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1.COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS 审中-公开
Title translation: 化合物作为S-NITROSOGOSETUTIONIONE还原酶抑制剂公开(公告)号:WO2012170371A1
公开(公告)日:2012-12-13
申请号:PCT/US2012/040821
申请日:2012-06-05
Applicant: N30 PHARMACEUTICALS, LLC , SUN, Xicheng , QIU, Jian , STOUT, Adam
Inventor: SUN, Xicheng , QIU, Jian , STOUT, Adam
CPC classification number: C07D417/10 , A61K31/08 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/275 , A61K31/341 , A61K31/352 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/4192 , A61K31/4245 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4418 , A61K31/47 , A61K31/4709 , A61K31/4965 , A61K31/498 , A61K31/50 , A61K31/505 , A61K31/517 , A61K31/53 , A61K31/5375 , C07C59/115 , C07D213/55 , C07D215/20 , C07D215/46 , C07D215/60 , C07D217/02 , C07D237/24 , C07D239/26 , C07D239/74 , C07D241/12 , C07D241/42 , C07D253/10 , C07D295/155 , C07D311/22 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D409/04 , C07D413/10
Abstract: The present invention is directed to compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
Abstract translation: 本发明涉及可用作S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂的化合物,包含这些化合物的药物组合物及其制备和使用方法。
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2.NOVEL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS 审中-公开
Title translation: 新型取代的双环芳香化合物作为S-硝基葡萄糖糖醛酸还原酶抑制剂公开(公告)号:WO2012083171A1
公开(公告)日:2012-06-21
申请号:PCT/US2011/065502
申请日:2011-12-16
Applicant: N30 PHARMACEUTICALS, LLC , SUN, Xicheng , QIU, Jian , STOUT, Adam
Inventor: SUN, Xicheng , QIU, Jian , STOUT, Adam
IPC: C07C63/36
CPC classification number: A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
Abstract: The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
Abstract translation: 本发明涉及可用作S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂的新型取代双环芳族化合物,包含此类化合物的药物组合物及其制备和使用方法。 p> p> p>
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3.NOVEL SUBSTITUTED QUINOLINE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS 审中-公开
Title translation: 新型取代的喹啉化合物作为S-硝基葡萄糖硫代还原酶抑制剂公开(公告)号:WO2012048181A1
公开(公告)日:2012-04-12
申请号:PCT/US2011055200
申请日:2011-10-07
Applicant: N30 PHARMACEUTICALS LLC , SUN XICHENG , QIU JIAN , STOUT ADAM
Inventor: SUN XICHENG , QIU JIAN , STOUT ADAM
CPC classification number: C07D215/20 , A61K31/47 , A61K31/4706 , A61K31/4709 , C07D215/00 , C07D215/42 , C07D215/46 , C07D215/54 , C07D215/60 , C07D401/04 , C07D401/10 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10
Abstract: The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
Abstract translation: 本发明涉及可用作S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂的新型喹啉化合物,包含此类化合物的药物组合物及其制备和使用方法。
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公开(公告)号:WO2012048181A4
公开(公告)日:2012-04-12
申请号:PCT/US2011/055200
申请日:2011-10-07
Applicant: N30 PHARMACEUTICALS, LLC , SUN, Xicheng , QIU, Jian , STOUT, Adam
Inventor: SUN, Xicheng , QIU, Jian , STOUT, Adam
Abstract: The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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5.NOVEL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS 审中-公开
Title translation: 新型取代的双环芳族化合物作为S-NITROSOGSUTATHIONE还原酶抑制剂公开(公告)号:WO2012083165A1
公开(公告)日:2012-06-21
申请号:PCT/US2011/065490
申请日:2011-12-16
Applicant: N30 PHARMACEUTICALS, LLC , SUN, Xicheng , QIU, Jian , STOUT, Adam
Inventor: SUN, Xicheng , QIU, Jian , STOUT, Adam
IPC: A01N43/42
CPC classification number: A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
Abstract: The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
Abstract translation: 本发明涉及用作S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂的新型取代的双环芳族化合物,包含这些化合物的药物组合物及其制备和使用方法。
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