公开(公告)号：CA180848A

公开(公告)日：1917-12-04

申请号：CA180848D

申请日：1917-02-17

Applicant: SPRINGMETER EDWARD JR ,  KENNEDY JOSEPH M ,  SEMI AUTOMATIC TRANSMITTER COMPANY

Inventor： SPRINGMETER EDWARD JR ,  KENNEDY JOSEPH M

公开(公告)号：WO2012083122A1

公开(公告)日：2012-06-21

申请号：PCT/US2011/065389

申请日：2011-12-16

Applicant: VERTEX PHARMACEUTICAL INCORPORATED ,  CHARIFSON, Paul, S. ,  CLARK, Michael P. ,  BANDARAGE, Upul K. ,  DENG, Hongbo ,  DAVIES, Ioana ,  DUFFY, John P. ,  FARMER, Luc J. ,  GAO, Huai ,  GU, Wenxin ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  LEDFORD, Brian ,  MALTAIS, François ,  PEROLA, Emanuele ,  WANNAMAKER, Marion W. ,  WANG, Tiansheng

Inventor： CHARIFSON, Paul, S. ,  CLARK, Michael P. ,  BANDARAGE, Upul K. ,  DENG, Hongbo ,  DAVIES, Ioana ,  DUFFY, John P. ,  FARMER, Luc J. ,  GAO, Huai ,  GU, Wenxin ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  LEDFORD, Brian ,  MALTAIS, François ,  PEROLA, Emanuele ,  WANNAMAKER, Marion W. ,  WANG, Tiansheng

IPC: C07D471/04 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/497 ,  A61K31/53

CPC classification number: C07D471/04

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Abstract translation: 抑制生物样品或患者中流感病毒的复制，减少生物样品或患者中流感病毒的量以及治疗患者中的流感的方法包括向所述生物样品或患者 样品或患者施用有效量的由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 药物组合物包含有效量的这样的化合物或其药学上可接受的盐和药学上可接受的载体，佐剂或媒介物。

公开(公告)号：WO2013019828A1

公开(公告)日：2013-02-07

申请号：PCT/US2012/049097

申请日：2012-08-01

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  CHARIFSON, Paul, S. ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  BETHIEL, Randy, S. ,  BOYD, Michael, J. ,  DAVIES, Iona ,  DENG, Hongbo ,  DUFFY, John, P. ,  FARMER, Luc, J. ,  GAO, Huai ,  GU, Wenxin ,  KENNEDY, Joseph, M. ,  LEDFORD, Brian ,  LEDEBOER, Mark, W. ,  MALTAIS, Francois ,  PEROLA, Emanuele ,  WANG, Tiansheng

Inventor： CHARIFSON, Paul, S. ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  BETHIEL, Randy, S. ,  BOYD, Michael, J. ,  DAVIES, Iona ,  DENG, Hongbo ,  DUFFY, John, P. ,  FARMER, Luc, J. ,  GAO, Huai ,  GU, Wenxin ,  KENNEDY, Joseph, M. ,  LEDFORD, Brian ,  LEDEBOER, Mark, W. ,  MALTAIS, Francois ,  PEROLA, Emanuele ,  WANG, Tiansheng

IPC: C07D471/04 ,  A61K31/506 ,  A61K31/444 ,  A61P31/16

CPC classification number: C07D471/04 ,  A61K31/215 ,  A61K31/351 ,  A61K31/444 ,  A61K31/497 ,  A61K31/506 ,  A61K45/06 ,  C07F9/6561

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Abstract translation: 抑制生物样品或患者中流感病毒复制，减少生物样品或患者中的流感病毒数量和治疗患者流感的方法包括向所述生物样本或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 化合物由结构式（I）表示或其药学上可接受的盐，其中结构式（I）的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐，以及药学上可接受的载体，佐剂或媒介物。

公开(公告)号：WO2012083117A1

公开(公告)日：2012-06-21

申请号：PCT/US2011/065371

申请日：2011-12-16

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  CHARIFSON, Paul, S. ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  DAVIES, Ioana ,  DUFFY, John, P. ,  GAO, Huai ,  FENG, Jun ,  LIANG, Jianglin ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  LEDFORD, Brian ,  MALTAIS, Francois ,  PEROLA, Emanuele

Inventor： CHARIFSON, Paul, S. ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  DAVIES, Ioana ,  DUFFY, John, P. ,  GAO, Huai ,  FENG, Jun ,  LIANG, Jianglin ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  LEDFORD, Brian ,  MALTAIS, Francois ,  PEROLA, Emanuele

IPC: C07D471/04 ,  A61K31/16

CPC classification number: C07D471/04 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：WO2010148197A1

公开(公告)日：2010-12-23

申请号：PCT/US2010/038988

申请日：2010-06-17

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  CHARIFSON, Paul ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  BETHIEL, Randy, S. ,  COURT, John, J. ,  DENG, Hongbo ,  DRUTU, Ioana ,  DUFFY, John, P. ,  FARMER, Luc ,  GAO, Huai ,  GU, Wenxin ,  JACOBS, Dylan, H. ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  LEDFORD, Brian ,  MALTAIS, Francois ,  PEROLA, Emanuele ,  WANG, Tiansheng ,  WANNAMAKER, M., Woods

Inventor： CHARIFSON, Paul ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  BETHIEL, Randy, S. ,  COURT, John, J. ,  DENG, Hongbo ,  DRUTU, Ioana ,  DUFFY, John, P. ,  FARMER, Luc ,  GAO, Huai ,  GU, Wenxin ,  JACOBS, Dylan, H. ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  LEDFORD, Brian ,  MALTAIS, Francois ,  PEROLA, Emanuele ,  WANG, Tiansheng ,  WANNAMAKER, M., Woods

IPC: A61K31/506 ,  A61P31/16

CPC classification number: A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  C07D239/30 ,  C07D401/04 ,  C07D401/10 ,  C07D471/04

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Abstract translation: 抑制生物样品或患者中流感病毒复制，减少生物样品或患者中的流感病毒数量和治疗患者流感的方法包括向所述生物样本或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（IA）的值如本文所述。 化合物由结构式（IA）或其药学上可接受的盐表示，其中结构式（IA）的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐，以及药学上可接受的载体，佐剂或媒介物。

公开(公告)号：WO2012083122A8

公开(公告)日：2013-12-05

申请号：PCT/US2011065389

申请日：2011-12-16

Applicant: VERTEX PHARMA ,  CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  DENG HONGBO ,  DAVIES IOANA ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANNAMAKER MARION W ,  WANG TIANSHENG ,  SALITURO FRANCESCO G

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  DENG HONGBO ,  DAVIES IOANA ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANNAMAKER MARION W ,  WANG TIANSHENG ,  SALITURO FRANCESCO G

IPC: C07D471/04 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/53

CPC classification number: C07D471/04

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Abstract translation: 抑制生物样品或患者中流感病毒的复制，减少生物样品或患者中流感病毒的量以及治疗患者中的流感的方法包括向所述生物样品或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 药物组合物包含有效量的这样的化合物或其药学上可接受的盐和药学上可接受的载体，助剂或媒介物。

公开(公告)号：WO2012083121A1

公开(公告)日：2012-06-21

申请号：PCT/US2011/065388

申请日：2011-12-16

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  CHARIFSON, Paul, S. ,  CLARK, Michael, P. ,  DAVIES, Ioana ,  GAO, Huai ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  MALTAIS, Francois ,  PEROLA, Emanuele

Inventor： CHARIFSON, Paul, S. ,  CLARK, Michael, P. ,  DAVIES, Ioana ,  GAO, Huai ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  MALTAIS, Francois ,  PEROLA, Emanuele

IPC: C07D471/04 ,  A61K31/16

CPC classification number: C07D471/04

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Abstract translation: 抑制生物样品或患者中流感病毒复制，减少生物样品或患者中的流感病毒数量和治疗患者流感的方法包括向所述生物样本或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 化合物由结构式（I）表示或其药学上可接受的盐，其中结构式（I）的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐，以及药学上可接受的载体，佐剂或媒介物。

公开(公告)号：US1797869A

公开(公告)日：1931-03-24

申请号：US40872929

申请日：1929-11-21

Applicant: KENNEDY JOSEPH M

Inventor： KENNEDY JOSEPH M

IPC: G01F11/26

CPC classification number: G01F11/263

公开(公告)号：US1938430A

公开(公告)日：1933-12-05

申请号：US57250231

申请日：1931-11-02

Applicant: KENNEDY JOSEPH M

Inventor： KENNEDY JOSEPH M

IPC: G01F11/26

CPC classification number: G01F11/263

公开(公告)号：US1177778A

公开(公告)日：1916-04-04

申请号：US1913804887

申请日：1913-12-05

Applicant: EDWARD SPRINGMEIER JR ,  KENNEDY JOSEPH M

Inventor： KENNEDY JOSEPH M

CPC classification number: H04L15/08