将细胞锁定到支架，而且将支架锁定到组织缺损。 本发明还提供适用于执行本发明方法的一组零件。

    ARTHROSCOPIC METHOD FOR CELL IMPLANTATION IN MAMMALS
    4.
    发明申请
    ARTHROSCOPIC METHOD FOR CELL IMPLANTATION IN MAMMALS 审中-公开
    用于细胞植入的神经元方法

    公开(公告)号：WO2005079881A1

    公开(公告)日：2005-09-01

    申请号：PCT/DK2005/000107

    申请日：2005-02-18

    Applicant: INTERFACE BIOTECH A/S ,  STORGAARD, Peter

    Inventor： STORGAARD, Peter

    IPC: A61L27/38

    CPC classification number: A61L27/3886 ,  A61B1/317 ,  A61B17/3468 ,  A61K35/32 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3895 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/442 ,  C12N5/0655 ,  C12N2501/70

    Abstract: The present invention relates to an endoscopic method for treating cartilage or bone defects in a mammal, said method comprising the steps of: i.-dentifying the position of the defect, ii.-applying a cell suspension comprising cells selected from the group consisting of chondrocytes, chondroblasts, osteocytes and osteoblasts and combinations thereof into the cartilage or bone defect, the defect being positioned in such a manner that the cell suspension substantially does not flow out of the defect upon application.

    Abstract translation: 本发明涉及一种用于治疗哺乳动物软骨或骨缺损的内窥镜检查方法，所述方法包括以下步骤：i。 - 修复缺损位置，ii。 - 施用包含选自下组的细胞的细胞悬液： 软骨细胞，软骨细胞，骨细胞和成骨细胞及其组合进入软骨或骨缺损，所述缺陷以使得细胞悬浮液在施用时基本上不会流出缺陷的方式定位。

    BIOSYNTHETIC CARTILAGINOUS MATRIX AND METHODS FOR THEIR PRODUCTION
    5.
    发明申请
    BIOSYNTHETIC CARTILAGINOUS MATRIX AND METHODS FOR THEIR PRODUCTION 审中-公开
    生物活性基质及其生产方法

    公开(公告)号：WO2009106642A1

    公开(公告)日：2009-09-03

    申请号：PCT/EP2009/052432

    申请日：2009-03-02

    Applicant: COLOPLAST A/S ,  EVERLAND, Hanne ,  SAMUELSEN, Peter ,  VANGE, Jakob ,  CLAUSEN, Christian ,  INTERFACE BIOTECH A/S

    Inventor： EVERLAND, Hanne ,  SAMUELSEN, Peter ,  VANGE, Jakob ,  CLAUSEN, Christian

    IPC: A61L27/38 ,  A61L27/54 ,  A61L27/58

    CPC classification number: A61L27/58 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/414

    Abstract: An isolated, acellular biosynthetic cartilaginous matrix substantially devoid of synthetic biodegradable scaffold structure is provided. Through a method with the steps of a) contacting in vitro a population of chondrogenic cells with a synthetic biodegradable scaffold; b) culturing in vitro for a period of time said chondrogenic cells within said synthetic biodegradable scaffold so that the chondrogenic cells produce a biosynthetic cartilaginous matrix; c) substantially removing any antigen derived from said chondrogenic cells a matrix suitable of implantation into a living individual mammal, such as a human being is obtained.

    Abstract translation: 提供了一种基本上没有合成可生物降解的脚手架结构的分离的，无细胞的生物合成软骨基质。 通过以下步骤的方法：a）将体细胞群体的软骨细胞与合成的生物可降解支架接触; b）在体外培养所述合成可生物降解的支架内的所述软骨形成细胞的一段时间，使得软骨形成细胞产生生物合成的软骨基质; c）基本上除去源自所述软骨形成细胞的任何抗原，获得适合植入活体个体哺乳动物（例如人）的基质。

    A METHOD FOR CELL IMPLANTATION
    6.
    发明申请
    A METHOD FOR CELL IMPLANTATION 审中-公开

    公开(公告)号：WO2004110512A3

    公开(公告)日：2004-12-23

    申请号：PCT/DK2004/000408

    申请日：2004-06-11

    Applicant: INTERFACE BIOTECH A/S ,  OSTHER, Kurt

    Inventor： OSTHER, Kurt

    IPC: A61L27/38

    Abstract: An endoscopic method for treating cartilage or bone defects in an animal, said method comprising the steps of: I) identifying the position of the defect, ii) applying cells selected from the group consisting of chondrocytes, chondroblasts, osteocytes and osteoblasts and combinations thereof into the cartilage or bone defect. In particular, the invention relates to a method for arthroscopic or endoscopic implantation of homologous or autologous cells into a defect of an animal body, the method comprising a step of I) arthroscopic or endoscopic application of a fluid to a cavity or surface containing the defect, and the steps of ii) application of the cells to the defect substantially simultaneously with a support material, the application being performed at the defect covered by the fluid, iii) mixing of the cells and the supporting material, iv) solidification of the supporting material so that the defect is covered by a mixture of cells and support material without any significant amount of fluid, and v) optionally, removal of the fluid from the cavity or surface by drainage or suction.

    AN IMPROVED IN VITRO METHOD OF CULTURING MAMMALIAN CELLS FOR AUTOLOGOUS CELL IMPLANTATION/TRANSPLANTATION METHODS
    7.
    发明申请
    AN IMPROVED IN VITRO METHOD OF CULTURING MAMMALIAN CELLS FOR AUTOLOGOUS CELL IMPLANTATION/TRANSPLANTATION METHODS 审中-公开
    改进用于自体细胞植入/移植方法的培养MAMMALIAN细胞的体外培养方法

    公开(公告)号：WO2002061052A2

    公开(公告)日：2002-08-08

    申请号：PCT/DK2002/000065

    申请日：2002-01-29

    Applicant: INTERFACE BIOTECH A/S ,  STORGAARD, Peter ,  OSTHER, Kurt

    Inventor： STORGAARD, Peter ,  OSTHER, Kurt

    IPC: C12N5/00

    CPC classification number: C12N5/0655 ,  C12N5/0668 ,  C12N2500/60 ,  C12N2509/00 ,  C12N2523/00

    Abstract: A production method for producing cell colony forming units in vitro from a mammalian tissue explant, the method comprises the steps of a) growing a piece of the mammalian tissue explant in a growth medium to obtain cell colony forming units from immature cells from the piece of explant, and b) harvesting cells from one or more of the cell colony forming units for use in Autologous Cell Implantation/transplantation methods. The mammalian tissue explant is selected from the group consisting of cartilage; bone such as, e.g., bone marrow; connective tissue; muscle tissue such as, e.g., smooth muscle tissue, heart tissue, liver tissue and skeletal muscle tissue; skin tissue such as, e.g., periosteum; mucosal tissue; brain tissue, pancreas tissue and blood vessels. In particularly, the mammalian tissue explant is cartilage, such as elastic, fibro, hyalin or articular hyalin cartilage. The cells obtained are suitable for use in autologous implantation/transplantation methods. In a specific embodiment, the cell obtained are chondroytes, especially for use in autologous chondrocyte implantation (ACI) methods.

    Abstract translation: 一种用于从哺乳动物组织外植体体外产生细胞集落形成单元的生产方法，所述方法包括以下步骤：a）在生长培养基中培养一片哺乳动物组织外植体以获得细胞集落形成单位 来自所述外植体的未成熟细胞，以及b）从用于自体细胞植入/移植方法的一个或多个细胞集落形成单位收获细胞。 哺乳动物组织外植体选自软骨; 骨，例如骨髓; 结缔组织; 肌肉组织，例如平滑肌组织，心脏组织，肝组织和骨骼肌组织; 皮肤组织，例如骨膜; 粘膜组织; 脑组织，胰腺组织和血管。 特别地，哺乳动物组织外植体是软骨，例如弹性，纤维，透明质或关节透明质软骨。 获得的细胞适合用于自体植入/移植方法。 在具体实施方案中，所获得的细胞是软骨细胞，特别是用于自体软骨细胞植入（ACI）方法。

    A METHOD FOR CELL IMPLANTATION
    8.
    发明公开
    A METHOD FOR CELL IMPLANTATION 审中-公开
    方法细胞移植

    公开(公告)号：EP1635887A2

    公开(公告)日：2006-03-22

    申请号：EP04736630.7

    申请日：2004-06-11

    Applicant: Interface Biotech A/S

    Inventor： OSTHER, Kurt

    IPC: A61L27/38 ,  A61L27/54 ,  A61K35/32 ,  C12N5/06 ,  A61B17/32

    CPC classification number: A61L27/3821 ,  A61B17/00491 ,  A61K35/12 ,  A61K35/32 ,  A61L27/3817 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/418 ,  C12N5/0655 ,  C12N2533/54 ,  C12N2533/56

    Abstract: An endoscopic method for treating cartilage or bone defects in an animal, said method comprising the steps of: I) identifying the position of the defect, ii) applying cells selected from the group consisting of chondrocytes, chondroblasts, osteocytes and osteoblasts and combinations thereof into the cartilage or bone defect. In particular, the invention relates to a method for arthroscopic or endoscopic implantation of homologous or autologous cells into a defect of an animal body, the method comprising a step of I) arthroscopic or endoscopic application of a fluid to a cavity or surface containing the defect, and the steps of ii) application of the cells to the defect substantially simultaneously with a support material, the application being performed at the defect covered by the fluid, iii) mixing of the cells and the supporting material, iv) solidification of the supporting material so that the defect is covered by a mixture of cells and support material without any significant amount of fluid, and v) optionally, removal of the fluid from the cavity or surface by drainage or suction.

    AN IMPROVED IN VITRO METHOD OF CULTURING MAMMALIAN CELLS FOR AUTOLOGOUS CELL IMPLANTATION/TRANSPLANTATION METHODS
    10.
    发明公开
    AN IMPROVED IN VITRO METHOD OF CULTURING MAMMALIAN CELLS FOR AUTOLOGOUS CELL IMPLANTATION/TRANSPLANTATION METHODS 审中-公开
    改进的体外方法，再培养自体细胞植入哺乳动物细胞 - / - 移植手术

    公开(公告)号：EP1356024A2

    公开(公告)日：2003-10-29

    申请号：EP02709984.5

    申请日：2002-01-29

    Applicant: Interface Biotech A/S

    Inventor： STORGAARD, Peter ,  OSTHER, Kurt

    IPC: C12N5/00 ,  A61K35/12

    CPC classification number: C12N5/0655 ,  C12N5/0668 ,  C12N2500/60 ,  C12N2509/00 ,  C12N2523/00

    Abstract: A production method for producing cell colony forming units in vitro from a mammalian tissue explant, the method comprises the steps of a) growing a piece of the mammalian tissue explant in a growth medium to obtain cell colony forming units from immature cells from the piece of explant, and b) harvesting cells from one or more of the cell colony forming units for use in Autologous Cell Implantation/transplantation methods. The mammalian tissue explant is selected from the group consisting of cartilage; bone such as, e.g., bone marrow; connective tissue; muscle tissue such as, e.g., smooth muscle tissue, heart tissue, liver tissue and skeletal muscle tissue; skin tissue such as, e.g., periosteum; mucosal tissue; brain tissue, pancreas tissue and blood vessels. In particularly, the mammalian tissue explant is cartilage, such as elastic, fibro, hyalin or articular hyalin cartilage. The cells obtained are suitable for use in autologous implantation/transplantation methods. In a specific embodiment, the cell obtained are chondroytes, especially for use in autologous chondrocyte implantation (ACI) methods.

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