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1.
公开(公告)号:WO1980001986A1
公开(公告)日:1980-10-02
申请号:PCT/GB1980000055
申请日:1980-03-27
Applicant: SANDERSON A
IPC: A61K39/00
CPC classification number: A61K39/385 , A61K47/6849 , A61K2039/55516 , A61K2039/6031 , A61K2039/605 , A61K2039/622 , C07K16/2833 , Y10S424/809 , Y10S530/806 , Y10S530/807 , Y10S530/866
Abstract: Antigenic materials are combined with MHC (Major Histocompatibility Complex) antigens through the use of the MHC antigen in the form of a complex with a protein, with which it occurs naturally, for example a HLA-B uM (Human Lymphocyte Antigen -B u Microglobulin) or analogous non-human complex, the antigenic material being attached to the protein of the complex through antibody to that protein. The immunogenicity of the antigenic material used in the combination is increased and the combination is useful in human or veterinary immunological preparations. Also disclosed are a combination of an antigenic material with antibody against a protein with which an MHC antigen is normally present in nature and a method for the purification of such a combination.
Abstract translation: 将抗原物质与MHC(主要组织相容性复合物)抗原结合使用与蛋白质复合物形式的MHC抗原(天然存在的蛋白质),例如HLA-BuM(人类淋巴细胞抗原 - B u微球蛋白)或类似的非人类复合物,抗原物质通过该蛋白的抗体与复合物的蛋白质连接。 组合中使用的抗原性材料的免疫原性增加,并且该组合可用于人或兽用免疫制剂。 还公开了抗原物质与抗体相对于天然存在MHC抗原的蛋白质的抗体以及纯化这种组合的方法的组合。
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2.
公开(公告)号:WO1979000160A1
公开(公告)日:1979-04-05
申请号:PCT/GB1978000016
申请日:1978-09-27
Applicant: NAT RESEARCH DEV CORP , SANDERSON A
Inventor: NAT RESEARCH DEV CORP
IPC: A61K39/00
CPC classification number: A61K39/385 , A61K2039/55516 , A61K2039/605 , Y10S530/806 , Y10S530/807 , Y10S530/825 , Y10S530/826 , Y10S530/83 , Y10S530/838
Abstract: An immunologically active preparation for human or veterinary use, comprising an antigenic material in combination with an MHC (major histocompatibility complex) antigen, e.g. a HLA (human lymphocyte antigen) antigen in order to increase the immunogenicity of the former.
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公开(公告)号:GB2004744B
公开(公告)日:1982-05-26
申请号:GB7838177
申请日:1978-09-26
Applicant: SANDERSON A R
IPC: A61K39/385 , A61K39/00
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公开(公告)号:GB2045256A
公开(公告)日:1980-10-29
申请号:GB8010301
申请日:1980-03-27
Applicant: SANDERSON A R
IPC: A61K39/385 , C07G7/00
Abstract: Antigenic materials are combined with MHC antigens through the use of the MHC antigen in the form of a complex with a protein, with which it occurs naturally, for example an HLA-B2M or analogous non-human complex, the antigenic material being attached to the protein of the complex through antibody to that protein.
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公开(公告)号:GB2004744A
公开(公告)日:1979-04-11
申请号:GB7838177
申请日:1978-09-26
Applicant: SANDERSON A R
IPC: A61K39/385 , A61K39/00
Abstract: An immunologically active preparation for human or veterinary use comprises an antigenic material in combination with an MHC (Major Histocompatibility Complex) antigen, especially Human Lymphocyte Antigen (HLA). The MHC may be papain- solubilized, and the antigenic material may be a bacterial, viral, protozoal or fungal antigen, a toxoid or toxin, a peptide hormone or a hapten. The combination is brought about with a conventional coupling agent.
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公开(公告)号:GB2045256B
公开(公告)日:1983-02-09
申请号:GB8010301
申请日:1980-03-27
Applicant: SANDERSON A R
IPC: A61K39/385 , C07G7/00
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公开(公告)号:US3787172A
公开(公告)日:1974-01-29
申请号:US3787172D
申请日:1973-04-02
Applicant: SANDERSON A
Inventor: SANDERSON A
CPC classification number: F27D1/18
Abstract: A refractory furnace having a cover resting on supports outside the furnace and sealed by an air curtain, in which the peripheral duct in the cover frame supplying the air curtain is fed through the support means from a remote source of pressurized air.
Abstract translation: 一种耐火炉,其具有搁置在炉外的支撑件上并由气幕密封的盖,其中提供气帘的盖框架中的周边导管通过支撑装置从远程压缩空气源供给。
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