公开(公告)号：WO2018071454A1

公开(公告)日：2018-04-19

申请号：PCT/US2017/055993

申请日：2017-10-10

Applicant: ANDREWS, Steven W. ,  ARONOW, Sean ,  BLAKE, James F. ,  BRANDHUBER, Barbara J. ,  COLLIER, James ,  COOK, Adam ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  MCNULTY, Oren T. ,  METCALF, Andrew T. ,  MORENO, David A. ,  RAMANN, Ginelle A. ,  TANG, Tony P. ,  REN, Li ,  WALLS, Shane M.

Inventor： ANDREWS, Steven W. ,  ARONOW, Sean ,  BLAKE, James F. ,  BRANDHUBER, Barbara J. ,  COLLIER, James ,  COOK, Adam ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R. ,  MCFADDIN, Elizabeth A. ,  MCKENNEY, Megan L. ,  MCNULTY, Oren T. ,  METCALF, Andrew T. ,  MORENO, David A. ,  RAMANN, Ginelle A. ,  TANG, Tony P. ,  REN, Li ,  WALLS, Shane M.

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Provided herein are compounds of the Formula I: (I) or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X 1 , X 2 , X 3 , X 4 , Ring D, E, R a , R b , n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract translation: 本文提供了式I的化合物：（I）或其药学上可接受的盐或溶剂合物，其中A，B，X 1，X 2， X 3，X 4，D环，E，R a，R b，n和 m具有在说明书中给出的含义，它们是RET激酶的抑制剂，并且可用于治疗和预防可以用RET激酶抑制剂治疗的疾病，包括RET相关的疾病和病症。

公开(公告)号：MA46463A

公开(公告)日：2019-08-14

申请号：MA46463

申请日：2017-10-10

Applicant: ARRAY BIOPHARMA INC ,  MCFADDIN ELIZABETH A ,  MCKENNEY MEGAN L ,  MCNULTY OREN T ,  METCALF ANDREW T ,  MORENO DAVID A ,  RAMANN GINELLE A ,  REN LI ,  TANG TONY P ,  WALLS SHANE M

Inventor： ANDREWS STEVEN W ,  ARONOW SEAN ,  BLAKE JAMES F ,  BRANDENHUBER BARBARA J ,  COLLIER JAMES ,  COOK ADAM ,  HAAS JULIA ,  JIANG YUTONG ,  KOLAKOWSKI GABRIELLE R

IPC: A61K31/437 ,  A61P35/00 ,  C07D471/04

公开(公告)号：EP3523302A1

公开(公告)日：2019-08-14

申请号：EP17787844.4

申请日：2017-10-10

Applicant: Array Biopharma, Inc. ,  McFaddin, Elizabeth A. ,  McKenney, Megan L. ,  McNulty, Oren T. ,  Metcalf, Andrew T. ,  Moreno, David A. ,  Ramann, Ginelle A. ,  Tang, Tony P. ,  Ren, Li ,  Walls, Shane M.

Inventor： ANDREWS, Steven W. ,  ARONOW, Sean ,  BLAKE, James F. ,  BRANDENHUBER, Barbara J. ,  COLLIER, James ,  COOK, Adam ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI, Gabrielle R.

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00