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公开(公告)号：WO2007100634A3
公开(公告)日：2007-10-25
申请号：PCT/US2007004673
申请日：2007-02-21
Applicant: 3M INNOVATIVE PROPERTIES CO , STOERMER DORIS , GRIESGRABER GEORGE W , MENDOZA JAMES D , BONK JASON D
Inventor： STOERMER DORIS , GRIESGRABER GEORGE W , MENDOZA JAMES D , BONK JASON D
IPC: A61K31/4745 , A61P37/00
CPC classification number: A61K47/48384 , A61K31/4745 , A61K47/6803 , A61K47/6843 , A61K47/6849 , C07K16/2815 , C07K16/2878 , C07K16/2887
Abstract: The present invention provides IRM conjugates that includes an IRM moiety and a second active moiety covalently linked to the IRM moiety in which the covalent link does not depend on UV irradiation.
Abstract translation: 本发明提供了IRM缀合物，其包含IRM部分和与IRM部分共价连接的第二活性部分，其中共价键不依赖于UV辐射。
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公开(公告)号：WO2006026760A2
公开(公告)日：2006-03-09
申请号：PCT/US2005031414
申请日：2005-09-02
Applicant: 3M INNOVATIVE PROPERTIES CO , STOERMER DORIS , DRESSEL LUKE T , MANSKE KARL J , GRIESGRABER GEORGE W , ZIMMERMANN BERNHARD M , DELLARIA JOSEPH F JR
Inventor： STOERMER DORIS , DRESSEL LUKE T , MANSKE KARL J , GRIESGRABER GEORGE W , ZIMMERMANN BERNHARD M , DELLARIA JOSEPH F JR
IPC: A61K31/4745
CPC classification number: C07D471/04
Abstract: Imidazo-containing compounds (e.g., imidazonaphthyridines, imidazopyridines) with an amino substituent at the 1-position, pharmaceutical compositions containing the compounds and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
Abstract translation: 在1位具有氨基取代基的含咪唑化合物（例如咪唑并吡啶，咪唑并吡啶），含有这些化合物的化合物的药物组合物和这些化合物作为免疫调节剂的方法，用于诱导动物中的细胞因子生物合成和治疗包括病毒 并发现肿瘤性疾病。
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公开(公告)号：WO2008079924A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/088277
申请日：2007-12-20
Applicant: 3M INNOVATIVE PROPERTIES COMPANY , STOERMER, Doris , GRIESGRABER, George, W. , KSHIRSAGAR, Tushar, A.
Inventor： STOERMER, Doris , GRIESGRABER, George, W. , KSHIRSAGAR, Tushar, A.
IPC: C07D213/73 , C07D487/02 , C07D471/04 , C07D487/12 , C07D471/14 , A61K39/395 , A61K31/437 , A61P37/00
CPC classification number: C07D471/04 , A01K13/002 , A01K13/003 , A46B11/0013 , A46B11/0055 , A46B11/0062 , A46B11/0079 , A46B2200/104 , A61K31/437 , A61K47/556 , A61K47/66 , A61K47/68 , A61K47/6801 , C07D513/04
Abstract: The present invention provides an immune response modifier (IRM) composition that includes an IRM moiety and a second active moiety covalently linked to the IRM moiety, wherein the covalent link comprises a labile bond directly attached to the IRM moiety.
Abstract translation: 本发明提供免疫应答调节剂（IRM）组合物，其包含与IRM部分共价连接的IRM部分和第二活性部分，其中共价连接包含直接连接至IRM部分的不稳定键。
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公开(公告)号：WO2006121528A3
公开(公告)日：2007-09-13
申请号：PCT/US2006012022
申请日：2006-03-31
Applicant: COLEY PHARM GROUP INC , HAYS DAVID S , MACKEY SONJA S , MOSER WILLIAM H , STOERMER DORIS , RADMER MATTHEW R , NIWAS SHRI
Inventor： HAYS DAVID S , MACKEY SONJA S , MOSER WILLIAM H , STOERMER DORIS , RADMER MATTHEW R , NIWAS SHRI
IPC: C07D235/02 , C07D233/54 , C07D233/64 , C07D471/04 , C07D471/14
CPC classification number: C07D471/04 , C07D233/90 , C07D471/14
Abstract: Methods and intermediates useful for making compounds of the formula: and the preparation of compounds of Formula I, preferably including the formation of intermediate compounds of the formula:
Abstract translation: 可用于制备下式化合物的方法和中间体：和式I化合物的制备，优选包括形成下式的中间体化合物：
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5.发明申请SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZOPYRIDINES, AND IMIDAZONAPHTHYRIDINES 审中-公开取代的咪唑啉酮，咪唑并吡啶和咪唑并噻吩
公开(公告)号：WO2006028545A3
公开(公告)日：2007-08-23
申请号：PCT/US2005021445
申请日：2005-06-17
Applicant: 3M INNOVATIVE PROPERTIES CO , STOERMER DORIS , DELLARIA JOSEPH F JR , AMOS DAVID T , ZIMMERMANN BERNHARD M , DRESSEL LUKE T , BONK JASON D , RADMER MATTHEW R
Inventor： STOERMER DORIS , DELLARIA JOSEPH F JR , AMOS DAVID T , ZIMMERMANN BERNHARD M , DRESSEL LUKE T , BONK JASON D , RADMER MATTHEW R
IPC: C07D471/14 , A61K31/437
CPC classification number: C07D471/04 , C07D471/14
Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是喹啉，四氢喹啉，吡啶，[1,5]萘啶，[1,5]四氢萘并噻嗪）在1位被环状取代基取代的药物组合物 公开了制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。
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Patent Agency Ranking
公开(公告)号：WO2007100634A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/004673
申请日：2007-02-21
Applicant: 3M INNOVATIVE PROPERTIES COMPANY , STOERMER, Doris , GRIESGRABER, George, W. , MENDOZA, James, D. , BONK, Jason, D.
Inventor： STOERMER, Doris , GRIESGRABER, George, W. , MENDOZA, James, D. , BONK, Jason, D.
CPC classification number: A61K47/48384 , A61K31/4745 , A61K47/6803 , A61K47/6843 , A61K47/6849 , C07K16/2815 , C07K16/2878 , C07K16/2887
Abstract: The present invention provides IRM conjugates that includes an IRM moiety and a second active moiety covalently linked to the IRM moiety in which the covalent link does not depend on UV irradiation.
Abstract translation: 本发明提供IRM缀合物，其包括IRM部分和与IRM部分共价连接的第二活性部分，其中共价连接不依赖于UV照射。
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7.发明申请COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF IMMUNE RESPONSE MODIFIERS 审中-公开用于定向递送免疫应答改性剂的组合物和方法
公开(公告)号：WO2006091720A2
公开(公告)日：2006-08-31
申请号：PCT/US2006006387
申请日：2006-02-23
Applicant: 3M INNOVATIVE PROPERTIES CO , ALKAN SEFIK , KIEPER WILLIAM C , VASILAKOS JOHN P , BONK JASON D , GRIESGRABER GEORGE W , LIPSON KENNETH E , LIU JIE J , MENDOZA JAMES D , STOERMER DORIS , WIGHTMAN PAUL D , JING NAIYONG , SCHULTZ WILLIAM J
Inventor： ALKAN SEFIK , KIEPER WILLIAM C , VASILAKOS JOHN P , BONK JASON D , GRIESGRABER GEORGE W , LIPSON KENNETH E , LIU JIE J , MENDOZA JAMES D , STOERMER DORIS , WIGHTMAN PAUL D , JING NAIYONG , SCHULTZ WILLIAM J
IPC: A61K31/4745
CPC classification number: A61K31/4745 , A61K47/6803 , A61K47/6849 , A61K47/6851
Abstract: The present invention provides immunomodulatory compositions include an immune response modifier moiety coupled to a targeting moiety. In another aspect, the invention provides methods of providing targeted delivery of an IRM, generating a localized immune response, and treating a condition in a subject. Generally, the methods include administering to the subject an immunomodulatory composition that includes an immune response modifier moiety coupled to a targeting moiety that recognizes a delivery target.
Abstract translation: 本发明提供免疫调节组合物包括与靶向部分偶联的免疫应答调节剂部分。 在另一方面，本发明提供了提供IRM的靶向递送，产生局部免疫应答和治疗受试者的病症的方法。 通常，所述方法包括向受试者施用免疫调节组合物，其包含与识别递送目标的靶向部分偶联的免疫应答调节剂部分。
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公开(公告)号：WO2006026760A3
公开(公告)日：2006-03-09
申请号：PCT/US2005/031414
申请日：2005-09-02
Applicant: 3M INNOVATIVE PROPERTIES COMPANY , STOERMER, Doris , DRESSEL, Luke T. , MANSKE, Karl J. , GRIESGRABER, George W. , ZIMMERMANN, Bernhard M. , DELLARIA, Joseph F. Jr.
Inventor： STOERMER, Doris , DRESSEL, Luke T. , MANSKE, Karl J. , GRIESGRABER, George W. , ZIMMERMANN, Bernhard M. , DELLARIA, Joseph F. Jr.
IPC: A61K31/437 , A61K31/4375 , C07D471/02 , C07D401/02
Abstract: Imidazo-containing compounds (e.g., imidazonaphthyridines, imidazopyridines) with an amino substituent at the 1-position, pharmaceutical compositions containing the compounds and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
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9.发明申请SUBSTITUTED 4H-IMIDAZO [4, 5, 1-IJ] [1, 6] NAPHTHYRIDINE-9-AMINES AND THEIR PHARMACEUTICAL USE 审中-公开取代的4H-咪唑并[4，5,1-IJ] [1,6]萘啶-9-氨基酸及其药物用途
公开(公告)号：WO2008045543A1
公开(公告)日：2008-04-17
申请号：PCT/US2007/021839
申请日：2007-10-12
Applicant: COLEY PHARMACEUTICAL GROUP, INC. , STOERMER, Doris
Inventor： STOERMER, Doris
IPC: C07D471/16 , A61K31/437 , A61P31/00 , A61P35/00 , A61P37/00
CPC classification number: C07D471/16
Abstract: Substituted 4 H -imidazo[4,5, 1- ij ][1,6]naphthyridine-9-amines of the Formula I : pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
Abstract translation: 式I的取代的4H-咪唑并[4,5，1-i] [1,6]萘啶-9-胺：含有化合物的药物组合物，中间体，制备该化合物的方法以及这些化合物的使用方法如 公开了用于在动物中诱导细胞因子生物合成和用于治疗包括病毒和肿瘤疾病的疾病的免疫调节剂。
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公开(公告)号：WO2006121528A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/012022
申请日：2006-03-31
Applicant: 3M INNOVATIVE PROPERTIES COMPANY , HAYS, David S., , MACKEY, Sonja S., , MOSER, William H., , STOERMER, Doris , RADMER, Matthew R., , NIWAS, Shri
Inventor： HAYS, David S., , MACKEY, Sonja S., , MOSER, William H., , STOERMER, Doris , RADMER, Matthew R., , NIWAS, Shri
IPC: G06Q50/00
CPC classification number: C07D471/04 , C07D233/90 , C07D471/14
Abstract: Methods and intermediates useful for making compounds of the formula: and the preparation of compounds of Formula I, preferably including the formation of intermediate compounds of the formula:
Abstract translation: 可用于制备下式化合物的方法和中间体：和式I化合物的制备，优选包括形成下式的中间体化合物：
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