公开(公告)号：WO2008157697A2

公开(公告)日：2008-12-24

申请号：PCT/US2008/067508

申请日：2008-06-19

Applicant: MOMENTA PHARMACEUTICALS, INC. ,  D'ALESSANDRO, Josephine S. ,  KISHIMOTO, Takashi Kei ,  HEALY, Aileen

Inventor： D'ALESSANDRO, Josephine S. ,  KISHIMOTO, Takashi Kei ,  HEALY, Aileen

IPC: G01N33/50 ,  C07K14/00

CPC classification number: C07K14/001 ,  G01N33/5008 ,  G01N2333/52

Abstract: The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer.

Abstract translation: 本发明提供用于评估氨基酸共聚物的一种或多种性质的方法和组合物。

公开(公告)号：WO2002062948A2

公开(公告)日：2002-08-15

申请号：PCT/US2001/050620

申请日：2001-12-21

Applicant: MILLENNIUM PHARMACEUTICALS, INC. ,  BANDARU, Rajasekhar ,  HEALY, Aileen

Inventor： BANDARU, Rajasekhar ,  HEALY, Aileen

IPC: C12N

CPC classification number: C12N9/48

Abstract: The invention provides isolated nucleic acids molecules, designated 25828 nucleic acid molecules, which encode a novel aminopeptidase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25828 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 25828 gene has been introduced or disrupted. The invention still further provides isolated 25828 proteins, fusion proteins, antigenic peptides and anti-25828 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract translation: 本发明提供编码新氨基肽酶的分离的核酸分子，命名为25828核酸分子。 本发明还提供了反义核酸分子，含有25828个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中25828基因被引入或破坏的非人转基因动物。 本发明还进一步提供了分离的25828蛋白，融合蛋白，抗原肽和抗25828抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：WO2003051180A2

公开(公告)日：2003-06-26

申请号：PCT/US2002/040194

申请日：2002-12-17

Applicant: MILLENNIUM PHARMACEUTICALS, INC. ,  CARROLL, Joseph, M. ,  HEALY, Aileen

Inventor： CARROLL, Joseph, M. ,  HEALY, Aileen

IPC: A61B

CPC classification number: C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  Y02A50/58

Abstract: The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 252, 304, 1980, 14717, 9941, 19310, OR 17832 genes in tissues relating to hematological disorders disease states, and/or in response to manipulations relevant to evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.

Abstract translation: 本发明涉及诊断和治疗血液病的方法。 具体而言，本发明鉴定了252,304,1980,14717,9941,19310，或ORF 17832基因在与血液疾病疾病状态有关的组织中的差异表达，和/或响应于与各种血液疾病的评估和预后相关的操作 以及用于鉴定表现出这种状况倾向的受试者。 本发明还提供了鉴定能够调节血液病的化合物的方法。 本发明还提供了鉴定和治疗用作血液病治疗的化合物的方法。

公开(公告)号：WO2004063340A3

公开(公告)日：2005-07-14

申请号：PCT/US2004000393

申请日：2004-01-13

Applicant: MILLENNIUM PHARM INC ,  STAGLIANO NANCY E ,  HEALY AILEEN ,  ACTON SUSAN L ,  GALVIN KATHERINE M ,  DONOGHUE MARY A ,  ROGRIGUE-WAY AMELIE ,  TOMLINSON JAMES E

Inventor： STAGLIANO NANCY E ,  HEALY AILEEN ,  ACTON SUSAN L ,  GALVIN KATHERINE M ,  DONOGHUE MARY A ,  ROGRIGUE-WAY AMELIE ,  TOMLINSON JAMES E

IPC: C07K14/47 ,  G01N33/53 ,  A61K38/00 ,  C07K14/00

CPC classification number: C07K14/47

Abstract: The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 and 2419 genes in cardiovascular disease states, relative to their expression in normal, or non­cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

Abstract translation: 本发明涉及用于诊断和治疗心血管疾病的方法，包括但不限于动脉粥样硬化，再灌注损伤，高血压，再狭窄，动脉炎症，血栓形成和内皮细胞疾病。 具体地说，本发明鉴定了1722,1028,8059917,85553,1063,53235,26668,17794,2210,6169,1010,21061,17662,1468,12282,65050,9035,1820,236522,7301,6005的标准差， 8925,8701,33533,9462,9123,12788,17729,65552,1261,21476,33770,9380,2569654,33556,5366,44143,32612,10677,261,44570,41922,2552,2417,19319,4399， 8921,8993,905,232345,996,1920,17318,1510,14180,26205,554,16408,42028,112091,13886,13942,1673,5496和2419中的基因，相对于它们在正常的表达，心血管疾病状态， 或非心血管疾病状态，和/或响应与心血管疾病相关的操作。 本发明描述了各种心血管疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。 本发明还提供了鉴定能调节心血管疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为心血管疾病治疗的方法。

公开(公告)号：WO2008157697A3

公开(公告)日：2009-03-26

申请号：PCT/US2008067508

申请日：2008-06-19

Applicant: MOMENTA PHARMACEUTICALS INC ,  D ALESSANDRO JOSEPHINE S ,  KISHIMOTO TAKASHI KEI ,  HEALY AILEEN

Inventor： D ALESSANDRO JOSEPHINE S ,  KISHIMOTO TAKASHI KEI ,  HEALY AILEEN

IPC: G01N33/50 ,  C07K14/00

CPC classification number: C07K14/001 ,  G01N33/5008 ,  G01N2333/52

Abstract: The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer.

Abstract translation: 本发明提供用于评估氨基酸共聚物的一种或多种性质的方法和组合物。

公开(公告)号：WO2004072242A3

公开(公告)日：2004-08-26

申请号：PCT/US2004/003417

申请日：2004-02-05

Applicant: MILLENNIUM PHARMACEUTICALS, INC. ,  KELLY, Louise, M. ,  CARROLL, Joseph, M. ,  FARLOW, Deborah ,  HEALY, Aileen

Inventor： KELLY, Louise, M. ,  CARROLL, Joseph, M. ,  FARLOW, Deborah ,  HEALY, Aileen

IPC: G01N33/53

Abstract: The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 17600, 25584, 27824, 28469, 38947, 53003, 965, 56639, 9661, 16052, 1521, 6662, 13913, 12405 and 5014 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.

公开(公告)号：WO2004072242A2

公开(公告)日：2004-08-26

申请号：PCT/US2004003417

申请日：2004-02-05

Applicant: MILLENNIUM PHARM INC ,  KELLY LOUISE M ,  CARROLL JOSEPH M ,  FARLOW DEBORAH ,  HEALY AILEEN

Inventor： KELLY LOUISE M ,  CARROLL JOSEPH M ,  FARLOW DEBORAH ,  HEALY AILEEN

IPC: A61K38/00 ,  C07K14/47 ,  C12N

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 17600, 25584, 27824, 28469, 38947, 53003, 965, 56639, 9661, 16052, 1521, 6662, 13913, 12405 and 5014 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.

Abstract translation: 本发明涉及诊断和治疗血液病症的方法。 具体而言，本发明鉴定了9118,990,17662,81982,630,2172,27892,19290,21620,21689,28899,53659,64549,9465,23544,7366,27417,57259,21844,943的差异表达， 2061,5981,9137,13908,177600,3554,27824,28469,3897,53003,965,5666,99661,16052,1521,6662,13913,12405和5014基因在与血液学障碍感觉有关的组织中相对于它们的表达 在正常或非血液学疾病疾病状态，和/或响应于与血液学疾病相关的操作。 本发明描述了各种血液学疾病的诊断评价和预后的方法，以及用于鉴定表现出对这种病症倾向的受试者。 本发明还提供了鉴定能够调节血液学疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为血液学疾病治疗的方法。

公开(公告)号：WO2003065984A3

公开(公告)日：2003-08-14

申请号：PCT/US2003/002571

申请日：2003-01-29

Applicant: MILLENNIUM PHARMACEUTICALS, INC. ,  LOGAN, Thomas, Joseph ,  CHUN, Miyoung ,  GALVIN, Katherine, M. ,  HEALY, Aileen ,  ACTON, Susan, L. ,  DONAGHUE, Mary ,  STAGLIANO, Nancy ,  PERODIN, Jacqueline ,  RODRIGUE-WAY, Amelie

Inventor： LOGAN, Thomas, Joseph ,  CHUN, Miyoung ,  GALVIN, Katherine, M. ,  HEALY, Aileen ,  ACTON, Susan, L. ,  DONAGHUE, Mary ,  STAGLIANO, Nancy ,  PERODIN, Jacqueline ,  RODRIGUE-WAY, Amelie

IPC: C12Q1/00

Abstract: The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, heart failure, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1682, 6169, 6193, 7771, 14395, 29002, 33216, 43726, 69292, 21656, 32427, 2402, 7747, 1720, 9151, 60491, 1371, 7077, 33207, 1419, 18036, 16105, 38650, 14245, 58848, 1870, 25856, 32394, 3484, 345, 9252, 9135, 10532, 18610, 8165, 2448, 2445, 64624, 84237, 8912, 2868, 283, 2554, 9464, 17799, 26686, 43848, 32135, 12208, 2914, 51130, 19489, 21833, 2917, 59590, 15992, 2094, 2252, 3474, 9792, 15400, 1452 and 6585 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition touch conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

公开(公告)号：WO2003065871A3

公开(公告)日：2003-08-14

申请号：PCT/US2003/002484

申请日：2003-01-28

Applicant: MILLENNIUM PHARMACEUTICALS INC. ,  CARROLL, Joseph, M. ,  HEALY, Aileen ,  WEICH, Nadine, S. ,  KELLY, Louise, M.

Inventor： CARROLL, Joseph, M. ,  HEALY, Aileen ,  WEICH, Nadine, S. ,  KELLY, Louise, M.

IPC: G01N33/53

Abstract: The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 131, 148, 199, 12303, 13906, 15513, 17822, 302, 5677, 194, 14393, 28059, 7366, 12212, 1981, 261, 12416, 270, 1410, 137, 1871, 13051, 1847, 1849, 15402, 340, 10217, 837, 1761, 8990 and 13249 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.

公开(公告)号：WO2002062948A3

公开(公告)日：2002-08-15

申请号：PCT/US2001/050620

申请日：2001-12-21

Applicant: MILLENNIUM PHARMACEUTICALS, INC. ,  BANDARU, Rajasekhar ,  HEALY, Aileen

Inventor： BANDARU, Rajasekhar ,  HEALY, Aileen

IPC: C12N9/48

Abstract: The invention provides isolated nucleic acids molecules, designated 25828 nucleic acid molecules, which encode a novel aminopeptidase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25828 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 25828 gene has been introduced or disrupted. The invention still further provides isolated 25828 proteins, fusion proteins, antigenic peptides and anti-25828 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.