公开(公告)号：WO1993006096A1

公开(公告)日：1993-04-01

申请号：PCT/JP1992001164

申请日：1992-09-11

Applicant: SANKYO COMPANY, LIMITED ,  YOSHIDA, Akira ,  ODA, Kozo ,  KASAI, Takashi ,  KOGA, Teiichiro ,  HASEGAWA, Kazuo

Inventor： SANKYO COMPANY, LIMITED

IPC: C07D311/82

CPC classification number: C07D407/12 ,  C07D311/82 ,  C07D311/84 ,  C07D311/90 ,  C07D335/12 ,  C07D335/14 ,  C07D335/20

Abstract: [Constitution] A tricyclic heterocyclic compound represented by general formula (I) wherein R and R represent each hydrogen, lower alkyl, lower alkoxy, halogen or halogenated lower alkyl; R represents hydrogen or lower alkyl; R represents substituted phenyl or naphthyl; R represents hydrogen or lower alkyl; A represents lower alkylene; B represents -O- or -S-; and n represents 0 or 1. [Effect] It is excellent in the inhibition of acyl-CoA-cholesterol acyltransferase (ACAT) and is useful for treating or preventing arteriosclerosis.

Abstract translation: [结构]由通式（I）表示的三环杂环化合物，其中R 1和R 2各自代表氢，低级烷基，低级烷氧基，卤素或卤代低级烷基; R 3表示氢或低级烷基; R 4表示取代的苯基或萘基; R 5表示氢或低级烷基; A代表低级亚烷基; B表示-O-或-S-; n表示0或1. [效果]酰基辅酶A胆固醇酰基转移酶（ACAT）的抑制性优异，可用于治疗或预防动脉硬化。

公开(公告)号：WO2011148778A8

公开(公告)日：2012-02-23

申请号：PCT/JP2011060714

申请日：2011-05-10

Applicant: OMRON TATEISI ELECTRONICS CO ,  ST MICROELECTRONICS SRL ,  KASAI TAKASHI ,  UCHIDA YUKI ,  HORIMOTO YASUHIRO ,  CONTI SEBASTIANO

Inventor： KASAI TAKASHI ,  UCHIDA YUKI ,  HORIMOTO YASUHIRO ,  CONTI SEBASTIANO

IPC: H04R19/04

CPC classification number: H04R3/00 ,  H04R19/016

Abstract: In an acoustic sensor (11), a vibrating membrane (22) and a fixed membrane (23) are formed on the upper face of a semiconductor substrate, and an acoustic wave is detected by the change of capacitance between a vibration electrode (22a) of the vibrating membrane (22) and a fixed electrode (23a) of the fixed membrane (23). The fixed membrane(23) is provided with a plurality of sound holes (32) for delivering the acoustic wave from the outside to the vibrating membrane (22), and the fixed electrode (23a) is formed so that the boundary of the edge portion (40) does not intersect the sound holes (32).

Abstract translation: 在声学传感器（11）中，在半导体衬底的上表面上形成振动膜（22）和固定膜（23），并且通过振动电极（22a） 的振动膜（22）和固定膜（23）的固定电极（23a）。 固定膜（23）设有多个用于将声波从外部输送到振动膜（22）的声孔（32），并且固定电极（23a）形成为使得边缘部分 （40）不与声孔（32）相交。

公开(公告)号：WO2010122383A1

公开(公告)日：2010-10-28

申请号：PCT/IB2010/000567

申请日：2010-03-18

Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA ,  NISHIMURA, Akira ,  WATANABE, Akihiro ,  KASAI, Takashi

Inventor： NISHIMURA, Akira ,  WATANABE, Akihiro ,  KASAI, Takashi

IPC: G01N33/32

CPC classification number: G01N33/32

Abstract: The orientation of pigments (11) when a paint (12) is applied is set, and the orientation of the pigments (11) at time (t) at which a predetermined period of time has elapsed from when the paint is applied is calculated on the basis of a shrinkage rate gradient of the paint (12) in a thickness direction of a coating in the process of drying the paint. Thus, by assuming the state where the pigments (11) are dispersed in the paint (12) as the state where spheroids are present in viscous fluid, and applying the motion model in which the spheroids present in the fluid rotate by a difference in velocity of flow of the fluid, the orientation of the pigments (11) depending on the characteristic of a paint and a painting condition is estimated.

Abstract translation: 涂布涂料（12）时颜料（11）的取向被设定，并且在涂布涂料之后经过了预定时间的时间（t）的颜料（11）的取向被计算在 在涂料干燥过程中涂料（12）在涂层的厚度方向上的收缩率梯度的基础。 因此，通过假设颜料（11）分散在涂料（12）中作为粘合流体中存在球体的状态的状态，并且施加其中存在于流体中的球体的运动模型以不同的速度旋转 流体的流动，根据涂料的特性和涂装条件估计颜料（11）的取向。

公开(公告)号：WO1996003378A1

公开(公告)日：1996-02-08

申请号：PCT/JP1995001481

申请日：1995-07-26

Applicant: SANKYO COMPANY, LIMITED ,  YOSHIDA, Akira ,  KOGEN, Hiroshi ,  HAYAKAWA, Ichiro ,  ODA, Kozo ,  KASAI, Takashi ,  SIMADA, Kousei ,  YOSHIDA, Yumi ,  ISHIHARA, Sadao ,  SAITO, Fujio ,  OHHATA, Yasuo ,  KOGA, Teiichiro ,  KITAZAWA, Eiichi ,  TOKUI, Taro

Inventor： SANKYO COMPANY, LIMITED

IPC: C07D213/40

CPC classification number: C07D231/12 ,  C07D233/64 ,  C07D295/135 ,  C07D317/58 ,  C07D405/12

Abstract: Novel N-phenylated amide and urea derivatives represented by general formula (I) and salts thereof, which have excellent ACAT inhibitory activity and peroral absorbability and are useful as a remedy and/or a preventive for arteriosclerosis, wherein R represents C1-C12 alkyl or cycloalkyl-alkyl; R represents H or any of the groups defined above with respect to R ; R , R and R represent each independently H, optionally protected OH, nitro, C1-C12 alkyl, optionally mono- to pentafluorinated C1-C4 alkyl, alkoxy, halogeno, optionally C1-C4-alkylated mono- or dialkylamino, or five- or six-membered nitrogenous saturated heterocycle, or alternatively adjacent groups R and R are combined together to form -O-(CH2)m-O- (m being an integer of 1 to 3); R represents C1-C6 alkyl; R represents A -R (A being C1-C6 alkylene or C3-C5 alkenylene; and R being a heterocyclic group selected from among those belonging to the following group alpha and optionally substituted by halogeno, C1-C4 alkyl or C1-C4 hydroxyalkyl) or A -X-A -R (A being C1-C6 alkylene or C3-C5 alkenylene; X being O, S, NH, C1-C4 alkylimino, sulfinyl or sulfonyl; A being a single bond, C1-C6 alkylene or C3-C5 alkenylene; and R being as defined above, provided that the total number of the carbon atoms of A and A is 1 to 8 and that when A represents a single bond, the heterocyclic group R is bonded to X at the ring carbon atom); and n represents 0 or 1. Group alpha : imidazolyl, pyrazolyl, pyrazolidinyl, 1,2,4-triazolyl, tetrazolyl, morpholino, piperazinyl,2-pyridon-1-yl, 2-pyrimidinyl, pyridyl, pyrazinyl, 1,3,5-triazin-2-yl, benzimidazolyl, piperidinyl, pyrrolidinyl and azetidinyl groups.

Abstract translation: 具有优异的ACAT抑制活性和口服吸收性的由通式（I）表示的新型N-苯基酰胺和脲衍生物及其盐，可用作动脉硬化的补救剂和/或预防药物，其中R 1a表示C1- C12烷基或环烷基 - 烷基; R 16表示H或上述关于R 1a定义的任何基团; R 2a，R 2b和R 2c各自独立地表示H，任选保护的OH，硝基，C 1 -C 12烷基，任选一至五氟化的C 1 -C 4烷基，烷氧基，卤代，任选被C 1 -C 4烷基化 单 - 或二烷基氨基或五或六元含氮饱和杂环，或者相邻基团R 2a和R 2b组合在一起形成-O-（CH 2）m O-（m是1〜 3）; R 3表示C 1 -C 6烷基; R 4表示A 1 -R 5（A 1）是C 1 -C 6亚烷基或C 3 -C 5亚烯基; R 5是选自以下组中的α和 任选被卤代，C 1 -C 4烷基或C 1 -C 4羟烷基取代）或A 2 -XA 3 -R 5（A 2是C 1 -C 6亚烷基或C 3 -C 5亚烯基; X是O， S，NH，C 1 -C 4烷基亚氨基，亚磺酰基或磺酰基; A 3为单键，C 1 -C 6亚烷基或C 3 -C 5亚烯基; R 5如上所定义，条件是碳 A 2和A 3的原子为1〜8，当A 3表示单键时，杂环基R 5在环碳原子上与X键合）; 组α：咪唑基，吡唑基，吡唑烷基，1,2,4-三唑基，四唑基，吗啉代，哌嗪基，2-吡啶酮-1-基，2-嘧啶基，吡啶基，吡嗪基，1,3， 5-三嗪-2-基，苯并咪唑基，哌啶基，吡咯烷基和氮杂环丁烷基。