公开(公告)号：WO2004072242A3

公开(公告)日：2004-08-26

申请号：PCT/US2004/003417

申请日：2004-02-05

Applicant: MILLENNIUM PHARMACEUTICALS, INC. ,  KELLY, Louise, M. ,  CARROLL, Joseph, M. ,  FARLOW, Deborah ,  HEALY, Aileen

Inventor： KELLY, Louise, M. ,  CARROLL, Joseph, M. ,  FARLOW, Deborah ,  HEALY, Aileen

IPC: G01N33/53

Abstract: The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 17600, 25584, 27824, 28469, 38947, 53003, 965, 56639, 9661, 16052, 1521, 6662, 13913, 12405 and 5014 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.

公开(公告)号：WO2004072242A2

公开(公告)日：2004-08-26

申请号：PCT/US2004003417

申请日：2004-02-05

Applicant: MILLENNIUM PHARM INC ,  KELLY LOUISE M ,  CARROLL JOSEPH M ,  FARLOW DEBORAH ,  HEALY AILEEN

Inventor： KELLY LOUISE M ,  CARROLL JOSEPH M ,  FARLOW DEBORAH ,  HEALY AILEEN

IPC: A61K38/00 ,  C07K14/47 ,  C12N

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 17600, 25584, 27824, 28469, 38947, 53003, 965, 56639, 9661, 16052, 1521, 6662, 13913, 12405 and 5014 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.

Abstract translation: 本发明涉及诊断和治疗血液病症的方法。 具体而言，本发明鉴定了9118,990,17662,81982,630,2172,27892,19290,21620,21689,28899,53659,64549,9465,23544,7366,27417,57259,21844,943的差异表达， 2061,5981,9137,13908,177600,3554,27824,28469,3897,53003,965,5666,99661,16052,1521,6662,13913,12405和5014基因在与血液学障碍感觉有关的组织中相对于它们的表达 在正常或非血液学疾病疾病状态，和/或响应于与血液学疾病相关的操作。 本发明描述了各种血液学疾病的诊断评价和预后的方法，以及用于鉴定表现出对这种病症倾向的受试者。 本发明还提供了鉴定能够调节血液学疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为血液学疾病治疗的方法。

公开(公告)号：WO2003065871A3

公开(公告)日：2003-08-14

申请号：PCT/US2003/002484

申请日：2003-01-28

Applicant: MILLENNIUM PHARMACEUTICALS INC. ,  CARROLL, Joseph, M. ,  HEALY, Aileen ,  WEICH, Nadine, S. ,  KELLY, Louise, M.

Inventor： CARROLL, Joseph, M. ,  HEALY, Aileen ,  WEICH, Nadine, S. ,  KELLY, Louise, M.

IPC: G01N33/53

Abstract: The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 131, 148, 199, 12303, 13906, 15513, 17822, 302, 5677, 194, 14393, 28059, 7366, 12212, 1981, 261, 12416, 270, 1410, 137, 1871, 13051, 1847, 1849, 15402, 340, 10217, 837, 1761, 8990 and 13249 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.

公开(公告)号：WO2003065871A2

公开(公告)日：2003-08-14

申请号：PCT/US2003/002484

申请日：2003-01-28

Applicant: MILLENNIUM PHARMACEUTICALS INC. ,  CARROLL, Joseph, M. ,  HEALY, Aileen ,  WEICH, Nadine, S. ,  KELLY, Louise, M.

Inventor： CARROLL, Joseph, M. ,  HEALY, Aileen ,  WEICH, Nadine, S. ,  KELLY, Louise, M.

IPC: A61B

CPC classification number: G01N33/9413 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2500/04 ,  G01N2500/10

Abstract: The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 131, 148, 199, 12303, 13906, 15513, 17822, 302, 5677, 194, 14393, 28059, 7366, 12212, 1981, 261, 12416, 270, 1410, 137, 1871, 13051, 1847, 1849, 15402, 340, 10217, 837, 1761, 8990 and 13249 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.

Abstract translation: 本发明涉及诊断和治疗血液病症的方法。 具体地，本发明鉴定131,148,199,12303,13906,15513,17822,302,5677,194,14393,28059,7366,121212,1981,261,12416,270,1410,137的差异表达， 1871,13051,1847,1849,15402,340,10217,837,1761,8990和13249涉及血液学疾病感觉的组织中的基因，相对于它们在正常或非血液学疾病疾病状态中的表达和/或应答 与血液学疾病相关的操作。 本发明描述了各种血液学疾病的诊断评价和预后的方法，以及用于鉴定表现出对这种病症倾向的受试者。 本发明还提供了鉴定能够调节血液学疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为血液学疾病治疗的方法。