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公开(公告)号：CA2935677C
公开(公告)日：2022-07-26
申请号：CA2935677
申请日：2014-12-12
Applicant: RXBIO INC
Inventor： SINGIDI RAMA KRISHNA REDDY , GUDUDURU VEERESH , MIRMEHRABI MAHMOUD , THOMPSON KARIN EMMONS , TIGYI GABOR JOZSEF , YATES CHARLES RYAN , STROBOS JURRIAAN
IPC: C07F9/173 , A61K31/661
Abstract: Here provided are a salt of Z)-O-octadec-9-en-1-yl O,O-dihydrogen phosphorothioate with an L-lysine addition in crystalline form and methods of making and using the same.
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公开(公告)号：AU2009310374A1
公开(公告)日：2010-05-06
申请号：AU2009310374
申请日：2009-03-03
Applicant: RXBIO INC
Inventor： GUDUDURU VEERESA
IPC: A01N57/10
Abstract: Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.
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3.发明授权Crystalline salts of (Z)-O-octadec-9-en-1-yl O,O-dihydrogen phosphorothioate 有权（Z）-O-十八碳-9-烯-1-基O，O-二硫代磷酸酯的结晶盐公开(公告)号：US09567288B2
公开(公告)日：2017-02-14
申请号：US14569383
申请日：2014-12-12
Applicant: RxBio Inc.
Inventor： Rama Krishna Reddy Singidi , Veeresh Gududuru , Mahmoud Mirmehrabi , Karin Emmons Thompson , Gabor Jozsef Tigyi , Charles Ryan Yates , Jurriaan Strobos
CPC classification number: C07C229/26 , C07B2200/13 , C07F9/203 , C07F9/205 , C07F9/206 , C07F9/2408
Abstract: Here provided are a salt of Z)—O-octadec-9-en-1-yl O,O-dihydrogen phosphorothioate with an L-lysine addition in crystalline form and methods of making and using the same.
Abstract translation: 这里提供的是Z）-O-十八碳-9-烯-1-基O，O-二硫代磷酸硫酸盐，其结晶形式为L-赖氨酸加成盐，以及制备和使用它们的方法。
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公开(公告)号：US20170226139A1
公开(公告)日：2017-08-10
申请号：US15429972
申请日：2017-02-10
Applicant: RxBio Inc.
Inventor： Rama Krishna Reddy Singidi , Veeresh Gududuru , Mahmoud Mirmehrabi , Karin Emmons Thompson , Gabor Jozsef Tigyi , Charles Ryan Yates , Jurriaan Strobos
IPC: C07F9/06 , C07C229/26
CPC classification number: C07F9/062 , C07B2200/13 , C07C229/26 , C07F9/203 , C07F9/205 , C07F9/206 , C07F9/2408
Abstract: Here provided are a salt of Z)—O-octadec-9-en-1-yl O,O-dihydrogen phosphorothioate with an L-lysine addition in crystalline form and methods of making and using the same.
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5.发明申请CRYSTALLINE SALTS OF (Z)-O-OCTADEC-9-EN-1-YL O,O-DIHYDROGEN PHOSPHOROTHIOATE 审中-公开（Z）-O-OCTADEC-9-EN-1-YL O，O-二氢磷酸盐的晶体沉淀
公开(公告)号：WO2015102856A1
公开(公告)日：2015-07-09
申请号：PCT/US2014/070133
申请日：2014-12-12
Applicant: RXBIO INC.
Inventor： SINGIDI, Rama Krishna Reddy , GUDUDURU, Veeresh , MIRMEHRABI, Mahmoud , THOMPSON, Karin Emmons , TIGYI, Gabor Jozsef , YATES, Charles Ryan , STROBOS, Jurriaan
CPC classification number: C07C229/26 , C07B2200/13 , C07F9/203 , C07F9/205 , C07F9/206 , C07F9/2408
Abstract: Here provided are a salt of Z)-O-octadec-9-en-1-yl O,O-dihydrogen phosphorothioate with an L-lysine addition in crystalline form and methods of making and using the same.
Abstract translation: 这里提供的是Z）-O-十八碳-9-烯-1-基O，O-二硫代磷酸硫酸盐，其结晶形式为L-赖氨酸加成盐，以及制备和使用它们的方法。
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Patent Agency Ranking
公开(公告)号：WO2015013422A1
公开(公告)日：2015-01-29
申请号：PCT/US2014/047845
申请日：2014-07-23
Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , RXBIO, INC.
Inventor： MILLER, Duane Douglas , YATES, Charles Ryan , ABREO, Melwyn
IPC: A61K31/16 , A61K31/34 , A61K31/195
CPC classification number: A61K31/365 , A61K31/343 , A61K31/661 , A61K31/665 , A61K2300/00
Abstract: Here provided are new immunosuppressive compounds and novel therapeutics for improving tissue transplantation.
Abstract translation: 这里提供了新的免疫抑制化合物和用于改善组织移植的新型治疗剂。
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公开(公告)号：WO2010051053A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/035931
申请日：2009-03-03
Applicant: RXBIO, INC. , GUDUDURU, Veeresa
Inventor： GUDUDURU, Veeresa
IPC: A01N57/10
CPC classification number: C07F9/1411 , C07F9/091 , C07F9/1651 , C07F9/1652 , C07F9/1653 , C07F9/173
Abstract: Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.
Abstract translation: 公开了根据式（I）的化合物以及包括这些化合物的药物组合物。 还公开了使用这些化合物的方法，其具有活性作为LPA受体的激动剂或拮抗剂; 这些方法包括治疗癌症，产生放射免疫和/或放射疗法，增强细胞增殖，治疗伤口，治疗细胞，组织或器官中的凋亡或维持或恢复功能，培养细胞，保存器官或组织功能，以及治疗皮肤 逻辑条件。
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公开(公告)号：CA2754551C
公开(公告)日：2016-09-13
申请号：CA2754551
申请日：2009-03-03
Applicant: RXBIO INC
Inventor： GUDUDURU VEERESH
IPC: A61K31/661
Abstract: Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.
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公开(公告)号：AU2009310374B2
公开(公告)日：2014-06-19
申请号：AU2009310374
申请日：2009-03-03
Applicant: RXBIO INC
Inventor： GUDUDURU VEERESA
Abstract: Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.
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公开(公告)号：CA2935677A1
公开(公告)日：2015-07-09
申请号：CA2935677
申请日：2014-12-12
Applicant: RXBIO INC
Inventor： SINGIDI RAMA KRISHNA REDDY , GUDUDURU VEERESH , MIRMEHRABI MAHMOUD , THOMPSON KARIN EMMONS , TIGYI GABOR JOZSEF , YATES CHARLES RYAN , STROBOS JURRIAAN
IPC: C07F9/173 , A61K31/661
Abstract: Here provided are a salt of Z)-O-octadec-9-en-1-yl O,O-dihydrogen phosphorothioate with an L-lysine addition in crystalline form and methods of making and using the same.
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