公开(公告)号：IL242540A

公开(公告)日：2020-05-31

申请号：IL24254015

申请日：2015-11-10

Applicant: MICELL TECHNOLOGIES INC ,  JAMES B MCCLAIN

Inventor： JAMES B MCCLAIN

IPC: A61F2/90 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  B29C48/00 ,  B29K67/00 ,  B29L31/00

Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average thickness of no more than 150 μm. Methods for making the bioabsorbable biomedical implant, including the methods for making the fiber-reinforced polymer composite materials for the tubular scaffold, are also disclosed.

公开(公告)号：IL241421D0

公开(公告)日：2015-11-30

申请号：IL24142115

申请日：2015-09-09

Applicant: MICELL TECHNOLOGIES INC ,  JAMES B MCCLAIN ,  CHARLES DOUGLAS TAYLOR ,  ROBERT STEVEN BURGERMEISTER

IPC: A61F20060101

Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average thickness of no more than 120 μm. Methods for making the bioabsorbable biomedical implant, including the methods for making the polymer materials for the tubular scaffold, are also disclosed.

公开(公告)号：IL241421A

公开(公告)日：2019-05-30

申请号：IL24142115

申请日：2015-09-09

Applicant: MICELL TECHNOLOGIES INC ,  JAMES B MCCLAIN ,  CHARLES DOUGLAS TAYLOR ,  ROBERT STEVEN BURGERMEISTER

Inventor： JAMES B MCCLAIN ,  CHARLES DOUGLAS TAYLOR ,  ROBERT STEVEN BURGERMEISTER

IPC: A61F2/00

Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average thickness of no more than 120 μm. Methods for making the bioabsorbable biomedical implant, including the methods for making the polymer materials for the tubular scaffold, are also disclosed.

公开(公告)号：AU7705800A

公开(公告)日：2001-04-30

申请号：AU7705800

申请日：2000-09-20

Applicant: MICELL TECHNOLOGIES INC ,  JAMES B MCCLAIN

Inventor： MCCLAIN JAMES B ,  BRAINARD DAVID E ,  COLE MICHAEL E ,  WORM STEVE L

IPC: D06F43/00 ,  D06F43/08

Abstract: A method for conserving carbon dioxide vapor in a carbon dioxide dry cleaning system employing a liquid carbon dioxide cleaning solution to clean articles, where the method includes removing carbon dioxide vapor from a wash tank to a vapor tank, storing the carbon dioxide vapor in the vapor tank; and charging the wash tank with carbon dioxide vapor from the vapor tank. The method may be performed as part of a wash cycle that includes filling the wash tank with cleaning solution, washing articles to be cleaned in the wash tank, and emptying the cleaning solution out of the wash tank. An apparatus may also be employed for conserving carbon dioxide vapor in a carbon dioxide dry cleaning system employing a liquid carbon dioxide cleaning solution to clean articles, where the apparatus includes a wash tank for contacting the articles to be cleaned with the liquid carbon dioxide cleaning solution, a working tank for storing liquid carbon dioxide cleaning solution, a vapor tank for storing carbon dioxide vapor, a first piping system providing fluid communication between the wash tank and the vapor tank, where the first piping system includes a first line and a first valve residing in the first line, and a second piping system providing fluid communication between the working tank and the wash tank. Methods and apparatus for collecting liquid carbon dioxide in a collecting tank are also provided.

公开(公告)号：US11369498B2

公开(公告)日：2022-06-28

申请号：US13014632

申请日：2011-01-26

Applicant: James B. McClain ,  Douglas Taylor ,  David Enscore

Inventor： James B. McClain ,  Douglas Taylor ,  David Enscore

IPC: A61F2/958 ,  A61F2/00 ,  A61F2/82

Abstract: Stent delivery systems having improved deliverability comprising an elongate member having an inflation lumen and a guidewire lumen therein; a balloon having an interior that is in fluid communication with the inflation lumen; and a stent comprising a coating mounted on the balloon. Methods for making stent delivery systems having improved deliverability. Methods for delivering two stent delivery systems concurrently through a guiding catheter, each stent delivery system comprising elongate member having an inflation lumen and a guidewire lumen therein, a balloon having an interior that is in fluid communication with the inflation lumen, and a stent comprising a coating mounted on the balloon. Stent coatings may comprise a pharmaceutical agent at least a portion of which is in crystalline form.

公开(公告)号：US09789233B2

公开(公告)日：2017-10-17

申请号：US12426198

申请日：2009-04-17

Applicant: James B. McClain ,  Douglas Taylor

Inventor： James B. McClain ,  Douglas Taylor

IPC: A61F2/06 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/148 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2250/0035 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/63 ,  A61L2420/08

Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

公开(公告)号：US09510856B2

公开(公告)日：2016-12-06

申请号：US13384216

申请日：2010-07-16

Applicant: James B. McClain ,  Charles Douglas Taylor ,  John Neet ,  Brett G. Zani

Inventor： James B. McClain ,  Charles Douglas Taylor ,  John Neet ,  Brett G. Zani

IPC: A61M31/00 ,  A61M37/00 ,  A61B17/20 ,  A61B17/3207 ,  A61L29/08 ,  A61L29/16 ,  A61B17/00 ,  A61B17/22 ,  A61M25/10

CPC classification number: A61M25/10 ,  A61B17/320725 ,  A61B2017/00893 ,  A61B2017/22051 ,  A61B2017/22061 ,  A61B2017/22065 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61M2025/105

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

Abstract translation: 提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时 一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。

公开(公告)号：US08834913B2

公开(公告)日：2014-09-16

申请号：US12648106

申请日：2009-12-28

Applicant: Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

Inventor： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

IPC: A61F2/00 ,  A61K31/727

CPC classification number: A61L31/10 ,  A61K31/727 ,  A61L31/16 ,  A61L2300/42 ,  A61L2400/18

Abstract: A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

Abstract translation: 一种具有氧化表面的基底和与氧化表面共价结合的硅烷衍生物涂层的医用植入装置。 生物活性剂与硅烷衍生物涂层共价键合。 一种可植入支架装置，其包括具有氧化表面的支架芯，其具有与其共价键合的硅烷衍生物层。 包含聚乙二醇（PEG）的间隔层与硅烷衍生物层共价键合，蛋白质与PEG共价键合。 一种制造医疗植入装置的方法，包括提供具有表面的基底，氧化表面并与衍生的硅烷反应以形成共价键合到该表面的硅烷涂层。 然后将生物活性剂共价键合到硅烷涂层。 在特定情况下，生物吸收性聚合物和/或药剂的附加涂层沉积在生物活性剂上。

公开(公告)号：US20120323311A1

公开(公告)日：2012-12-20

申请号：US13445723

申请日：2012-04-12

Applicant: James B. McCLAIN ,  Charles Douglas TAYLOR

Inventor： James B. McCLAIN ,  Charles Douglas TAYLOR

IPC: A61F2/82 ,  B05D1/06

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/63

Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

Abstract translation: 本文提供的装置包括：a。 支架; b。 在所述支架框架上的多个层以形成所述装置; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

公开(公告)号：US07141496B2

公开(公告)日：2006-11-28

申请号：US10762905

申请日：2004-01-22

Applicant: James P. DeYoung ,  James B. McClain ,  Stephen M. Gross ,  Doug Taylor ,  Mark I. Wagner ,  David Brainard

Inventor： James P. DeYoung ,  James B. McClain ,  Stephen M. Gross ,  Doug Taylor ,  Mark I. Wagner ,  David Brainard

IPC: H01L21/44

CPC classification number: H01L21/32051 ,  H01L21/283 ,  H01L21/288 ,  H01L21/76814 ,  H01L21/76843 ,  H01L21/76871

Abstract: A method of treating a dielectric surface portion of a semiconductor substrate, comprising the steps of: (a) providing a semiconductor substrate having a dielectric surface portion; and then (b) treating said dielectric surface portion with a coating reagent, the coating reagent comprising a reactive group coupled to a coordinating group, with the coordinating group having a metal bound thereto, so that the metal is deposited on the dielectric surface portion to produce a surface portion treated with a metal.

Abstract translation: 一种处理半导体衬底的电介质表面部分的方法，包括以下步骤：（a）提供具有电介质表面部分的半导体衬底; 然后（b）用涂层试剂处理所述电介质表面部分，所述涂覆试剂包含与配位基团偶联的反应基团，所述配位基团与其结合金属，使得金属沉积在电介质表面部分上 产生用金属处理的表面部分。