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    ABETA (X-38..43) OLIGOMERS, AND PROCESSES, COMPOSITIONS, AND USES THEREOF
    3.
    发明申请
    ABETA (X-38..43) OLIGOMERS, AND PROCESSES, COMPOSITIONS, AND USES THEREOF 审中-公开
    ABETA（X-38..43）低聚体及其过程，组合物及其用途

    公开(公告)号：WO2010010469A2

    公开(公告)日：2010-01-28

    申请号：PCT/IB2009/006636

    申请日：2009-07-24

    Applicant: ABBOTT GMBH & CO. KG ,  HILLEN, Heinz ,  STRIEBINGER, Andreas ,  GIAISI, Simone ,  BARGHORN, Stefan ,  GELLERMANN, Gerald ,  EBERT, Ulrich

    Inventor： HILLEN, Heinz ,  STRIEBINGER, Andreas ,  GIAISI, Simone ,  BARGHORN, Stefan ,  GELLERMANN, Gerald ,  EBERT, Ulrich

    IPC: C07K14/435

    CPC classification number: C07K14/4711 ,  A61K39/0007 ,  A61K2039/55566 ,  C07K16/18 ,  G01N33/6896 ,  G01N2800/2821

    Abstract: The present invention relates to an Aβ(X - 38.. 43) oligomer having a high molecular weight, or a derivative thereof, a process for preparing the oligomer or derivative, compositions comprising the oligomer or derivative, and uses of the oligomer or derivative such as its use for treating or preventing an amyloidosis (e.g. by active immunization), for diagnosing an amyloidosis, and for providing agents that are capable of binding to the Aβ(X - 38.. 43) oligomer or derivative. The subject invention also describes agents that are capable of binding to the Aβ(X - 38.. 43) oligomer or derivative, e.g. antibodies, compositions comprising the agents, and uses of the agents such as their use for treating or preventing an amyloidosis (e.g. by passive immunization) and for diagnosing an amyloidosis.

    Abstract translation: 本发明涉及具有高分子量的Aß（X-38.43）低聚物或其衍生物，制备低聚物或衍生物的方法，包含低聚物或衍生物的组合物，以及低聚物或衍生物的用途 例如其用于治疗或预防淀粉样变性（例如通过主动免疫）用于诊断淀粉样变性的用途，以及用于提供能够结合Aβ（X-38,43）低聚物或衍生物的试剂。 本发明还描述了能够结合Aβ（X-38,43）低聚物或衍生物的试剂，例如。 抗体，包含该试剂的组合物，以及该药剂的用途，例如其用于治疗或预防淀粉样变性（例如通过被动免疫）和用于诊断淀粉样变性的用途。

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