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1.发明申请
公开(公告)号：WO2022020356A1
公开(公告)日：2022-01-27
申请号：PCT/US2021/042378
申请日：2021-07-20
Applicant: PHOTOTHERMAL SPECTROSCOPY CORP.
Inventor： PRATER, Craig
Abstract: Embodiments disclosed include methods and apparatus for Fluorescent Enhanced Photothermal Infrared (FE-PTIR) spectroscopy and chemical imaging, which enables high sensitivity and high spatial resolution measurements of IR absorption with simultaneous confocal fluorescence imaging. In various embodiments, the FE-PTIR technique utilizes combined/simultaneous OPTIR and fluorescence imaging that provides significant improvements and benefits compared to previous work by simultaneous detection of both IR absorption and confocal fluorescence using the same optical detector at the same time.
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2.发明申请
公开(公告)号：WO2021155363A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/016070
申请日：2021-02-01
Applicant: PHOTOTHERMAL SPECTROSCOPY CORP.
Inventor： PRATER, Craig , DECKER, Derek , GRIGG, David
Abstract: A system for infrared analysis over a wide field area of a sample is disclosed herein that relies on interference of non-diffractively separated beams of light containing image data corresponding to the sample, as well as a photothermal effect on the sample.
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公开(公告)号：WO2021263083A1
公开(公告)日：2021-12-30
申请号：PCT/US2021/039053
申请日：2021-06-25
Applicant: PHOTOTHERMAL SPECTROSCOPY CORP.
Inventor： PRATER, Craig
IPC: G01N21/35 , G01J3/28 , G01J3/427 , G01N21/02 , G01N21/17 , G01N21/3563 , A61K2039/505 , A61K45/06 , A61P25/00 , C07K16/18
Abstract: Improvements in spectroscopy are disclosed herein that rely on the interaction of both an infrared beam and a probe beam with a sample. These beams are used in a pump-probe arrangement, with a fiber optic probe collecting the beams of infrared and probe radiation from the infrared source and delivering it to the sample. At least a portion of the beam of infrared radiation and the beam of probe radiation overlap one another on the sample. The fiber also collects probe radiation that has interacted with the sample. A detector can use this collected signal to indicate an intensity of the collected probe radiation, and an analyzer can generate a signal indicative of infrared absorption of the sample adjacent the fiber.
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公开(公告)号：WO2019232399A1
公开(公告)日：2019-12-05
申请号：PCT/US2019/034944
申请日：2019-05-31
Applicant: PHOTOTHERMAL SPECTROSCOPY CORP.
Inventor： PRATER, Craig , DECKER, Derek , SHETTY, Roshan
Abstract: Apparatuses and methods for microscopic analysis of a sample by simultaneously characterizing infrared absorption characteristics of a plurality of spatially resolved locations are described herein. These apparatuses and methods improve sampling times while collecting microscopic data regarding composition of a sample across a wide field.
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5.发明申请
公开(公告)号：WO2018165591A1
公开(公告)日：2018-09-13
申请号：PCT/US2018/021814
申请日：2018-03-09
Applicant: PHOTOTHERMAL SPECTROSCOPY CORP.
Inventor： YANG, Honghua , PRATER, Craig
Abstract: Systems and methods may be provided for measuring an infrared absorption of a sub micrometer region of a sample. An Infrared light source may illuminate a sample in a region that is interacting with the tip of a Scanning Probe Microscope (SPM), stimulating the sample in a way that produces measurable optical properties related to Infrared absorption of the sample region. A probe light source is directed at the region of the sample and SPM tip, and probe light emanating from the tip and sample region is collected. The collected light may be used to derive infrared absorption spectrum information of the sample region, possibly on a sub-micron scale.
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Patent Agency Ranking
公开(公告)号：US20250003865A1
公开(公告)日：2025-01-02
申请号：US18886739
申请日：2024-09-16
Applicant: Photothermal Spectroscopy Corp.
Inventor： Craig Prater , Kevin Kjoller , Roshan Shetty
Abstract: System for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including dual beam photo-thermal spectroscopy with confocal microscopy, Raman spectroscopy, fluorescence detection, various vacuum analytical techniques and/or mass spectrometry. In embodiments described herein, the light beams of a dual-beam system are used for heating and sensing.
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公开(公告)号：US20230236112A1
公开(公告)日：2023-07-27
申请号：US18162385
申请日：2023-01-31
Applicant: Photothermal Spectroscopy Corp
Inventor： Craig Prater , Kevin Kjoller , Roshan Shetty
CPC classification number: G01N21/171 , G01J3/2823 , G01J3/427 , G01J3/4406 , G01J3/4412 , G01N21/6458 , G01N21/65 , G01N2021/1714
Abstract: System for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including dual beam photo-thermal spectroscopy with confocal microscopy, Raman spectroscopy, fluorescence detection, various vacuum analytical techniques and/or mass spectrometry. In embodiments described herein, the light beams of a dual-beam system are used for heating and sensing.
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8.发明申请公开(公告)号：US20230063843A1
公开(公告)日：2023-03-02
申请号：US17796822
申请日：2021-02-01
Applicant: Photothermal Spectroscopy Corp.
Inventor： Craig Prater , Derek Decker , David Grigg
Abstract: A system for infrared analysis over a wide field area of a sample is disclosed herein that relies on interference of non-diffractively separated beams of light containing image data corresponding to the sample, as well as a photothermal effect on the sample.
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公开(公告)号：US10969405B2
公开(公告)日：2021-04-06
申请号：US15826147
申请日：2017-11-29
Applicant: Photothermal Spectroscopy Corp.
Inventor： Roshan Shetty , Kevin Kjoller , Craig Prater
IPC: G01N21/17 , G01N21/31 , G01N21/65 , G01Q30/02 , G01N21/3563
Abstract: Methods and apparatus for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including atomic force microscopy, infrared spectroscopy, confocal microscopy, Raman spectroscopy and mass spectrometry. For infrared spectroscopy, a sample is illuminated with infrared light and the resulting sample distortion is read out with either a focused UV/visible light beam and/or AFM tip. Using the AFM tip or the UV/visible light beam it is possible to measure the IR absorption characteristics of a sample with spatial resolution ranging from around 1 μm or less to the nanometer scale. The combination of both techniques provides a rapid and large area survey scan with the UV/visible light and a high resolution measurement with the AFM tip. The methods and apparatus also include the ability to analyze light reflected/scattered from the sample via a Raman spectrometer for complementary analysis by Raman spectroscopy. Using a UV/vis source or IR source at higher intensity it is possible to thermally desorb material from a sample for analysis by mass spectrometry. The AFM tip can also be heated to desorb material for mass spec analysis at even higher spatial resolution.
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公开(公告)号：US20190120753A1
公开(公告)日：2019-04-25
申请号：US16155089
申请日：2018-10-09
Applicant: Photothermal Spectroscopy Corp.
Inventor： Craig Prater , Kevin Kjoller , Roshan Shetty
IPC: G01N21/35 , G01N21/65 , G01N21/59 , G01N21/552 , G01N23/20091 , G01N23/207 , H01J49/26 , H01J37/26
Abstract: System for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including dual beam photo-thermal spectroscopy with confocal microscopy, Raman spectroscopy, fluorescence detection, various vacuum analytical techniques and/or mass spectrometry. In embodiments described herein, the light beams of a dual-beam system are used for heating and sensing.
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