公开(公告)号：EP3157921A1

公开(公告)日：2017-04-26

申请号：EP15735808.6

申请日：2015-06-23

Applicant: Dr. Reddy's Laboratories Ltd. ,  Sasmal, Pradip Kumar ,  Ahmed, Shahadat ,  Tehim, Ashok ,  Paradkar, Vidyadhar

Inventor： SASMAL, Pradip, Kumar ,  AHMED, Shahadat ,  TEHIM, Ashok ,  PARADKAR, Vidyadhar

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/04

CPC classification number: A61K31/437 ,  A61K31/4025 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/635 ,  C07D471/04 ,  C07K5/06 ,  Y02A50/414

Abstract: The present application relates to a series of substituted imidazo[1,2-a]pyridine compounds of formula (I), pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

Abstract translation: 本申请涉及式（I）的一系列取代的咪唑并[1,2-a]吡啶化合物，其药学上可接受的盐，药学上可接受的溶剂合物或立体异构体，其用作原肌球蛋白受体激酶（Trk）家族蛋白激酶抑制剂， 制备方法和包含这些化合物的药物组合物。

公开(公告)号：IL233067D0

公开(公告)日：2014-07-31

申请号：IL23306714

申请日：2014-06-10

Applicant: REDDYS LAB LTD DR ,  SASMAL PRADIP KUMAR ,  AHMED SHAHADAT ,  TEHIM ASHOK ,  PRADKAR VIDYADHAR ,  DATTATREYA PRASANNA M ,  MAVINAHALLI NANJEGOWDA JAGADEESH

IPC: C07D20060101

公开(公告)号：WO2012012410A3

公开(公告)日：2012-05-18

申请号：PCT/US2011044513

申请日：2011-07-19

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  SASMAL PRADIP KUMAR ,  CHINTAKUNTA VAMSEE KRISHNA ,  POTLURI VIJAY ,  KHANNA ISH KUMAR ,  TEHIM ASHOK ,  JALEEL MAHABOOBI ,  HOGBERG THOMAS ,  RIST OYSTEIN ,  ELSTER LISBETH ,  FRIMURER THOMAS MICHAEL ,  GERLACH LARS-OLE

Inventor： SASMAL PRADIP KUMAR ,  CHINTAKUNTA VAMSEE KRISHNA ,  POTLURI VIJAY ,  KHANNA ISH KUMAR ,  TEHIM ASHOK ,  JALEEL MAHABOOBI ,  HOGBERG THOMAS ,  RIST OYSTEIN ,  ELSTER LISBETH ,  FRIMURER THOMAS MICHAEL ,  GERLACH LARS-OLE

IPC: C07D207/09 ,  A61K31/40 ,  A61K31/4709 ,  A61P25/04 ,  C07D207/06 ,  C07D207/16 ,  C07D401/12 ,  C07D413/12

CPC classification number: C07D419/12 ,  C07D207/09 ,  C07D207/12 ,  C07D209/34 ,  C07D213/76 ,  C07D215/12 ,  C07D215/227 ,  C07D231/56 ,  C07D249/18 ,  C07D261/20 ,  C07D263/56 ,  C07D263/58 ,  C07D275/06 ,  C07D277/30 ,  C07D279/02 ,  C07D295/13 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. (I) Wherein A, m, Rls R2, R3, R4 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (?) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

Abstract translation: 本发明涉及一系列具有通式（I）的取代的化合物，包括其立体异构体和/或其药学上可接受的盐。 （I）其中A，m，R 2，R 2，R 3，R 4如本文所定义。 本发明还涉及制备这些化合物包括中间体的方法。 本发明的化合物在κ（κ）阿片受体（KOR）位点是有效的。 因此，本发明的化合物可用作药物，特别是用于治疗和/或预防各种中枢神经系统疾病（CNS），包括但不限于急性和慢性疼痛以及相关疾病，特别是周边功能 在CNS。

公开(公告)号：WO2007002461A1

公开(公告)日：2007-01-04

申请号：PCT/US2006/024572

申请日：2006-06-23

Applicant: DR. REDDY'S LABORATORIES LTD. ,  DR. REDDY'S LABORATORIES, INC. ,  POTLURI, Vijay Kumar ,  DAS, Saibal Kumar ,  SASMAL, Pradip Kumar ,  IQBAL, Javed ,  MISRA, Parimal ,  CHAKRABARTI, Ranjan ,  TALWAR, Rashmi

Inventor： POTLURI, Vijay Kumar ,  DAS, Saibal Kumar ,  SASMAL, Pradip Kumar ,  IQBAL, Javed ,  MISRA, Parimal ,  CHAKRABARTI, Ranjan ,  TALWAR, Rashmi

IPC: A61K31/426 ,  A61K31/427 ,  C07D277/38 ,  C07D417/02

CPC classification number: C07D277/42 ,  C07D417/12

Abstract: The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5'-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds.

Abstract translation: 本申请提供了可用作腺苷5'-单磷酸激活蛋白激酶的激活剂的新型噻唑衍生物和含有这些化合物的药物组合物。

公开(公告)号：WO2013131408A1

公开(公告)日：2013-09-12

申请号：PCT/CN2013/000230

申请日：2013-03-05

Applicant: DR.REDDY'S LABORATORIES LTD. ,  SASMAL, Pradip Kumar ,  VAMSEEKRISHNA, Chintakunta ,  POTLURI, Vijay ,  TEHIM, Ashok ,  GAI, Yonghua ,  ZHANG, Hang

Inventor： SASMAL, Pradip Kumar ,  VAMSEEKRISHNA, Chintakunta ,  POTLURI, Vijay ,  TEHIM, Ashok ,  GAI, Yonghua ,  ZHANG, Hang

IPC: C07D207/12 ,  A61K31/40 ,  C07D207/04 ,  C07D217/12

CPC classification number: C07D417/14 ,  A61K31/404 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/538 ,  A61K31/5415 ,  C07D209/34 ,  C07D215/227 ,  C07D241/52 ,  C07D263/58 ,  C07D265/36 ,  C07D275/06 ,  C07D277/68 ,  C07D279/16 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 . R 4 , R 5 , and R 6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

Abstract translation: 本发明涉及一系列具有通式（I）的取代的化合物，其包括它们的重组异构体和/或其药学上可接受的盐，其中R1，R2，R3。 R4，R5和R6如本文所定义。 本发明还涉及制备这些化合物包括中间体的方法。 本发明的化合物在κ（κ）阿片样物质受体（KOR）位点是有效的。 因此，本发明的化合物可用作药物，特别是用于治疗和/或预防各种中枢神经系统疾病（CNS），包括但不限于急性和慢性疼痛以及相关疾病，特别是周边功能 在中枢神经系统。

公开(公告)号：WO2007005785A1

公开(公告)日：2007-01-11

申请号：PCT/US2006/025898

申请日：2006-06-30

Applicant: DR. REDDY'S LABORATORIES LTD. ,  DR. REDDY'S LABORATORIES, INC. ,  POTLURI, Vijay Kumar ,  DAS, Saibal Kumar ,  SASMAL, Pradip Kumar ,  IQBAL, Javed ,  MISRA, Parimal ,  CHAKRABARTI, Ranjan ,  TALWAR, Rashmi

Inventor： POTLURI, Vijay Kumar ,  DAS, Saibal Kumar ,  SASMAL, Pradip Kumar ,  IQBAL, Javed ,  MISRA, Parimal ,  CHAKRABARTI, Ranjan ,  TALWAR, Rashmi

IPC: C07D277/14 ,  C07D265/32 ,  A61K31/426 ,  A61K31/5377

CPC classification number: C07D277/42

Abstract: The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5'-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds.

Abstract translation: 本申请提供了可用作腺苷5'-一磷酸 - 活化蛋白激酶的活化剂的新型噻唑衍生物和含有这些化合物的药物组合物。

公开(公告)号：WO2009019600A2

公开(公告)日：2009-02-12

申请号：PCT/IB2008/002140

申请日：2008-08-08

Applicant: DR. REDDY'S LABORATORIES LTD. ,  MISRA, Parimal ,  CHAKRABARTI, Ranjan ,  MADHURAREKHA, Chinnaboina ,  HASHAM, Sumera Nikhat ,  POTLURI, Vijay Kumar ,  SASMAL, Pradip Kumar ,  DAS, Saibal Kumar ,  IQBAL, Javed

Inventor： MISRA, Parimal ,  CHAKRABARTI, Ranjan ,  MADHURAREKHA, Chinnaboina ,  HASHAM, Sumera Nikhat ,  POTLURI, Vijay Kumar ,  SASMAL, Pradip Kumar ,  DAS, Saibal Kumar ,  IQBAL, Javed

IPC: G01N33/53

CPC classification number: C12Q1/485 ,  G01N2800/044

Abstract: A method for identifying an AMPK activator is provided. The method includes providing a sample of cells that include AMPK and perilipin, providing a sample of an AMPK activator-candidate, contacting the cell sample and the activator-candidate, and measuring a quantitative indicator of the AMPK activation within the cell sample after the contacting step.

Abstract translation: 提供了一种鉴定AMPK激活因子的方法。 该方法包括提供包括AMPK和perilipin的细胞样品，提供AMPK活化剂候选物的样品，使细胞样品和活化剂候选物接触，并测量接触后细胞样品中AMPK活化的定量指示剂 步骤

公开(公告)号：WO2015200341A1

公开(公告)日：2015-12-30

申请号：PCT/US2015/037214

申请日：2015-06-23

Applicant: DR. REDDY'S LABORATORIES LTD. ,  SASMAL, Pradip, Kumar ,  AHMED, Shahadat ,  TEHIM, Ashok ,  PARADKAR, Vidyadhar

Inventor： SASMAL, Pradip, Kumar ,  AHMED, Shahadat ,  TEHIM, Ashok ,  PARADKAR, Vidyadhar

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/04

CPC classification number: A61K31/437 ,  A61K31/4025 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/635 ,  C07D471/04 ,  C07K5/06 ,  Y02A50/414

Abstract: The present application relates to a series of substituted imidazo[l,2-a]pyridine compounds of formula (I), pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

Abstract translation: 本申请涉及一系列取代的式（I）咪唑并[1,2-a]吡啶化合物，其药学上可接受的盐，药学上可接受的溶剂合物或立体异构体，其用作原肌球蛋白受体激酶（Trk）家族蛋白激酶抑制剂， 制备方法和包含这些化合物的药物组合物。

公开(公告)号：WO2012012410A2

公开(公告)日：2012-01-26

申请号：PCT/US2011/044513

申请日：2011-07-19

Applicant: DR. REDDY'S LABORATORIES LTD. ,  DR. REDDY'S LABORATORIES, INC. ,  SASMAL, Pradip Kumar ,  CHINTAKUNTA, Vamsee Krishna ,  POTLURI, Vijay ,  KHANNA, Ish Kumar ,  TEHIM, Ashok ,  JALEEL, Mahaboobi ,  HOGBERG, Thomas ,  RIST, Oystein ,  ELSTER, Lisbeth ,  FRIMURER, Thomas Michael ,  GERLACH, Lars-Ole

Inventor： SASMAL, Pradip Kumar ,  CHINTAKUNTA, Vamsee Krishna ,  POTLURI, Vijay ,  KHANNA, Ish Kumar ,  TEHIM, Ashok ,  JALEEL, Mahaboobi ,  HOGBERG, Thomas ,  RIST, Oystein ,  ELSTER, Lisbeth ,  FRIMURER, Thomas Michael ,  GERLACH, Lars-Ole

IPC: C07D207/09 ,  C07D207/16 ,  C07D207/06 ,  C07D401/12 ,  C07D413/12 ,  A61K31/40 ,  A61K31/4709 ,  A61P25/04

CPC classification number: C07D419/12 ,  C07D207/09 ,  C07D207/12 ,  C07D209/34 ,  C07D213/76 ,  C07D215/12 ,  C07D215/227 ,  C07D231/56 ,  C07D249/18 ,  C07D261/20 ,  C07D263/56 ,  C07D263/58 ,  C07D275/06 ,  C07D277/30 ,  C07D279/02 ,  C07D295/13 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. (I) Wherein A, m, Rls R2, R3, R4 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

Abstract translation: 本发明涉及一系列具有通式（I）的取代的化合物，包括其立体异构体和/或其药学上可接受的盐。 （I）其中A，m，R 1，R 2，R 3，R 4如本文所定义。 本发明还涉及制备这些包括中间体的化合物的方法。 本发明化合物在κ（κ）阿片受体（KOR）位点是有效的。 因此，本发明化合物可用作药物，特别是用于治疗和/或预防多种中枢神经系统疾病（CNS），包括但不限于急性和慢性疼痛以及相关疾病，特别是在外周功能 在CNS。

公开(公告)号：WO2009019600A3

公开(公告)日：2009-12-30

申请号：PCT/IB2008002140

申请日：2008-08-08

Applicant: REDDYS LAB LTD DR ,  MISRA PARIMAL ,  CHAKRABARTI RANJAN ,  MADHURAREKHA CHINNABOINA ,  HASHAM SUMERA NIKHAT ,  POTLURI VIJAY KUMAR ,  SASMAL PRADIP KUMAR ,  DAS SAIBAL KUMAR ,  IQBAL JAVED

Inventor： MISRA PARIMAL ,  CHAKRABARTI RANJAN ,  MADHURAREKHA CHINNABOINA ,  HASHAM SUMERA NIKHAT ,  POTLURI VIJAY KUMAR ,  SASMAL PRADIP KUMAR ,  DAS SAIBAL KUMAR ,  IQBAL JAVED

IPC: G01N33/00

CPC classification number: C12Q1/485 ,  G01N2800/044

Abstract: A method for identifying an AMPK activator is provided. The method includes providing a sample of cells that include AMPK and perilipin, providing a sample of an AMPK activator-candidate, contacting the cell sample and the activator-candidate, and measuring a quantitative indicator of the AMPK activation within the cell sample after the contacting step.

Abstract translation: 提供了一种用于鉴定AMPK激活剂的方法。 该方法包括提供包含AMPK和肾上腺素的细胞样品，提供AMPK激活剂候选物的样品，接触细胞样品和活化剂候选物，并测量接触后细胞样品中AMPK活化的定量指标 步。