公开(公告)号：IL224225A

公开(公告)日：2018-07-31

申请号：IL22422513

申请日：2013-01-14

Applicant: HANMI SCIENCE CO LTD ,  SE CHANG KWON ,  SUNG MIN BAE ,  SUNG HEE HONG ,  BYUNG SUN LEE ,  DEA SEONG IM ,  JEA MIN LEE

Inventor： SE CHANG KWON ,  SUNG MIN BAE ,  SUNG HEE HONG ,  BYUNG SUN LEE ,  DEA SEONG IM ,  JEA MIN LEE

IPC: A61K20060101

Abstract: Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.