公开(公告)号：GB0322472D0

公开(公告)日：2003-10-29

申请号：GB0322472

申请日：2003-09-25

Applicant: STEWART MICHELLE

公开(公告)号：GB2413056A

公开(公告)日：2005-10-19

申请号：GB0408266

申请日：2004-04-13

Applicant: STEWART MICHELLE

Inventor： STEWART MICHELLE

IPC: A41D20/00 ,  A45F5/00

Abstract: A magnetic holder comprises a flexible magnetic panel 3 with a weather-proof cover panel 1 held on the forearm of the user by elastic straps 8 that are detachably fastened together by Velcro (RTM) 6, 7. Nails, screws, nuts, bolts needles etc are held by the holder allowing the user to have free hands. The magnetic panel is mounted on a flexible backing material 5 such as leather, fabric or neoprene, a comfort pad 9 may be attached to the underside of the backing material for additional comfort. Preferably tapered bolsters 10 running the length of the holder eg elbow to wrist are positioned between the comfort pad and backing material on either side of the holder with the bolsters at their widest at the wrist. The bolsters allow the magnetic panel to lie flat and hold larger and heavier objects. Preferably the magnetic panel has a canvas cover that is detachably attached on three sides of the panel, that protects the objects held on the panel from moisture or being accidentally knocked off whilst in or out of use.

公开(公告)号：GB0322470D0

公开(公告)日：2003-10-29

申请号：GB0322470

申请日：2003-09-25

Applicant: STEWART MICHELLE

公开(公告)号：GB0322468D0

公开(公告)日：2003-10-29

申请号：GB0322468

申请日：2003-09-25

Applicant: STEWART MICHELLE

公开(公告)号：GB0322471D0

公开(公告)日：2003-10-29

申请号：GB0322471

申请日：2003-09-25

Applicant: STEWART MICHELLE

公开(公告)号：GB0320349D0

公开(公告)日：2003-10-01

申请号：GB0320349

申请日：2003-08-29

Applicant: STEWART MICHELLE

公开(公告)号：GB0408266D0

公开(公告)日：2004-05-19

申请号：GB0408266

申请日：2004-04-13

Applicant: STEWART MICHELLE

IPC: A41D20/00 ,  A45F5/00

公开(公告)号：GB0322469D0

公开(公告)日：2003-10-29

申请号：GB0322469

申请日：2003-09-25

Applicant: STEWART MICHELLE

公开(公告)号：WO2006127587A1

公开(公告)日：2006-11-30

申请号：PCT/US2006/019711

申请日：2006-05-22

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  LEDEBOER, Mark, W. ,  WANNAMAKER, Marion, W. ,  FARMER, Luc, J. ,  WANG, Tiansheng ,  PIERCE, Albert, C. ,  MARTINEZ-BOTELLA, Gabriel ,  BETHIEL, Randy, S. ,  BEMIS, Guy, W. ,  WANG, Jian ,  SALITURO, Francesco, G. ,  ARNOST, Michael, J. ,  COME, Jon, H. ,  GREEN, Jeremy ,  STEWART, Michelle ,  MARHEFKA, Craig

Inventor： LEDEBOER, Mark, W. ,  WANNAMAKER, Marion, W. ,  FARMER, Luc, J. ,  WANG, Tiansheng ,  PIERCE, Albert, C. ,  MARTINEZ-BOTELLA, Gabriel ,  BETHIEL, Randy, S. ,  BEMIS, Guy, W. ,  WANG, Jian ,  SALITURO, Francesco, G. ,  ARNOST, Michael, J. ,  COME, Jon, H. ,  GREEN, Jeremy ,  STEWART, Michelle ,  MARHEFKA, Craig

IPC: C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: The present invention relates to compounds of formula (I) wherein Q, Z, R 1 , R 2 , and R 3 are as described in claim 1 useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract translation: 本发明涉及其中Q，Z，R 1，R 2和R 3的式（I）化合物如 权利要求1用作蛋白激酶的抑制剂，特别是JAK家族和ROCK家族激酶的抑制剂。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

公开(公告)号：WO2011094708A3

公开(公告)日：2012-01-12

申请号：PCT/US2011023220

申请日：2011-01-31

Applicant: DANA FARBER CANCER INST INC ,  WALENSKY LOREN D ,  STEWART MICHELLE L ,  COHEN NICOLE

Inventor： WALENSKY LOREN D ,  STEWART MICHELLE L ,  COHEN NICOLE

IPC: C07C251/20 ,  A61K31/41 ,  A61P35/00 ,  C07D215/16 ,  C07D249/08

CPC classification number: C07D513/04 ,  C07C251/20 ,  C07C251/84 ,  C07C311/20 ,  C07C335/16 ,  C07C337/08 ,  C07C2602/10 ,  C07D239/60 ,  C07D249/12 ,  C07D277/34 ,  C07D279/06 ,  C07D307/54 ,  C07D327/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/08 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.

Abstract translation: 本发明涉及以高亲和性和选择性选择性结合生存蛋白MCL-1的化合物，含有这些化合物的药物组合物以及用于调节MCL-1活性和用于治疗过度增殖性疾病，血管生成障碍，细胞的这些化合物或组合物的用途 循环调节障碍，自噬调节障碍，炎性疾病和/或感染性疾病和/或用于增强细胞移植和/或伤口修复，作为唯一的试剂或与其它活性成分组合。