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1.发明申请PANTOTHENIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF MICROBIAL INFECTIONS 审中-公开泛酸衍生物及其在治疗微生物感染中的应用
公开(公告)号：WO2011152720A1
公开(公告)日：2011-12-08
申请号：PCT/NL2011/050384
申请日：2011-05-31
Applicant: UMC ST. RADBOUD , STICHTING KATHOLIEKE UNIVERSITEIT, RADBOUD UNIVERSITY NIJMEGEN , STICHTING KATHOLIEKE UNIVERSITEIT, RADBOUD UNIVERSITY NIJMEGEN , ZEEUWEN, Patrick Laurentius Johannes Maria , JANSEN, Patrick Antonius Martinus , SCHALKWIJK, Josephus , RUTJES, Floris Petrus Johannes Theodorus , RITZEN, Bas , HERMKENS, Pedro Harold Han
Inventor： ZEEUWEN, Patrick Laurentius Johannes Maria , JANSEN, Patrick Antonius Martinus , SCHALKWIJK, Josephus , RUTJES, Floris Petrus Johannes Theodorus , RITZEN, Bas , HERMKENS, Pedro Harold Han
IPC: A61K31/16 , A61K31/164 , A61K31/275 , A61K31/277 , A61K31/4155 , A61K31/417 , A61K31/4174 , A61K31/4178
CPC classification number: A61K45/06 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/275 , A61K31/277 , A61K31/4155 , A61K31/417 , A61K31/4174 , A61K31/4178 , Y02A50/411 , A61K2300/00
Abstract: The present invention concerns novel amides derived from pantothenic acid having antibiotic activity and novel analogues of pantetheine inhibiting the activity of pantetheinase. Combinations of such substances can suitably beused in therapeutic and or prophylactic treatment of bacterial infections, fungal and yeast infections in a human or animal subject. The present invention resides in the findingthat pantothenamidesaloneare not at antibiotically active in the presence of plasma due to the breakdown of pantothenamides by enzymes with pantetheinase activityandthat inhibition of these enzymes prevented breakdown of pantothenamides,thuspreserving their antibiotic activity under physiological conditions in mammals. The present invention thus, for the first time, makes available treatment relying on interference with microbial CoA dependent pathways and, simultaneously, inhibiting or reducing pantetheinase activity.
Abstract translation: 本发明涉及衍生自具有抗生素活性的泛酸的新型酰胺，以及泛酸胺基的新类似物抑制泛肽酶的活性。 这些物质的组合可以适当地用于人或动物受试者的细菌感染，真菌和酵母菌感染的治疗和/或预防性治疗。 本发明在于由于泛酸酰胺酶活性降低泛酸酰胺的作用而在血浆存在下不具有抗生素活性，因此这些酶的抑制可防止泛酰胺的分解，从而在哺乳动物的生理条件下保护其抗生素活性。 因此，本发明首次能够依赖于干扰微生物CoA依赖途径的治疗，同时抑制或减少泛酰胺氨基酸酶活性。
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2.发明申请
公开(公告)号：WO2011152721A1
公开(公告)日：2011-12-08
申请号：PCT/NL2011/050385
申请日：2011-05-31
Applicant: UMC ST. RADBOUD , STICHTING KATHOLIEKE UNIVERSITEIT, RADBOUD UNIVERSITY NIJMEGEN , STICHTING KATHOLIEKE UNIVERSITEIT, RADBOUD , JANSEN, Patrick Antonius Martinus , SCHALKWIJK, Josephus , RUTJES, Floris Petrus Johannes Theodorus , SAUERWEIN, Robert , HERMKENS, Pedro Harold Han
Inventor： JANSEN, Patrick Antonius Martinus , SCHALKWIJK, Josephus , RUTJES, Floris Petrus Johannes Theodorus , SAUERWEIN, Robert , HERMKENS, Pedro Harold Han
IPC: A61K31/16 , A61K31/164 , A61K31/165 , A61K31/275 , A61K31/417 , A61K31/4174 , A61K31/4178 , A61K31/4155 , A61K31/277 , A61K45/06 , A61P33/06
CPC classification number: A61K45/06 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/275 , A61K31/277 , A61K31/4155 , A61K31/417 , A61K31/4174 , A61K31/4178 , Y02A50/411 , A61K2300/00
Abstract: The present invention concerns novel pantothenone compounds having pantetheinase inhibitory activity as well as antiplasmodial activity. These compounds can suitably be used in therapeutic and or prophylactic treatment of malaria. Furthermore, the present invention provides combinations of pantothenone compounds and pantothenamides. Combining a pantothenone with a pantothenamide increases the antimalarial potency by an order of magnitude. It is hypothesized that inhibition of pantetheinase activity could protect pantothenamides against degradation by serum-derived pantetheinases, thereby revealing the hitherto unknown antimalaria activity of pantothenamides. The present invention thus, for the first time, makes available compounds and combinations of compounds for use in therapeutic and or prophylactic treatment of malaria infection in a human or animal subject in need thereof, relying on interference with host or pathogen-derived pantetheinase dependent pathways.
Abstract translation: 本发明涉及具有泛肽酶抑制活性以及抗血浆活性的新型泛氢化合物。 这些化合物可适用于治疗和/或预防性治疗疟疾。 此外，本发明提供了泛醌化合物和泛酸酰胺的组合。 将泛氢化合物与泛酸盐组合使抗疟药效力提高一个数量级。 假设抑制泛酰胺酶活性可以保护泛酸酰胺免受血清衍生的泛酰胺氨基酸酶的降解，从而揭示迄今未知的泛酰胺的抗疟疾活性。 因此，本发明首次使得可用的化合物和化合物的组合用于治疗和/或预防性治疗有需要的人或动物受试者中的疟疾感染，依赖于干扰宿主或病原体衍生的泛酰胺氨基酸酶依赖途径 。
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公开(公告)号：US20170065698A1
公开(公告)日：2017-03-09
申请号：US15354102
申请日：2016-11-17
Inventor： Hester Jeanette Bootsma , Pieter Jan Burghout , Peter Wilhelmus Maria Hermans , Johanna Jacoba Elisabeth Bijlsma , Oscar Paul Kuipers , Tomas Gerrit Kloosterman
CPC classification number: A61K39/092 , A61K9/0019 , A61K9/107 , A61K39/09 , A61K47/22 , A61K2039/54 , A61K2039/545 , A61K2039/55594
Abstract: The present invention provides proteins/genes, which are essential for survival, and consequently, for virulence of Streptococcus pneumoniae in vivo, and thus are ideal vaccine candidates for a vaccine preparation against pneumococcal infection. Further, also antibodies against said protein(s) are included in the invention.
Abstract translation: 本发明提供蛋白质/基因，其对于存活是必需的，因此提供了肺炎链球菌在体内的毒力，因此是针对肺炎球菌感染的疫苗制剂的理想疫苗候选物。 此外，本发明还包括针对所述蛋白质的抗体。
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公开(公告)号：WO2011049442A2
公开(公告)日：2011-04-28
申请号：PCT/NL2010/050693
申请日：2010-10-19
Applicant: STICHTING KATHOLIEKE UNIVERSITEIT, RADBOUD UNIVERSITEIT NIJMEGEN , LOOF, Arnoud Harmen , VAN HEERDE, Waander Laurens
Inventor： LOOF, Arnoud Harmen , VAN HEERDE, Waander Laurens
IPC: G01N33/86
CPC classification number: G01N33/86 , G01N33/6848
Abstract: The present invention is concerned with a method for measuring blood coagulation status in a saliva sample from a subject by measuring the concentration of various proteins which have been demonstrated to correlate with the international normalized ratio in said saliva. The invention further relates to a non-invasive device for performing said method, as well as a kit suitable for performing said method.
Abstract translation: 本发明涉及通过测量已经被证明与所述唾液中的国际标准化比例相关联的各种蛋白质的浓度来测量来自受试者的唾液样品中的凝血状态的方法。 本发明还涉及一种用于执行所述方法的非侵入性装置，以及适于执行所述方法的套件。
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公开(公告)号：WO2011049431A1
公开(公告)日：2011-04-28
申请号：PCT/NL2009/050629
申请日：2009-10-19
Applicant: Stichting Katholieke Universiteit, Radboud Universiteit Nijmegen , LOOF, Arnoud Harmen , VAN HEERDE, Waander Laurens
Inventor： LOOF, Arnoud Harmen , VAN HEERDE, Waander Laurens
IPC: G01N33/86
CPC classification number: G01N33/86 , G01N33/6848
Abstract: The present invention is concerned with a method for measuring blood coagulation status in a saliva sample from a subject by measuring the concentration of various proteins which have been demonstrated to correlate with the international normalized ratio in said saliva. The invention further relates to a non-invasive device for performing said method, as well as a kit suitable for performing said method.
Abstract translation: 本发明涉及通过测量已证实与所述唾液中的国际标准化比率相关的各种蛋白质的浓度来测量来自受试者的唾液样品中的凝血状态的方法。 本发明进一步涉及用于执行所述方法的非侵入式装置，以及适于执行所述方法的套件。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2010117264A1
公开(公告)日：2010-10-14
申请号：PCT/NL2010/050171
申请日：2010-04-02
Applicant: Stichting Katholieke Universiteit, Radboud Universiteit Nijmegen , DESAIN, Petrus Wilhelmus Maria , MCQUEEN, James Maurice
Inventor： DESAIN, Petrus Wilhelmus Maria , MCQUEEN, James Maurice
IPC: A61B5/00 , A61B5/0484 , A61B5/16
CPC classification number: A61B5/04845 , A61B5/16 , A61B5/486
Abstract: Method for training of a perceptual skill, e.g. using a brain computer interface, which method comprises measuring electrophysiological activity in reaction to a sequence of perceptual stimuli. Furthermore, matching the measured electrophysiological activity signal with a predefined electrophysiological signature signal is performed, in which the predefined electrophysiological signature signal corresponds to an early electrophysiological component. Feedback is provided when a match is detected.
Abstract translation: 用于训练感知技能的方法，例如 使用脑计算机界面，该方法包括测量对感知刺激序列的反应的电生理活性。 此外，执行将测量的电生理活动信号与预定的电生理学签名信号进行匹配，其中预定的电生理特征信号对应于早期的电生理学成分。 检测到匹配时提供反馈。
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7.发明申请
公开(公告)号：WO2010008276A1
公开(公告)日：2010-01-21
申请号：PCT/NL2009/050421
申请日：2009-07-10
Applicant: STICHTING KATHOLIEKE UNIVERSITEIT, RADBOUD UNIVERSITEIT NIJMEGEN , DESAIN, Petrus Wilhelmus Maria , FURQUHAR, Jason
Inventor： DESAIN, Petrus Wilhelmus Maria , FURQUHAR, Jason
IPC: A61B5/0484 , G06F17/00
CPC classification number: A61B5/04845 , G06F3/015 , G06K9/00496
Abstract: Method and brain computer interface for processing a brain wave signal (14) obtained from a person using a brain wave detector (5). One or more stimuli are applied to the person which each comprise a pseudo random noise component (11a, 11b). A brain wave signal (14) is detected and mental processing of the one or more stimuli (11a, 11b) is tracked by correlating the pseudo random noise component and the brain wave signal.
Abstract translation: 用于处理从使用脑波检测器的人获得的脑波信号（14）的方法和脑计算机接口（5）。 一个或多个刺激被应用于每个包括伪随机噪声分量（11a，11b）的人。 检测脑波信号（14），并通过将伪随机噪声分量与脑波信号相关联来跟踪一个或多个刺激（11a，11b）的心理处理。
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公开(公告)号：WO2009013018A3
公开(公告)日：2009-01-29
申请号：PCT/EP2008/006182
申请日：2008-07-24
Applicant: STICHTING KATHOLIEKE UNIVERSITEIT RADBOUD UNIVERSITY NIJMEGEN MEDICAL CENTRE , DE VRIES, Ingrid, Jolanda, Monique , FIGDOR, Carl , BENITEZ RIBAS, Daniel
IPC: A61K39/00
Abstract: The invention relates to a method for providing an activated antigen-presenting cell or a composition that comprises at least one activated antigen-presenting cell, which method at least comprises the steps of providing a composition that comprises at least one antigen-presenting cell and contacting said composition with a vaccine. Suitably, the at least one dendritic cell is brought into a state in which it is capable of stimulating T-cells and/or a T-cell mediated response.
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9.发明申请
公开(公告)号：WO2009013018A2
公开(公告)日：2009-01-29
申请号：PCT/EP2008/006182
申请日：2008-07-24
Applicant: STICHTING KATHOLIEKE UNIVERSITEIT RADBOUD UNIVERSITY NIJMEGEN MEDICAL CENTRE , DE VRIES, Ingrid, Jolanda, Monique , FIGDOR, Carl , BENITEZ RIBAS, Daniel
IPC: A61K39/00
CPC classification number: A61K39/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , Y10T29/49888
Abstract: The invention relates to a method for providing an activated antigen-presenting cell or a composition that comprises at least one activated antigen-presenting cell, which method at least comprises the steps of providing a composition that comprises at least one antigen-presenting cell and contacting said composition with a vaccine. Suitably, the at least one dendritic cell is brought into a state in which it is capable of stimulating T-cells and/or a T-cell mediated response.
Abstract translation: 本发明涉及一种用于提供活化的抗原呈递细胞或包含至少一种活化的抗原呈递细胞的组合物的方法，该方法至少包括以下步骤：提供包含至少一种抗原呈递细胞和接触的组合物 所述组合物用疫苗。 适当地，使至少一个树突状细胞处于其能够刺激T细胞和/或T细胞介导的应答的状态。
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10.发明公开Method for deriving shape information of a person's dentition 审中-公开Verfahren zum Ableiten der Forminformation der Dentition einer Person
公开(公告)号：EP2368498A1
公开(公告)日：2011-09-28
申请号：EP10158059.5
申请日：2010-03-26
Applicant: Stichting voor de Technische Wetenschappen , Stichting Katholieke Universiteit, Radboud University Nijmegen Medical Centre
Inventor： Bergé, Stefaan Jozef , Kuijpers-Jagtman, Anne-Marie , Rangel, Frits , Maal, Thomas
CPC classification number: A61B6/14 , A61B6/466 , A61B6/5235 , A61B2090/3954 , A61C9/0053
Abstract: The present invention is related to a method for deriving shape information of a person's dentition. The method comprises the steps of
- obtaining a first data set by taking a 3D scan of the person's dentition with markers fixed in the person's intra-oral cavity,
- digitizing an impression of the person's dentition with the markers fixed, yielding a second data set,
- fusing the first and the second data set based on corresponding pairs of the markers,
- deriving the shape information from the fused first and second data sets.Abstract translation: 本发明涉及一种用于导出人牙列形状信息的方法。 该方法包括以下步骤：通过对固定在人的口腔内的标记进行人体牙列的3D扫描来获得第一数据集; - 使用固定的标记数字化人的牙列的印象，产生第二数据集 ， - 基于对应的标记对来融合第一和第二数据集， - 从融合的第一和第二数据集导出形状信息。
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