公开(公告)号：WO2010006059A8

公开(公告)日：2010-09-02

申请号：PCT/US2009049953

申请日：2009-07-08

Applicant: ABBOTT LAB ,  GU JIJIE ,  HUTCHINS CHARLES W ,  ZHU RONG-RONG ,  SHEN JIANWEI ,  HARRIS MARIA C ,  BELANGER EILEEN ,  MURTAZA ANWAR ,  TARCSA EDIT ,  STINE WILLIAM B ,  HSIEH CHUNG-MING

Inventor： GU JIJIE ,  HUTCHINS CHARLES W ,  ZHU RONG-RONG ,  SHEN JIANWEI ,  HARRIS MARIA C ,  BELANGER EILEEN ,  MURTAZA ANWAR ,  TARCSA EDIT ,  STINE WILLIAM B ,  HSIEH CHUNG-MING

IPC: A61K39/395

CPC classification number: C07K16/18 ,  A61K31/405 ,  A61K31/573 ,  A61K39/39533 ,  A61K2039/505 ,  C07K16/26 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76

Abstract: The present invention encompasses prostaglandin E2 (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.

Abstract translation: 本发明包括前列腺素E2（PGE2）结合蛋白。 本发明涉及野生型，嵌合，CDR移植和人源化的抗体。 优选的抗体对前列腺素E2具有高亲和力并且在体外和体内中和前列腺素E2的活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗原结合部分可用于检测前列腺素E2和用于抑制前列腺素E2活性，例如，在患有前列腺素E2活性是有害的病症的人类受试者中。

公开(公告)号：WO2011116090A1

公开(公告)日：2011-09-22

申请号：PCT/US2011/028659

申请日：2011-03-16

Applicant: ABBOTT RESEARCH B.V. ,  FRAUNHOFER, Wolfgang ,  CHARI, Ravi ,  KUMAR, Vineet ,  SAEDLER, Rainer ,  SIEDLER, Michael ,  STINE, William, B. ,  WEBER, Carsten

Inventor： FRAUNHOFER, Wolfgang ,  CHARI, Ravi ,  KUMAR, Vineet ,  SAEDLER, Rainer ,  SIEDLER, Michael ,  STINE, William, B. ,  WEBER, Carsten

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/28 ,  C07K16/22

CPC classification number: C07K16/22 ,  A61K39/39591 ,  A61K47/183 ,  C07K2317/53 ,  C07K2317/94

Abstract: The present invention relates to stable compositions of anti-NGF antibodies, and antigen-binding fragments thereof, and their uses in the prevention and/or treatment of various diseases and disorders in which NGF activity is detrimental, e.g., pain disorders.

Abstract translation: 本发明涉及抗NGF抗体及其抗原结合片段的稳定组合物及其在预防和/或治疗其中NGF活性有害的各种疾病和病症（例如疼痛障碍）中的用途。

公开(公告)号：WO2010006059A1

公开(公告)日：2010-01-14

申请号：PCT/US2009/049953

申请日：2009-07-08

Applicant: ABBOTT LABORATORIES ,  GU, Jijie ,  HUTCHINS, Charles, W. ,  ZHU, Rong-Rong ,  SHEN, Jianwei ,  HARRIS, Maria, C. ,  BELANGER, Eileen ,  MURTAZA, Anwar ,  TARCSA, Edit ,  STINE, William, B. ,  HSIEH, Chung-ming

Inventor： GU, Jijie ,  HUTCHINS, Charles, W. ,  ZHU, Rong-Rong ,  SHEN, Jianwei ,  HARRIS, Maria, C. ,  BELANGER, Eileen ,  MURTAZA, Anwar ,  TARCSA, Edit ,  STINE, William, B. ,  HSIEH, Chung-ming

IPC: A61K39/395

CPC classification number: C07K16/18 ,  A61K31/405 ,  A61K31/573 ,  A61K39/39533 ,  A61K2039/505 ,  C07K16/26 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  Y02A50/386 ,  Y02A50/401 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/478 ,  Y02A50/481

Abstract: The present invention encompasses prostaglandin E2 (PGE 2 ) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E 2 and neutralize prostaglandin E 2 activity in vitro and in vivo . An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E 2 and for inhibiting prostaglandin E 2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E 2 activity is detrimental.

Abstract translation: 本发明包括前列腺素E2（PGE2）结合蛋白。 本发明涉及野生型，嵌合型，CDR移植和人源化的抗体。 优选的抗体对前列腺素E2具有高亲和力，并在体外和体内中和前列腺素E2活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗原结合部分可用于检测前列腺素E2和用于抑制前列腺素E2活性，例如在患有前列腺素E2活性有害的病症的人类受试者中。