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公开(公告)号：AU2003208505A1
公开(公告)日：2003-09-29
申请号：AU2003208505
申请日：2003-03-06
Applicant: MODI RAJIV INDRAVADAN , DAVE BRIJESH , RAMANI CHANDIR CHIMANDAS , NAIK PRAFUL , KHAMAR BAKULESH MAFATLAL
Inventor： KHAMAR BAKULESH MAFATLAL
Abstract: The invention relates to the method of treating tuberculosis comprises use of a microorganism Mycobacterium w for the treatment of tuberculosis.
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公开(公告)号：AU2003208505A8
公开(公告)日：2003-09-29
申请号：AU2003208505
申请日：2003-03-06
Applicant: RAMANI CHANDIR CHIMANDAS , NAIK PRAFUL , DAVE BRIJESH , MODI RAJIV INDRAVADAN , KHAMAR BAKULESH MAFATLAL
Inventor： KHAMAR BAKULESH MAFATLAL
IPC: A61K35/74 , A61P31/06 , A61K31/4439 , A61K9/24
Abstract: The invention relates to the method of treating tuberculosis comprises use of a microorganism Mycobacterium w for the treatment of tuberculosis.
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Patent Agency Ranking3.发明申请SOLID COMPOSITION FOR CONTROLLED RELEASE OF IONIZABLE ACTIVE AGENTS WITH POOR AQUEOUS SOLUBILITY AT LOW PH AND METHODS OF USE THEREOF 审中-公开用于控制释放具有低PH值的低水溶性溶剂的可离子化活性剂的固体组合物及其使用方法
公开(公告)号：WO2010057036A3
公开(公告)日：2011-06-09
申请号：PCT/US2009064455
申请日：2009-11-13
Applicant: PORTOLA PHARM INC , PATHEON INC , RAMANI CHANDIR , WANG JUAN , KANE ANIL , CHOW KWOK , LAMBING JOE
Inventor： RAMANI CHANDIR , WANG JUAN , KANE ANIL , CHOW KWOK , LAMBING JOE
IPC: A61K9/20 , A61K31/19 , A61K31/192 , A61K31/405 , A61K31/517 , A61P7/02 , A61P9/00
CPC classification number: A61K47/38 , A61K9/0002 , A61K9/0065 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K47/10
Abstract: A novel solid composition and methods for making and using the solid composition are provided. The solid composition comprises: (a) at least one active agent with a solubility of less than about 0.3 mg/ml in an aqueous solution with a pH of at most about 6.8 at a temperature of about 37oC; and (b) a hydrophilic polymer matrix composition comprising: i) a hydrophilic polymer selected from the group consisting of METHOCELTM, POLYOXTM WSR 1105 and combinations thereof; and optionally ii) a hydrophobic polymer selected from the group consisting of Ethocel 20 premium; and (c) an alkalizer selected from the group consisting of calcium carbonate, magnesium oxide heavy and sodium bicarbonate; wherein the composition provides at least about 70% release of the active between about 7 to about 12 hours following oral administration.
Abstract translation: 提供了一种新颖的固体组合物和制备和使用该固体组合物的方法。 固体组合物包含：（a）至少一种在约37℃的温度下，pH至多约6.8的水溶液中溶解度小于约0.3mg / ml的活性剂; 和（b）亲水性聚合物基质组合物，其包含：i）选自METHOCEL TM，POLYOXTM WSR 1105的亲水性聚合物及其组合; 和任选地ii）选自Ethocel 20溢价的疏水性聚合物; 和（c）选自碳酸钙，氧化镁重质和碳酸氢钠的碱化剂; 其中所述组合物在口服给药后提供约7至约12小时之间的至少约70％的活性释放。
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4.发明申请PHARMACEUTICAL COMPOSITION AND DOSAGE FORMS OF ELINOGREL AND METHODS OF USE THEREOF 审中-公开药物组合物及其用量及其使用方法
公开(公告)号：WO2011088152A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/021029
申请日：2011-01-12
Applicant: PORTOLA PHARMACEUTICALS, INC. , NOVARTIS PHARMA AG , WANG, Juan , RAMANI, Chandir , LAMBING, Joe , YE, Christine , VADAS, Elizabeth , TAILLEMITE, Julian , FILLIOT, Marie-Pierre , BECKER, Dieter
Inventor： WANG, Juan , RAMANI, Chandir , LAMBING, Joe , YE, Christine , VADAS, Elizabeth , TAILLEMITE, Julian , FILLIOT, Marie-Pierre , BECKER, Dieter
IPC: A61K9/20 , A61K9/48 , A61K31/517
CPC classification number: A61K9/2054 , A61K9/1623 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2095 , A61K31/64
Abstract: The present invention is concerned with a solid delivery form of elinogrel for the treatment of thrombosis which is notable for its multi-pH dissolution, immediate release and improved pharmacokinetic properties and stability in storage. The delivery and dosage form is a solid, oral formulation comprising: a) at least about 15 % by weight elinogrel or a pharmaceutically acceptable salt thereof relative to the total weight of the overall pharmaceutical composition, and b) at least one pharmaceutically acceptable carrier. A further aspect of the present invention concerns the preparation and use of such a formulation.
Abstract translation: 本发明涉及用于治疗血栓形成的固体递送形式，其对于其多pH溶解，即时释放和改善的药代动力学性质和储存稳定性是显着的。 递送和剂型是固体口服制剂，其包含：a）相对于总体药物组合物的总重量，至少约15重量％的依依格雷或其药学上可接受的盐，和b）至少一种药学上可接受的载体。 本发明的另一方面涉及这种制剂的制备和用途。
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5.发明申请SOLID COMPOSITION FOR CONTROLLED RELEASE OF IONIZABLE ACTIVE AGENTS WITH POOR AQUEOUS SOLUBILITY AT LOW PH AND METHODS OF USE THEREOF 审中-公开用于控制释放具有低PH值的低水溶性溶剂的可离子化活性剂的固体组合物及其使用方法
公开(公告)号：WO2010057036A2
公开(公告)日：2010-05-20
申请号：PCT/US2009/064455
申请日：2009-11-13
Applicant: PORTOLA PHARMACEUTICALS, INC. , PATHEON INC. , RAMANI, Chandir , WANG, Juan , KANE, Anil , CHOW, Kwok , LAMBING, Joe
Inventor： RAMANI, Chandir , WANG, Juan , KANE, Anil , CHOW, Kwok , LAMBING, Joe
IPC: A61K9/20 , A61K31/192 , A61K31/405 , A61K31/19 , A61K31/517 , A61P9/00 , A61P7/02
CPC classification number: A61K47/38 , A61K9/0002 , A61K9/0065 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K47/10
Abstract: A novel solid composition and methods for making and using the solid composition are provided. The solid composition comprises: (a) at least one active agent with a solubility of less than about 0.3 mg/ml in an aqueous solution with a pH of at most about 6.8 at a temperature of about 37 o C; and (b) a hydrophilic polymer matrix composition comprising: i) a hydrophilic polymer selected from the group consisting of METHOCELTM, POLYOX TM WSR 1105 and combinations thereof; and optionally ii) a hydrophobic polymer selected from the group consisting of Ethocel 20 premium; and (c) an alkalizer selected from the group consisting of calcium carbonate, magnesium oxide heavy and sodium bicarbonate; wherein the composition provides at least about 70% release of the active between about 7 to about 12 hours following oral administration.
Abstract translation: 提供了一种新颖的固体组合物和制备和使用该固体组合物的方法。 固体组合物包含：（a）至少一种在约37℃的温度下，pH至多约6.8的水溶液中溶解度小于约0.3mg / ml的活性剂; 和（b）亲水性聚合物基质组合物，其包含：i）选自METHOCEL TM，POLYOXTM WSR 1105的亲水性聚合物及其组合; 和任选地ii）选自Ethocel 20溢价的疏水性聚合物; 和（c）选自碳酸钙，氧化镁重质和碳酸氢钠的碱化剂; 其中所述组合物在口服给药后提供约7至约12小时之间的至少约70％的活性释放。
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公开(公告)号：WO2008005742A3
公开(公告)日：2008-07-10
申请号：PCT/US2007072075
申请日：2007-06-26
Applicant: MCNEIL PPC INC , DOWNEY DAWN DENISE , FULPER LESTER DAVID , JIN XIAO PIN , KANE ANIL , LAW TAK KAU URI , RAMANI CHANDIR , WYNN DAVID W
Inventor： DOWNEY DAWN DENISE , FULPER LESTER DAVID , JIN XIAO PIN , KANE ANIL , LAW TAK KAU URI , RAMANI CHANDIR , WYNN DAVID W
CPC classification number: A61K9/4858 , A61K9/1075 , A61K9/485 , A61K31/19
Abstract: The present invention relates to ibuprofen-containing pharmaceutically acceptable solutions for filling hard capsules.
Abstract translation: 本发明涉及用于填充硬胶囊的含有布洛芬的药学上可接受的溶液。
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公开(公告)号：WO2008005742A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/072075
申请日：2007-06-26
Applicant: MCNEIL-PPC, INC. , DOWNEY, Dawn Denise , FULPER, Lester David , JIN, Xiao Pin , KANE, Anil , LAW, Tak Kau Uri , RAMANI, Chandir , WYNN, David W.
Inventor： DOWNEY, Dawn Denise , FULPER, Lester David , JIN, Xiao Pin , KANE, Anil , LAW, Tak Kau Uri , RAMANI, Chandir , WYNN, David W.
CPC classification number: A61K9/4858 , A61K9/1075 , A61K9/485 , A61K31/19
Abstract: The present invention relates to ibuprofen-containing pharmaceutically acceptable solutions for filling hard capsules.
Abstract translation: 本发明涉及用于填充硬胶囊的含有布洛芬的药学上可接受的溶液。
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