公开(公告)号：WO03062241A8

公开(公告)日：2004-10-21

申请号：PCT/US0240598

申请日：2002-12-18

Applicant: SQUIBB BRISTOL MYERS CO ,  SALVATI MARK E ,  BALOG JAMES AARON ,  PICKERING DACIA A ,  GIESE SOREN ,  FURA ABERRA ,  LI WENYING ,  PATEL RAMESH N ,  HANSON RONALD L ,  MITT TOOMAS ,  ROBERGE JACQUES ,  CORTE JAMES R ,  SPERGEL STEVEN H ,  RAMPULLA RICHARD A ,  MISRA RAJ ,  XIAO HAI-YUN

Inventor： SALVATI MARK E ,  BALOG JAMES AARON ,  PICKERING DACIA A ,  GIESE SOREN ,  FURA ABERRA ,  LI WENYING ,  PATEL RAMESH N ,  HANSON RONALD L ,  MITT TOOMAS ,  ROBERGE JACQUES ,  CORTE JAMES R ,  SPERGEL STEVEN H ,  RAMPULLA RICHARD A ,  MISRA RAJ ,  XIAO HAI-YUN

IPC: C07D487/18 ,  A61K31/40 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/433 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/7052 ,  A61P1/14 ,  A61P3/06 ,  A61P3/10 ,  A61P5/26 ,  A61P5/28 ,  A61P5/32 ,  A61P5/46 ,  A61P7/00 ,  A61P9/04 ,  A61P13/08 ,  A61P15/00 ,  A61P15/02 ,  A61P15/04 ,  A61P15/08 ,  A61P15/18 ,  A61P17/08 ,  A61P17/10 ,  A61P17/14 ,  A61P19/10 ,  A61P21/02 ,  A61P25/18 ,  A61P25/28 ,  A61P25/30 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  C07D471/18 ,  C07D491/00 ,  C07D491/18 ,  C07D491/22 ,  C07D495/18 ,  C07D519/00 ,  C07H17/00

CPC classification number: C07D491/18 ,  C07D491/22 ,  C07D519/00

Abstract: Fused cyclic compounds method of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

Abstract translation: 使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的融合的环状化合物的方法，以及含有这些化合物的药物组合物。

公开(公告)号：WO2003062241A1

公开(公告)日：2003-07-31

申请号：PCT/US2002/040598

申请日：2002-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  SALVATI, Mark, E. ,  BALOG, James, Aaron ,  PICKERING, Dacia, A. ,  GIESE, Soren ,  FURA, Aberra ,  LI, Wenying ,  PATEL, Ramesh, N. ,  HANSON, Ronald, L. ,  MITT, Toomas ,  ROBERGE, Jacques ,  CORTE, James, R. ,  SPERGEL, Steven, H. ,  RAMPULLA, Richard, A. ,  MISRA, Raj ,  XIAO, Hai-Yun

Inventor： SALVATI, Mark, E. ,  BALOG, James, Aaron ,  PICKERING, Dacia, A. ,  GIESE, Soren ,  FURA, Aberra ,  LI, Wenying ,  PATEL, Ramesh, N. ,  HANSON, Ronald, L. ,  MITT, Toomas ,  ROBERGE, Jacques ,  CORTE, James, R. ,  SPERGEL, Steven, H. ,  RAMPULLA, Richard, A. ,  MISRA, Raj ,  XIAO, Hai-Yun

IPC: C07D491/00

CPC classification number: C07D491/18 ,  C07D491/22 ,  C07D519/00

Abstract: Fused cyclic compounds method of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

Abstract translation: 使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的融合的环状化合物的方法，以及含有这些化合物的药物组合物。

公开(公告)号：CA2098033A1

公开(公告)日：1994-01-14

申请号：CA2098033

申请日：1993-06-09

Applicant: SINGH JANAK ,  BISACCHI GREGORY S ,  GODFREY JOLLIE D ,  MITT TOOMAS ,  MUELLER RICHARD H ,  ZAHLER ROBERT ,  KISSICK THOMAS P

Inventor： SINGH JANAK ,  BISACCHI GREGORY S ,  GODFREY JOLLIE D ,  MITT TOOMAS ,  MUELLER RICHARD H ,  ZAHLER ROBERT ,  KISSICK THOMAS P

IPC: A61K31/52 ,  A61P31/12 ,  C07C211/63 ,  C07D473/00 ,  C07D473/32 ,  C07D473/40 ,  C07H23/00 ,  C07F7/10 ,  C07H19/16 ,  C07F9/547

Abstract: Process For Preparing Guanine-Containing Antiviral Agents And Purinyl Salts Useful In Such Process A purine salt of the formula wherein Y1 is chloro, bromo, or iodo, and R1, R2, R3, and R4 are independently selected from alkyl and substituted alkyl is reacted with the compound of the formula Z1-X to yield the purine of the formula wherein X is a leaving group, and Z1 is a protected form of the carbohydrate surrogate Z. Several routes are disclosed for converting this intermediate to the antiviral agent

公开(公告)号：CA2031586A1

公开(公告)日：1991-06-19

申请号：CA2031586

申请日：1990-12-05

Applicant: BISACCHI GREGORY S ,  MITT TOOMAS

Inventor： BISACCHI GREGORY S ,  MITT TOOMAS

IPC: A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  A61P31/22 ,  C07C235/40 ,  C07C243/08 ,  C07D473/00 ,  C07D473/18 ,  C07F7/18 ,  C07F7/10

Abstract: GY16 A process for the preparation of the optically active compound ¢1R-(1.alpha.,2.beta.,3.alpha.)!-2-amino-9-¢2,3-bis(hydroxymethyl)cyclobutyl!-6H-purin-6-one, represented by the formula: and novel intermediates are described.