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公开(公告)号：IL318530A
公开(公告)日：2025-03-01
申请号：IL31853025
申请日：2025-01-21
Inventor： PERL NICHOLAS ROBERT , KUNTZ KEVIN WAYNE
Abstract: The present invention relates to quinazolinones and related compounds which degrade PARP14 and are useful, for example, in the treatment of cancer and inflammatory diseases.
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公开(公告)号：IL318518A
公开(公告)日：2025-03-01
申请号：IL31851825
申请日：2025-01-21
Applicant: ABBVIE OPERATIONS SINGAPORE PTE LTD , PERL NICHOLAS ROBERT , KUNTZ KEVIN WAYNE , DOWNING JENNIFER
Inventor： PERL NICHOLAS ROBERT , KUNTZ KEVIN WAYNE , DOWNING JENNIFER
Abstract: The present invention relates to quinazolinones and related compounds which degrade PARP14 and are useful, for example, in the treatment of cancer and inflammatory diseases.
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公开(公告)号：WO2014047325A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/060680
申请日：2013-09-19
Applicant: IRONWOOD PHARMACEUTICALS, INC. , NAKAI, Takashi , PERL, Nicholas, Robert , MOORE, Joel
Inventor： NAKAI, Takashi , PERL, Nicholas, Robert , MOORE, Joel
IPC: C07D413/14 , A61K31/506 , A61P7/00 , A61P9/00 , A61P15/00
CPC classification number: A61K31/513 , A61K31/4155 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D413/14 , C07D487/04 , A61K2300/00
Abstract: The present patent application discloses at least the compounds according to Formula I or Formula lb shown below, or pharmaceutically acceptable salts thereof, wherein ring B, J B , n, J D , J, o, X, R C and R A are as described herein.
Abstract translation: 本专利申请公开了至少下述式I或式Ib的化合物或其药学上可接受的盐，其中环B，JB，n，JD，J，o，X，RC和RA如本文所述。
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4.发明申请2 - BENZYL, 3 - (PYRIMIDIN- 2 -YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS 审中-公开2 - 苄基，3-（吡咯烷-2-基）取代的吡唑可用作SGC刺激物
公开(公告)号：WO2013101830A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/071654
申请日：2012-12-26
Applicant: IRONWOOD PHARMACEUTICALS, INC. , KIM, Charles , NAKAI, Takashi , MOORE, Joel , PERL, Nicholas, Robert , IM, G-yoon, Jamie , BARDEN, Timothy, Claude , IYENGAR, Rajesh, R. , ZIMMER, Daniel, P. , FRETZEN, Angelika , RENHOWE, Paul, Allan
Inventor： KIM, Charles , NAKAI, Takashi , MOORE, Joel , PERL, Nicholas, Robert , IM, G-yoon, Jamie , BARDEN, Timothy, Claude , IYENGAR, Rajesh, R. , ZIMMER, Daniel, P. , FRETZEN, Angelika , RENHOWE, Paul, Allan
IPC: C07D413/14 , C07D403/04 , C07D417/14 , A61K31/4155 , A61P43/00
CPC classification number: A61K31/52 , A61K31/4439 , A61K31/506 , A61K31/513 , A61K31/519 , A61K45/06 , C07D403/04 , C07D413/14 , C07D417/14 , C07D473/00 , C07D487/04 , C07D513/22
Abstract: 2-Benzyl, 3 - (pyrimidin- 2 -YL) substituted pyrazoles are described. They are useful as stimulators of sGC, particularly NO - independent, heme - dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述2-苄基，3-（嘧啶-2-基）取代的吡唑。 它们可用作sGC的刺激剂，特别是NO-不依赖于血红素依赖性刺激物。 这些化合物可用于治疗，预防或治疗本文公开的各种疾病。
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Patent Agency Ranking
公开(公告)号：WO2012064559A1
公开(公告)日：2012-05-18
申请号：PCT/US2011/058902
申请日：2011-11-02
Applicant: IRONWOOD PHARMACEUTICALS, INC. , KIM, Charles , NAKAI, Takashi , LEE, Thomas, Wai-ho , MOORE, Joel , PERL, Nicholas, Robert , ROHDE, Jason
Inventor： KIM, Charles , NAKAI, Takashi , LEE, Thomas, Wai-ho , MOORE, Joel , PERL, Nicholas, Robert , ROHDE, Jason
IPC: A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , C07D401/04 , C07D401/14 , C07D403/04 , C07D407/14 , C07D413/14 , C07D417/04 , C07D417/14 , A61P7/02 , A61P9/08
CPC classification number: A61K31/5377 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Compounds of Formula (IA) and Formula (IB) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述了式（IA）和式（IB）的化合物。 它们作为sGC的刺激剂是有用的，特别是NO不依赖于血红素依赖性刺激物。 这些化合物可用于治疗，预防或治疗本文公开的各种疾病。
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公开(公告)号：WO2014144100A3
公开(公告)日：2014-11-06
申请号：PCT/US2014028370
申请日：2014-03-14
Applicant: NAKAI TAKASHI , MOORE JOEL , PERL NICHOLAS ROBERT , IYENGAR RAJESH R , MERMERIAN ARA , IM G-YOON JAMIE , LEE THOMAS WAI-HO , HUDSON COLLEEN , RENNIE GLEN ROBERT , JIA JAMES , RENHOWE PAUL ALLEN , BARDEN TIMOTHY CLAUDE , YU XIANG Y , SHEPPECK JAMES EDWARD , IYER KARTHIK , JUNG JOON
Inventor： NAKAI TAKASHI , MOORE JOEL , PERL NICHOLAS ROBERT , IYENGAR RAJESH R , MERMERIAN ARA , IM G-YOON JAMIE , LEE THOMAS WAI-HO , HUDSON COLLEEN , RENNIE GLEN ROBERT , JIA JAMES , RENHOWE PAUL ALLEN , BARDEN TIMOTHY CLAUDE , YU XIANG Y , SHEPPECK JAMES EDWARD , IYER KARTHIK , JUNG JOON
IPC: C07D413/14 , A61K31/506 , A61P3/00 , A61P9/00 , A61P15/00 , A61P25/00 , C07D403/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
CPC classification number: A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04
Abstract: Compounds of Formulae (I') and (I) are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述了式（I'）和（I）的化合物，其可用作sGC的刺激剂，特别是NO-非依赖性血红素依赖性刺激物。 这些化合物也可用于治疗，预防或治疗本文公开的各种疾病。
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公开(公告)号：WO2014144100A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/028370
申请日：2014-03-14
Applicant: NAKAI, Takashi , MOORE, Joel , PERL, Nicholas Robert , IYENGAR, Rajesh R. , MERMERIAN, Ara , IM, G-Yoon Jamie , LEE, Thomas Wai-Ho , HUDSON, Colleen , RENNIE, Glen Robert , JIA, James , RENHOWE, Paul Allen , BARDEN, Timothy Claude , YU, Xiang Y , SHEPPECK, James Edward , IYER, Karthik , JUNG, Joon
Inventor： NAKAI, Takashi , MOORE, Joel , PERL, Nicholas Robert , IYENGAR, Rajesh R. , MERMERIAN, Ara , IM, G-Yoon Jamie , LEE, Thomas Wai-Ho , HUDSON, Colleen , RENNIE, Glen Robert , JIA, James , RENHOWE, Paul Allen , BARDEN, Timothy Claude , YU, Xiang Y , SHEPPECK, James Edward , IYER, Karthik , JUNG, Joon
IPC: C07D413/14
CPC classification number: A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04
Abstract: Compounds of Formulae (I') and (I) are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述了式（I'）和（I）的化合物，其可用作sGC的刺激物，特别是不依赖NO的血红素依赖性刺激物。 这些化合物也可用于治疗，预防或管理本文公开的各种病症。
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公开(公告)号：WO2012003405A4
公开(公告)日：2012-02-23
申请号：PCT/US2011042716
申请日：2011-06-30
Applicant: IRONWOOD PHARMACEUTICALS INC , KIM CHARLES , NAKAI TAKASHI , WAI-HO LEE THOMAS , MOORE JOEL , PERL NICHOLAS ROBERT , ROHDE JASON , IYENGAR RAJESH R , MERMERIAN ARA
Inventor： KIM CHARLES , NAKAI TAKASHI , WAI-HO LEE THOMAS , MOORE JOEL , PERL NICHOLAS ROBERT , ROHDE JASON , IYENGAR RAJESH R , MERMERIAN ARA
IPC: C07D401/04 , A61K31/4155 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
CPC classification number: C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , A61K2300/00
Abstract: Compounds of Formula (I) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述了式（I）的化合物。 它们可用作sGC的刺激物，特别是不依赖于NO的血红素依赖性刺激物。 这些化合物可用于治疗，预防或控制本文公开的各种病症。
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公开(公告)号：WO2012003405A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042716
申请日：2011-06-30
Applicant: IRONWOOD PHARMACEUTICALS, INC. , KIM, Charles , NAKAI, Takashi , WAI-HO LEE, Thomas , MOORE, Joel , PERL, Nicholas, Robert , ROHDE, Jason , IYENGAR, Rajesh, R. , MERMERIAN, Ara
Inventor： KIM, Charles , NAKAI, Takashi , WAI-HO LEE, Thomas , MOORE, Joel , PERL, Nicholas, Robert , ROHDE, Jason , IYENGAR, Rajesh, R. , MERMERIAN, Ara
IPC: C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/4155
CPC classification number: C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , A61K2300/00
Abstract: Compounds of Formula (I) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述式（I）的化合物。 它们作为sGC的刺激剂是有用的，特别是NO不依赖于血红素依赖性刺激物。 这些化合物可用于治疗，预防或治疗本文公开的各种疾病。
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