公开(公告)号：WO2007035576A3

公开(公告)日：2007-06-14

申请号：PCT/US2006036193

申请日：2006-09-15

Applicant: NORTHERN ADVANCEMENT CT FOR SC ,  HAKOMORI SENITIROH ,  TAYA MINORU ,  SU FENGYU ,  XU CHUNYE ,  HANDA KAZUKO ,  MURAYAMA KIMIE ,  FUJIMURA TSUTOMU

Inventor： HAKOMORI SENITIROH ,  TAYA MINORU ,  SU FENGYU ,  XU CHUNYE ,  HANDA KAZUKO ,  MURAYAMA KIMIE ,  FUJIMURA TSUTOMU

IPC: G01N33/53 ,  C12N11/00 ,  C12Q1/00

CPC classification number: G01N33/57423 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N33/54373 ,  G01N33/57415 ,  G01N33/57434 ,  G01N33/57446 ,  G01N33/57492

Abstract: The present invention provides an SPR system and corresponding methods of use, for determining the presence or concentration of tumor-associated antigens in cancer patient samples. The SPR system may have multiple channels, with each channel having operably affixed thereto an antibody specific for a tumor-associated antigen, so as to allow detection of multiple tumor-associated antigens simultaneously. When a biological sample from a patient is applied to the SPR system, the presence of two or more tumor-associated antigens can be determined by measuring an SPR signal shift from each channel. The SPR system may detect the presence or concentration of a tumor-associated carbohydrate antigen, where the sensor surface contains affixed thereto an antibody specific for the glycosyl epitope, as well as an antibody specific for the polypeptide to which the carbohydrate antigen is naturally associated in cancer patients.

Abstract translation: 本发明提供了用于确定癌症患者样品中肿瘤相关抗原的存在或浓度的SPR系统和相应的使用方法。 SPR系统可以具有多个通道，每个通道可操作地附着有对肿瘤相关抗原特异性的抗体，从而允许同时检测多种肿瘤相关抗原。 当将来自患者的生物样品应用于SPR系统时，可以通过测量来自每个通道的SPR信号移位来确定两种或更多种肿瘤相关抗原的存在。 SPR系统可检测肿瘤相关糖抗原的存在或浓度，其中传感器表面含有附着有对糖基表位特异性的抗体以及对糖抗原天然相关的多肽具有特异性的抗体 癌症患者。

公开(公告)号：WO2006029344A2

公开(公告)日：2006-03-16

申请号：PCT/US2005/032211

申请日：2005-09-09

Applicant: UNIVERSITY OF WASHINGTON ,  LIU, Lu ,  XU, Chunye ,  TAYA, Minoru ,  NING, Dai ,  KANEKO, Calen

Inventor： LIU, Lu ,  XU, Chunye ,  TAYA, Minoru ,  NING, Dai ,  KANEKO, Calen

IPC: G03C1/00

CPC classification number: C09K9/02 ,  C07D495/04 ,  C09K2211/1051 ,  C09K2211/1092 ,  G03C1/73

Abstract: Three green EC materials based on thiophene, and a green EC material based on pyrazine are disclosed. A first thiophene derivative (2,3-Di-thiophen-2-yl-thieno[3,4-b]pyrazine), which was previously investigated as a nonlinear optical material, is here disclosed for its use as an EC material, and for its incorporation into an EC device. Synthesis of two new thiophene derivatives (2,5-di(thien-2-yl)-3,4-di(2,2,2-trifluoro-ethoxy)-thiophene and 2,5-(2,3-dihydro-thieno[3,4-b][1,4]dioxin-5-yl)-3,4-di(2,2,2-trifluoro-ethoxy)-thiophene), and a new pyrazine derivative (2,3-dibenzyl-5,7-di(thien-2-yl) thieno[3,4-b]pyrazine) are also disclosed, since these materials are all able to selectively change to a green color state, and can be polymerized to achieve a green EC polymer.

Abstract translation: 公开了基于噻吩的三种绿色EC材料和基于吡嗪的绿色EC材料。 作为非线性光学材料，先前研究的第一个噻吩衍生物（2,3-二噻吩-2-基 - 噻吩并[3,4-b]吡嗪）在此被公开用作EC材料，并且 将其并入EC设备。 合成两种新的噻吩衍生物（2,5-二（噻吩-2-基）-3,4-二（2,2,2-三氟 - 乙氧基） - 噻吩和2,5-（2,3-二氢 - 噻吩并[3,4-b] [1,4]二恶英-5-基）-3,4-二（2,2,2-三氟 - 乙氧基） - 噻吩）和新的吡嗪衍生物 还公开了二苄基-5,7-二（噻吩-2-基）噻吩并[3,4-b]吡嗪），因为这些材料都能够选择性地变为绿色状态，并且可以聚合以实现 绿色EC聚合物。

公开(公告)号：WO2017087494A1

公开(公告)日：2017-05-26

申请号：PCT/US2016/062238

申请日：2016-11-16

Applicant: THE UNIVERSITY OF WASHINGTON ,  KADOOKA, Kevin ,  TAYA, Minoru ,  REJAI, Sepehr

Inventor： KADOOKA, Kevin ,  TAYA, Minoru ,  REJAI, Sepehr ,  HEMBRADOR, Sheena, M.

IPC: A61B5/00 ,  A61B5/02 ,  A61B5/04 ,  B82Y5/00 ,  B82Y30/00

CPC classification number: A61B5/681 ,  A61B5/0033 ,  A61B5/026 ,  A61B5/489 ,  A61B5/6843 ,  A61B5/7445 ,  A61B2562/0247 ,  A61B2562/046 ,  B82Y15/00 ,  B82Y30/00

Abstract: An artery mapper is attached over a target artery, and includes a sensor array that detects pressure changes corresponding to pulsatile flow through the artery. The signals from the sensor array are processed to identify signals having a frequency within a predetermined pulsatile range, and that define an elongate path across the sensor array. A display is provided directly over the sensor array. A digital controller circuit receives the signals from the detector array, and produces an image on the display directly over the detected signals, providing the practitioner with an image corresponding to the location of the artery, to facilitate cannulation of the artery.

Abstract translation: 动脉映射器附着在目标动脉上，并且包括传感器阵列，该传感器阵列检测对应于通过动脉的脉动流动的压力变化。 处理来自传感器阵列的信号以识别具有在预定脉动范围内的频率的信号，并且定义穿过传感器阵列的细长路径。 显示器直接位于传感器阵列上方。 数字控制器电路接收来自检测器阵列的信号，并在显示器上直接在检测到的信号上产生图像，为从业者提供与动脉位置相对应的图像，以便于插管动脉。

公开(公告)号：WO2010039141A1

公开(公告)日：2010-04-08

申请号：PCT/US2008/078599

申请日：2008-10-02

Applicant: UNIVERSITY OF WASHINGTON ,  XU, Chunye ,  MA, Chao ,  TAYA, Minoru

Inventor： XU, Chunye ,  MA, Chao ,  TAYA, Minoru

IPC: G01F1/115

CPC classification number: G02F1/161 ,  G02F1/133305 ,  G02F2001/1515

Abstract: A flexible electrochromic (EC) panel that is usable for a display device or for other applications in which at least a region of the panel is selectively caused to change opacity. An exemplary panel includes an EC working layer or electrode formed of a PProDOT-Me 2 polymer film that is deposited on an indium tin oxide (ITO)-coated polyethylene terephthalate (PET) flexible substrate. Similarly, a counter electrode is formed by depositing a vanadium oxide-titanium oxide (V 2 O 5 -TiO 2 ) composite film on another ITO PET coated flexible substrate. An ultraviolet light-cured film sealant is employed to seal the flexible panel and also serves as a spacer between the electrodes. The film sealant is patterned to define a volume for injecting an electrolyte solution through an inlet port provided in the film sealant. The inlet port is then closed. The EC panel can readily be flexed without damage.

Abstract translation: 一种柔性电致变色（EC）面板，可用于显示设备或其他应用中，其中面板的至少一个区域被选择性地引起改变不透明度。 示例性面板包括EC工作层或由沉积在氧化铟锡（ITO）涂覆的聚对苯二甲酸乙二醇酯（PET）柔性基底上）的PProDOT-Me2聚合物膜形成的电极。 类似地，通过在另一个ITO PET涂覆的柔性衬底上沉积氧化钒 - 氧化钛（V2O5-TiO2）复合膜来形成对电极。 使用紫外光固化膜密封剂来密封柔性板，并且还用作电极之间的间隔物。 图案化膜密封剂以限定用于通过设置在膜密封剂中的入口注入电解质溶液的体积。 然后关闭入口。 EC面板可以轻松地弯曲而不受损坏。

公开(公告)号：WO2009059332A1

公开(公告)日：2009-05-07

申请号：PCT/US2008/082302

申请日：2008-11-03

Applicant: UNIVERSITY OF WASHINGTON ,  TAYA, Minoru

Inventor： TAYA, Minoru

IPC: B32B15/01 ,  B32B7/02

CPC classification number: B29C61/0608 ,  B29L2031/22 ,  F03G7/065 ,  Y10T428/24612 ,  Y10T428/249922 ,  Y10T428/2925 ,  Y10T428/31678

Abstract: A plurality of reversible active composite materials are disclosed, including composites based on a shape memory alloy member (SMA) and a shape memory polymer member (SMP), as well as composites based on two different SMP members. Each different member (SMA or SMP) will be trained to remember a specific shape at a specific temperature. Where two different SMP members are employed, the members exhibit different glass transition temperatures. Such composite materials can be implemented in many form factors, including two generally planar members, a single generally planar SMP member with SMA fibers distributed throughout the SMP, and a SMA fiber/wire coated with a SMP coating. In particular, the SMA fiber/wire coated with a SMP layer can be used to form helical coils that can be used in paired hinges to achieve reversible bending of a structure into which such paired hinges are incorporated.

Abstract translation: 公开了多种可逆活性复合材料，包括基于形状记忆合金构件（SMA）和形状记忆聚合物构件（SMP）的复合材料，以及基于两种不同SMP构件的复合材料。 将训练每个不同的成员（SMA或SMP）以记住特定温度下的特定形状。 当使用两种不同的SMP构件时，构件表现出不同的玻璃化转变温度。 这种复合材料可以以许多形状因子实现，包括两个通常为平面的构件，具有分布在整个SMP中的SMA纤维的单个大体平坦的SMP构件和涂覆有SMP涂层的SMA纤维/线。 特别地，涂覆有SMP层的SMA纤维/线可以用于形成螺旋线圈，其可以用于成对的铰链中，以实现将这种成对的铰链结合到其中的结构的可逆弯曲。

公开(公告)号：WO2005084350A3

公开(公告)日：2007-03-01

申请号：PCT/US2005006806

申请日：2005-03-01

Applicant: UNIV WASHINGTON ,  LU LIU ,  XU CHUNYE ,  LEGENSKI SUSAN ,  TAYA MINORU

Inventor： LIU LU ,  XU CHUNYE ,  LEGENSKI SUSAN ,  TAYA MINORU

IPC: G02F1/15

CPC classification number: G02F1/15 ,  C08G61/124 ,  C08G61/126 ,  C09K9/02 ,  C09K2211/1458 ,  G02F1/155 ,  G02F2001/133374 ,  G02F2001/1515

Abstract: Syntheses of a new blue EC monomer (ProDOT-MePro), and a new red EC monomer (ProDOP-Et2) are described. Two additional new types of EC monomers (15) based on 3,4-alkylenedioxythiophene include fluorinated EC monomers (15) and an EC monomer including silicon. EC polymer devices having more than one different color EC polymer to enable additional colors to be provided using subtractive color mixing are also described, as well as EC polymer devices incorporating a logo, image, or text, are generally obscured when the device is colored, but become visible when the device is not colored. Also described are EC polymer devices that include a cathodic EC polymer layer, a gel electrolyte, a counter electrode, and reference electrode. Working prototypes of such devices exhibit significant increases in the speed of transition of the EC device from a colored state to a transparent state.

Abstract translation: 描述了新的蓝色EC单体（ProDOT-MePro）和新的红色EC单体（ProDOP-Et2）的合成。 基于3,4-亚烷基二氧噻吩的另外两种新型EC单体（15）包括氟化EC单体（15）和包含硅的EC单体。 还描述了具有多于一种不同颜色的EC聚合物的EC聚合物装置，以使得能够使用减色混合来提供附加的颜色，以及包含标志，图像或文本的EC聚合物装置在装置着色时通常是模糊的， 但当设备未着色时变得可见。 还描述了EC聚合物装置，其包括阴极EC聚合物层，凝胶电解质，对电极和参比电极。 这种装置的工作原型表现出EC装置从有色状态转变为透明状态的速度的显着增加。

公开(公告)号：WO2005084350A2

公开(公告)日：2005-09-15

申请号：PCT/US2005/006806

申请日：2005-03-01

Applicant: UNIVERSITY OF WASHINGTON ,  LU, Liu ,  XU, Chunye ,  LEGENSKI, Susan ,  TAYA, Minoru

Inventor： LU, Liu ,  XU, Chunye ,  LEGENSKI, Susan ,  TAYA, Minoru

CPC classification number: G02F1/15 ,  C08G61/124 ,  C08G61/126 ,  C09K9/02 ,  C09K2211/1458 ,  G02F1/155 ,  G02F2001/133374 ,  G02F2001/1515

Abstract: Syntheses of a new blue EC monomer (ProDOT-MePro), and a new red EC monomer (ProDOP-Et2) are described. Two additional new types of EC monomers based on 3, 4-alkylenedioxythiophene include fluorinated EC monomers and an EC monomer including silicon. EC polymer devices having more than one different color EC polymer to enable additional colors to be provided using subtractive color mixing are also described, as well as EC polymer devices incorporating a logo, image, or text, are generally obscured when the device is colored, but become visible when the device is not colored. Also described are EC polymer devices that include a cathodic EC polymer layer, a gel electrolyte, a counter electrode, and a reference electrode. Working prototypes of such devices exhibit significant increases in the speed of transition of the EC device from a colored state to a transparent state.

Abstract translation: 描述了新的蓝色EC单体（ProDOT-MePro）和新的红色EC单体（ProDOP-Et2）的合成。 基于3,4-亚烷基二氧噻吩的另外两种新型EC单体包括氟化EC单体和包含硅的EC单体。 还描述了具有多于一种不同颜色的EC聚合物的EC聚合物装置，以使得能够使用减色混合来提供附加的颜色，以及包含标志，图像或文本的EC聚合物装置在装置着色时通常是模糊的， 但当设备未着色时变得可见。 还描述了包括阴极EC聚合物层，凝胶电解质，对电极和参比电极的EC聚合物装置。 这种装置的工作原型表现出EC装置从有色状态转变为透明状态的速度的显着增加。

公开(公告)号：WO2004076701A3

公开(公告)日：2005-06-02

申请号：PCT/US2004006098

申请日：2004-02-27

Applicant: UNIV WASHINGTON ,  TAYA MINORU ,  WADA TAISHI ,  KUSAKA MASAHIRO ,  CHEN HSIUHUNG

Inventor： TAYA MINORU ,  WADA TAISHI ,  KUSAKA MASAHIRO ,  CHEN HSIUHUNG

IPC: C22C20060101 ,  F01B29/10 ,  F02G1/04 ,  F16F1/02 ,  F16F1/06 ,  F16K31/00 ,  H01F1/03 ,  H01F7/16 ,  H01L41/12 ,  H01L41/20

CPC classification number: H01F1/0308 ,  C08L2201/12 ,  F03G7/065 ,  F05B2250/70 ,  F05C2201/021 ,  F05C2201/0475 ,  F05C2201/0487 ,  F05C2253/04 ,  F16F1/021 ,  F16F2224/0258 ,  F16K31/002 ,  H01H2300/034 ,  H01L41/12 ,  H01L41/20 ,  H02N2/10

Abstract: The present invention employs an optimized cross-sectional shape for a ferromagnetic shape memory alloy (FSMA) composite that is used in a spring-type actuator, an improved hybrid magnetic trigger for use in FSMA based actuators, an a FSMA composite based spring type actuator, an a FSMA based spring type actuator including a stack of triggering units and FSMA springs, a FSMA composite based torque actuator. The invention also includes a model that can be employed to evaluate different materials being considered as components a FSMA for a FSMA composite used in either a FSMA based torque actuator or a FSMA spring actuator.

Abstract translation: 本发明对于用于弹簧式致动器的铁磁形状记忆合金（FSMA）复合材料采用优化的横截面形状，用于基于FSMA的致动器的改进的混合磁触发器，基于FSMA复合材料的弹簧型致动器 ，一个基于FSMA的弹簧式致动器，包括一组触发单元和FSMA弹簧，一个基于FSMA复合材料的扭矩致动器。 本发明还包括可以用于评估不同材料的模型，该材料被认为是在基于FSMA的扭矩致动器或FSMA弹簧致动器中使用的FSMA复合材料的FSMA的组件。

公开(公告)号：WO2006029174A2

公开(公告)日：2006-03-16

申请号：PCT/US2005/031767

申请日：2005-09-08

Applicant: UNIVERSITY OF WASHINGTON ,  TAYA, Minoru ,  URUSHIYAMA, Yuta ,  ZHAO, Ying

Inventor： TAYA, Minoru ,  URUSHIYAMA, Yuta ,  ZHAO, Ying

IPC: C25D3/00

CPC classification number: C25D5/18 ,  C25D3/562 ,  C25D5/48 ,  Y10T428/12479

Abstract: A method for making a ductile and porous shape memory alloy (SMA) using spark plasma sintering, and an energy absorbing structure including a ductile and porous SMA are disclosed. In an exemplary structure, an SMA spring encompasses a generally cylindrical energy absorbing material. The function of the SMA spring is to resist the bulging of the cylinder under large compressive loading, thereby increasing a buckling load that the cylindrical energy absorbing material can accommodate. The SMA spring also contributes to the resistance of the energy absorbing structure to an initial compressive loading. Preferably, the cylinder is formed of ductile, porous and super elastic SMA. A working prototype includes a NiTi spring, and a porous NiTi cylinder or rod.

Abstract translation: 公开了一种使用火花等离子体烧结制造延性和多孔形状记忆合金（SMA）的方法，以及包括延性和多孔SMA的能量吸收结构。 在示例性结构中，SMA弹簧包围大致圆柱形的能量吸收材料。 SMA弹簧的功能是在大的压缩载荷下抵抗气缸的膨胀，从而增加圆柱形能量吸收材料可以容纳的屈曲载荷。 SMA弹簧还有助于能量吸收结构抵抗初始压缩载荷。 优选地，圆筒由延性，多孔和超弹性SMA形成。 工作原型包括NiTi弹簧和多孔NiTi圆筒或棒。

公开(公告)号：WO2005050294A2

公开(公告)日：2005-06-02

申请号：PCT/US2004/038888

申请日：2004-11-18

Applicant: UNIVERSITY OF WASHINGTON ,  XU, Chunye ,  LIU, Lu ,  TAYA, Minoru

Inventor： XU, Chunye ,  LIU, Lu ,  TAYA, Minoru

IPC: G02F

CPC classification number: C09K9/02 ,  C08G61/123 ,  C08G61/124 ,  C08G61/126 ,  C09K2211/1029 ,  C09K2211/1096 ,  C09K2211/1458 ,  C09K2211/1466 ,  C09K2211/1491 ,  G01N21/553 ,  G02F1/155 ,  G02F2001/1515 ,  G02F2001/1555

Abstract: Electropolymerization of EC monomers is employed to obtain an EC polymer film deposited on a substrate. A first embodiment of a method to produce the film employs cyclic voltammetry alone, while a second embodiment deposits a very thin homogeneous layer using chronoamperometry, and then cyclic voltammetry is employed to increase the density of the film. Another aspect of the present invention is directed to specific web like configurations for a grid of conductive material deposited onto a transparent substrate. The web like configuration is based either on concentric circles, or on concentric ellipses. Yet another aspect of the present invention is directed to an imaging system including a digital window that is disposed between a prism and a patterned analytic layer.

Abstract translation: 使用EC单体的电聚合来获得沉积在基材上的EC聚合物膜。 制造薄膜的方法的第一实施例单独使用循环伏安法，而第二实施方案使用计时电流法沉积非常薄的均匀层，然后循环伏安法用于增加膜的密度。 本发明的另一方面涉及沉积在透明基底上的导电材料格栅的特定网状结构。 网状配置基于同心圆或同心椭圆。 本发明的另一方面涉及一种成像系统，其包括设置在棱镜和图案化分析层之间的数字窗口。