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公开(公告)号：AU2015317823A1
公开(公告)日：2017-03-23
申请号：AU2015317823
申请日：2015-09-16
Applicant: BARDEN TIMOTHY CLAUDE , MERMERIAN ARA , IYENGAR RAJESH R , PERL NICHOLAS , JUNG JOON , IM G-YOON JAMIE , RENNIE GLEN ROBERT , JIA JAMES , IRONWOOD PHARMACEUTICALS INC
Inventor： RENNIE GLEN ROBERT , PERL NICHOLAS , MERMERIAN ARA , JUNG JOON , JIA JAMES , IYENGAR RAJESH R , IM G-YOON JAMIE , BARDEN TIMOTHY CLAUDE , SHEPPECK JAMES EDWARD , RENHOWE PAUL ALLAN , NAKAI TAKASHI , LEE THOMAS WAI-HO , IYER KARTHIK
IPC: C07D401/14 , A61K31/4155 , A61P9/08 , A61P37/06 , C07D401/04 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: The present patent application discloses at least the compounds according to Formula I' shown below, or pharmaceutically acceptable salts thereof, Formula (I) wherein ring D, ring A, ring E, J
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公开(公告)号：WO2007137107A3
公开(公告)日：2008-01-10
申请号：PCT/US2007069112
申请日：2007-05-17
Applicant: ABBOTT LAB , IYENGAR RAJESH R , ZHAO GANG , FREEMAN JENNIFER C , GAO JU , JUDD ANDREW S , KYM PHILIP R , LYNCH JOHN K , MULHERN MATHEW M , SOUERS ANDREW J
Inventor： IYENGAR RAJESH R , ZHAO GANG , FREEMAN JENNIFER C , GAO JU , JUDD ANDREW S , KYM PHILIP R , LYNCH JOHN K , MULHERN MATHEW M , SOUERS ANDREW J
IPC: C07C211/22 , A61K31/155 , A61K31/17 , A61K31/381 , A61K31/4164 , A61K31/435 , A61P3/04 , C07C275/30 , C07C279/18 , C07C335/16 , C07D213/55 , C07D213/75 , C07D277/28 , C07D333/36
CPC classification number: C07C335/22 , C07C229/46 , C07C275/30 , C07C275/32 , C07C275/38 , C07C279/28 , C07C2601/08 , C07C2601/14 , C07D213/55 , C07D213/75 , C07D277/30 , C07D333/22 , C07D333/36 , C07D401/04 , C07D401/12 , C07D409/12 , C07D409/14
Abstract: The present invention relates to compounds of formula (I) wherein R 1 , R 3 , X, Q, Z, A, D, m, and n are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.
Abstract translation: 本发明涉及式（I）化合物，其中R 1，R 3，X，Q，Z，A，D，m和n如本文所定义。 还公开了治疗DGAT-1相关疾病或病症的药物组合物和方法。
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公开(公告)号：WO2016044446A2
公开(公告)日：2016-03-24
申请号：PCT/US2015/050467
申请日：2015-09-16
Applicant: IRONWOOD PHARMACEUTICALS, INC. , RENNIE, Glen Robert , PERL, Nicholas , MERMERIAN, Ara , JUNG, Joon , JIA, James , IYENGAR, Rajesh R. , IM, G-Yoon Jamie , BARDEN, Timothy Claude
Inventor： RENNIE, Glen Robert , PERL, Nicholas , MERMERIAN, Ara , JUNG, Joon , JIA, James , IYENGAR, Rajesh R. , IM, G-Yoon Jamie , BARDEN, Timothy Claude , SHEPPECK, James Edward , RENHOWE, Paul Allan , NAKAI, Takashi , LEE, Thomas Wai-Ho , IYER, Karthik
IPC: C07D401/14
CPC classification number: C07D487/04 , A61P9/10 , A61P15/00 , A61P29/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D498/04
Abstract: The present patent application discloses at least the compounds according to Formula I' shown below, or pharmaceutically acceptable salts thereof, Formula (I) wherein ring D, ring A, ring E, J B , n, J D , J, X, Z, Z 1 , R C1 , R C2 , Y, R 9 , o and W are as defined herein.
Abstract translation: 本专利申请公开了至少下述式I'的化合物或其药学上可接受的盐，其中环D，环A，环E，JB，n，JD，J，X，Z，Z1 ，RC1，RC2，Y，R9，o和W如本文所定义。
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公开(公告)号：WO2012003405A4
公开(公告)日：2012-02-23
申请号：PCT/US2011042716
申请日：2011-06-30
Applicant: IRONWOOD PHARMACEUTICALS INC , KIM CHARLES , NAKAI TAKASHI , WAI-HO LEE THOMAS , MOORE JOEL , PERL NICHOLAS ROBERT , ROHDE JASON , IYENGAR RAJESH R , MERMERIAN ARA
Inventor： KIM CHARLES , NAKAI TAKASHI , WAI-HO LEE THOMAS , MOORE JOEL , PERL NICHOLAS ROBERT , ROHDE JASON , IYENGAR RAJESH R , MERMERIAN ARA
IPC: C07D401/04 , A61K31/4155 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
CPC classification number: C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , A61K2300/00
Abstract: Compounds of Formula (I) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述了式（I）的化合物。 它们可用作sGC的刺激物，特别是不依赖于NO的血红素依赖性刺激物。 这些化合物可用于治疗，预防或控制本文公开的各种病症。
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公开(公告)号：WO2012003405A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042716
申请日：2011-06-30
Applicant: IRONWOOD PHARMACEUTICALS, INC. , KIM, Charles , NAKAI, Takashi , WAI-HO LEE, Thomas , MOORE, Joel , PERL, Nicholas, Robert , ROHDE, Jason , IYENGAR, Rajesh, R. , MERMERIAN, Ara
Inventor： KIM, Charles , NAKAI, Takashi , WAI-HO LEE, Thomas , MOORE, Joel , PERL, Nicholas, Robert , ROHDE, Jason , IYENGAR, Rajesh, R. , MERMERIAN, Ara
IPC: C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/4155
CPC classification number: C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , A61K2300/00
Abstract: Compounds of Formula (I) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述式（I）的化合物。 它们作为sGC的刺激剂是有用的，特别是NO不依赖于血红素依赖性刺激物。 这些化合物可用于治疗，预防或治疗本文公开的各种疾病。
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Patent Agency Ranking
公开(公告)号：WO2008067257A3
公开(公告)日：2008-06-05
申请号：PCT/US2007/085543
申请日：2007-11-26
Applicant: ABBOTT LABORATORIES , SOUERS, Andrew J. , GAO, Ju , HANSEN, Todd Matthew , IYENGAR, Rajesh R. , KYM, Philip R. , LIU, Bo X , PEI, Zhonghua , YEH, Vince , ZHAO, Gang
Inventor： SOUERS, Andrew J. , GAO, Ju , HANSEN, Todd Matthew , IYENGAR, Rajesh R. , KYM, Philip R. , LIU, Bo X , PEI, Zhonghua , YEH, Vince , ZHAO, Gang
IPC: A61K31/17 , C07C229/40 , A61P1/16 , A61P3/00
Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseases or conditions.
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公开(公告)号：WO2007137107A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/069112
申请日：2007-05-17
Applicant: ABBOTT LABORATORIES , IYENGAR, Rajesh, R. , ZHAO, Gang , FREEMAN, Jennifer, C. , GAO, Ju , JUDD, Andrew, S. , KYM, Philip, R. , LYNCH, John, K. , MULHERN, Mathew, M. , SOUERS, Andrew, J.
Inventor： IYENGAR, Rajesh, R. , ZHAO, Gang , FREEMAN, Jennifer, C. , GAO, Ju , JUDD, Andrew, S. , KYM, Philip, R. , LYNCH, John, K. , MULHERN, Mathew, M. , SOUERS, Andrew, J.
IPC: C07C211/22 , C07C275/30 , C07C279/18 , C07C335/16 , C07D213/55 , C07D213/75
CPC classification number: C07C335/22 , C07C229/46 , C07C275/30 , C07C275/32 , C07C275/38 , C07C279/28 , C07C2601/08 , C07C2601/14 , C07D213/55 , C07D213/75 , C07D277/30 , C07D333/22 , C07D333/36 , C07D401/04 , C07D401/12 , C07D409/12 , C07D409/14
Abstract: The present invention relates to compounds of formula (I) wherein R 1 , R 3 , X, Q, Z, A, D, m, and n are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.
Abstract translation: 本发明涉及式（I）化合物，其中R 1，R 3，X，Q，Z，A，D，m和n如本文所定义。 还公开了治疗DGAT-1相关疾病或病症的药物组合物和方法。
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公开(公告)号：WO2014144100A3
公开(公告)日：2014-11-06
申请号：PCT/US2014028370
申请日：2014-03-14
Applicant: NAKAI TAKASHI , MOORE JOEL , PERL NICHOLAS ROBERT , IYENGAR RAJESH R , MERMERIAN ARA , IM G-YOON JAMIE , LEE THOMAS WAI-HO , HUDSON COLLEEN , RENNIE GLEN ROBERT , JIA JAMES , RENHOWE PAUL ALLEN , BARDEN TIMOTHY CLAUDE , YU XIANG Y , SHEPPECK JAMES EDWARD , IYER KARTHIK , JUNG JOON
Inventor： NAKAI TAKASHI , MOORE JOEL , PERL NICHOLAS ROBERT , IYENGAR RAJESH R , MERMERIAN ARA , IM G-YOON JAMIE , LEE THOMAS WAI-HO , HUDSON COLLEEN , RENNIE GLEN ROBERT , JIA JAMES , RENHOWE PAUL ALLEN , BARDEN TIMOTHY CLAUDE , YU XIANG Y , SHEPPECK JAMES EDWARD , IYER KARTHIK , JUNG JOON
IPC: C07D413/14 , A61K31/506 , A61P3/00 , A61P9/00 , A61P15/00 , A61P25/00 , C07D403/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
CPC classification number: A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04
Abstract: Compounds of Formulae (I') and (I) are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述了式（I'）和（I）的化合物，其可用作sGC的刺激剂，特别是NO-非依赖性血红素依赖性刺激物。 这些化合物也可用于治疗，预防或治疗本文公开的各种疾病。
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公开(公告)号：WO2014144100A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/028370
申请日：2014-03-14
Applicant: NAKAI, Takashi , MOORE, Joel , PERL, Nicholas Robert , IYENGAR, Rajesh R. , MERMERIAN, Ara , IM, G-Yoon Jamie , LEE, Thomas Wai-Ho , HUDSON, Colleen , RENNIE, Glen Robert , JIA, James , RENHOWE, Paul Allen , BARDEN, Timothy Claude , YU, Xiang Y , SHEPPECK, James Edward , IYER, Karthik , JUNG, Joon
Inventor： NAKAI, Takashi , MOORE, Joel , PERL, Nicholas Robert , IYENGAR, Rajesh R. , MERMERIAN, Ara , IM, G-Yoon Jamie , LEE, Thomas Wai-Ho , HUDSON, Colleen , RENNIE, Glen Robert , JIA, James , RENHOWE, Paul Allen , BARDEN, Timothy Claude , YU, Xiang Y , SHEPPECK, James Edward , IYER, Karthik , JUNG, Joon
IPC: C07D413/14
CPC classification number: A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/107 , C07D495/04 , C07D498/04
Abstract: Compounds of Formulae (I') and (I) are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
Abstract translation: 描述了式（I'）和（I）的化合物，其可用作sGC的刺激物，特别是不依赖NO的血红素依赖性刺激物。 这些化合物也可用于治疗，预防或管理本文公开的各种病症。
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公开(公告)号：WO2008134693A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/061951
申请日：2008-04-30
Applicant: ABBOTT LABORATORIES , JUDD, Andrew S , MULHERN, Mathew M , IYENGAR, Rajesh R , KYM, Philip R , SOUERS, Andrew J
Inventor： JUDD, Andrew S , MULHERN, Mathew M , IYENGAR, Rajesh R , KYM, Philip R , SOUERS, Andrew J
IPC: C07D277/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D493/08 , A61K31/427 , A61K31/44 , A61P3/04 , A61P3/10
CPC classification number: C07D417/04 , C07D213/40 , C07D213/75 , C07D277/28 , C07D277/82 , C07D405/04 , C07D417/12 , C07D417/14 , C07D498/08
Abstract: The present invention relates to compounds of formula (I): wherein Q, G 1 , G 2 , and G 3 , are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.
Abstract translation: 本发明涉及式（I）的化合物：其中Q，G 1，G 2和G 3在本文中定义。 还公开了治疗DGAT-1相关疾病或病症的药物组合物和方法。
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