公开(公告)号：WO2002064586A3

公开(公告)日：2002-08-22

申请号：PCT/US2002/003791

申请日：2002-02-08

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  CAO, Jingrong ,  GREEN, Jeremy ,  HALE, Michael ,  MALTAIS, Francois ,  STRAUB, Judy ,  TANG, Qing ,  ARONOV, Alex

Inventor： CAO, Jingrong ,  GREEN, Jeremy ,  HALE, Michael ,  MALTAIS, Francois ,  STRAUB, Judy ,  TANG, Qing ,  ARONOV, Alex

IPC: C07D403/04

Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula (I) wherein Z 1 and Z 2 are each independently nitrogen or CH and Ring A, T m R 1 , QR 2 , U n R 3 , and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

公开(公告)号：WO02064586A2

公开(公告)日：2002-08-22

申请号：PCT/US0203791

申请日：2002-02-08

Applicant: VERTEX PHARMA ,  CAO JINGRONG ,  GREEN JEREMY ,  HALE MICHAEL ,  MALTAIS FRANCOIS ,  STRAUB JUDY ,  TANG QING ,  ARONOV ALEX

Inventor： CAO JINGRONG ,  GREEN JEREMY ,  HALE MICHAEL ,  MALTAIS FRANCOIS ,  STRAUB JUDY ,  TANG QING ,  ARONOV ALEX

IPC: A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/551 ,  A61P1/16 ,  A61P3/10 ,  A61P5/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P17/06 ,  A61P19/00 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula (I) wherein Z and Z are each independently nitrogen or CH and Ring A, TmR , QR , UnR , and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

Abstract translation: 本文描述了可用作具有式（I）的蛋白激酶抑制剂的化合物，其中Z 1和Z 2各自独立地为氮或CH，环A，TmR 1，QR 2，UnR 3 >和Sp如说明书中所述。 该化合物特别可用作ERK2的抑制剂，并且用于治疗由蛋白激酶抑制剂，特别是癌症，炎性疾病，再狭窄，糖尿病和心血管疾病等疾病缓解的哺乳动物疾病。