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    (METH)ACRYLOYL-CONTAINING MATERIALS, COMPOSITIONS, AND METHODS
    4.
    发明申请
    (METH)ACRYLOYL-CONTAINING MATERIALS, COMPOSITIONS, AND METHODS 审中-公开
    （METH）含丙烯酸的材料，组合物和方法

    公开(公告)号：WO2008082881A1

    公开(公告)日：2008-07-10

    申请号：PCT/US2007/087202

    申请日：2007-12-12

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  ABUELYAMAN, Ahmed, S. ,  MITRA, Sumita, B.

    Inventor： ABUELYAMAN, Ahmed, S. ,  MITRA, Sumita, B.

    IPC: A61K6/083 ,  A61K6/00 ,  C07C69/54 ,  C07C271/16 ,  C07C69/80 ,  C07C67/03

    CPC classification number: C07C69/54 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/083 ,  A61K6/087 ,  C07C67/03 ,  C07C69/80 ,  C07C271/16 ,  C07C69/675 ,  C08L33/00 ,  C08L67/04

    Abstract: Di-, tri-, and/or tetra-(meth)acryloyl-containing materials and compositions are provided. Such materials and compositions can preferably be hardened, without undue shrinkage, to provide hardened materials and/or compositions with properties useful, for example, in dental applications. In one aspect, the present invention provides a compound of the formula (Formula I) wherein: each X independently represents an oxygen atom (O) or a nitrogen atom (N); Y and A each independently represent an organic group, with the proviso that Y does not represent -NHCH 2 CH 2 - if (i) p = O and R 1 represents -C(O)C(CH 3 )=CH 2 , and/or (ii) q = 0 and R 2 represents -C(O)C(CH 3 )=CH 2 ; m = 1 to 5; n = 0 to 5; p and q are independently 0 or 1; and R 1 and R 2 each independently represent H, -C(O)CH=CH 2 , or -C(O)C(CH 3 )=CH 2 .

    Abstract translation: 提供二 - ，三 - 和/或四（甲基）丙烯酰基的材料和组合物。 这样的材料和组合物可以优选地硬化，而不会有不适当的收缩，以提供具有例如在牙齿应用中有用的性质的硬化材料和/或组合物。 一方面，本发明提供式（I）的化合物，其中：各X独立地表示氧原子（O）或氮原子（N）; Y和A各自独立地表示有机基团，条件是Y不表示-NHCH 2 CH 2 - ，如果（i）p = O和R' 1表示-C（O）C（CH 3 CH 3）= CH 2，和/或（ii）q = 0和R 2， / O 2表示-C（O）C（CH 3 CH 3）= CH 2; m = 1〜5; n = 0〜5; p和q独立地为0或1; 和R 1和R 2各自独立地表示H，-C（O）CH = CH 2或-C（O）C（ CH 3 ）= CH 2 。

    IMMUNE RESPONSE MODIFIERS FOR THE TREATMENT OF PERIODONTAL DISEASE
    5.
    发明申请
    IMMUNE RESPONSE MODIFIERS FOR THE TREATMENT OF PERIODONTAL DISEASE 审中-公开
    用于治疗周围疾病的免疫反应调节剂

    公开(公告)号：WO2002102377A1

    公开(公告)日：2002-12-27

    申请号：PCT/US2002/018944

    申请日：2002-06-14

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  MITRA, Sumita, B. ,  SHELBURNE, Charles, E. ,  TOMAI, Mark, A.

    Inventor： MITRA, Sumita, B. ,  SHELBURNE, Charles, E. ,  TOMAI, Mark, A.

    IPC: A61K31/429

    CPC classification number: A61K31/4745

    Abstract: The disclosure provides methods for the treatment and prevention of periodontal disease. In preferred embodiments, the invention provides for local treatment of periodontal tissues with a pharmaceutical composition including an immune response modifier (IRM) selected from the group of immune response modifiers comprising imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, imidazonaphthyridine amines, oxazoloquinoline amines, thiazoloquinoline amines and 1,2-bridged imidazoquinoline amines.

    Abstract translation: 本公开提供了治疗和预防牙周病的方法。 在优选的实施方案中，本发明提供了用包含免疫应答调节剂（IRM）的药物组合物局部治疗牙周组织，所述免疫应答调节剂包括咪唑并喹啉胺，咪唑并吡啶胺，6,7-稠合的环烷基咪唑并吡啶胺，咪唑并吡啶胺 ，恶唑啉喹啉胺，噻唑并喹啉胺和1,2-桥连的咪唑并喹啉胺。

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