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公开(公告)号：AU1922092A
公开(公告)日：1992-12-21
申请号：AU1922092
申请日：1992-05-01
Inventor： JAMES M WILSON , MARIANN GROSSMAN , CATHERINE H WU , NAMITA ROY CHOWDHURY , GEORGE Y WU , JAYANTA ROY CHOWDHURY
IPC: A61K38/17 , A61K48/00 , C07K14/705 , C12N15/87
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公开(公告)号：US20160023904A1
公开(公告)日：2016-01-28
申请号：US14444845
申请日：2014-07-28
Applicant: Massachusetts Institute of Technology , University of Michigan, The Board of Regents Acting For and On behalf of the C/O Technology Man
Inventor： Anastasios John Hart , Sei Jin Park , Sameh Hani Tawfick , Michael FI De Volder
CPC classification number: C01B31/0233 , B81C1/00626 , C01B32/162 , C01B2202/02 , C01B2202/06 , C01B2202/08 , C01B2202/20 , C01B2202/36 , C23C16/52
Abstract: The present invention generally relates to articles comprising microstructures and methods for forming microstructures. The microstructures may be mechanically coupled to impart complex three dimensional shapes. For example, one or more microstructures may be grown on a substrate at different average growth rates, resulting in curved microstructures.
Abstract translation: 本发明一般涉及包含微结构的制品和用于形成微结构的方法。 微结构可以机械耦合以赋予复杂的三维形状。 例如，一个或多个微结构可以以不同的平均生长速率在衬底上生长，导致弯曲的微结构。
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公开(公告)号：WO1985001936A1
公开(公告)日：1985-05-09
申请号：PCT/US1984001736
申请日：1984-10-26
IPC: C04B35/48
CPC classification number: C04B35/645 , C04B35/10 , C04B35/119 , C04B35/185 , F02B3/06
Abstract: Novel transformation toughened ceramic compositions comprising finely divided ZrO2-HfO2 solid solution particles dispersed in a Al2O3-Cr2O3 (alumina) or 3Al2O3 . 2SiO2-3Cr2O3 . 2SiO2 (mullite) solid solution matrix phase. It is found that increased hardness and modulus associated with higher relative Cr2O3 content (e.g. 20 mole %) in the matrix phase and increased fracture toughness associated with higher relative HfO2 content (e.g. 10 to 20 mole %) in the disperse phase represent viable and improved ceramic compositions. Such transformation toughened ceramic compsitions are considered useful in superhot light diesel engine applications, high temperature gas turbines and ultrahigh temperature ceramic heat exchangers.
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公开(公告)号：WO2016018888A1
公开(公告)日：2016-02-04
申请号：PCT/US2015/042421
申请日：2015-07-28
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , UNIVERSITY OF MICHIGAN, THE BOARD OF REGENTS ACTING FOR AND ON BEHALF OF THE C/O TECHNOLOGY.. , IMEC VZW , KATHOLIEKE UNIVERSITEIT LEUVEN KU LEUVEN R&D
IPC: B81C1/00
CPC classification number: C01B31/0233 , B81C1/00626 , C01B32/162 , C01B2202/02 , C01B2202/06 , C01B2202/08 , C01B2202/20 , C01B2202/36 , C23C16/52
Abstract: The present invention generally relates to articles comprising microstructures and methods for forming microstructures. The microstructures may be mechanically coupled to impart complex three dimensional shapes. For example, one or more microstructures may be grown on a substrate at different average growth rates, resulting in curved microstructures.
Abstract translation: 本发明一般涉及包含微结构的制品和用于形成微结构的方法。 微结构可以机械耦合以赋予复杂的三维形状。 例如，一个或多个微结构可以以不同的平均生长速率在衬底上生长，导致弯曲的微结构。
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公开(公告)号：WO2010147656A3
公开(公告)日：2010-12-23
申请号：PCT/US2010/001745
申请日：2010-06-17
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , UNIVERSITY OF MICHIGAN, THE BOARD OF REGENTS ACTING FOR AND ON BEHALF OF THE C/O TECHNOLOGY MANAGEMENT OFFICE , WOODS HOLE OCEANOGRAPHIC INSTITUTE , PLATA, Desiree, L. , GSCHWEND, Philip, S. , HART, Anastasios, John , MESHOT, Eric, R. , REDDY, Christopher, M.
Inventor： PLATA, Desiree, L. , GSCHWEND, Philip, S. , HART, Anastasios, John , MESHOT, Eric, R. , REDDY, Christopher, M.
IPC: C01B31/02
Abstract: The present invention relates to the formation and processing of nanostructures including nanotubes. Some embodiments provide processes for nanostructure growth using relatively mild conditions (e.g., low temperatures). In some cases, methods of the invention may improve the efficiency (e.g., catalyst efficiency) of nanostructure formation and may reduce the production of undesired byproducts during nanostructure formation, including volatile organic compounds and/or polycylic aromatic hydrocarbons. Such methods can both reduce the costs associated with nanostructure formation, as well as reduce the harmful effects of nanostructure fabrication on environmental and public health and safety.
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Patent Agency Ranking6.发明申请SYNTHESIS OF N-GLYCOSYLATED COMPOUNDS WITH THE USE OF A MILD, IODINE-CATALYZED REACTION 审中-公开N-甲酰化合物的合成与使用微量的碘化反应
公开(公告)号：WO1994007900A1
公开(公告)日：1994-04-14
申请号：PCT/US1993009036
申请日：1993-09-23
IPC: C07H05/04
Abstract: The invention concerns N-glycosylated derivatives of nitrogen nucleophile compounds. The invention also concerns a mild, cost effective, stereoselective, regioselective, and generally applicable method for the preparation of N-glycosides by N-glycosylation of azide and amide nucleophile compounds. The method employs iodine in a catalytic amount that uniquely does not pose an environmental hazard. The invention provides efficient access to key intermediates for the synthesis inter alia of analogs of AZT and DDI and for the synthesis of conventional N-nucleoside antibiotic drugs and their novel N-glycosylated analogs.
Abstract translation: 本发明涉及氮亲核化合物的N-糖基化衍生物。 本发明还涉及通过叠氮化物和酰胺亲核化合物的N-糖基化制备N-糖苷的温和，成本有效的立体选择性，区域选择性和通常适用的方法。 该方法采用催化量的碘，其独特地不会造成环境危害。 本发明提供了用于合成特别是AZT和DDI的类似物以及用于合成常规N-核苷抗生素药物及其新型N-糖基化类似物的关键中间体的有效接触。
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公开(公告)号：WO1991002796A1
公开(公告)日：1991-03-07
申请号：PCT/CA1990000267
申请日：1990-08-20
Applicant: HSC RESEARCH DEVELOPMENT CORPORATION , THE BOARD OF REGENTS acting for and on behalf of ...
Inventor： HSC RESEARCH DEVELOPMENT CORPORATION , THE BOARD OF REGENTS acting for and on behalf of ... , TSUI, Lap-Chee , RIORDAN, John, R. , COLLINS, Francis, S. , ROMMENS, Johanna, M. , IANNUZZI, Michael, C. , KEREM, Bat-Sheva , DRUMM, Mitchell, L. , BUCHWALD, Manual
IPC: C12N15/12
CPC classification number: C07K16/28 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A61K48/00 , B82Y5/00 , C07K14/4712 , C07K16/18 , C12N15/8509
Abstract: The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.
Abstract translation: 描述了囊性纤维化基因及其基因产物，用于正常和突变形式。 遗传和蛋白质信息用于开发DNA诊断，蛋白质诊断，载体和患者筛选，药物和基因治疗，克隆基因和制造蛋白质，以及发展囊性纤维化受影响的动物。
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公开(公告)号：WO1995032956A1
公开(公告)日：1995-12-07
申请号：PCT/US1995006715
申请日：1995-05-26
Inventor： THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN , KOREEDA, Masato , SHULL, Brian, K. , YANG, Wu
IPC: C07D327/06
CPC classification number: C07H15/26
Abstract: Novel water-soluble mono and disaccharides of 1,2-dithiins, as well as methods for their synthesis and the synthesis of 3,6-bis(hydroxymethyl)-1,2-dithiin, are provided. The water-soluble compounds have useful medicinal applications, e.g., as an antifungal agent or antibacterial agent in a pharmaceutically acceptable carrier.
Abstract translation: 提供了1,2-二噻吩的新型水溶性单二糖和二糖，以及它们的合成方法和3,6-双（羟甲基）-1,2-二噻吩的合成。 水溶性化合物具有有用的医学应用，例如在药学上可接受的载体中作为抗真菌剂或抗菌剂。
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9.发明申请SYNTHESIS OF C-GLYCOSYLATED COMPOUNDS WITH THE USE OF A MILD, IODINE-CATALYZED REACTION 审中-公开使用C-GLYCOSYLATED化合物与微量元素催化反应的合成
公开(公告)号：WO1994007899A1
公开(公告)日：1994-04-14
申请号：PCT/US1993009037
申请日：1993-09-23
Inventor： THE BOARD OF REGENTS acting for and on behalf of ... , KOREEDA, Masato , HOUSTON, Todd, A.
IPC: C07H01/00
CPC classification number: C07D307/32 , C07D309/30
Abstract: The invention concerns C-glycosylated derivatives of soft carbon nucleophile compounds, particularly compounds which contain acid-labile structural units. The invention further concerns a mild, cost-effective, non-hazardous and stereoselective method of general application employing a glycal as a glycosylating agent and iodine as a catalyst for the preparation of C-glycosylated soft carbon nucleophile compounds.
Abstract translation: 本发明涉及软碳亲核试剂化合物的C-糖基化衍生物，特别是含酸不稳定结构单元的化合物。 本发明还涉及使用甘氨酸作为糖基化剂和碘作为制备C-糖基化的软碳亲核化合物的催化剂的一般应用的温和的，具有成本效益的非危险和立体选择性方法。
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公开(公告)号：WO1992019749A1
公开(公告)日：1992-11-12
申请号：PCT/US1992003639
申请日：1992-05-01
Applicant: THE BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ... , UNIVERSITY OF CONNECTICUT , ALBERT EINSTEIN COLLEGE OF MEDICINE, A DIVISION ...
Inventor： THE BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ... , UNIVERSITY OF CONNECTICUT , ALBERT EINSTEIN COLLEGE OF MEDICINE, A DIVISION ... , WILSON, James, M. , GROSSMAN, Mariann , WU, Catherine, H. , CHOWDHURY, Namita, Roy , WU, George, Y. , CHOWDHURY, Jayanta, Roy
IPC: C12N15/87
CPC classification number: A61K48/00 , A61K38/00 , C07K14/705 , C12N15/87
Abstract: Molecular complexes for targeting a gene encoding a cell surface receptor to a specific cell in vivo and obtaining expression of the gene and insertion of the gene-encoded receptor in the cell membrane. An expressible gene encoding a desired cell surface receptor is complexed with a carrier of a cell-specific binding agent and a gene-binding agent. The cell-specific binding agent is specific for a cellular surface structure which mediates internalization of ligands by endocytosis. An example is the asialoglycoprotein receptor of hepatocytes. The gene-binding agent is a compound such as a polycation which stably complexes the gene under extracellular conditions and releases the gene under intracellular conditions so that it can function within a cell. The molecular complex is stable and soluble in physiological fluids and can be used in gene therapy to selectively transfect cells in vivo to provide for production, membrane insertion and function of a cellular surface receptor.
Abstract translation: 分子复合物，用于靶向编码体内特定细胞的细胞表面受体的基因，并获得基因表达和基因编码的受体在细胞膜中的插入。 编码所需细胞表面受体的可表达基因与细胞特异性结合剂和基因结合剂的载体复合。 细胞特异性结合剂对通过内吞作用介导配体内化的细胞表面结构是特异性的。 一个例子是肝细胞的脱唾液酸糖蛋白受体。 基因结合剂是诸如聚阳离子的化合物，其在细胞外条件下稳定地复合基因并在细胞内条件下释放基因，使得其可以在细胞内起作用。 分子复合物是稳定的并且可溶于生理液体，可用于基因治疗以选择性转染体内细胞，以提供细胞表面受体的产生，膜插入和功能。
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