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公开(公告)号：IL203288A
公开(公告)日：2016-02-29
申请号：IL20328810
申请日：2010-01-13
Applicant: DAE HAE SONG , CHANG KI LIM , SE CHANG KWON , YOUNG HOON KIM , GWAN SUN LEE , SUNG MIN BAE , SUNG YOUB JUNG , HANMI SCIENCE CO LTD , HANMI SCIENCE CO LTD
Inventor： DAE HAE SONG , CHANG KI LIM , SE CHANG KWON , YOUNG HOON KIM , GWAN SUN LEE , SUNG MIN BAE , SUNG YOUB JUNG
Abstract: The present invention relates to an N-terminal amino acid-modified insulinotropic peptide having a high activity, and to a pharmaceutical composition comprising the same. The insulinotropic peptide derivatives according to the present invention exhibit therapeutic effects, which are not observed in native and other insulinotropic peptide analogs. Therefore, the insulinotropic peptide derivatives and the pharmaceutical composition comprising the same according to the present invention can be effectively provided for the treatment of the diseases.
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公开(公告)号：IL224225A
公开(公告)日：2018-07-31
申请号：IL22422513
申请日：2013-01-14
Applicant: HANMI SCIENCE CO LTD , SE CHANG KWON , SUNG MIN BAE , SUNG HEE HONG , BYUNG SUN LEE , DEA SEONG IM , JEA MIN LEE
Inventor： SE CHANG KWON , SUNG MIN BAE , SUNG HEE HONG , BYUNG SUN LEE , DEA SEONG IM , JEA MIN LEE
IPC: A61K20060101
Abstract: Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.
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公开(公告)号：IL222319D0
公开(公告)日：2012-12-31
申请号：IL22231912
申请日：2012-10-09
Applicant: DAE HAE SONG , SE CHANG KWON , SUNG MIN BAE , YOUNG JIN PARK , JAE HEE SHIN , HANMI SCIENCE CO LTD , DAE SEONG IM
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公开(公告)号：IL222319A
公开(公告)日：2019-10-31
申请号：IL22231912
申请日：2012-10-09
Applicant: DAE HAE SONG , SE CHANG KWON , SUNG MIN BAE , YOUNG JIN PARK , JAE HEE SHIN , HANMI SCIENCE CO LTD , DAE SEONG IM
Inventor： DAE HAE SONG , SE CHANG KWON , SUNG MIN BAE , YOUNG JIN PARK , JAE HEE SHIN , DAE SEONG IM
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公开(公告)号：US09061072B2
公开(公告)日：2015-06-23
申请号：US13809783
申请日：2011-07-14
Applicant: Sung Hee Hong , Byung Sun Lee , Dae Seong Im , Jae Min Lee , Sung Min Bae , Se Chang Kwon
Inventor： Sung Hee Hong , Byung Sun Lee , Dae Seong Im , Jae Min Lee , Sung Min Bae , Se Chang Kwon
CPC classification number: A61K47/48415 , A61K9/0019 , A61K9/08 , A61K38/27 , A61K47/12 , A61K47/26 , A61K47/60 , A61K47/68 , C07K2319/30
Abstract: Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.
Abstract translation: 公开了长效人生长激素（hGH）缀合物的液体制剂，其不含白蛋白，其可以长期保存长效hGH缀合物的稳定性，其中长效人生长激素 缀合物包括与免疫球蛋白Fc区连接的人生长激素，并且与天然形式相比具有延长的体内稳定性。 包含pH 5.0〜6.0缓冲液，糖醇，盐和非离子表面活性剂的hGH缀合物的液体制剂不含人血清白蛋白和潜在的病毒污染的其他有害因素，可提供优良的储存稳定性 对于由hGH多肽和具有较高分子量和体内耐久性的免疫球蛋白Fc区组成的长效hGH缀合物，与天然产物相比。
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Patent Agency Ranking
公开(公告)号：US20130287734A1
公开(公告)日：2013-10-31
申请号：US13881976
申请日：2011-10-26
Applicant: Dae Seong Im , Jae Min Lee , Jong Soo Lee , Sung Min Bae , Se Chang Kwon
Inventor： Dae Seong Im , Jae Min Lee , Jong Soo Lee , Sung Min Bae , Se Chang Kwon
CPC classification number: A61K47/48415 , A61K9/0019 , A61K38/212 , A61K47/26 , A61K47/68 , A61K47/6813 , C07K14/56 , C07K16/46 , C07K2319/30
Abstract: Disclosed is a liquid formulation in which a long-acting INFα conjugate that has improved in vivo duration and stability can be stored stably for a long period of time. It comprises a stabilizer comprising a buffer, a sugar alcohol, a non-ionic surfactant and an isotonic agent. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting INFα conjugates.
Abstract translation: 公开了一种液体制剂，其中可长期稳定地储存具有改善的体内持续时间和稳定性的长效INFalpha缀合物。 它包括稳定剂，其包含缓冲剂，糖醇，非离子表面活性剂和等渗剂。 没有人体血清白蛋白和其他对身体有害的潜在因素，液体制剂没有对病毒感染的担忧，并保证对长效INFalpha缀合物的优良储存稳定性。
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公开(公告)号：US20130115231A1
公开(公告)日：2013-05-09
申请号：US13809783
申请日：2011-07-14
Applicant: Sung Hee Hong , Byung Sun Lee , Dae Seong Im , Jae Min Lee , Sung Min Bae , Se Chang Kwon
Inventor： Sung Hee Hong , Byung Sun Lee , Dae Seong Im , Jae Min Lee , Sung Min Bae , Se Chang Kwon
IPC: A61K47/48
CPC classification number: A61K47/48415 , A61K9/0019 , A61K9/08 , A61K38/27 , A61K47/12 , A61K47/26 , A61K47/60 , A61K47/68 , C07K2319/30
Abstract: Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.
Abstract translation: 公开了长效人生长激素（hGH）缀合物的液体制剂，其不含白蛋白，其可以长期保存长效hGH缀合物的稳定性，其中长效人生长激素 缀合物包括与免疫球蛋白Fc区连接的人生长激素，并且与天然形式相比具有延长的体内稳定性。 包含pH 5.0〜6.0缓冲液，糖醇，盐和非离子表面活性剂的hGH缀合物的液体制剂不含人血清白蛋白和其他可能被病毒污染的危险因素，可以提供优良的储存稳定性 对于由hGH多肽和具有较高分子量和体内耐久性的免疫球蛋白Fc区组成的长效hGH缀合物，与天然产物相比。
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公开(公告)号：US20120296069A1
公开(公告)日：2012-11-22
申请号：US13574029
申请日：2011-01-18
Applicant: Sung Min Bae , Dae Seong Im , Min Young Kim , Chang Ki Lim , Sung Youb Jung , Se Chang Kwon
Inventor： Sung Min Bae , Dae Seong Im , Min Young Kim , Chang Ki Lim , Sung Youb Jung , Se Chang Kwon
IPC: C07K16/00
CPC classification number: A61K47/02 , A61K9/0019 , A61K38/00 , A61K47/10 , A61K47/183 , A61K47/26 , A61K47/6811 , A61K47/6835
Abstract: Disclosed is a liquid formulation which allows long-acting EPO conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting EPO conjugates.
Abstract translation: 公开了一种液体制剂，其允许具有改善的体内持续时间和稳定性的长效EPO缀合物在长时间储存时是稳定的。 它包括以缓冲液和甘露醇为特征的稳定剂组合物。 没有人血清白蛋白和其他对身体有害的潜在因素，液体制剂没有对病毒感染的担忧，并保证了对长效EPO共轭物的极好的储存稳定性。
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9.发明授权Physiologically active polypeptide conjugate having prolonged in vivo half-life 有权具有延长体内半衰期的生理活性多肽缀合物公开(公告)号：US08163889B2
公开(公告)日：2012-04-24
申请号：US12603757
申请日：2009-10-22
Applicant: Young-Min Kim , Dae-Jin Kim , Sung-Min Bae , Chang-Ki Lim , Se-Chang Kwon , Gwan-Sun Lee
Inventor： Young-Min Kim , Dae-Jin Kim , Sung-Min Bae , Chang-Ki Lim , Se-Chang Kwon , Gwan-Sun Lee
IPC: C07K16/00
CPC classification number: C07K16/00 , A61K47/60 , A61K47/643 , A61K47/6811 , A61K47/6883
Abstract: A protein conjugate having a prolonged in vivo half-life of a physiological activity, comprising i) a physiologically active polypeptide, ii) a non-peptidic polymer, and iii) an immunoglobulin, is useful for the development of a polypeptide drug due to the enhanced in vivo stability and prolonged half-life in blood, while reducing the possibility of inducing an immune response.
Abstract translation: 具有延长的生理活性的体内半衰期的蛋白质缀合物，其包含i）生理活性多肽，ii）非肽聚合物和iii）免疫球蛋白，可用于开发多肽药物，因为 增强血液中的体内稳定性和延长的半衰期，同时降低诱导免疫应答的可能性。
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10.发明申请Physiologically active polypeptide conjugate having prolonged in vivo half-life 审中-公开具有延长体内半衰期的生理活性多肽缀合物公开(公告)号：US20050176108A1
公开(公告)日：2005-08-11
申请号：US10659195
申请日：2003-09-09
Applicant: Young-Min Kim , Dae-Jin Kim , Sung-Min Bae , Chang-Ki Lim , Se-Chang Kwon , Gwan-Sun Lee
Inventor： Young-Min Kim , Dae-Jin Kim , Sung-Min Bae , Chang-Ki Lim , Se-Chang Kwon , Gwan-Sun Lee
CPC classification number: C07K16/00 , A61K47/60 , A61K47/643 , A61K47/6811 , A61K47/6883
Abstract: A protein conjugate having a prolonged in vivo half-life of a physiological activity, comprising i) a physiologically active polypeptide, ii) a biocompatible non-peptidic polymer, and iii) an immunoglobulin, is useful for the development of a peptide drug due to the enhanced in vivo stability and prolonged half-life in blood, while reducing the possibility of inducing an immune response.
Abstract translation: 具有延长的生理活性的体内半衰期的蛋白质缀合物，其包含i）生理活性多肽，ii）生物相容性非肽聚合物，和iii）免疫球蛋白，可用于开发肽药物，因为 提高体内稳定性和延长血液半衰期，同时降低诱导免疫应答的可能性。
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