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    Method to use fibroblast or supernatant from fibroblast for immune response inhibition in transplantation, and composition of the same
    1.
    发明专利
    Method to use fibroblast or supernatant from fibroblast for immune response inhibition in transplantation, and composition of the same 审中-公开
    使用FIBROBLAST或来自FIBROBLAST的免疫调节免疫反应抑制方法及其组合

    公开(公告)号：JP2011037865A

    公开(公告)日：2011-02-24

    申请号：JP2010213040

    申请日：2010-09-24

    Applicant: Osiris Therapeutics Inc ,  オシリス セラピューティクス,インコーポレイテッド

    Inventor： MC INTOSH KEVIN R ,  MOSCA JOSEPH D ,  KLYUSHNENKOVA ELENA N

    IPC: A61K35/12 ,  A61K45/00 ,  A61K35/14 ,  A61K35/28 ,  A61K35/36 ,  A61P37/06 ,  C12N5/071

    CPC classification number: A61K35/33

    Abstract: PROBLEM TO BE SOLVED: To provide a method and a composition for immune response inhibition in transplantation.
    SOLUTION: The method is one method to induce so as to reduce an immune response in a recipient by treating the recipient with a quantity of a fibroblast or a supernatant from a fibroblast culture substance effective to reduce or inhibit host rejection of a transplant. The fibroblast or the supernatant from the fibroblast culture substance is administered before, at the same time as, or after the transplantation. The method is effective in reducing the immune response to the transplant without compromising the immune response to other external antigen. Furthermore, a method to induce reducing the immune response against a host by external tissue, that is, graft versus host disease is disclosed.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 待解决的问题：提供移植中免疫应答抑制的方法和组合物。 解决方案：该方法是通过用有效减少或抑制移植物宿主排斥的成纤维细胞培养物质的成纤维细胞或上清液处理受体而诱导接受者免疫应答的一种方法 。 来自成纤维细胞培养物质的成纤维细胞或上清液在移植之前，同时或之后施用。 该方法在减少对移植物的免疫应答而不损害对其它外部抗原的免疫应答方面是有效的。 此外，公开了一种通过外部组织诱导降低针对宿主的免疫应答的方法，即移植物抗宿主病。 版权所有（C）2011，JPO＆INPIT

    Mesenchymal stem cells and uses therefor
    5.
    发明专利
    Mesenchymal stem cells and uses therefor 有权
    MESENCHYMAL STEM CELLS AND USES THEREFOR

    公开(公告)号：JP2012176948A

    公开(公告)日：2012-09-13

    申请号：JP2012058539

    申请日：2012-03-15

    Applicant: Osiris Therapeutics Inc ,  オシリス セラピューティクス,インコーポレイテッド

    Inventor： PITTENGER MARK F ,  AGGARWAL SUDEEPTA

    IPC: A61K35/12 ,  A61K35/14 ,  A61L27/00 ,  A61P17/00 ,  A61P17/02 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/06 ,  C12N5/00 ,  C12N5/0775 ,  H04Q7/20

    CPC classification number: A61K35/28 ,  C12N5/0663

    Abstract: PROBLEM TO BE SOLVED: To provide a method of treating autoimmune diseases, allergic diseases, cancer, or inflammatory diseases in animals, a method of promoting would healing, and a method of promoting angiogenesis in an organ or tissue of an animal.SOLUTION: Mesenchymal stem cells, that are a homogeneous composition obtained by culturing adherent marrow or periosteal cells or a mixed cell population enriched in MSCs, are administered in an amount of from about 1×10cells/kg to about 1×10cells/kg, alternatively in an amount of from about 1×10cells/kg to about 5×10cells/kg.

    Abstract translation: 要解决的问题：提供一种治疗动物的自身免疫性疾病，过敏性疾病，癌症或炎性疾病的方法，促进愈合的方法，以及促进动物器官或组织中血管生成的方法。 解决方案：通过培养粘附的骨髓或骨膜细胞或富含MSC的混合细胞群体获得的均质组合的间充质干细胞以约1×10 10 SP SP =“POST” 5×SP细胞/ kg至约1×10 6个细胞/ kg，或者以约1×10 < / SP>细胞/ kg至约5×10 6 细胞/ kg。 版权所有（C）2012，JPO＆INPIT

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