公开(公告)号：WO2006091720A3

公开(公告)日：2006-08-31

申请号：PCT/US2006/006387

申请日：2006-02-23

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  ALKAN, Sefik ,  KIEPER, William C. ,  VASILAKOS, John P. ,  BONK, Jason D. ,  GRIESGRABER, George W. ,  LIPSON, Kenneth E. ,  LIU, Jie J. ,  MENDOZA, James D. ,  STOERMER, Doris ,  WIGHTMAN, Paul D. ,  JING, Naiyong ,  SCHULTZ, William J.

Inventor： ALKAN, Sefik ,  KIEPER, William C. ,  VASILAKOS, John P. ,  BONK, Jason D. ,  GRIESGRABER, George W. ,  LIPSON, Kenneth E. ,  LIU, Jie J. ,  MENDOZA, James D. ,  STOERMER, Doris ,  WIGHTMAN, Paul D. ,  JING, Naiyong ,  SCHULTZ, William J.

IPC: A61K31/4745 ,  A61K31/4748 ,  A61K31/437 ,  A61K31/4738

Abstract: The present invention provides immunomodulatory compositions include an immune response modifier moiety coupled to a targeting moiety. In another aspect, the invention provides methods of providing targeted delivery of an IRM, generating a localized immune response, and treating a condition in a subject. Generally, the methods include administering to the subject an immunomodulatory composition that includes an immune response modifier moiety coupled to a targeting moiety that recognizes a delivery target.

公开(公告)号：WO2012061811A2

公开(公告)日：2012-05-10

申请号：PCT/US2011059589

申请日：2011-11-07

Applicant: FIBROGEN INC ,  LIPSON KENNETH E

Inventor： LIPSON KENNETH E

IPC: A61K39/395 ,  A61P11/00 ,  C07K16/22

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76

Abstract: The present invention relates to methods and medicaments useful for pre-treatment, treatment, or amelioration of lung remodeling disease. Methods and medicaments for reducing, preventing, or reversing increased lung density, improving lung function, and increasing survivability in subjects having lung remodeling disease are also provided.

Abstract translation: 本发明涉及可用于肺重塑疾病的预处理，治疗或改善的方法和药物。 还提供了用于减少，预防或逆转增加的肺密度，改善肺功能以及提高具有肺重塑疾病的受试者的生存能力的方法和药物。

公开(公告)号：WO2011056234A1

公开(公告)日：2011-05-12

申请号：PCT/US2010/002922

申请日：2010-11-08

Applicant: FIBROGEN, INC. ,  LIPSON, Kenneth, E.

Inventor： LIPSON, Kenneth, E.

IPC: A61K39/395 ,  C07K16/22 ,  A61P9/00 ,  A61P11/00 ,  A61P35/00 ,  A61P39/00

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76 ,  A61K2300/00

Abstract: The present invention relates to methods and medicaments useful for treatment of radiation-induced disorders by administering anti-CTGF agents, particularly anti-CTGF antibodies. Methods and medicaments for pre-treating individuals having or at risk for having exposure to ionizing radiation to prevent or reduce radiation-induced disorders are also provided.

Abstract translation: 本发明涉及通过施用抗CTGF试剂，特别是抗CTGF抗体来治疗放射诱导的病症的方法和药物。 还提供了用于预处理暴露于电离辐射或具有暴露于电离辐射的风险的个体的预处理方法和药物以预防或减少辐射诱发的疾病。

公开(公告)号：WO2006091720A2

公开(公告)日：2006-08-31

申请号：PCT/US2006006387

申请日：2006-02-23

Applicant: 3M INNOVATIVE PROPERTIES CO ,  ALKAN SEFIK ,  KIEPER WILLIAM C ,  VASILAKOS JOHN P ,  BONK JASON D ,  GRIESGRABER GEORGE W ,  LIPSON KENNETH E ,  LIU JIE J ,  MENDOZA JAMES D ,  STOERMER DORIS ,  WIGHTMAN PAUL D ,  JING NAIYONG ,  SCHULTZ WILLIAM J

Inventor： ALKAN SEFIK ,  KIEPER WILLIAM C ,  VASILAKOS JOHN P ,  BONK JASON D ,  GRIESGRABER GEORGE W ,  LIPSON KENNETH E ,  LIU JIE J ,  MENDOZA JAMES D ,  STOERMER DORIS ,  WIGHTMAN PAUL D ,  JING NAIYONG ,  SCHULTZ WILLIAM J

IPC: A61K31/4745

CPC classification number: A61K31/4745 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851

Abstract: The present invention provides immunomodulatory compositions include an immune response modifier moiety coupled to a targeting moiety. In another aspect, the invention provides methods of providing targeted delivery of an IRM, generating a localized immune response, and treating a condition in a subject. Generally, the methods include administering to the subject an immunomodulatory composition that includes an immune response modifier moiety coupled to a targeting moiety that recognizes a delivery target.

Abstract translation: 本发明提供免疫调节组合物包括与靶向部分偶联的免疫应答调节剂部分。 在另一方面，本发明提供了提供IRM的靶向递送，产生局部免疫应答和治疗受试者的病症的方法。 通常，所述方法包括向受试者施用免疫调节组合物，其包含与识别递送目标的靶向部分偶联的免疫应答调节剂部分。

公开(公告)号：WO2012061811A3

公开(公告)日：2012-05-10

申请号：PCT/US2011/059589

申请日：2011-11-07

Applicant: FIBROGEN, INC. ,  LIPSON, Kenneth, E.

Inventor： LIPSON, Kenneth, E.

IPC: A61K39/395 ,  A61P11/00 ,  C07K16/22

Abstract: The present disclosure relates to methods and medicaments useful for pre - treatment, treatment, or amelioration of lung remodeling disease. Methods and medicaments for reducing, preventing, or reversing increased lung density, improving lung function, and increasing survivability in subjects having lung remodeling disease are also provided.